Heterobicyclic compounds

ABSTRACT

The present invention provides a compound represented by formula (I):  
                 
 
[wherein X—Y-Z represents R 5 N—C═O (wherein R 5  represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted lower alkenyl, or substituted or unsubstituted lower alkynyl), etc; R 1  and R 2  may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, etc; and R 3  and R 4  may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, etc], or a pharmaceutically acceptable salt thereof.

TECHNICAL FIELD OF THE INVENTION

The present invention relates to heterobicyclic compounds orpharmaceutically acceptable salts thereof which have glucoseconcentration-dependent insulin secretion promoting action or suitablehypoglycemic action and is useful as a therapeutic agent for diabetes.

BACKGROUND OF THE INVENTION

Diabetes is caused by a metabolic abnormality mainly of glycometabolism,resulting from insufficient insulin secretion, decreased sensitivity oftarget cells of insulin or the like, and principally characterized bynoticeable hyperglycemia. If the hyperglycemia continues for a longperiod of time, serious complications arise in various organs andnerves, such as retinopathy, nephropathy, or neuropathy, which arecaused mainly by vascular lesion. Therefore, for the treatment ofdiabetes, it is extremely important to control and maintain a bloodglucose level at a normal level, and methods for that purpose have beenstudied since old days.

For a type of diabetes where onset is gradual and insulin therapy is notnecessarily required for life support (non-insulin dependent diabetesmellitus: NIDDM), a blood glucose level can be controlled by combinationof exercise therapy and drug therapy. As the drugs, insulin secretionpromoters, one of orally available hypoglycemic agents, have widely beenused clinically. However, since currently available insulin secretionpromoters all promote insulin secretion independent of a glucose level,they cause problems of severe hypoglycemia or insufficient control ofblood glucose if doses are not appropriate, and are not fullysatisfactory drugs. If a hypoglycemic agent can be provided that iscapable of promoting insulin secretion depending on a blood glucoselevel, the agent is expected to be extremely useful for blood glucosecontrol of patients suffering from diabetes because the risk ofhypoglycemia due to an excess dosage can be avoided.

Japanese Published Unexamined Patent Application (Kokai) No. 91-204880;Journal of Medicinal Chemistry (J. Med. Chem.), vol. 35, p. 3578, 1992;Journal of Medicinal Chemistry (J. Med. Chem.), vol. 36, p. 2508, 1993;WO98/15555 and WO00/1388 disclose that compounds including a2,3-dihydroimidazo[1,2-c]pyrimidine or 2,3-dihydroimidazo[1,2-α]pyridinestructure as a part of their structure have diuretic action,antiasthmatic action, antidemential action, bronchodilatation action,antiallergic action, antiulcer action, or hypoglycemic action.

Also WO01/47931 discloses that condensed purine derivatives have insulinsecretion promoting action and hypoglycemic action.

SUMMARY OF THE INVENTION

An object of the present invention is to provide a compound useful forpreventive and/or therapeutic treatment of diabetes or complications ofdiabetes.

The present invention thus relates to the following (1) to (24).(1) A compound represented by Formula (I):

{wherein X—Y-Z represents R⁵N—C═O (wherein R⁵ represents a hydrogenatom, substituted or unsubstituted lower alkyl, substituted orunsubstituted aralkyl, substituted or unsubstituted lower alkenyl, orsubstituted or unsubstituted lower alkynyl), N═C—NR⁶R⁷ [wherein R⁶ andR⁷ may be the same or different and each represents a hydrogen atom,substituted or unsubstituted lower alkyl, substituted or unsubstitutedaralkyl, substituted or unsubstituted lower alkenyl, substituted orunsubstituted lower alkynyl, substituted or unsubstituted aryl, or asubstituted or unsubstituted heterocyclic group; or R⁶ and R⁷, arecombined together with the adjacent nitrogen atom thereto to form:

(wherein n represents an integer of 1 to 3; W represents —CH₂—, —CH═CH—,—NH—, a sulfur atom, or an oxygen atom; and R⁸ and R⁹ may be the same ordifferent and each represents a hydrogen atom, substituted orunsubstituted lower alkyl, substituted or unsubstituted aralkyl,substituted or unsubstituted aryl, a substituted or unsubstitutedheterocyclic group, substituted or unsubstituted lower alkoxycarbonyl,substituted or unsubstituted lower alkanoyl, substituted orunsubstituted aroyl, substituted or unsubstituted heteroaroyl, a halogenatom, amino, nitro, cyano, hydroxy, oxo, carboxy, carbamoyl, mono ordi(substituted or unsubstituted lower alkyl)amino, substituted orunsubstituted lower alkanoylamino, substituted or unsubstituted loweralkoxy, substituted or unsubstituted aralkyloxy, or substituted orunsubstituted lower alkanoyloxy)], or C═C—NR^(6a)R^(7a) (wherein R^(6a)and R^(7a) have the same meanings as R⁶ and R⁷ defined above,respectively); R¹ and R² may be the same or different and eachrepresents a hydrogen atom, substituted or unsubstituted lower alkyl,substituted or unsubstituted aralkyl, substituted or unsubstituted loweralkenyl, substituted or unsubstituted lower alkynyl, substituted orunsubstituted aryl, a substituted or unsubstituted heterocyclic group, ahalogen atom, carboxy, substituted or unsubstituted loweralkoxycarbonyl, or C(═O)—NR^(6b)R^(7b) (wherein R^(6b) and R^(7b) havethe same meanings as R⁶ and R⁷ defined above, respectively); and R³ andR⁴ may be the same or different and each represents a hydrogen atom,substituted or unsubstituted lower alkyl, substituted or unsubstitutedlower alkenyl, substituted or unsubstituted aralkyl, or a substituted orunsubstituted heterocyclic group; or R³ and R⁴ are combined togetherwith the adjacent nitrogen atom thereto to form:

(wherein na, W^(a), R^(8a), and R^(9a) have the same meanings as n, W,R⁸, and R⁹ defined above, respectively)}, or a pharmaceuticallyacceptable salt thereof. (2) The compound or the pharmaceuticallyacceptable salt thereof according to (1), wherein X—Y-Z is R⁵N—C═O(wherein R⁵ has the same meaning as defined above). (3) The compound orthe pharmaceutically acceptable salt thereof according to (1), whereinX—Y-Z is N═C—NR⁶R⁷ (wherein R⁶ and R⁷ have the same meanings as definedabove, respectively). (4) The compound or the pharmaceuticallyacceptable salt thereof according to (3), wherein R⁶ and R⁷ are nothydrogen atoms simultaneously. (5) The compound or the pharmaceuticallyacceptable salt thereof according to (3), wherein R⁶ is a hydrogen atomand R⁷ is substituted or unsubstituted pyrrolidinyl. (6) The compound orthe pharmaceutically acceptable salt thereof according to (1), whereinX—Y-Z is C═C—NR^(6a)R^(7a) (wherein R^(6a) and R^(7a) have the samemeanings as defined above, respectively). (7) The compound or thepharmaceutically acceptable salt thereof according to (6), whereinR^(6a) and R^(7a) are not hydrogen atoms simultaneously. (8) Thecompound or the pharmaceutically acceptable salt thereof according toany one of (1) to (7), wherein either R¹ or R² is a hydrogen atom andthe other is substituted or unsubstituted lower alkyl, or substituted orunsubstituted aralkyl; or R¹ and R² may be the same or different andeach is substituted or unsubstituted lower alkyl. (9) The compound orthe pharmaceutically acceptable salt thereof according to any one of (1)to (7), wherein R¹ is a hydrogen atom and R² is aralkyl. (10) Thecompound or the pharmaceutically acceptable salt thereof according toany one of (1) to (9), wherein R³ is a hydrogen atom and R⁴ is loweralkyl. (11) The compound or the pharmaceutically acceptable salt thereofaccording to any one of (1) to (9), wherein R³ is a hydrogen atom and R⁴is substituted or unsubstituted aralkyl. (12) A pharmaceuticalcomposition which comprises the compound or the pharmaceuticallyacceptable salt thereof according to any one of (1) to (11). (13) Apreventive and/or therapeutic agent for diabetes, which comprises thecompound or the pharmaceutically acceptable salt thereof according toany one of (1) to (11). (14) A preventive and/or therapeutic agent forcomplication of diabetes, which comprises the compound or thepharmaceutically acceptable salt thereof according to any one of (1) to(11). (15) An insulin secretion promoter which comprises the compound orthe pharmaceutically acceptable salt thereof according to any one of (1)to (11). (16) A hypoglycemic agent which comprises the compound or thepharmaceutically acceptable salt thereof according to any one of (1) to(11). (17) A method for preventing and/or treating diabetes, whichcomprises administering an effective amount of the compound or thepharmaceutically acceptable salt thereof according to any one of (1) to(11). (18) A method for preventing and/or treating a complication ofdiabetes, which comprises administering an effective amount of thecompound or the pharmaceutically acceptable salt thereof according toany one of (1) to (11). (19) A method for promoting insulin secretion,which comprises administering an effective amount of the compound or thepharmaceutically acceptable salt thereof according to any one of (1) to(11). (20) A method for decreasing blood glucose level, which comprisesadministering an effective amount of the compound or thepharmaceutically acceptable salt thereof according to any one of (1) to(11). (21) Use of the compound or the pharmaceutically acceptable saltthereof according to any one of (1) to (11) for the manufacture of apreventive and/or therapeutic agent for diabetes. (22) Use of thecompound or the pharmaceutically acceptable salt thereof according toany one of (1) to (11) for the manufacture of a preventive and/ortherapeutic agent for a complication of diabetes. (23) Use of thecompound or the pharmaceutically acceptable salt thereof according toany one of (1) to (11) for the manufacture of an insulin secretionpromoter. (24) Use of the compound or the pharmaceutically acceptablesalt thereof according to any one of (1) to (11) for the manufacture ofa hypoglycemic agent.

Hereinafter, the compounds represented by Formula (I) are referred to asCompound (I). The same shall apply to the compounds of the other formulanumbers.

Explanations of terminologies used to define each group in formula (I)are as follows:

Examples of the lower alkyl and the lower alkyl moieties of the loweralkoxy, lower alkoxycarbonyl, mono or di(lower alkyl)amino, loweralkanoyl, lower alkanoyloxy, and lower alkanoylamino include, forexample, straight-chain, branched, or cyclic alkyl, as well as acombination thereof, which have 1 to 10 carbon atoms, such as methyl,ethyl, propyl, isopropyl, cyclopropylmethyl, butyl, sec-butyl,tert-butyl, cyclobutyl, pentyl, neopentyl, cyclopentyl, hexyl,cyclohexyl, cyclohexylmethyl, heptyl, cycloheptyl, octyl, cyclooctyl,nonyl, decyl and the like. Two lower alkyl moieties of the di(loweralkyl)amino may be the same or different.

Examples of the lower alkenyl include, for example, straight-chain,branched, or cyclic alkenyl, as well as a combination thereof, whichhave 3 to 10 carbon atoms, such as allyl, 2-butenyl, 3-butenyl,4-pentenyl, 2-(1-cyclohexenyl)ethyl, 6-octenyl, 2,6-octadienyl, decenyland the like.

Examples of the lower alkynyl include, for example, straight-chain orbranched alkynyl which have 3 to 6 carbon atoms, such as propargyl,3-butynyl, 5-hexynyl and the like.

Examples of the aryl and the aryl moiety of the aroyl include, forexample, 5- to 14-membered monocyclic, bicyclic, or tricyclic aryl, suchas phenyl, naphthyl, indenyl, anthranyl and the like.

Examples of the aralkyl and the aralkyl moiety of the aralkyloxyinclude, for example, aralkyl which have 7 to 13 carbon atoms, such asbenzyl, phenethyl, phenylpropyl, benzhydryl, naphthylmethyl and thelike. Bicyclic aralkyl formed by aryl bonded to branched alkyl at twopositions, such as indanyl, 1,2,3,4-tetrahydronaphthyl,6,7,8,9-tetrahydro-5H-benzocycloheptyl and the like, are also includedthereto.

Examples of the heterocyclic group include an alicyclic heterocyclicgroup and an aromatic heterocyclic group. Examples of the alicyclicheterocyclic group include, for example, a 3- to 8-membered monocyclicalicyclic heterocyclic group containing at least one atom selected froma nitrogen atom, an oxygen atom, and a sulfur atom; and a bicyclic ortricyclic condensed alicyclic heterocyclic group in which 3- to8-membered rings are condensed and containing at least one atom selectedfrom a nitrogen atom, an oxygen atom, and a sulfur atom. More specificexamples include tetrahydropyranyl, tetrahydrofuranyl, pyranyl,thiopyranyl, pyrrolidinyl, piperidino, piperidyl, perhydroazepinyl,perhydroazocinyl, morpholino, morpholinyl, thiomorpholino,thiomorpholinyl, piperadinyl, homopiperadinyl, dioxolanyl,imidazolidinyl, imidazolinyl, pyrazolidinyl, indolinyl, isoindolinyl,2-pyrrolinyl, 2-pyrrolidonyl, 3-pyrrolidonyl, 2-piperidonyl,3-piperidonyl, 4-piperidonyl, perhydro-2-azepinonyl,perhydro-3-azepinonyl, perhydro-4-azepinonyl, 2-thiazolidonyl,4-thiazolidonyl, 2-oxazolidonyl, 4-oxazolidonyl, succinimido,phthalimido, glutarimido, maleimido, hydantoinyl, thiazolidinedionyl,oxazolidinedionyl, and the like. Examples of the aromatic heterocyclicgroup include, for example, a 3- to 8-membered monocyclic aromaticheterocyclic group containing at least one atom selected from a nitrogenatom, an oxygen atom, and a sulfur atom; and a bicyclic or tricycliccondensed aromatic heterocyclic group in which 3- to 8-membered ringsare condensed and containing at least one atom selected from a nitrogenatom, an oxygen atom, a sulfur atom. More specific examples includefuryl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl,oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, 1,2,3-oxadiazolyl,1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl,1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, furazanyl, pyridyl, pyrimidinyl,triazinyl, pyrazinyl, pyridazinyl, quinolyl, isoquinolyl, quinazolinyl,phthalazinyl, purinyl, benzodioxolyl, benzoxazolyl, benzothiazolyl,benzimidazolyl, indolyl, isoindolyl, 2-pyridonyl, 4-pyridonyl, uracilyl,and the like.

The heterocyclic moiety of the heteroaroyl has the same meaning as theabove-defined aromatic heterocyclic group.

The halogen atom represents a fluorine atom, a chlorine atom, a bromineatom, and an iodine atom.

Examples of substituents of the substituted lower alkenyl, substitutedlower alkoxycarbonyl, substituted lower alkanoyl, mono or di(substitutedlower alkyl)amino, substituted lower alkanoylamino, substituted loweralkoxy, substituted lower alkynyl, substituted lower alkanoyloxy,substituted aralkyl, substituted aryl, a substituted heterocyclic group,substituted aralkyloxy, substituted aroyl, and substituted heteroaroyl,which may be the same or different and, for example, in number of 1 to 3include a hydroxy, carboxy, nitro, cyano, amino, lower alkyl,trifluoromethyl, lower alkoxy, (lower alkoxy)lower alkyl, lower alkenyl,lower alkynyl, lower alkoxycarbonyl, lower alkanoyl, trifluoroacetyl,lower alkanoyloxy, lower alkanoylamino, lower alkylaminocarbonyl, monoor di(lower alkyl)amino, carbamoyl, methylenedioxy, lower alkylsulfinyl,lower alkylsulfonyl, mercapto, lower alkylthio, a halogen atom, aryl,aralkyl, aryloxy, aralkyloxy, aroyl, and a heterocyclic group. Thesesubstituents may contain other functional groups, such as, chlorophenyl,methylcarbamoyl, chlorobenzyl, and lower alkoxybenzyl. Herein, loweralkyl, lower alkoxy, lower alkenyl, lower alkynyl, lower alkoxycarbonyl,lower alkanoyl, lower alkanoyloxy, lower alkanoylamino, mono or di(loweralkyl)amino, aryl, aralkyl, aralkyloxy, aroyl, a heterocyclic group, anda halogen atom have the same meaning as defined above. Lower alkylmoieties of the lower alkylaminocarbonyl, lower alkylsulfinyl, loweralkylsulfonyl, lower alkylthio, and lower alkoxybenzyl are the same asthe above-defined lower alkyl. Aryl moieties of the aryloxy are the sameas the above-defined aryl. Lower alkyl moiety of the terminal loweralkoxy moiety in the (lower alkoxy)lower alkyl are the same as theabove-defined lower alkyl, and alkylene moiety correspond to thatobtained by eliminating one hydrogen atom from the above defined loweralkyl.

Examples of substituents of the substituted lower alkyl, which may bethe same or different, and in number of 1 to 3 include , for example,hydroxy, carboxy, nitro, cyano, amino, carbamoyl, methylenedioxy, loweralkoxy, (lower alkoxy)lower alkyl, (lower alkoxy)lower alkoxy, loweralkenyl, lower alkynyl, lower alkoxycarbonyl, lower alkanoyl,trifluoroacetyl, lower alkanoyloxy, lower alkanoylamino, loweralkylaminocarbonyl, mono or di(lower alkyl)amino, lower alkylsulfinyl,lower alkylsulfonyl, mercapto, lower alkylthio, a halogen atom, aryl,aralkyl, aryloxy, aralkyloxy, aroyl, or a substituted or unsubstitutedheterocyclic group. These substituents may contain other functionalgroups, such as chlorophenyl, methylcarbamoyl, chlorobenzyl, loweralkoxybenzyl, and the like. Herein, lower alkoxy, (lower alkoxy)loweralkyl, lower alkenyl, lower alkynyl, lower alkoxycarbonyl, loweralkanoyl, lower alkanoyloxy, lower alkanoylamino, loweralkylaminocarbonyl, mono or di(lower alkyl)amino, lower alkylsulfinyl,lower alkylsulfonyl, lower alkylthio, aryl, aralkyl, aryloxy,aralkyloxy, aroyl, a heterocyclic group, a halogen atom, and loweralkoxybenzyl have the same meaning as defined above and lower alkylmoiety of the terminal lower alkoxy moiety is the same as theabove-defined lower alkyl, and alkylene moiety correspond to thatobtained by eliminating one hydrogen atom from the above defined loweralkyl in (lower alkoxy)lower alkoxy. Substituents of the substitutedheterocyclic group are the same as the above-defined substituents of thesubstituted heterocyclic group.

Examples of the pharmaceutically acceptable salts of Compound (I)include, for example, metal salts, ammonium salts, organic amineaddition salts, amino acid addition salts, acid addition salts and thelike. Examples of the pharmaceutically acceptable metal salts include,for example, alkaline metal salts such as sodium salts and potassiumsalts, alkaline earth metal salts such as magnesium salts and calciumsalts, as well as aluminum salts, zinc salts and the like. Examples ofpharmaceutically acceptable ammonium salts include salts of an ammoniumsalt, tetramethylammonium salt and the like. Examples ofpharmaceutically acceptable organic amine addition salts include, forexample, addition salts such as morpholine and piperidine. Examples ofpharmaceutically acceptable amino acid addition salts include, forexample, addition salts with amino acids such as lysine, glycine,phenylalanine and the like. Examples of pharmaceutically acceptable acidaddition salts include, for example, inorganic acid salts such ashydrochlorides, sulfates, and phosphates; and organic acid salts such asacetates, maleates, fumarates, tartrates, and citrates.

Compound (I) of the present invention may have a stereoisomer, aregioisomer, a tautomer, or the like. Any possible isomers and mixturesthereof fall within the scope of the present invention in any mixingratio.

Compound (I) can be produced, for example, by the following preparationmethod.

When any defined group changes under a given reaction condition or isnot suitable for carrying out a reaction process, in the preparationmethod mentioned below, preparation may be readily carried out byapplying methods commonly used in the field of synthetic organicchemistry such as protection and deprotection of a functional group(see,for example, T. W. Greene, Protective Groups in Organic Synthesis, thirdedition, John Wiley & Sons, Inc. (1999) and the like). The order of thereaction steps such as introduction of the substituents can be changed,if necessary.

Production Method 1: Compound (I-A) which corresponds to Compound (I)wherein X—Y-Z represents R⁵N—C═O (wherein R⁵ has the same meaning asdefined above) can be synthesized according to Steps 1 to 5 describedbelow:

(wherein R¹, R², R³, R⁴ and R⁵ have the same meanings as defined above,respectively)[Step 1]

Compound (IV) can be obtained by reacting commercially availableCompound (II) with 1 equivalent to large excess, preferably 1 to 3equivalents of Compound (III) in an inert solvent. Compound (III) iscommercially available or can be synthesized by known methods. Thereaction is usually performed at a temperature between 0° C. and 100°C., preferably at a temperature between 0° C. and 50° C., for about 10minutes to 24 hours. Any solvent can be used, so long as it is inert tothe reaction. Examples of the inert solvent include tetrahydrofuran,dioxane, diethyl ether, diisopropyl ether, benzene, toluene, xylene,ethyl acetate, acetonitrile, dichloromethane, chloroform,dichloroethane, dimethylformamide, dimethylacetamide,N-methylpyrrolidone, dimethyl sulfoxide, pyridine, and any mixturethereof, preferably, tetrahydrofuran, chloroform, and mixtures thereof,although there is no limitation thereto. The reaction may be perfomed byadding a base with, 1 equivalent to large excess, preferably, 1 to 10equivalents. Examples of the base include, for example, various organicor inorganic bases such as triethylamine, diisopropylethylamine,1,8-diazabicyclo[5.4.0]-7-undecene (DBU), N,N-dimethylaniline, pyridine,quinoline, potassium carbonate, sodium carbonate, lithium carbonate,sodium hydrogen carbonate, potassium hydroxide, sodium hydroxide,lithium hydroxide, potassium tert-butoxide and the like; various basicanion exchange resins such as Amberlyst A-21 (ROHM AND HAAS), AG 1-X8(Bio-Rad Laboratories), and the like; and various bases immobilized onsolid-phases such as polyvinylpyridine morpholinomethyl polystyrene andthe like, preferably, triethylamine.

[Step 2]

Compound (V) can be obtained by treating Compound (IV) synthesized inStep 1 with 1 to 5 equivalents of a chlorinating agent such as thionylchloride and phosphorus oxychloride in an inert solvent. The reaction isusually performed at a temperature between room temperature and 200° C.,preferably at a temperature between 50° C. and 100° C., for about 1 to50 hours. Any solvent can be used, so long as it is inert to thereaction. Examples of the inert solvent include tetrahydrofuran,dioxane, diisopropyl ether, benzene, toluene, xylene, ethyl acetate,dichloromethane, chloroform, dichloroethane, pyridine, triethylamine,and any mixture thereof preferably, chloroform, although there is nolimitation thereto. The reaction may be performed, by adding 1equivalent to large excess, preferably, 1 to 10 equivalents of a base.Examples of the base include various organic bases such astriethylamine, diisopropylethylamine, DBU, N,N-dimethylaniline,pyridine, quinoline and the like; and various bases immobilized onsolid-phases such as polyvinylpyridine, morpholinomethyl polystyrene andthe like, preferably, polyvinylpyridine.

[Step 3]

Compound (IV) can be obtained by treating Compound (V) synthesized inStep 2 with 1 equivalent to large excess, preferably 3 to 10 equivalentsof a base in a protic solvent. The reaction is usually performed at atemperature between room temperature and 200° C., preferably at atemperature between 50° C. and 120° C., for 1 to 100 hours. Examples ofthe solvent for the reaction include, for example, protic solvents suchas water, methanol, ethanol, propanol, butanol and the like, used eachalone or as a mixture thereof; or a mixture of any of these proticsolvents and non-protic solvents such as tetrahydrofuran, dioxane,diethyl ether, diisopropyl ether, benzene, toluene, xylene, ethylacetate, acetonitrile, dichloromethane, chloroform, dichloroethane,dimethylformamide, dimethylacetamide, N-methylpyrrolidone, dimethylsulfoxide, pyridine and the like; and preferably, a water-chloroformmixture and a water-ethanol mixture. Examples of the base include, forexample, potassium carbonate, sodium carbonate, sodium hydrogencarbonate, lithium carbonate, potassium hydroxide, sodium hydroxide,lithium hydroxide, potassium tert-butoxide, Amberlyst A-21 (ROHM ANDHAAS), AG 1-X8 (Bio-Rad Laboratories) and the like.

[Step 4]

Compound (VIII) can be obtained by reacting Compound

(VI) synthesized in Step 3 with 1 to 5 equivalents of Compound (VII) inthe presence of 1 to 10 equivalents of a condensing agent in an inertsolvent. Compound (VII) is commercially available or can be synthesizedby known methods. The reaction is usually performed at a temperaturebetween 0° C. and 150° C., preferably at a temperature between roomtemperature and 80° C., for about 1 to 120 hours. Any solvent can beused, so long as it is inert to the reaction. Examples of the inertsolvent include dichloromethane, chloroform, dichloroethane,dimethylformamide, dimethylacetamide, N-methylpyrrolidone, dimethylsulfoxide, tetrahydrofuran, dioxane, diethyl ether, diisopropyl ether,benzene, toluene, xylene, ethyl acetate, acetonitrile, and any mixturethereof, preferably, chloroform, tetrahydrofuran, and any mixturesthereof, although there is no limitation thereto. Examples of thecondensing agent include, for example, dicyclohexylcarbodiimide,diisopropylcarbodiimide, N-ethyl-N′-(3-dimethylaminopropyl)carbodiimideor its hydrochloride, N-ethyl-N′-(3-dimethylaminopropyl)carbodiimidesupported on polystyrene, N-benzyl-N′-cyclohexylcarbodiimide supportedon polystyrene, benzotriazol-1-yl-tris(dimethylamino)phosphoniumhexafluorophosphide salt, and diphenylphosphoryl azide, preferably,N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide or its hydrochloride, andN-ethyl-N′-(3-dimethylaminopropyl)carbodiimide supported on polystyrene.The reaction may be performed in the coexistence of 1 to 5 equivalentsof an additive, and examples of which include, for example,N-hydroxysuccinimide, 1-hydroxybenzotriazole,3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine and the like,preferably, 1-hydroxybenzotriazole.

[Step 5]

Compound (I-A) can be obtained by subjecting Compound (VIII) synthesizedin Step 4 with 1 to 5 equivalents of Compound (IX) to a Mitsunobureaction in an inert solvent. Compound (IX) is commercially available orcan be synthesized by known methods. The reaction is usually performedat a temperature between 0° C. and 100° C., preferably at a temperaturebetween room temperature and 60° C., for about 1 to 50 hours. Anysolvent can be used, so long as it is inert to the reaction. Examples ofthe inert solvent include dichloromethane, chloroform, dichloroethane,dimethylformamide, dimethylacetamide, N-methylpyrrolidone, dimethylsulfoxide, tetrahydrofuran, dioxane, diethyl ether, diisopropyl ether,benzene, toluene, xylene, ethyl acetate, acetonitrile, and mixturesthereof, preferably, tetrahydrofuran, although there is no limitationthereto. Condensing agents necessary for the Mitsunobu reaction may beany agents generally used in the reaction, such as a combination of 1 to10 equivalents of dialkyl azodicarboxylate and 1 to 10 equivalents oftriphenylphosphine or trialkylphosphine; and 1 to 10 equivalents of(cyanomethylene)triphenylphosphorane and the like, preferably, acombination of 1 to 3 equivalents of diethylazodicarboxylate (DEAD) and1 to 3 equivalents of triphenyl phosphine.

Preparation Method 2: Compound (I-B) which corresponds to Compound (I)wherein X—Y-Z represents N═C—NR⁶R⁷ (wherein R⁶ and R⁷ have the samemeanings as defined above, respectively) can be synthesized according toSteps 6 to 9 described below:

(wherein R¹, R², R³, R⁴, R⁶ and R⁷ have the same meanings as definedabove, respectively)[Step 6]

Compound (X) can be obtained by treating Compound (IV) synthesized inStep 1 of the Preparation Method 1 with 1 equivalent to large excess,preferably 3 to 10 equivalents of a base in a protic solvent. Thereaction is usually performed at a temperature between 0° C. and 100°C., preferably at a temperature between room temperature and 80° C., for1 to 100 hours. Examples of the solvent for the reaction include, forexample, protic solvents such as water, methanol, ethanol, propanol,butanol and the like used each alone or a mixture thereof; or a mixtureof any of these protic solvents and non-protic solvents such astetrahydrofuran, dioxane, diethyl ether, diisopropyl ether, benzene,toluene, xylene, ethyl acetate, acetonitrile, dichloromethane,chloroform, dichloroethane, dimethylformamide, dimethyl acetamide,N-methylpyrrolidone, dimethyl sulfoxide, pyridine and the like,preferably, a water-ethanol mixture. Examples of the base include, forexample, potassium carbonate, sodium carbonate, sodium hydrogencarbonate, lithium carbonate, potassium hydroxide, sodium hydroxide,lithium hydroxide, potassium tert-butoxide, Amberlyst A-21 (ROHM ANDHAAS), AG1-X8 (Bio-Rad Laboratories), and the like.

[Step 7]

Compound (XI) can be obtained by reacting Compound (X) synthesized inStep 6 with 1 to 5 equivalents of Compound (VII) in the presence of 1 to10 equivalents of a condensing agent in an inert solvent. Compound (VII)is commercially available or can be synthesized by known methods. Thereaction is usually performed at a temperature between 0° C. and 150°C., preferably at a temperature between room temperature and 60° C., forabout 1 to 120 hours. Any solvent can be used, so long as it is inert tothe reaction. Examples of the inert solvent include dichloromethane,chloroform, dichloroethane, dimethylformamide, dimethylacetamide,N-methylpyrrolidone, dimethyl sulfoxide, tetrahydrofuran, dioxane,diethyl ether, diisopropyl ether, benzene, toluene, xylene, ethylacetate, acetonitrile, and any mixture thereof preferably, chloroform,tetrahydrofuran, and mixtures thereof, although there is no limitationthereto. Examples of the condensing agent include, for example,dicyclohexylcarbodiimide, diisopropylcarbodiimide,N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide or its hydrochloride,N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide supported on polystyrene,N-benzyl-N′-cyclohexylcarbodiimide supported on polystyrene,benzotriazol-1-yl-tris(dimethylamino)phosphonium hexafluorophosphidesalt, diphenylphosphoryl azide and the like, preferably,N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide or its hydrochloride,N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide supported on polystyrene.The reaction may be performed in the coexistence of 1 to 5 equivalentsof an additive, examples of which include N-hydroxysuccinimide,1-hydroxybenzotriazole, 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazineand the like, preferably, 1-hydroxybenzotriazole.

[Step 8]

Compound (XII) can be obtained by treating Compound (XI) synthesized inStep 7 with 1 to 5 equivalents of a chlorinating agent such as thionylchloride, phosphorus oxychloride and the like, in an inert solvent. Thereaction is usually performed at a temperature between room temperatureand 200° C., preferably at a temperature between 50° C. and 100° C., forabout 1 to 50 hours. Any Solvent can be used, so long as it is inert tothe reaction. Examples of the inert solvent include tetrahydrofuran,dioxane, diisopropyl ether, benzene, toluene, xylene, ethyl acetate,dichloromethane, chloroform, dichloroethane, pyridine, triethylamine,and any mixture thereof, preferably, chloroform, although there is nolimitation thereto. In the reaction, 1 equivalent to large excess,preferably 1 to 10 equivalents of a base may be added. Examples of thebase include, for example, various organic bases such as triethylamine,diisopropylethylamine, DBU, N,N-dimethylaniline, pyridine, quinoline andthe like; and various bases immobilized on solid-phases such aspolyvinylpyridine morpholinomethyl polystyrene and the like, preferably,polyvinylpyridine.

[Step 9]

Compound (I-B) can be obtained by reacting Compound (XII) synthesized inStep 8 with 1 to 10 equivalents, preferably 2 to 5 equivalents ofCompound (XIII) in an inert solvent. The reaction is usually performedat a temperature between room temperature and 200° C., preferably at atemperature between 50° C. and 100° C., for about 1 to 100 hours. Anysolvent can be used, so long as it is inert to the reaction. Examples ofthe inert solvent include tetrahydrofuran, dioxane, diethyl ether,diisopropyl ether, benzene, toluene, xylene, ethyl acetate,acetonitrile, dichloromethane, chloroform, dichloroethane,dimethylformamide, dimethylacetamide, N-methylpyrrolidone, dimethylsulfoxide, pyridine, and any mixture thereof, preferably,tetrahydrofuran, chloroform, and mixtures thereof, although there is nolimitation thereto. In the reaction, 1 equivalent to large excess,preferably 1 to 10 equivalents of a base may be added. Examples of thebase include various organic and inorganic bases such as triethylamine,diisopropylethylamine, DBU, N,N-dimethylaniline, pyridine, quinoline,potassium carbonate, sodium carbonate, lithium carbonate, sodiumhydrogen carbonate, potassium hydroxide, sodium hydroxide, lithiumhydroxide, potassium tert-butoxide and the like; various basic anionexchange resins such as Amberlyst A-21 (ROHM AND HAAS) AG1-X8 (Bio-RadLaboratories) and the like; and various bases immobilized onsolid-phases such as polyvinylpyridine morpholinomethyl polystyrene andthe like preferably, polyvinylpyridine.

Preparation Method 3: Compound (I-C), which corresponds to Compound (I)wherein X—Y-Z represents C═C—NR^(6a)R^(7a) (wherein R^(6a) and R^(7a)have the same meanings as defined above, respectively) can besynthesized according to Steps 10 to 13 described below:

(wherein R¹, R², R³, R⁴, R^(6a) and R^(7a) have the same meanings asdefined above, respectively)[Step 10]

Compound (XV) can be obtained by reacting commercially availableCompound (XIV) with 1 equivalent to large excess, preferably 1 to 3equivalents of Compound (III) in an inert solvent. Compound (III) iscommercially available or can be synthesized by known methods. Thereaction is usually performed at a temperature between 50° C. and 200°C., preferably at a temperature between 80° C. and 150° C., for about 1hour to 10 days. Any solvent can be used, so long as it is inert to thereaction. Examples of the inert solvent include tetrahydrofuran,dioxane, diethyl ether, diisopropyl ether, benzene, toluene, xylene,ethyl acetate, acetonitrile, dichloromethane, chloroform,dichloroethane, dimethylformamide, dimethylacetamide,N-methylpyrrolidone, dimethyl sulfoxide, pyridine, and any mixturethereof, preferably, dioxane, although there is no limitation thereto.In the reaction, 1 equivalent to large excess, preferably 1 to 10equivalents of a base may be added. Examples of the base include variousorganic or inorganic bases such as triethylamine, diisopropylethylamine,DBU, N,N-dimethylaniline, pyridine, quinoline, potassium carbonate,sodium carbonate, lithium carbonate, sodium hydrogen carbonate,potassium hydroxide, sodium hydroxide, lithium hydroxide, potassiumtert-butoxide and the like; various basic anion exchange resins such asAmberlyst A-21 (ROHM AND HAAS), AG1-X8 (Bio-Rad Laboratories) and thelike; and various bases immobilized on solid-phases such aspolyvinylpyridine, morpholinomethyl polystyrene, and the likepreferably, triethylamine.

[Step 11]

Compound (XVI) can be obtained by reacting Compound (XV) synthesized inStep 10, in a similar manner described in Step 7, with 1 to 5equivalents of Compound (VII) in the presence of 1 to 10 equivalents ofa condensing agent in an inert solvent at a temperature between 0° C.and 150° C., preferably at a temperature between room temperature and60° C. for 1 to 120 hours.

[Step 12]

Compound (XVII) can be obtained by treating Compound (XVI) synthesizedin Step 11, in a similar manner described in Step 8, with 1 to 5equivalents of a chlorinating agent in the presence or absence of a basein an inert solvent at a temperature between room temperature and 200°C., preferably at a temperature between 50° C. and 120° C. for 1 to 50hours.

[Step 13]

Compound (I-C) can be obtained by reacting Compound (XVII) synthesizedin Step 12 with 1 to 5 equivalents, preferably 2 to 5 equivalents ofCompound (XIIIa) in the presence of 1 to 10 equivalents, preferably 2 to5 equivalents of a condensing agent in an inert solvent. The reaction isusually performed at a temperature between 0° C. and 100° C., preferablyat a temperature between room temperature and 80° C., for about 1 to 100hours. Any solvent can be used, so long as it is inert to the reaction.Examples of the inert solvent include dichloromethane, chloroform,dichloroethane, dimethylformamide, dimethylacetamide,N-methylpyrrolidone, dimethyl sulfoxides, tetrahydrofuran, dioxane,diethyl ether, diisopropyl ether, benzene, toluene, xylene, ethylacetate, acetonitrile, and any mixture thereof, preferably,tetrahydrofuran, although there is no limitation thereto. Examples ofthe condensing agent include, for example, a combination ofdialkylazodicarboxylate and triphenylphosphine or trialkylphosphine,(cyanomethylene)triphenylphosphorane and the like, preferably,(cyanomethylene)triphenylphosphorane.

Intermediates and target compounds obtained in the aforementionedpreparation methods can be isolated and purified by separation andpurification methods ordinarily used in the field of synthetic organicchemistry, such as, filtration, extraction, washing, drying,concentration, recrystallization, various chromatographic techniques,and the like. Furthermore, these compounds may be purified bypurification methods that are generally used in typical parallelsynthesis processes with, for example, a scavenger resin or an ionexchange resin. Intermediates may also be used for subsequent reactionswithout particular purification. For the preparation of salts ofCompound (I), the final products may be purified without modificationwhen they are obtained as salts in the aforementioned reactionprocesses. When the final products are obtained as compounds in a freeform, they may be dissolved or suspended in a suitable solvent withaddition of an acid or a base to form a salt which may be isolated andpurified. It is also possible to convert a final product obtained in aform of a salt into a compound in a free form and then convert theresulting product into a desired salt.

Specific examples of compounds suitable as medicinally activeingredients of the present invention in Compound (I) are shown below.These examples, however, are not intended to limit the scope of thepresent invention.

Partial structures of the compounds are listed in Tables 1 through 3,wherein Me and Et represent methyl and ethyl, respectively. TABLE 1-1Number

A-01

A-02

A-03

A-04

A-05

A-06

A-07

A-08

A-09

A-10

A-11

A-12

A-13

A-14

A-15

A-16

A-17

A-18

A-19

A-20

A-21

A-22

TABLE 1-2 Number

A-23

A-24

A-25

A-26

A-27

A-28

A-29

A-30

A-31

A-32

A-33

A-34

A-35

A-36

A-37

A-38

A-39

A-40

A-41

A-42

A-43

A-44

TABLE 1-3 Number

A-45

A-46

A-47

A-48

A-49

A-50

A-51

A-52

A-53

A-54

A-55

A-56

A-57

A-58

A-59

A-60

A-61

A-62

A-63

A-64

A-65

A-66

TABLE 1-4 Number

A-67

A-67

A-69

A-70

A-71

A-72

TABLE 2-1 Number

B-01

B-02

B-03

B-04

B-05

B-06

B-07

B-08

B-09

B-10

B-11

B-12

B-13

B-14

B-15

B-16

B-17

B-18

B-19

B-20

B-21

B-22

TABLE 2-2 Number

B-23

B-24

B-25

B-26

B-27

B-28

B-29

B-30

B-31

B-32

B-33

B-34

B-35

B-36

B-37

B-38

B-39

B-40

B-41

B-42

B-43

B-44

TABLE 2-3 Number

B-45

B-46

B-47

B-48

B-49

B-50

B-51

B-52

B-53

B-54

B-55

B-56

B-57

B-58

TABLE 3-1 Number

C-01

C-02

C-03

C-04

C-05

C-06

C-07

C-08

C-09

C-10

C-11

C-12

C-13

C-14

C-15

C-16

C-17

C-18

C-19

C-20

C-21

C-22

TABLE 3-2 Number

C-23

C-24

C-25

C-26

C-27

C-28

C-29

C-30

C-31

C-32

C-33

C-34

C-35

C-36

C-37

C-38

C-39

C-40

C-41

C-42

C-43

C-44

TABLE 3-3 Number

C-45

C-46

C-47

C-48

(a) The examples of compounds described in

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —R⁵ and spectrum data thereof.

-   1-1; A-01; B-01; MS m/z 351 (M+H)⁺-   1-2; A-01; B-02; MS m/z 355 (M+H)⁺-   1-3; A-01; B-03; MS m/z 313 (M+H)⁺-   1-4; A-01; B-04; MS m/z 371 (M+H)⁺-   1-5; A-01; B-05; MS m/z 383 (M+H)⁺-   1-6; A-01; B-06; MS m/z 423 (M+H)⁺-   1-7; A-01; B-07; MS m/z 403 (M+H)⁺-   1-8; A-01; B-08; MS m/z 409 (M+H)⁺-   1-9; A-01; B-09; MS m/z 411 (M+H)⁺-   1-10; A-01; B-10; MS m/z 433 (M+H)⁺-   1-11; A-01; B-11; MS m/z 437 (M+H)⁺-   1-12; A-01; B-12; MS m/z 445 (M+H)⁺-   1-13; A-01; B-13; MS m/z 359 (M+H)⁺-   1-14; A-01; B-14; MS m/z 367 (M+H)⁺-   1-15; A-01; B-15; MS m/z 381 (M+H)⁺-   1-16; A-01; B-16; MS m/z 387 (M+H)⁺-   1-17; A-01; B-17; MS m/z 393 (M+H)⁺-   1-18; A-01; B-18; MS m/z 397 (M+H)⁺-   1-19; A-01; B-19; MS m/z 407 (M+H)⁺-   1-20; A-01; B-20; MS m/z 409 (M+H)⁺-   1-21; A-01; B-21; MS m/z 413 (M+H)⁺-   1-22; A-01; B-22; MS m/z 417 (M+H)⁺-   1-23; A-01; B-23; MS m/z 429 (M+H)⁺-   1-24; A-01; B-24; MS m/z 429 (M+H)⁺-   1-25; A-01; B-25; MS m/z 398 (M+H)⁺-   1-26; A-01; B-26; MS m/z 438 (M+H)⁺-   1-27; A-01; B-27; MS m/z 438 (M+H)⁺-   1-28; A-01; B-28; MS m/z 431 (M+H)⁺-   1-29; A-01; B-29; MS m/z 435 (M+H)⁺-   1-30; A-01; B-30; MS m/z 447 (M+H)⁺-   1-31; A-01; B-31; MS m/z 449 (M+H)⁺-   1-32; A-01; B-32; MS m/z 451 (M+H)⁺-   1-33; A-01; B-33; MS m/z 451 (M+H)⁺-   1-34; A-01; B-34; MS m/z 461 (M+H)⁺-   1-35; A-01; B-35; MS m/z 475 (M+H)⁺-   1-36; A-01; B-36; MS m/z 493 (M+H)⁺-   1-37; A-02; B-01; MS m/z 363 (M+H)⁺-   1-38; A-02; B-02; MS m/z 367 (M+H)⁺-   1-39; A-02; B-03; MS m/z 325 (M+H)⁺-   1-40; A-02; B-04; MS m/z 383 (M+H)⁺-   1-41; A-02; B-05; MS m/z 395 (M+H)⁺-   1-42; A-02; B-06; MS m/z 435 (M+H)⁺-   1-43; A-02; B-07; MS m/z 415 (M+H)⁺-   1-44; A-02; B-08; MS m/z 421 (M+H)⁺-   1-45; A-02; B-09; MS m/z 423 (M+H)⁺-   1-46; A-02; B-10; MS m/z 445 (M+H)⁺-   1-47; A-02; B-11; MS m/z 449 (M+H)⁺-   1-48; A-02; B-12; MS m/z 457 (M+H)⁺-   1-49; A-02; B-13; MS m/z 371 (M+H)⁺-   1-50; A-02; B-14; MS m/z 379 (M+H)⁺-   1-51; A-02; B-15; MS m/z 393 (M+H)⁺-   1-52; A-02; B-16; MS m/z 399 (M+H)⁺-   1-53; A-02; B-17; MS m/z 405 (M+H)⁺-   1-54; A-02; B-18; MS m/z 409 (M+H)⁺-   1-55; A-02; B-19; MS m/z 419 (M+H)⁺-   1-56; A-02; B-20; MS m/z 421 (M+H)⁺-   1-57; A-02; B-21; MS m/z 425 (M+H)⁺-   1-58; A-02; B-22; MS m/z 429 (M+H)⁺-   1-59; A-02; B-23; MS m/z 441 (M+H)⁺-   1-60; A-02; B-24; MS m/z 441 (M+H)⁺-   1-61; A-02; B-25; MS m/z 410 (M+H)⁺-   1-62; A-02; B-26; MS m/z 450 (M+H)⁺-   1-63; A-02; B-27; MS m/z 450 (M+H)⁺-   1-64; A-02; B-28; MS m/z 443 (M+H)⁺-   1-65; A-02; B-29; MS m/z 447 (M+H)⁺-   1-66; A-02; B-30; MS m/z 459 (M+H)⁺-   1-67; A-02; B-31; MS m/z 461 (M+H)⁺-   1-68; A-02; B-32; MS m/z 463 (M+H)⁺-   1-69; A-02; B-33; MS m/z 463 (M+H)⁺-   1-70; A-02; B-34; MS m/z 473 (M+H)⁺-   1-71; A-02; B-35; MS m/z 487 (M+H)⁺-   1-72; A-02; B-36; MS m/z 505 (M+H)⁺-   1-73; A-03; B-01; MS m/z 363 (M+H)⁺-   1-74; A-03; B-02; MS m/z 367 (M+H)⁺-   1-75; A-03; B-03; MS m/z 325 (M+H)⁺-   1-76; A-03; B-04; MS m/z 383 (M+H)⁺-   1-77; A-03; B-05; MS m/z 395 (M+H)⁺-   1-78; A-03; B-06; MS m/z 435 (M+H)⁺-   1-79; A-03; B-07; MS m/z 415 (M+H)⁺-   1-80; A-03; B-08; MS m/z 421 (M+H)⁺-   1-81; A-03; B-09; MS m/z 423 (M+H)⁺-   1-82; A-03; B-10; MS m/z 445 (M+H)⁺-   1-83; A-03; B-11; MS m/z 449 (M+H)⁺-   1-84; A-03; B-12; MS m/z 457 (M+H)⁺-   1-85; A-03; B-13; MS m/z 371 (M+H)⁺-   1-86; A-03; B-14; MS m/z 379 (M+H)⁺-   1-87; A-03; B-15; MS m/z 393 (M+H)⁺-   1-88; A-03; B-16; MS m/z 399 (M+H)⁺-   1-89; A-03; B-17; MS m/z 405 (M+H)⁺-   1-90; A-03; B-18; MS m/z 409 (M+H)⁺-   1-91; A-03; B-19; MS m/z 419 (M+H)⁺-   1-92; A-03; B-20; MS m/z 421 (M+H)⁺-   1-93; A-03; B-21; MS m/z 425 (M+H)⁺-   1-94; A-03; B-22; MS m/z 429 (M+H)⁺-   1-95; A-03; B-23; MS m/z 441 (M+H)⁺-   1-96; A-03; B-24; MS m/z 441 (M+H)⁺-   1-97; A-03; B-25; MS m/z 410 (M+H)⁺-   1-98; A-03; B-26; MS m/z 450 (M+H)⁺-   1-99; A-03; B-27; MS m/z 450 (M+H)⁺-   1-100; A-03; B-28; MS m/z 443 (M+H)⁺-   1-101; A-03; B-29; MS m/z 447 (M+H)⁺-   1-102; A-03; B-30; MS m/z 459 (M+H)⁺-   1-103; A-03; B-31; MS m/z 461 (M+H)⁺-   1-104; A-03; B-32; MS m/z 463 (M+H)⁺-   1-105; A-03; B-33; MS m/z 463 (M+H)⁺-   1-106; A-03; B-34; MS m/z 473 (M+H)⁺-   1-107; A-03; B-35; MS m/z 487 (M+H)⁺-   1-108; A-03; B-36; MS m/z 505 (M+H)⁺-   1-109; A-04; B-01; MS m/z 365 (M+H)⁺-   1-110; A-04; B-02; MS m/z 369 (M+H)⁺-   1-111; A-04; B-03; MS m/z 327 (M+H)⁺-   1-112; A-04; B-04; MS m/z 385 (M+H)⁺-   1-113; A-04; B-05; MS m/z 397 (M+H)⁺-   1-114; A-04; B-06; MS m/z 437 (M+H)⁺-   1-115; A-04; B-07; MS m/z 417 (M+H)⁺-   1-116; A-04; B-08; MS m/z 423 (M+H)⁺-   1-117; A-04; B-09; MS m/z 425 (M+H)⁺-   1-118; A-04; B-10; MS m/z 447 (M+H)⁺-   1-119; A-04; B-11; MS m/z 451 (M+H)⁺-   1-120; A-04; B-12; MS m/z 459 (M+H)⁺-   1-121; A-04; B-13; MS m/z 373 (M+H)⁺-   1-122; A-04; B-14; MS m/z 381 (M+H)⁺-   1-123; A-04; B-15; MS m/z 395 (M+H)⁺-   1-124; A-04; B-16; MS m/z 401 (M+H)⁺-   1-125; A-04; B-17; MS m/z 407 (M+H)⁺-   1-126; A-04; B-18; MS m/z 411 (M+H)⁺-   1-127; A-04; B-19; MS m/z 421 (M+H)⁺-   1-128; A-04; B-20; MS m/z 423 (M+H)⁺-   1-129; A-04; B-21; MS m/z 427 (M+H)⁺-   1-130; A-04; B-22; MS m/z 431 (M+H)⁺-   1-131; A-04; B-23; MS m/z 443 (M+H)⁺-   1-132; A-04; B-24; MS m/z 443 (M+H)⁺-   1-133; A-04; B-25; MS m/z 412 (M+H)⁺-   1-134; A-04; B-26; MS m/z 452 (M+H)⁺-   1-135; A-04; B-27; MS m/z 452 (M+H)⁺-   1-136; A-04; B-28; MS m/z 445 (M+H)⁺-   1-137; A-04; B-29; MS m/z 449 (M+H)⁺-   1-138; A-04; B-30; MS m/z 461 (M+H)⁺-   1-139; A-04; B-31; MS m/z 463 (M+H)⁺-   1-140; A-04; B-32; MS m/z 465 (M+H)⁺-   1-141; A-04; B-33; MS m/z 465 (M+H)⁺-   1-142; A-04; B-34; MS m/z 475 (M+H)⁺-   1-143; A-04; B-35; MS m/z 489 (M+H)⁺-   1-144; A-04; B-36; MS m/z 507 (M+H)⁺-   1-145; A-05; B-01; MS m/z 379 (M+H)⁺-   1-146; A-05; B-02; MS m/z 383 (M+H)⁺-   1-147; A-05; B-03; MS m/z 341 (M+H)⁺-   1-148; A-05; B-04; MS m/z 399 (M+H)⁺-   1-149; A-05; B-05; MS m/z 411 (M+H)⁺-   1-150; A-05; B-06; MS m/z 451 (M+H)⁺-   1-151; A-05; B-07; MS m/z 431 (M+H)⁺-   1-152; A-05; B-08; MS m/z 437 (M+H)⁺-   1-153; A-05; B-09; MS m/z 439 (M+H)⁺-   1-154; A-05; B-10; MS m/z 461 (M+H)⁺-   1-155; A-05; B-11; MS m/z 465 (M+H)⁺-   1-156; A-05; B-12; MS m/z 473 (M+H)⁺-   1-157; A-05; B-13; MS m/z 387 (M+H)⁺-   1-158; A-05; B-14; MS m/z 395 (M+H)⁺-   1-159; A-05; B-15; MS m/z 409 (M+H)⁺-   1-160; A-05; B-16; MS m/z 415 (M+H)⁺-   1-161; A-05; B-17; MS m/z 421 (M+H)⁺-   1-162; A-05; B-18; MS m/z 425 (M+H)⁺-   1-163; A-05; B-19; MS m/z 435 (M+H)⁺-   1-164; A-05; B-20; MS m/z 437 (M+H)⁺-   1-165; A-05; B-21; MS m/z 441 (M+H)⁺-   1-166; A-05; B-22; MS m/z 445 (M+H)⁺-   1-167; A-05; B-23; MS m/z 457 (M+H)⁺-   1-168; A-05; B-24; MS m/z 457 (M+H)⁺-   1-169; A-05; B-25; MS m/z 426 (M+H)⁺-   1-170; A-05; B-26; MS m/z 466 (M+H)⁺-   1-171; A-05; B-27; MS m/z 466 (M+H)⁺-   1-172; A-05; B-28; MS m/z 459 (M+H)⁺-   1-173; A-05; B-29; MS m/z 463 (M+H)⁺-   1-174; A-05; B-30; MS m/z 475 (M+H)⁺-   1-175; A-05; B-31; MS m/z 477 (M+H)⁺-   1-176; A-05; B-32; MS m/z 479 (M+H)⁺-   1-177; A-05; B-33; MS m/z 479 (M+H)⁺-   1-178; A-05; B-34; MS m/z 489 (M+H)⁺-   1-179; A-05; B-35; MS m/z 503 (M+H)⁺-   1-180; A-05; B-36; MS m/z 521 (M+H)⁺-   1-181; A-06; B-01; MS m/z 381 (M+H)⁺-   1-182; A-06; B-02; MS m/z 385 (M+H)⁺-   1-183; A-06; B-03; MS m/z 343 (M+H)⁺-   1-184; A-06; B-04; MS m/z 401 (M+H)⁺-   1-185; A-06; B-05; MS m/z 413 (M+H)⁺-   1-186; A-06; B-06; MS m/z 453 (M+H)⁺-   1-187; A-06; B-07; MS m/z 433 (M+H)⁺-   1-188; A-06; B-08; MS m/z 439 (M+H)⁺-   1-189; A-06; B-09; MS m/z 441 (M+H)⁺-   1-190; A-06; B-10; MS m/z 463 (M+H)⁺-   1-191; A-06; B-11; MS m/z 467 (M+H)⁺-   1-192; A-06; B-12; MS m/z 475 (M+H)⁺-   1-193; A-06; B-13; MS m/z 389 (M+H)⁺-   1-194; A-06; B-14; MS m/z 397 (M+H)⁺-   1-195; A-06; B-15; MS m/z 411 (M+H)⁺-   1-196; A-06; B-16; MS m/z 417 (M+H)⁺-   1-197; A-06; B-17; MS m/z 423 (M+H)⁺-   1-198; A-06; B-18; MS m/z 427 (M+H)⁺-   1-199; A-06; B-19; MS m/z 437 (M+H)⁺-   1-200; A-06; B-20; MS m/z 439 (M+H)⁺-   1-201; A-06; B-21; MS m/z 443 (M+H)⁺-   1-202; A-06; B-22; MS m/z 447 (M+H)⁺-   1-203; A-06; B-23; MS m/z 459 (M+H)⁺-   1-204; A-06; B-24; MS m/z 459 (M+H)⁺-   1-205; A-06; B-25; MS m/z 428 (M+H)⁺-   1-206; A-06; B-26; MS m/z 468 (M+H)⁺-   1-207; A-06; B-27; MS m/z 468 (M+H)⁺-   1-208; A-06; B-28; MS m/z 461 (M+H)⁺-   1-209; A-06; B-29; MS m/z 465 (M+H)⁺-   1-210; A-06; B-30; MS m/z 477 (M+H)⁺-   1-211; A-06; B-31; MS m/z 479 (M+H)⁺-   1-212; A-06; B-32; MS m/z 481 (M+H)⁺-   1-213; A-06; B-33; MS m/z 481 (M+H)⁺-   1-214; A-06; B-34; MS m/z 491 (M+H)⁺-   1-215; A-06; B-35; MS m/z 505 (M+H)⁺-   1-216; A-06; B-36; MS m/z 523 (M+H)⁺-   1-217; A-07; B-01; MS m/z 379 (M+H)⁺-   1-218; A-07; B-02; MS m/z 383 (M+H)⁺-   1-219; A-07; B-03; MS m/z 341 (M+H)⁺-   1-220; A-07; B-04; MS m/z 399 (M+H)⁺-   1-221; A-07; B-05; MS m/z 411 (M+H)⁺-   1-222; A-07; B-06; MS m/z 451 (M+H)⁺-   1-223; A-07; B-07; MS m/z 431 (M+H)⁺-   1-224; A-07; B-08; MS m/z 437 (M+H)⁺-   1-225; A-07; B-09; MS m/z 439 (M+H)⁺-   1-226; A-07; B-10; MS m/z 461 (M+H)⁺-   1-227; A-07; B-11; MS m/z 465 (M+H)⁺-   1-228; A-07; B-12; MS m/z 473 (M+H)⁺-   1-229; A-07; B-13; MS m/z 387 (M+H)⁺-   1-230; A-07; B-14; MS m/z 395 (M+H)⁺-   1-231; A-07; B-15; MS m/z 409 (M+H)⁺-   1-232; A-07; B-16; MS m/z 415 (M+H)⁺-   1-233; A-07; B-17; MS m/z 421 (M+H)⁺-   1-234; A-07; B-18; MS m/z 425 (M+H)⁺-   1-235; A-07; B-19; MS m/z 435 (M+H)⁺-   1-236; A-07; B-20; MS m/z 437 (M+H)⁺-   1-237; A-07; B-21; MS m/z 441 (M+H)⁺-   1-238; A-07; B-22; MS m/z 445 (M+H)⁺-   1-239; A-07; B-23; MS m/z 457 (M+H)⁺-   1-240; A-07; B-24; MS m/z 457 (M+H)⁺-   1-241; A-07; B-25; MS m/z 426 (M+H)⁺-   1-242; A-07; B-26; MS m/z 466 (M+H)⁺-   1-243; A-07; B-27; MS m/z 466 (M+H)⁺-   1-244; A-07; B-28; MS m/z 459 (M+H)⁺-   1-245; A-07; B-29; MS m/z 463 (M+H)⁺-   1-246; A-07; B-30; MS m/z 475 (M+H)⁺-   1-247; A-07; B-31; MS m/z 477 (M+H)⁺-   1-248; A-07; B-32; MS m/z 479 (M+H)⁺-   1-249; A-07; B-33; MS m/z 479 (M+H)⁺-   1-250; A-07; B-34; MS m/z 489 (M+H)⁺-   1-251; A-07; B-35; MS m/z 503 (M+H)⁺-   1-252; A-07; B-36; MS m/z 521 (M+H)⁺-   1-253; A-08; B-01; MS m/z 381 (M+H)⁺-   1-254; A-08; B-02; MS m/z 385 (M+H)⁺-   1-255; A-08; B-03; MS m/z 343 (M+H)⁺-   1-256; A-08; B-04; MS m/z 401 (M+H)⁺-   1-257; A-08; B-05; MS m/z 413 (M+H)⁺-   1-258; A-08; B-06; MS m/z 453 (M+H)⁺-   1-259; A-08; B-07; MS m/z 433 (M+H)⁺-   1-260; A-08; B-08; MS m/z 439 (M+H)⁺-   1-261; A-08; B-09; MS m/z 441 (M+H)⁺-   1-262; A-08; B-10; MS m/z 463 (M+H)⁺-   1-263; A-08; B-11; MS m/z 467 (M+H)⁺-   1-264; A-08; B-12; MS m/z 475 (M+H)⁺-   1-265; A-08; B-13; MS m/z 389 (M+H)⁺-   1-266; A-08; B-14; MS m/z 397 (M+H)⁺-   1-267; A-08; B-15; MS m/z 411 (M+H)⁺-   1-268; A-08; B-16; MS m/z 417 (M+H)⁺-   1-269; A-08; B-17; MS m/z 423 (M+H)⁺-   1-270; A-08; B-18; MS m/z 427 (M+H)⁺-   1-271; A-08; B-19; MS m/z 437 (M+H)⁺-   1-272; A-08; B-20; MS m/z 439 (M+H)⁺-   1-273; A-08; B-21; MS m/z 443 (M+H)⁺-   1-274; A-08; B-22; MS m/z 447 (M+H)⁺-   1-275; A-08; B-23; MS m/z 459 (M+H)⁺-   1-276; A-08; B-24; MS m/z 459 (M+H)⁺-   1-277; A-08; B-25; MS m/z 428 (M+H)⁺-   1-278; A-08; B-26; MS m/z 468 (M+H)⁺-   1-279; A-08; B-27; MS m/z 468 (M+H)⁺-   1-280; A-08; B-28; MS m/z 461 (M+H)⁺-   1-281; A-08; B-29; MS m/z 465 (M+H)⁺-   1-282; A-08; B-30; MS m/z 477 (M+H)⁺-   1-283; A-08; B-31; MS m/z 479 (M+H)⁺-   1-284; A-08; B-32; MS m/z 481 (M+H)⁺-   1-285; A-08; B-33; MS m/z 481 (M+H)⁺-   1-286; A-08; B-34; MS m/z 491 (M+H)⁺-   1-287; A-08; B-35; MS m/z 505 (M+H)⁺-   1-288; A-08; B-36; MS m/z 523 (M+H)⁺-   1-289; A-09; B-01; MS m/z 405 (M+H)⁺-   1-290; A-09; B-02; MS m/z 409 (M+H)⁺-   1-291; A-09; B-03; MS m/z 367 (M+H)⁺-   1-292; A-09; B-04; MS m/z 425 (M+H)⁺-   1-293; A-09; B-05; MS m/z 437 (M+H)⁺-   1-294; A-09; B-06; MS m/z 477 (M+H)⁺-   1-295; A-09; B-07; MS m/z 457 (M+H)⁺-   1-296; A-09; B-08; MS m/z 463 (M+H)⁺-   1-297; A-09; B-09; MS m/z 465 (M+H)⁺-   1-298; A-09; B-10; MS m/z 487 (M+H)⁺-   1-299; A-09; B-11; MS m/z 491 (M+H)⁺-   1-301; A-09; B-12; MS m/z 499 (M+H)⁺-   1-302; A-09; B-13; MS m/z 413 (M+H)⁺-   1-303; A-09; B-14; MS m/z 421 (M+H)⁺-   1-304; A-09; B-15; MS m/z 435 (M+H)⁺-   1-305; A-09; B-16; MS m/z 441 (M+H)⁺-   1-306; A-09; B-17; MS m/z 447 (M+H)⁺-   1-307; A-09; B-18; MS m/z 451 (M+H)⁺-   1-308; A-09; B-19; MS m/z 461 (M+H)⁺-   1-309; A-09; B-20; MS m/z 463 (M+H)⁺-   1-310; A-09; B-21; MS m/z 467 (M+H)⁺-   1-311; A-09; B-22; MS m/z 471 (M+H)⁺-   1-312; A-09; B-23; MS m/z 483 (M+H)⁺-   1-313; A-09; B-24; MS m/z 483 (M+H)⁺-   1-314; A-09; B-25; MS m/z 452 (M+H)⁺-   1-315; A-09; B-26; MS m/z 492 (M+H)⁺-   1-316; A-09; B-27; MS m/z 492 (M+H)⁺-   1-317; A-09; B-28; MS m/z 485 (M+H)⁺-   1-318; A-09; B-29; MS m/z 489 (M+H)⁺-   1-319; A-09; B-30; MS m/z 501 (M+H)⁺-   1-320; A-09; B-31; MS m/z 503 (M+H)⁺-   1-321; A-09; B-32; MS m/z 505 (M+H)⁺-   1-322; A-09; B-33; MS m/z 505 (M+H)⁺-   1-323; A-09; B-34; MS m/z 515 (M+H)⁺-   1-324; A-09; B-35; MS m/z 529 (M+H)⁺-   1-325; A-09; B-36; MS m/z 547 (M+H)⁺-   1-326; A-09; B-48; MS m/z 477 (M+H)⁺-   1-327; A-09; B-49; MS m/z 475 (M+H)⁺-   1-328; A-09; B-50; MS m/z 461 (M+H)⁺-   1-329; A-09; B-51; MS m/z 477 (M+H)⁺-   1-330; A-09; B-52; MS m/z 475 (M+H)⁺-   1-331; A-09; B-53; MS m/z 463 (M+H)⁺-   1-332; A-09; B-54; MS m/z 491 (M+H)⁺-   1-333; A-09; B-55; MS m/z 461 (M+H)⁺-   1-334; A-09; B-56; MS m/z 473 (M+H)⁺-   1-335; A-09; B-57; MS m/z 479 (M+H)⁺-   1-336; A-09; B-58; MS m/z 457 (M+H)⁺-   1-337; A-10; B-01; MS m/z 405 (M+H)⁺-   1-338; A-10; B-02; MS m/z 409 (M+H)⁺-   1-339; A-10; B-03; MS m/z 367 (M+H)⁺-   1-340; A-10; B-04; MS m/z 425 (M+H)⁺-   1-341; A-10; B-05; MS m/z 437 (M+H)⁺-   1-342; A-10; B-06; MS m/z 477 (M+H)⁺-   1-343; A-10; B-07; MS m/z 457 (M+H)⁺-   1-344; A-10; B-08; MS m/z 463 (M+H)⁺-   1-345; A-10; B-09; MS m/z 465 (M+H)⁺-   1-346; A-10; B-10; MS m/z 487 (M+H)⁺-   1-347; A-10; B-11; MS m/z 491 (M+H)⁺-   1-348; A-10; B-12; MS m/z 499 (M+H)⁺-   1-349; A-10; B-13; MS m/z 413 (M+H)⁺-   1-350; A-10; B-14; MS m/z 421 (M+H)⁺-   1-351; A-10; B-15; MS m/z 435 (M+H)⁺-   1-352; A-10; B-16; MS m/z 441 (M+H)⁺-   1-353; A-10; B-17; MS m/z 447 (M+H)⁺-   1-354; A-10; B-18; MS m/z 451 (M+H)⁺-   1-355; A-10; B-19; MS m/z 461 (M+H)⁺-   1-356; A-10; B-20; MS m/z 463 (M+H)⁺-   1-357; A-10; B-21; MS m/z 467 (M+H)⁺-   1-358; A-10; B-22; MS m/z 471 (M+H)⁺-   1-359; A-10; B-23; MS m/z 483 (M+H)⁺-   1-360; A-10; B-24; MS m/z 483 (M+H)⁺-   1-361; A-10; B-25; MS m/z 452 (M+H)⁺-   1-362; A-10; B-26; MS m/z 492 (M+H)⁺-   1-363; A-10; B-27; MS m/z 492 (M+H)⁺-   1-364; A-10; B-28; MS m/z 485 (M+H)⁺-   1-365; A-10; B-29; MS m/z 489 (M+H)⁺-   1-366; A-10; B-30; MS m/z 501 (M+H)⁺-   1-367; A-10; B-31; MS m/z 503 (M+H)⁺-   1-368; A-10; B-32; MS m/z 505 (M+H)⁺-   1-369; A-10; B-33; MS m/z 505 (M+H)⁺-   1-370; A-10; B-34; MS m/z 515 (M+H)⁺-   1-371; A-10; B-35; MS m/z 529 (M+H)⁺-   1-372; A-10; B-36; MS m/z 547 (M+H)⁺-   1-373; A-11; B-01; MS m/z 405 (M+H)⁺-   1-374; A-11; B-02; MS m/z 409 (M+H)⁺-   1-375; A-11; B-03; MS m/z 367 (M+H)⁺-   1-376; A-11; B-04; MS m/z 425 (M+H)⁺-   1-377; A-11; B-05; MS m/z 437 (M+H)⁺-   1-378; A-11; B-06; MS m/z 477 (M+H)⁺-   1-379; A-11; B-07; MS m/z 457 (M+H)⁺-   1-380; A-11; B-08; MS m/z 463 (M+H)⁺-   1-381; A-11; B-09; MS m/z 465 (M+H)⁺-   1-382; A-11; B-10; MS m/z 487 (M+H)⁺-   1-383; A-11; B-11; MS m/z 491 (M+H)⁺-   1-384; A-11; B-12; MS m/z 499 (M+H)⁺-   1-385; A-11; B-13; MS m/z 413 (M+H)⁺-   1-386; A-11; B-14; MS m/z 421 (M+H)⁺-   1-387; A-11; B-15; MS m/z 435 (M+H)⁺-   1-388; A-11; B-16; MS m/z 441 (M+H)⁺-   1-389; A-11; B-17; MS m/z 447 (M+H)⁺-   1-390; A-11; B-18; MS m/z 451 (M+H)⁺-   1-391; A-11; B-19; MS m/z 461 (M+H)⁺-   1-392; A-11; B-20; MS m/z 463 (M+H)⁺-   1-393; A-11; B-21; MS m/z 467 (M+H)⁺-   1-394; A-11; B-22; MS m/z 471 (M+H)⁺-   1-395; A-11; B-23; MS m/z 483 (M+H)⁺-   1-396; A-11; B-24; MS m/z 483 (M+H)⁺-   1-397; A-11; B-25; MS m/z 452 (M+H)⁺-   1-398; A-11; B-26; MS m/z 492 (M+H)⁺-   1-399; A-11; B-27; MS m/z 492 (M+H)⁺-   1-400; A-11; B-28; MS m/z 485 (M+H)⁺-   1-401; A-11; B-29; MS m/z 489 (M+H)⁺-   1-402; A-11; B-30; MS m/z 501 (M+H)⁺-   1-403; A-11; B-31; MS m/z 503 (M+H)⁺-   1-404; A-11; B-32; MS m/z 505 (M+H)⁺-   1-405; A-11; B-33; MS m/z 505 (M+H)⁺-   1-406; A-11; B-34; MS m/z 515 (M+H)⁺-   1-407; A-11; B-35; MS m/z 529 (M+H)⁺-   1-408; A-11; B-36; MS m/z 547 (M+H)⁺-   1-409; A-12; B-01; MS m/z 405 (M+H)⁺-   1-410; A-12; B-02; MS m/z 409 (M+H)⁺-   1-411; A-12; B-03; MS m/z 367 (M+H)⁺-   1-412; A-12; B-04; MS m/z 425 (M+H)⁺-   1-413; A-12; B-05; MS m/z 437 (M+H)⁺-   1-414; A-12; B-06; MS m/z 477 (M+H)⁺-   1-415; A-12; B-07; MS m/z 457 (M+H)⁺-   1-416; A-12; B-08; MS m/z 463 (M+H)⁺-   1-417; A-12; B-09; MS m/z 465 (M+H)⁺-   1-418; A-12; B-10; MS m/z 487 (M+H)⁺-   1-419; A-12; B-11; MS m/z 491 (M+H)⁺-   1-420; A-12; B-12; MS m/z 499 (M+H)⁺-   1-421; A-12; B-13; MS m/z 413 (M+H)⁺-   1-422; A-12; B-14; MS m/z 421 (M+H)⁺-   1-423; A-12; B-15; MS m/z 435 (M+H)⁺-   1-424; A-12; B-16; MS m/z 441 (M+H)⁺-   1-425; A-12; B-17; MS m/z 447 (M+H)⁺-   1-426; A-12; B-18; MS m/z 451 (M+H)⁺-   1-427; A-12; B-19; MS m/z 461 (M+H)⁺-   1-428; A-12; B-20; MS m/z 463 (M+H)⁺-   1-429; A-12; B-21; MS m/z 467 (M+H)⁺-   1-430; A-12; B-22; MS m/z 471 (M+H)⁺-   1-431; A-12; B-23; MS m/z 483 (M+H)⁺-   1-432; A-12; B-24; MS m/z 483 (M+H)⁺-   1-433; A-12; B-25; MS m/z 452 (M+H)⁺-   1-434; A-12; B-26; MS m/z 492 (M+H)⁺-   1-435; A-12; B-27; MS m/z 492 (M+H)⁺-   1-436; A-12; B-28; MS m/z 485 (M+H)⁺-   1-437; A-12; B-29; MS m/z 489 (M+H)⁺-   1-438; A-12; B-30; MS m/z 501 (M+H)⁺-   1-439; A-12; B-31; MS m/z 503 (M+H)⁺-   1-440; A-12; B-32; MS m/z 505 (M+H)⁺-   1-441; A-12; B-33; MS m/z 505 (M+H)⁺-   1-442; A-12; B-34; MS m/z 515 (M+H)⁺-   1-443; A-12; B-35; MS m/z 529 (M+H)⁺-   1-444; A-12; B-36; MS m/z 547 (M+H)⁺-   1-445; A-13; B-01; MS m/z 413 (M+H)⁺-   1-446; A-13; B-02; MS m/z 417 (M+H)⁺-   1-448; A-13; B-03; MS m/z 375 (M+H)⁺-   1-449; A-13; B-04; MS m/z 433 (M+H)⁺-   1-450; A-13; B-05; MS m/z 445 (M+H)⁺-   1-451; A-13; B-06; MS m/z 485 (M+H)⁺-   1-452; A-13; B-07; MS m/z 465 (M+H)⁺-   1-453; A-13; B-08; MS m/z 471 (M+H)⁺-   1-454; A-13; B-09; MS m/z 473 (M+H)⁺-   1-455; A-13; B-10; MS m/z 495 (M+H)⁺-   1-456; A-13; B-11; MS m/z 499 (M+H)⁺-   1-457; A-13; B-12; MS m/z 507 (M+H)⁺-   1-458; A-13; B-13; MS m/z 421 (M+H)⁺-   1-459; A-13; B-14; MS m/z 429 (M+H)⁺-   1-460; A-13; B-15; MS m/z 443 (M+H)⁺-   1-461; A-13; B-16; MS m/z 449 (M+H)⁺-   1-462; A-13; B-17; MS m/z 455 (M+H)⁺-   1-463; A-13; B-18; MS m/z 459 (M+H)⁺-   1-464; A-13; B-19; MS m/z 469 (M+H)⁺-   1-465; A-13; B-20; MS m/z 471 (M+H)⁺-   1-466; A-13; B-21; MS m/z 475 (M+H)⁺-   1-467; A-13; B-22; MS m/z 479 (M+H)⁺-   1-468; A-13; B-23; MS m/z 491 (M+H)⁺-   1-469; A-13; B-24; MS m/z 491 (M+H)⁺-   1-470; A-13; B-25; MS m/z 460 (M+H)⁺-   1-471; A-13; B-26; MS m/z 500 (M+H)⁺-   1-472; A-13; B-27; MS m/z 500 (M+H)⁺-   1-473; A-13; B-28; MS m/z 493 (M+H)⁺-   1-474; A-13; B-29; MS m/z 497 (M+H)⁺-   1-475; A-13; B-30; MS m/z 509 (M+H)⁺-   1-476; A-13; B-31; MS m/z 511 (M+H)⁺-   1-477; A-13; B-32; MS m/z 513 (M+H)⁺-   1-478; A-13; B-33; MS m/z 513 (M+H)⁺-   1-479; A-13; B-34; MS m/z 523 (M+H)⁺-   1-480; A-13; B-35; MS m/z 537 (M+H)⁺-   1-481; A-13; B-36; MS m/z 555 (M+H)⁺-   1-482; A-13; B-37; MS m/z 415 (M+H)⁺-   1-483; A-13; B-38; MS m/z 429 (M+H)⁺-   1-484; A-13; B-39; MS m/z 429 (M+H)⁺-   1-485; A-13; B-40; MS m/z 431 (M+H)⁺-   1-486; A-13; B-41; MS m/z 403 (M+H)⁺-   1-487; A-13; B-42; MS m/z 431 (M+H)⁺-   1-488; A-13; B-43; MS m/z 431 (M+H)⁺-   1-489; A-13; B-44; MS m/z 443 (M+H)⁺-   1-490; A-13; B-45; MS m/z 445 (M+H)⁺-   1-491; A-13; B-46; MS m/z 443 (M+H)⁺-   1-492; A-13; B-47; MS m/z 445 (M+H)⁺-   1-493; A-14; B-01; MS m/z 413 (M+H)⁺-   1-494; A-14; B-02; MS m/z 417 (M+H)⁺-   1-495; A-14; B-03; MS m/z 375 (M+H)⁺-   1-496; A-14; B-04; MS m/z 433 (M+H)⁺-   1-497; A-14; B-05; MS m/z 445 (M+H)⁺-   1-498; A-14; B-06; MS m/z 485 (M+H)⁺-   1-499; A-14; B-07; MS m/z 465 (M+H)⁺-   1-500; A-14; B-08; MS m/z 471 (M+H)⁺-   1-501; A-14; B-09; MS m/z 473 (M+H)⁺-   1-502; A-14; B-10; MS m/z 495 (M+H)⁺-   1-503; A-14; B-11; MS m/z 499 (M+H)⁺-   1-504; A-14; B-12; MS m/z 507 (M+H)⁺-   1-505; A-14; B-13; MS m/z 421 (M+H)⁺-   1-506; A-14; B-14; MS m/z 429 (M+H)⁺-   1-507; A-14; B-15; MS m/z 443 (M+H)⁺-   1-508; A-14; B-16; MS m/z 449 (M+H)⁺-   1-509; A-14; B-17; MS m/z 455 (M+H)⁺-   1-510; A-14; B-18; MS m/z 459 (M+H)⁺-   1-511; A-14; B-19; MS m/z 469 (M+H)⁺-   1-512; A-14; B-20; MS m/z 471 (M+H)⁺-   1-513; A-14; B-21; MS m/z 475 (M+H)⁺-   1-514; A-14; B-22; MS m/z 479 (M+H)⁺-   1-515; A-14; B-23; MS m/z 491 (M+H)⁺-   1-516; A-14; B-24; MS m/z 491 (M+H)⁺-   1-517; A-14; B-25; MS m/z 460 (M+H)⁺-   1-518; A-14; B-26; MS m/z 500 (M+H)⁺-   1-519; A-14; B-27; MS m/z 500 (M+H)⁺-   1-520; A-14; B-28; MS m/z 493 (M+H)⁺-   1-521; A-14; B-29; MS m/z 497 (M+H)⁺-   1-522; A-14; B-30; MS m/z 509 (M+H)⁺-   1-523; A-14; B-31; MS m/z 511 (M+H)⁺-   1-524; A-14; B-32; MS m/z 513 (M+H)⁺-   1-525; A-14; B-33; MS m/z 513 (M+H)⁺-   1-526; A-14; B-34; MS m/z 523 (M+H)⁺-   1-527; A-14; B-35; MS m/z 537 (M+H)⁺-   1-528; A-14; B-36; MS m/z 555 (M+H)⁺-   1-529; A-15; B-01; MS m/z 421 (M+H)⁺-   1-530; A-15; B-02; MS m/z 425 (M+H)⁺-   1-531; A-15; B-03; MS m/z 383 (M+H)⁺-   1-532; A-15; B-04; MS m/z 441 (M+H)⁺-   1-533; A-15; B-05; MS m/z 453 (M+H)⁺-   1-534; A-15; B-06; MS m/z 493 (M+H)⁺-   1-535; A-15; B-07; MS m/z 473 (M+H)⁺-   1-536; A-15; B-08; MS m/z 479 (M+H)⁺-   1-537; A-15; B-09; MS m/z 481 (M+H)⁺-   1-538; A-15; B-10; MS m/z 503 (M+H)⁺-   1-539; A-15; B-11; MS m/z 507 (M+H)⁺-   1-540; A-15; B-12; MS m/z 515 (M+H)⁺-   1-541; A-15; B-13; MS m/z 429 (M+H)⁺-   1-542; A-15; B-14; MS m/z 437 (M+H)⁺-   1-543; A-15; B-15; MS m/z 451 (M+H)⁺-   1-544; A-15; B-16; MS m/z 457 (M+H)⁺-   1-545; A-15; B-17; MS m/z 463 (M+H)⁺-   1-546; A-15; B-18; MS m/z 467 (M+H)⁺-   1-547; A-15; B-19; MS m/z 477 (M+H)⁺-   1-548; A-15; B-20; MS m/z 479 (M+H)⁺-   1-549; A-15; B-21; MS m/z 483 (M+H)⁺-   1-550; A-15; B-22; MS m/z 487 (M+H)⁺-   1-551; A-15; B-23; MS m/z 499 (M+H)⁺-   1-552; A-15; B-24; MS m/z 499 (M+H)⁺-   1-553; A-15; B-25; MS m/z 468 (M+H)⁺-   1-554; A-15; B-26; MS m/z 508 (M+H)⁺-   1-555; A-15; B-27; MS m/z 508 (M+H)⁺-   1-556; A-15; B-28; MS m/z 501 (M+H)⁺-   1-557; A-15; B-29; MS m/z 505 (M+H)⁺-   1-558; A-15; B-30; MS m/z 517 (M+H)⁺-   1-559; A-15; B-31; MS m/z 519 (M+H)⁺-   1-560; A-15; B-32; MS m/z 521 (M+H)⁺-   1-561; A-15; B-33; MS m/z 521 (M+H)⁺-   1-562; A-15; B-34; MS m/z 531 (M+H)⁺-   1-563; A-15; B-35; MS m/z 545 (M+H)⁺-   1-564; A-16; B-36; MS m/z 563 (M+H)⁺-   1-565; A-16; B-01; MS m/z 427 (M+H)⁺-   1-566; A-16; B-02; MS m/z 431 (M+H)⁺-   1-567; A-16; B-03; MS m/z 389 (M+H)⁺-   1-568; A-16; B-04; MS m/z 447 (M+H)⁺-   1-569; A-16; B-05; MS m/z 459 (M+H)⁺-   1-570; A-16; B-06; MS m/z 499 (M+H)⁺-   1-571; A-16; B-07; MS m/z 479 (M+H)⁺-   1-572; A-16; B-08; MS m/z 485 (M+H)⁺-   1-573; A-16; B-09; MS m/z 487 (M+H)⁺-   1-574; A-16; B-10; MS m/z 509 (M+H)⁺-   1-575; A-16; B-11; MS m/z 513 (M+H)⁺-   1-576; A-16; B-12; MS m/z 521 (M+H)⁺-   1-577; A-16; B-13; MS m/z 435 (M+H)⁺-   1-578; A-16; B-14; MS m/z 443 (M+H)⁺-   1-579; A-16; B-15; MS m/z 457 (M+H)⁺-   1-580; A-16; B-16; MS m/z 463 (M+H)⁺-   1-581; A-16; B-17; MS m/z 469 (M+H)⁺-   1-582; A-16; B-18; MS m/z 473 (M+H)⁺-   1-583; A-16; B-19; MS m/z 483 (M+H)⁺-   1-584; A-16; B-20; MS m/z 485 (M+H)⁺-   1-585; A-16; B-21; MS m/z 489 (M+H)⁺-   1-586; A-16; B-22; MS m/z 493 (M+H)⁺-   1-587; A-16; B-23; MS m/z 505 (M+H)⁺-   1-588; A-16; B-24; MS m/z 505 (M+H)⁺-   1-589; A-16; B-25; MS m/z 474 (M+H)⁺-   1-590; A-16; B-26; MS m/z 514 (M+H)⁺-   1-591; A-16; B-27; MS m/z 514 (M+H)⁺-   1-592; A-16; B-28; MS m/z 507 (M+H)⁺-   1-593; A-16; B-29; MS m/z 511 (M+H)⁺-   1-594; A-16; B-30; MS m/z 523 (M+H)⁺-   1-595; A-16; B-31; MS m/z 525 (M+H)⁺-   1-596; A-16; B-32; MS m/z 527 (M+H)⁺-   1-597; A-16; B-33; MS m/z 527 (M+H)⁺-   1-598; A-16; B-34; MS m/z 537 (M+H)⁺-   1-599; A-16; B-35; MS m/z 551 (M+H)⁺-   1-600; A-16; B-36; MS m/z 569 (M+H)⁺-   1-601; A-17; B-01; MS m/z 433 (M+H)⁺-   1-602; A-17; B-02; MS m/z 437 (M+H)⁺-   1-603; A-17; B-03; MS m/z 395 (M+H)⁺-   1-604; A-17; B-04; MS m/z 453 (M+H)⁺-   1-605; A-17; B-05; MS m/z 465 (M+H)⁺-   1-606; A-17; B-06; MS m/z 505 (M+H)⁺-   1-607; A-17; B-07; MS m/z 485 (M+H)⁺-   1-608; A-17; B-08; MS m/z 491 (M+H)⁺-   1-609; A-17; B-09; MS m/z 493 (M+H)⁺-   1-610; A-17; B-10; MS m/z 515 (M+H)⁺-   1-611; A-17; B-11; MS m/z 519 (M+H)⁺-   1-612; A-17; B-12; MS m/z 527 (M+H)⁺-   1-613; A-17; B-13; MS m/z 441 (M+H)⁺-   1-614; A-17; B-14; MS m/z 449 (M+H)⁺-   1-615; A-17; B-15; MS m/z 463 (M+H)⁺-   1-616; A-17; B-16; MS m/z 469 (M+H)⁺-   1-617; A-17; B-17; MS m/z 475 (M+H)⁺-   1-618; A-17; B-18; MS m/z 479 (M+H)⁺-   1-619; A-17; B-19; MS m/z 489 (M+H)⁺-   1-620; A-17; B-20; MS m/z 491 (M+H)⁺-   1-621; A-17; B-21; MS m/z 495 (M+H)⁺-   1-622; A-17; B-22; MS m/z 499 (M+H)⁺-   1-623; A-17; B-23; MS m/z 511 (M+H)⁺-   1-624; A-17; B-24; MS m/z 511 (M+H)⁺-   1-625; A-17; B-25; MS m/z 480 (M+H)⁺-   1-626; A-17; B-26; MS m/z 520 (M+H)⁺-   1-627; A-17; B-27; MS m/z 520 (M+H)⁺-   1-628; A-17; B-28; MS m/z 513 (M+H)⁺-   1-629; A-17; B-29; MS m/z 517 (M+H)⁺-   1-630; A-17; B-30; MS m/z 529 (M+H)⁺-   1-631; A-17; B-31; MS m/z 531 (M+H)⁺-   1-632; A-17; B-32; MS m/z 533 (M+H)⁺-   1-633; A-17; B-33; MS m/z 533 (M+H)⁺-   1-634; A-17; B-34; MS m/z 543 (M+H)⁺-   1-635; A-17; B-35; MS m/z 557 (M+H)⁺-   1-636; A-17; B-36; MS m/z 575 (M+H)⁺-   1-637; A-18; B-01; MS m/z 449 (M+H)⁺-   1-638; A-18; B-02; MS m/z 453 (M+H)⁺-   1-639; A-18; B-03; MS m/z 411 (M+H)⁺-   1-640; A-18; B-04; MS m/z 469 (M+H)⁺-   1-641; A-18; B-05; MS m/z 481 (M+H)⁺-   1-642; A-18; B-06; MS m/z 521 (M+H)⁺-   1-643; A-18; B-07; MS m/z 501 (M+H)⁺-   1-644; A-18; B-08; MS m/z 507 (M+H)⁺-   1-645; A-18; B-09; MS m/z 509 (M+H)⁺-   1-646; A-18; B-10; MS m/z 531 (M+H)⁺-   1-647; A-18; B-11; MS m/z 535 (M+H)⁺-   1-648; A-18; B-12; MS m/z 543 (M+H)⁺-   1-649; A-18; B-13; MS m/z 457 (M+H)⁺-   1-650; A-18; B-14; MS m/z 465 (M+H)⁺-   1-651; A-18; B-15; MS m/z 479 (M+H)⁺-   1-652; A-18; B-16; MS m/z 485 (M+H)⁺-   1-653; A-18; B-17; MS m/z 491 (M+H)⁺-   1-654; A-18; B-18; MS m/z 495 (M+H)⁺-   1-655; A-18; B-19; MS m/z 505 (M+H)⁺-   1-656; A-18; B-20; MS m/z 507 (M+H)⁺-   1-657; A-18; B-21; MS m/z 511 (M+H)⁺-   1-658; A-18; B-22; MS m/z 515 (M+H)⁺-   1-659; A-18; B-23; MS m/z 527 (M+H)⁺-   1-660; A-18; B-24; MS m/z 527 (M+H)⁺-   1-661; A-18; B-26; MS m/z 536 (M+H)⁺-   1-663; A-18; B-27; MS m/z 536 (M+H)⁺-   1-664; A-18; B-28; MS m/z 529 (M+H)⁺-   1-665; A-18; B-29; MS m/z 533 (M+H)⁺-   1-666; A-18; B-30; MS m/z 545 (M+H)⁺-   1-667; A-18; B-31; MS m/z 547 (M+H)⁺-   1-668; A-18; B-32; MS m/z 549 (M+H)⁺-   1-669; A-18; B-33; MS m/z 549 (M+H)⁺-   1-670; A-18; B-34; MS m/z 559 (M+H)⁺-   1-671; A-18; B-35; MS m/z 573 (M+H)⁺-   1-672; A-18; B-36; MS m/z 591 (M+H)⁺-   1-673; A-19; B-01; MS m/z 425 (M+H)⁺-   1-674; A-19; B-02; MS m/z 429 (M+H)⁺-   1-675; A-19; B-03; MS m/z 387 (M+H)⁺-   1-676; A-19; B-04; MS m/z 445 (M+H)⁺-   1-677; A-19; B-05; MS m/z 457 (M+H)⁺-   1-678; A-19; B-06; MS m/z 497 (M+H)⁺-   1-679; A-19; B-07; MS m/z 477 (M+H)⁺-   1-680; A-19; B-08; MS m/z 483 (M+H)⁺-   1-681; A-19; B-09; MS m/z 485 (M+H)⁺-   1-682; A-19; B-10; MS m/z 507 (M+H)⁺-   1-683; A-19; B-11; MS m/z 511 (M+H)⁺-   1-684; A-19; B-12; MS m/z 519 (M+H)⁺-   1-685; A-19; B-13; MS m/z 433 (M+H)⁺-   1-686; A-19; B-14; MS m/z 441 (M+H)⁺-   1-687; A-19; B-15; MS m/z 455 (M+H)⁺-   1-688; A-19; B-16; MS m/z 461 (M+H)⁺-   1-689; A-19; B-17; MS m/z 467 (M+H)⁺-   1-690; A-19; B-18; MS m/z 471 (M+H)⁺-   1-691; A-19; B-19; MS m/z 481 (M+H)⁺-   1-692; A-19; B-20; MS m/z 483 (M+H)⁺-   1-693; A-19; B-21; MS m/z 487 (M+H)⁺-   1-694; A-19; B-22; MS m/z 491 (M+H)⁺-   1-695; A-19; B-23; MS m/z 503 (M+H)⁺-   1-696; A-19; B-24; MS m/z 503 (M+H)⁺-   1-697; A-19; B-25; MS m/z 472 (M+H)⁺-   1-698; A-19; B-26; MS m/z 512 (M+H)⁺-   1-699; A-19; B-27; MS m/z 512 (M+H)⁺-   1-700; A-19; B-28; MS m/z 505 (M+H)⁺-   1-701; A-19; B-29; MS m/z 509 (M+H)⁺-   1-702; A-19; B-30; MS m/z 521 (M+H)⁺-   1-703; A-19; B-31; MS m/z 523 (M+H)⁺-   1-704; A-19; B-32; MS m/z 525 (M+H)⁺-   1-705; A-19; B-33; MS m/z 525 (M+H)⁺-   1-706; A-19; B-34; MS m/z 535 (M+H)⁺-   1-707; A-19; B-35; MS m/z 549 (M+H)⁺-   1-708; A-19; B-36; MS m/z 567 (M+H)⁺-   1-709; A-20; B-01; MS m/z 429 (M+H)⁺-   1-710; A-20; B-02; MS m/z 433 (M+H)⁺-   1-711; A-20; B-03; MS m/z 391 (M+H)⁺-   1-712; A-20; B-04; MS m/z 449 (M+H)⁺-   1-713; A-20; B-05; MS m/z 461 (M+H)⁺-   1-714; A-20; B-06; MS m/z 501 (M+H)⁺-   1-715; A-20; B-07; MS m/z 481 (M+H)⁺-   1-716; A-20; B-08; MS m/z 487 (M+H)⁺-   1-717; A-20; B-09; MS m/z 489 (M+H)⁺-   1-718; A-20; B-10; MS m/z 511 (M+H)⁺-   1-719; A-20; B-11; MS m/z 515 (M+H)⁺-   1-720; A-20; B-12; MS m/z 523 (M+H)⁺-   1-721; A-20; B-13; MS m/z 437 (M+H)⁺-   1-722; A-20; B-14; MS m/z 445 (M+H)⁺-   1-723; A-20; B-15; MS m/z 459 (M+H)⁺-   1-724; A-20; B-16; MS m/z 465 (M+H)⁺-   1-725; A-20; B-17; MS m/z 471 (M+H)⁺-   1-726; A-20; B-18; MS m/z 475 (M+H)⁺-   1-727; A-20; B-19; MS m/z 485 (M+H)⁺-   1-728; A-20; B-20; MS m/z 487 (M+H)⁺-   1-729; A-20; B-21; MS m/z 491 (M+H)⁺-   1-730; A-20; B-22; MS m/z 495 (M+H)⁺-   1-731; A-20; B-23; MS m/z 507 (M+H)⁺-   1-732; A-20; B-24; MS m/z 507 (M+H)⁺-   1-733; A-20; B-25; MS m/z 476 (M+H)⁺-   1-734; A-20; B-26; MS m/z 516 (M+H)⁺-   1-735; A-20; B-27; MS m/z 516 (M+H)⁺-   1-736; A-20; B-28; MS m/z 509 (M+H)⁺-   1-737; A-20; B-29; MS m/z 513 (M+H)⁺-   1-738; A-20; B-30; MS m/z 525 (M+H)⁺-   1-739; A-20; B-31; MS m/z 527 (M+H)⁺-   1-740; A-20; B-32; MS m/z 529 (M+H)⁺-   1-741; A-20; B-33; MS m/z 529 (M+H)⁺-   1-742; A-20; B-34; MS m/z 539 (M+H)⁺-   1-743; A-20; B-35; MS m/z 553 (M+H)⁺-   1-744; A-20; B-36; MS m/z 571 (M+H)⁺-   1-745; A-21; B-01; MS m/z 435 (M+H)⁺-   1-746; A-21; B-02; MS m/z 439 (M+H)⁺-   1-747; A-21; B-03; MS m/z 397 (M+H)⁺-   1-748; A-21; B-04; MS m/z 455 (M+H)⁺-   1-749; A-21; B-05; MS m/z 467 (M+H)⁺-   1-750; A-21; B-06; MS m/z 507 (M+H)⁺-   1-751; A-21; B-07; MS m/z 487 (M+H)⁺-   1-752; A-21; B-08; MS m/z 493 (M+H)⁺-   1-753; A-21; B-09; MS m/z 495 (M+H)⁺-   1-754; A-21; B-10; MS m/z 517 (M+H)⁺-   1-755; A-21; B-11; MS m/z 521 (M+H)⁺-   1-756; A-21; B-12; MS m/z 529 (M+H)⁺-   1-757; A-21; B-13; MS m/z 443 (M+H)⁺-   1-758; A-21; B-14; MS m/z 451 (M+H)⁺-   1-759; A-21; B-15; MS m/z 465 (M+H)⁺-   1-760; A-21; B-16; MS m/z 471 (M+H)⁺-   1-761; A-21; B-17; MS m/z 477 (M+H)⁺-   1-762; A-21; B-18; MS m/z 481 (M+H)⁺-   1-763; A-21; B-19; MS m/z 491 (M+H)⁺-   1-764; A-21; B-20; MS m/z 493 (M+H)⁺-   1-765; A-21; B-21; MS m/z 497 (M+H)⁺-   1-766; A-21; B-22; MS m/z 501 (M+H)⁺-   1-767; A-21; B-23; MS m/z 513 (M+H)⁺-   1-768; A-21; B-24; MS m/z 513 (M+H)⁺-   1-769; A-21; B-25; MS m/z 482 (M+H)⁺-   1-770; A-21; B-26; MS m/z 522 (M+H)⁺-   1-771; A-21; B-27; MS m/z 522 (M+H)⁺-   1-772; A-21; B-28; MS m/z 515 (M+H)⁺-   1-773; A-21; B-29; MS m/z 519 (M+H)⁺-   1-774; A-21; B-30; MS m/z 531 (M+H)⁺-   1-775; A-21; B-31; MS m/z 533 (M+H)⁺-   1-776; A-21; B-32; MS m/z 535 (M+H)⁺-   1-777; A-21; B-33; MS m/z 535 (M+H)⁺-   1-778; A-21; B-34; MS m/z 545 (M+H)⁺-   1-779; A-21; B-35; MS m/z 559 (M+H)⁺-   1-780; A-21; B-36; MS m/z 577 (M+H)⁺-   1-781; A-22; B-01; MS m/z 459 (M+H)⁺-   1-782; A-22; B-02; MS m/z 463 (M+H)⁺-   1-783; A-22; B-03; MS m/z 421 (M+H)⁺-   1-784; A-22; B-04; MS m/z 479 (M+H)⁺-   1-785; A-22; B-05; MS m/z 491 (M+H)⁺-   1-786; A-22; B-06; MS m/z 531 (M+H)⁺-   1-787; A-22; B-07; MS m/z 511 (M+H)⁺-   1-788; A-22; B-08; MS m/z 517 (M+H)⁺-   1-789; A-22; B-09; MS m/z 519 (M+H)⁺-   1-790; A-22; B-10; MS m/z 541 (M+H)⁺-   1-791; A-22; B-11; MS m/z 545 (M+H)⁺-   1-792; A-22; B-12; MS m/z 553 (M+H)⁺-   1-793; A-22; B-13; MS m/z 467 (M+H)⁺-   1-794; A-22; B-14; MS m/z 475 (M+H)⁺-   1-795; A-22; B-15; MS m/z 489 (M+H)⁺-   1-796; A-22; B-16; MS m/z 495 (M+H)⁺-   1-797; A-22; B-17; MS m/z 501 (M+H)⁺-   1-798; A-22; B-18; MS m/z 505 (M+H)⁺-   1-799; A-22; B-19; MS m/z 515 (M+H)⁺-   1-800; A-22; B-20; MS m/z 517 (M+H)⁺-   1-801; A-22; B-21; MS m/z 521 (M+H)⁺-   1-802; A-22; B-22; MS m/z 525 (M+H)⁺-   1-803; A-22; B-23; MS m/z 537 (M+H)⁺-   1-804; A-22; B-24; MS m/z 537 (M+H)⁺-   1-805; A-22; B-25; MS m/z 506 (M+H)⁺-   1-806; A-22; B-26; MS m/z 546 (M+H)⁺-   1-807; A-22; B-27; MS m/z 546 (M+H)⁺-   1-808; A-22; B-28; MS m/z 539 (M+H)⁺-   1-809; A-22; B-29; MS m/z 543 (M+H)⁺-   1-810; A-22; B-30; MS m/z 555 (M+H)⁺-   1-811; A-22; B-31; MS m/z 557 (M+H)⁺-   1-812; A-22; B-32; MS m/z 559 (M+H)⁺-   1-813; A-22; B-33; MS m/z 559 (M+H)⁺-   1-814; A-22; B-34; MS m/z 569 (M+H)⁺-   1-815; A-22; B-35; MS m/z 583 (M+H)⁺-   1-816; A-22; B-36; MS m/z 601 (M+H)⁺-   1-817; A-23; B-01; MS m/z 463 (M+H)⁺-   1-818; A-23; B-02; MS m/z 467 (M+H)⁺-   1-819; A-23; B-03; MS m/z 425 (M+H)⁺-   1-820; A-23; B-04; MS m/z 483 (M+H)⁺-   1-821; A-23; B-05; MS m/z.495 (M+H)⁺-   1-822; A-23; B-06; MS m/z 535 (M+H)⁺-   1-823; A-23; B-07; MS m/z 515 (M+H)⁺-   1-824; A-23; B-08; MS m/z 521 (M+H)⁺-   1-825; A-23; B-09; MS m/z 523 (M+H)⁺-   1-826; A-23; B-10; MS m/z 545 (M+H)⁺-   1-827; A-23; B-11; MS m/z 549 (M+H)⁺-   1-828; A-23; B-12; MS m/z 557 (M+H)⁺-   1-829; A-23; B-13; MS m/z 471 (M+H)⁺-   1-830; A-23; B-14; MS m/z 479 (M+H)⁺-   1-831; A-23; B-15; MS m/z 493 (M+H)⁺-   1-832; A-23; B-16; MS m/z 499 (M+H)⁺-   1-833; A-23; B-17; MS m/z 505 (M+H)⁺-   1-834; A-23; B-18; MS m/z 509 (M+H)⁺-   1-835; A-23; B-19; MS m/z 519 (M+H)⁺-   1-836; A-23; B-20; MS m/z 521 (M+H)⁺-   1-837; A-23; B-21; MS m/z 525 (M+H)⁺-   1-838; A-23; B-22; MS m/z 529 (M+H)⁺-   1-839; A-23; B-23; MS m/z 541 (M+H)⁺-   1-840; A-23; B-24; MS m/z 541 (M+H)⁺-   1-841; A-23; B-25; MS m/z 510 (M+H)⁺-   1-842; A-23; B-26; MS m/z 550 (M+H)⁺-   1-843; A-23; B-27; MS m/z 550 (M+H)⁺-   1-844; A-23; B-28; MS m/z 543 (M+H)⁺-   1-845; A-23; B-29; MS m/z 547 (M+H)⁺-   1-846; A-23; B-30; MS m/z 559 (M+H)⁺-   1-847; A-23; B-31; MS m/z 561 (M+H)⁺-   1-848; A-23; B-32; MS m/z 563 (M+H)⁺-   1-849; A-23; B-33; MS m/z 563 (M+H)⁺-   1-850; A-23; B-34; MS m/z 573 (M+H)⁺-   1-851; A-23; B-35; MS m/z 587 (M+H)⁺-   1-852; A-23; B-36; MS m/z 605 (M+H)⁺-   1-853; A-24; B-01; MS m/z 467 (M+H)⁺-   1-854; A-24; B-02; MS m/z 471 (M+H)⁺-   1-855; A-24; B-03; MS m/z 429 (M+H)⁺-   1-856; A-24; B-04; MS m/z 487 (M+H)⁺-   1-857; A-24; B-05; MS m/z 499 (M+H)⁺-   1-858; A-24; B-06; MS m/z 539 (M+H)⁺-   1-859; A-24; B-07; MS m/z 519 (M+H)⁺-   1-860; A-24; B-08; MS m/z 525 (M+H)⁺-   1-861; A-24; B-09; MS m/z 527 (M+H)⁺-   1-862; A-24; B-10; MS m/z 549 (M+H)⁺-   1-863; A-24; B-11; MS m/z 553 (M+H)⁺-   1-864; A-24; B-12; MS m/z 561 (M+H)⁺-   1-865; A-24; B-13; MS m/z 475 (M+H)⁺-   1-866; A-24; B-14; MS m/z 483 (M+H)⁺-   1-867; A-24; B-15; MS m/z 497 (M+H)⁺-   1-868; A-24; B-16; MS m/z 503 (M+H)⁺-   1-869; A-24; B-17; MS m/z 509 (M+H)⁺-   1-870; A-24; B-18; MS m/z 513 (M+H)⁺-   1-871; A-24; B-19; MS m/z 523 (M+H)⁺-   1-872; A-24; B-20; MS m/z 525 (M+H)⁺-   1-873; A-24; B-21; MS m/z 529 (M+H)⁺-   1-874; A-24; B-22; MS m/z 533 (M+H)⁺-   1-875; A-24; B-23; MS m/z 545 (M+H)⁺-   1-876; A-24; B-24; MS m/z 545 (M+H)⁺-   1-877; A-24; B-25; MS m/z 514 (M+H)⁺-   1-878; A-24; B-26; MS m/z 554 (M+H)⁺-   1-879; A-24; B-27; MS m/z 554 (M+H)⁺-   1-880; A-24; B-28; MS m/z 547 (M+H)⁺-   1-881; A-24; B-29; MS m/z 551 (M+H)⁺-   1-882; A-24; B-30; MS m/z 563 (M+H)⁺-   1-883; A-24; B-31; MS m/z 565 (M+H)⁺-   1-884; A-24; B-32; MS m/z 567 (M+H)⁺-   1-885; A-24; B-33; MS m/z 567 (M+H)⁺-   1-886; A-24; B-34; MS m/z 577 (M+H)⁺-   1-887; A-24; B-35; MS m/z 591 (M+H)⁺-   1-888; A-24; B-36; MS m/z 609 (M+H)⁺-   1-889; A-25; B-01; MS m/z 394 (M+H)⁺-   1-890; A-25; B-02; MS m/z 398 (M+H)⁺-   1-891; A-25; B-03; MS m/z 356 (M+H)⁺-   1-892; A-25; B-04; MS m/z 414 (M+H)⁺-   1-893; A-25; B-05; MS m/z 426 (M+H)⁺-   1-894; A-25; B-06; MS m/z 466 (M+H)⁺-   1-895; A-25; B-07; MS m/z 456 (M+H)⁺-   1-896; A-25; B-08; MS m/z 452 (M+H)⁺-   1-897; A-25; B-09; MS m/z 454 (M+H)⁺-   1-898; A-25; B-10; MS m/z 476 (M+H)⁺-   1-899; A-25; B-11; MS m/z 480 (M+H)⁺-   1-900; A-25; B-12; MS m/z 488 (M+H)⁺-   1-901; A-25; B-13; MS m/z 402 (M+H)⁺-   1-902; A-25; B-14; MS m/z 410 (M+H)⁺-   1-903; A-25; B-15; MS m/z 424 (M+H)⁺-   1-904; A-25; B-16; MS m/z 430 (M+H)⁺-   1-905; A-25; B-17; MS m/z 436 (M+H)⁺-   1-906; A-25; B-18; MS m/z 440 (M+H)⁺-   1-907; A-25; B-19; MS m/z 450 (M+H)⁺-   1-908; A-25; B-20; MS m/z 452 (M+H)⁺-   1-909; A-25; B-21; MS m/z 456 (M+H)⁺-   1-910; A-25; B-22; MS m/z 460 (M+H)⁺-   1-911; A-25; B-23; MS m/z 472 (M+H)⁺-   1-912; A-25; B-24; MS m/z 472 (M+H)⁺-   1-913; A-25; B-25; MS m/z 441 (M+H)⁺-   1-914; A-25; B-26; MS m/z 481 (M+H)⁺-   1-915; A-25; B-27; MS m/z 481 (M+H)⁺-   1-916; A-25; B-28; MS m/z 474 (M+H)⁺-   1-917; A-25; B-29; MS m/z 478 (M+H)⁺-   1-918; A-25; B-30; MS m/z 490 (M+H)⁺-   1-919; A-25; B-31; MS m/z 492 (M+H)⁺-   1-920; A-25; B-32; MS m/z 494 (M+H)⁺-   1-921; A-25; B-33; MS m/z 494 (M+H)⁺-   1-922; A-25; B-34; MS m/z 504 (M+H)⁺-   1-923; A-25; B-35; MS m/z 518 (M+H)⁺-   1-924; A-25; B-36; MS m/z 536 (M+H)⁺-   1-925; A-26; B-01; MS m/z 400 (M+H)⁺-   1-926; A-26; B-02; MS m/z 404 (M+H)⁺-   1-927; A-26; B-03; MS m/z 362 (M+H)⁺-   1-928; A-26; B-04; MS m/z 420 (M+H)⁺-   1-929; A-26; B-05; MS m/z 432 (M+H)⁺-   1-930; A-26; B-06; MS m/z 472 (M+H)⁺-   1-931; A-26; B-07; MS m/z 452 (M+H)⁺-   1-932; A-26; B-08; MS m/z 458 (M+H)⁺-   1-933; A-26; B-09; MS m/z 460 (M+H)⁺-   1-934; A-26; B-10; MS m/z 482 (M+H)⁺-   1-935; A-26; B-11; MS m/z 486 (M+H)⁺-   1-936; A-26; B-12; MS m/z 494 (M+H)⁺-   1-937; A-26; B-13; MS m/z 408 (M+H)⁺-   1-938; A-26; B-14; MS m/z 416 (M+H)⁺-   1-939; A-26; B-15; MS m/z 430 (M+H)⁺-   1-940; A-26; B-16; MS m/z 436 (M+H)⁺-   1-941; A-26; B-17; MS m/z 442 (M+H)⁺-   1-942; A-26; B-18; MS m/z 446 (M+H)⁺-   1-943; A-26; B-19; MS m/z 456 (M+H)⁺-   1-944; A-26; B-20; MS m/z 458 (M+H)⁺-   1-945; A-26; B-21; MS m/z 462 (M+H)⁺-   1-946; A-26; B-22; MS m/z 466 (M+H)⁺-   1-947; A-26; B-23; MS m/z 478 (M+H)⁺-   1-948; A-26; B-24; MS m/z 478 (M+H)⁺-   1-949; A-26; B-25; MS m/z 447 (M+H)⁺-   1-950; A-26; B-26; MS m/z 487 (M+H)⁺-   1-951; A-26; B-27; MS m/z 487 (M+H)⁺-   1-952; A-26; B-28; MS m/z 480 (M+H)⁺-   1-953; A-26; B-29; MS m/z 484 (M+H)⁺-   1-954; A-26; B-30; MS m/z 496 (M+H)⁺-   1-955; A-26; B-31; MS m/z 498 (M+H)⁺-   1-956; A-26; B-32; MS m/z 500 (M+H)⁺-   1-957; A-26; B-33; MS m/z 500 (M+H)⁺-   1-958; A-26; B-34; MS m/z 510 (M+H)⁺-   1-959; A-26; B-35; MS m/z 524 (M+H)⁺-   1-960; A-26; B-36; MS m/z 542 (M+H)⁺-   1-961; A-27; B-01; MS m/z 434 (M+H)⁺-   1-962; A-27; B-02; MS m/z 438 (M+H)⁺-   1-963; A-27; B-03; MS m/z 396 (M+H)⁺-   1-964; A-27; B-04; MS m/z 454 (M+H)⁺-   1-965; A-27; B-05; MS m/z 466 (M+H)⁺-   1-966; A-27; B-06; MS m/z 506 (M+H)⁺-   1-967; A-27; B-07; MS m/z 486 (M+H)⁺-   1-968; A-27; B-08; MS m/z 492 (M+H)⁺-   1-969; A-27; B-09; MS m/z 494 (M+H)⁺-   1-970; A-27; B-10; MS m/z 516 (M+H)⁺-   1-971; A-27; B-11; MS m/z 520 (M+H)⁺-   1-972; A-27; B-12; MS m/z 528 (M+H)⁺-   1-973; A-27; B-13; MS m/z 442 (M+H)⁺-   1-974; A-27; B-14; MS m/z 450 (M+H)⁺-   1-975; A-27; B-15; MS m/z 464 (M+H)⁺-   1-976; A-27; B-16; MS m/z 470 (M+H)⁺-   1-977; A-27; B-17; MS m/z 476 (M+H)⁺-   1-978; A-27; B-18; MS m/z 480 (M+H)⁺-   1-979; A-27; B-19; MS m/z 490 (M+H)⁺-   1-980; A-27; B-20; MS m/z 492 (M+H)⁺-   1-981; A-27; B-21; MS m/z 496 (M+H)⁺-   1-982; A-27; B-22; MS m/z 500 (M+H)⁺-   1-983; A-27; B-23; MS m/z 512 (M+H)⁺-   1-984; A-27; B-24; MS m/z 512 (M+H)⁺-   1-985; A-27; B-25; MS m/z 481 (M+H)⁺-   1-986; A-27; B-26; MS m/z 521 (M+H)⁺-   1-987; A-27; B-27; MS m/z 521 (M+H)⁺-   1-988; A-27; B-28; MS m/z 514 (M+H)⁺-   1-989; A-27; B-29; MS m/z 518 (M+H)⁺-   1-990; A-27; B-30; MS m/z 530 (M+H)⁺-   1-991; A-27; B-31; MS m/z 532 (M+H)⁺-   1-992; A-27; B-32; MS m/z 534 (M+H)⁺-   1-993; A-27; B-33; MS m/z 534 (M+H)⁺-   1-994; A-27; B-34; MS m/z 544 (M+H)⁺-   1-995; A-27; B-35; MS m/z 558 (M+H)⁺-   1-996; A-27; B-36; MS m/z 576 (M+H)⁺-   1-997; A-28; B-01; MS m/z 464 (M+H)⁺-   1-998; A-28; B-02; MS m/z 468 (M+H)⁺-   1-999; A-28; B-03; MS m/z 426 (M+H)⁺-   1-1000; A-28; B-04; MS m/z 484 (M+H)⁺-   1-1001; A-28; B-05; MS m/z 496 (M+H)⁺-   1-1002; A-28; B-06; MS m/z 536 (M+H)⁺-   1-1003; A-28; B-07; MS m/z 516 (M+H)⁺-   1-1004; A-28; B-08; MS m/z 522 (M+H)⁺-   1-1005; A-28; B-09; MS m/z 524 (M+H)⁺-   1-1006; A-28; B-10; MS m/z 546 (M+H)⁺-   1-1007; A-28; B-11; MS m/z 550 (M+H)⁺-   1-1008; A-28; B-12; MS m/z 558 (M+H)⁺-   1-1009; A-28; B-13; MS m/z 472 (M+H)⁺-   1-1010; A-28; B-14; MS m/z 480 (M+H)⁺-   1-1011; A-28; B-15; MS m/z 494 (M+H)⁺-   1-1012; A-28; B-16; MS m/z 500 (M+H)⁺-   1-1013; A-28; B-17; MS m/z 506 (M+H)⁺-   1-1014; A-28; B-18; MS m/z 510 (M+H)⁺-   1-1015; A-28; B-19; MS m/z 520 (M+H)⁺-   1-1016; A-28; B-20; MS m/z 522 (M+H)⁺-   1-1017; A-28; B-21; MS m/z 526 (M+H)⁺-   1-1018; A-28; B-22; MS m/z 530 (M+H)⁺-   1-1019; A-28; B-23; MS m/z 542 (M+H)⁺-   1-1020; A-28; B-24; MS m/z 542 (M+H)⁺-   1-1021; A-28; B-25; MS m/z 511 (M+H)⁺-   1-1022; A-28; B-26; MS m/z 551 (M+H)⁺-   1-1023; A-28; B-27; MS m/z 551 (M+H)⁺-   1-1024; A-28; B-28; MS m/z 544 (M+H)⁺-   1-1025; A-28; B-29; MS m/z 548 (M+H)⁺-   1-1026; A-28; B-30; MS m/z 560 (M+H)⁺-   1-1027; A-28; B-31; MS m/z 562 (M+H)⁺-   1-1028; A-28; B-32; MS m/z 564 (M+H)⁺-   1-1029; A-28; B-33; MS m/z 564 (M+H)⁺-   1-1030; A-28; B-34; MS m/z 574 (M+H)⁺-   1-1031; A-28; B-35; MS m/z 588 (M+H)⁺-   1-1032; A-28; B-36; MS m/z 606 (M+H)⁺-   1-1033; A-29; B-01-   1-1034; A-29; B-02-   1-1035; A-29; B-03; MS m/z 368 (M+H)⁺-   1-1036; A-29; B-04-   1-1037; A-29; B-05-   1-1038; A-29; B-06-   1-1039; A-29; B-07-   1-1040; A-29; B-08-   1-1041; A-29; B-09-   1-1042; A-29; B-10-   1-1043; A-29; B-11-   1-1044; A-29; B-12-   1-1045; A-29; B-13-   1-1046; A-29; B-14-   1-1047; A-29; B-15-   1-1048; A-29; B-16-   1-1049; A-29; B-17; MS m/z 448 (M+H)⁺-   1-1050; A-29; B-18-   1-1051; A-29; B-19-   1-1052; A-29; B-20-   1-1053; A-29; B-21-   1-1054; A-29; B-22; MS m/z 472 (M+H)⁺-   1-1055; A-29; B-23-   1-1056; A-29; B-24-   1-1057; A-29; B-25-   1-1058; A-29; B-26-   1-1059; A-29; B-27-   1-1060; A-29; B-28-   1-1061; A-29; B-29-   1-1062; A-29; B-30-   1-1063; A-29; B-31-   1-1064; A-29; B-32-   1-1065; A-29; B-33-   1-1066; A-29; B-34-   1-1067; A-29; B-35-   1-1068; A-29; B-36-   1-1069; A-30; B-01; MS m/z 422 (M+H)⁺-   1-1070; A-30; B-02; MS m/z 426 (M+H)⁺-   1-1071; A-30; B-03; MS m/z 384 (M+H)⁺-   1-1072; A-30; B-04; MS m/z 442 (M+H)⁺-   1-1073; A-30; B-05; MS m/z 454 (M+H)⁺-   1-1074; A-30; B-06; MS m/z 494 (M+H)⁺-   1-1075; A-30; B-07; MS m/z 474 (M+H)⁺-   1-1076; A-30; B-08; MS m/z 480 (M+H)⁺-   1-1077; A-30; B-09; MS m/z 482 (M+H)⁺-   1-1078; A-30; B-10; MS m/z 504 (M+H)⁺-   1-1079; A-30; B-11; MS m/z 508 (M+H)⁺-   1-1080; A-30; B-12; MS m/z 516 (M+H)⁺-   1-1081; A-30; B-13; MS m/z 430 (M+H)⁺-   1-1082; A-30; B-14; MS m/z 438 (M+H)⁺-   1-1083; A-30; B-15; MS m/z 452 (M+H)⁺-   1-1084; A-30; B-16; MS m/z 458 (M+H)⁺-   1-1085; A-30; B-17; MS m/z 464 (M+H)⁺-   1-1086; A-30; B-18; MS m/z 468 (M+H)⁺-   1-1087; A-30; B-19; MS m/z 478 (M+H)⁺-   1-1088; A-30; B-20; MS m/z 480 (M+H)⁺-   1-1089; A-30; B-21; MS m/z 484 (M+H)⁺-   1-1090; A-30; B-22; MS m/z 488 (M+H)⁺-   1-1091; A-30; B-23; MS m/z 500 (M+H)⁺-   1-1092; A-30; B-24; MS m/z 500 (M+H)⁺-   1-1093; A-30; B-25; MS m/z 469 (M+H)⁺-   1-1094; A-30; B-26; MS m/z 509 (M+H)⁺-   1-1095; A-30; B-27; MS m/z 509 (M+H)⁺-   1-1096; A-30; B-28; MS m/z 502 (M+H)⁺-   1-1097; A-30; B-29; MS m/z 506 (M+H)⁺-   1-1098; A-30; B-30; MS m/z 518 (M+H)⁺-   1-1099; A-30; B-31; MS m/z 520 (M+H)⁺-   1-1100; A-30; B-32; MS m/z 522 (M+H)⁺-   1-1101; A-30; B-33; MS m/z 522 (M+H)⁺-   1-1102; A-30; B-34; MS m/z 532 (M+H)⁺-   1-1103; A-30; B-35; MS m/z 546 (M+H)⁺-   1-1104; A-30; B-36; MS m/z 564 (M+H)⁺-   1-1105; A-31; B-01-   1-1106; A-31; B-02-   1-1107; A-31; B-03; MS m/z 384 (M+H)⁺-   1-1108; A-31; B-04-   1-1109; A-31; B-05-   1-1110; A-31; B-06-   1-1111; A-31; B-07-   1-1112; A-31; B-08-   1-1113; A-31; B-09-   1-1114; A-31; B-10; MS m/z 504 (M+H)⁺-   1-1115; A-31; B-11-   1-1116; A-31; B-12; MS m/z 516 (M+H)⁺-   1-1117; A-31; B-13-   1-1118; A-31; B-14; MS m/z 438 (M+H)⁺-   1-1119; A-31; B-15; MS m/z 452 (M+H)⁺-   1-1120; A-31; B-16; MS m/z 458 (M+H)⁺-   1-1121; A-31; B-17; MS m/z 464 (M+H)⁺-   1-1122; A-31; B-18; MS m/z 468 (M+H)⁺-   1-1123; A-31; B-19-   1-1124; A-31; B-20; MS m/z 480 (M+H)⁺-   1-1125; A-31; B-21; MS m/z 484 (M+H)⁺-   1-1126; A-31; B-22; MS m/z 488 (M+H)⁺-   1-1127; A-31; B-23; MS m/z 500 (M+H)⁺-   1-1128; A-31; B-24; MS m/z 500 (M+H)⁺-   1-1129; A-31; B-25-   1-1130; A-31; B-26; MS m/z 509 (M+H)⁺-   1-1131; A-31; B-27; MS m/z 509 (M+H)⁺-   1-1132; A-31; B-28; MS m/z 502 (M+H)⁺-   1-1133; A-31; B-29; MS m/z 506 (M+H)⁺-   1-1134; A-31; B-30; MS m/z 518 (M+H)⁺-   1-1135; A-31; B-31; MS m/z 520 (M+H)⁺-   1-1136; A-31; B-32; MS m/z 522 (M+H)⁺-   1-1137; A-31; B-33; MS m/z 522 (M+H)⁺-   1-1138; A-31; B-34; MS m/z 532 (M+H)⁺-   1-1139; A-31; B-35; MS m/z 546 (M+H)⁺-   1-1140; A-31; B-36; MS m/z 564 (M+H)⁺-   1-1141; A-32; B-01; MS m/z 448 (M+H)⁺-   1-1142; A-32; B-02; MS m/z 452 (M+H)⁺-   1-1143; A-32; B-03; MS m/z 410 (M+H)⁺-   1-1144; A-32; B-04; MS m/z 468 (M+H)⁺-   1-1145; A-32; B-05; MS m/z 480 (M+H)⁺-   1-1146; A-32; B-06; MS m/z 520 (M+H)⁺-   1-1147; A-32; B-07; MS m/z 500 (M+H)⁺-   1-1148; A-32; B-08; MS m/z 506 (M+H)⁺-   1-1149; A-32; B-09; MS m/z 508 (M+H)⁺-   1-1150; A-32; B-10; MS m/z 530 (M+H)⁺-   1-1151; A-32; B-11; MS m/z 534 (M+H)⁺-   1-1152; A-32; B-12; MS m/z 542 (M+H)⁺-   1-1153; A-32; B-13; MS m/z 456 (M+H)⁺-   1-1154; A-32; B-14; MS m/z 464 (M+H)⁺-   1-1155; A-32; B-15; MS m/z 478 (M+H)⁺-   1-1156; A-32; B-16; MS m/z 484 (M+H)⁺-   1-1157; A-32; B-17; MS m/z 490 (M+H)⁺-   1-1158; A-32; B-18; MS m/z 494 (M+H)⁺-   1-1159; A-32; B-19; MS m/z 504 (M+H)⁺-   1-1160; A-32; B-20; MS m/z 506 (M+H)⁺-   1-1161; A-32; B-21; MS m/z 510 (M+H)⁺-   1-1162; A-32; B-22; MS m/z 514 (M+H)⁺-   1-1163; A-32; B-23; MS m/z 526 (M+H)⁺-   1-1164; A-32; B-24; MS m/z 526 (M+H)⁺-   1-1165; A-32; B-25; MS m/z 495 (M+H)⁺-   1-1166; A-32; B-26; MS m/z 535 (M+H)⁺-   1-1167; A-32; B-27; MS m/z 535 (M+H)⁺-   1-1168; A-32; B-28; MS m/z 528 (M+H)⁺-   1-1169; A-32; B-29; MS m/z 532 (M+H)⁺-   1-1170; A-32; B-30; MS m/z 544 (M+H)⁺-   1-1171; A-32; B-31; MS m/z 546 (M+H)⁺-   1-1172; A-32; B-32; MS m/z 548 (M+H)⁺-   1-1173; A-32; B-33; MS m/z 548 (M+H)⁺-   1-1174; A-32; B-34; MS m/z 558 (M+H)⁺-   1-1175; A-32; B-35; MS m/z 572 (M+H)⁺-   1-1176; A-32; B-36; MS m/z 590 (M+H)⁺-   1-1177; A-33; B-01; MS m/z 363 (M+H)⁺-   1-1178; A-33; B-02; MS m/z 367 (M+H)⁺-   1-1179; A-33; B-03; MS m/z 325 (M+H)⁺-   1-1180; A-33; B-04; MS m/z 383 (M+H)⁺-   1-1181; A-33; B-05; MS m/z 395 (M+H)⁺-   1-1182; A-33; B-06; MS m/z 435 (M+H)⁺-   1-1183; A-33; B-07; MS m/z 415 (M+H)⁺-   1-1184; A-33; B-08; MS m/z 421 (M+H)⁺-   1-1185; A-33; B-09; MS m/z 423 (M+H)⁺-   1-1186; A-33; B-10; MS m/z 445 (M+H)⁺-   1-1187; A-33; B-11; MS m/z 449 (M+H)⁺-   1-1188; A-33; B-12; MS m/z 457 (M+H)⁺-   1-1189; A-33; B-13; MS m/z 371 (M+H)⁺-   1-1190; A-33; B-14; MS m/z 379 (M+H)⁺-   1-1191; A-33; B-15; MS m/z 393 (M+H)⁺-   1-1192; A-33; B-16; MS m/z 399 (M+H)⁺-   1-1193; A-33; B-17; MS m/z 405 (M+H)⁺-   1-1194; A-33; B-18; MS m/z 409 (M+H)⁺-   1-1195; A-33; B-19; MS m/z 419 (M+H)⁺-   1-1196; A-33; B-20; MS m/z 421 (M+H)⁺-   1-1197; A-33; B-21; MS m/z 425 (M+H)⁺-   1-1198; A-33; B-22; MS m/z 429 (M+H)⁺-   1-1199; A-33; B-23; MS m/z 441 (M+H)⁺-   1-1200; A-33; B-24; MS m/z 441 (M+H)⁺-   1-1201; A-33; B-25; MS m/z 410 (M+H)⁺-   1-1202; A-33; B-26; MS m/z 450 (M+H)⁺-   1-1203; A-33; B-27; MS m/z 450 (M+H)⁺-   1-1204; A-33; B-28; MS m/z 443 (M+H)⁺-   1-1205; A-33; B-29; MS m/z 447 (M+H)⁺-   1-1206; A-33; B-30; MS m/z 459 (M+H)⁺-   1-1207; A-33; B-31; MS m/z 461 (M+H)⁺-   1-1208; A-33; B-32; MS m/z 463 (M+H)⁺-   1-1209; A-33; B-33; MS m/z 463 (M+H)⁺-   1-1210; A-33; B-34; MS m/z 473 (M+H)⁺-   1-1211; A-33; B-35; MS m/z 487 (M+H)⁺-   1-1212; A-33; B-36; MS m/z 505 (M+H)⁺-   1-1213; A-34; B-01-   1-1214; A-34; B-02-   1-1215; A-34; B-03-   1-1216; A-34; B-04-   1-1217; A-34; B-05-   1-1218; A-34; B-06-   1-1219; A-34; B-07-   1-1220; A-34; B-08-   1-1221; A-34; B-09-   1-1222; A-34; B-10-   1-1223; A-34; B-11-   1-1224; A-34; B-12-   1-1225; A-34; B-13-   1-1226; A-34; B-14-   1-1227; A-34; B-15-   1-1228; A-34; B-16-   1-1229; A-34; B-17-   1-1230; A-34; B-18-   1-1231; A-34; B-19-   1-1232; A-34; B-20-   1-1233; A-34; B-21-   1-1234; A-34; B-22-   1-1235; A-34; B-23-   1-1236; A-34; B-24-   1-1237; A-34; B-25-   1-1238; A-34; B-26-   1-1239; A-34; B-27-   1-1240; A-34; B-28-   1-1241; A-34; B-29-   1-1242; A-34; B-30-   1-1243; A-34; B-31-   1-1244; A-34; B-32-   1-1245; A-34; B-33-   1-1246; A-34; B-34-   1-1247; A-34; B-35-   1-1248; A-34; B-36-   1-1249; A-35; B-01; MS m/z 391 (M+H)⁺-   1-1250; A-35; B-02; MS m/z 395 (M+H)⁺-   1-1251; A-35; B-03; MS m/z 353 (M+H)⁺-   1-1252; A-35; B-04; MS m/z 411 (M+H)⁺-   1-1253; A-35; B-05; MS m/z 423 (M+H)⁺-   1-1254; A-35; B-06; MS m/z 463 (M+H)⁺-   1-1255; A-35; B-07; MS m/z 443 (M+H)⁺-   1-1256; A-35; B-08; MS m/z 449 (M+H)⁺-   1-1257; A-35; B-09; MS m/z 451 (M+H)⁺-   1-1258; A-35; B-10; MS m/z 473 (M+H)⁺-   1-1259; A-35; B-11; MS m/z 477 (M+H)⁺-   1-1260; A-35; B-12; MS m/z 485 (M+H)⁺-   1-1261; A-35; B-13; MS m/z 399 (M+H)⁺-   1-1262; A-35; B-14; MS m/z 407 (M+H)⁺-   1-1263; A-35; B-15; MS m/z 421 (M+H)⁺-   1-1264; A-35; B-16; MS m/z 427 (M+H)⁺-   1-1265; A-35; B-17; MS m/z 433 (M+H)⁺-   1-1266; A-35; B-18; MS m/z 437 (M+H)⁺-   1-1267; A-35; B-19; MS m/z 447 (M+H)⁺-   1-1268; A-35; B-20; MS m/z 449 (M+H)⁺-   1-1269; A-35; B-21; MS m/z 453 (M+H)⁺-   1-1270; A-35; B-22; MS m/z 457 (M+H)⁺-   1-1271; A-35; B-23; MS m/z 469 (M+H)⁺-   1-1272; A-35; B-24; MS m/z 469 (M+H)⁺-   1-1273; A-35; B-25; MS m/z 438 (M+H)⁺-   1-1274; A-35; B-26; MS m/z 478 (M+H)⁺-   1-1275; A-35; B-27; MS m/z 478 (M+H)⁺-   1-1276; A-35; B-28; MS m/z 471 (M+H)⁺-   1-1277; A-35; B-29; MS m/z 475 (M+H)⁺-   1-1278; A-35; B-30; MS m/z 487 (M+H)⁺-   1-1279; A-35; B-31; MS m/z 489 (M+H)⁺-   1-1280; A-35; B-32; MS m/z 491 (M+H)⁺-   1-1281; A-35; B-33; MS m/z 491 (M+H)⁺-   1-1282; A-35; B-34; MS m/z 501 (M+H)⁺-   1-1283; A-35; B-35; MS m/z 515 (M+H)⁺-   1-1284; A-35; B-36; MS m/z 533 (M+H)⁺-   1-1285; A-36; B-01; MS m/z 405 (M+H)⁺-   1-1286; A-36; B-02; MS m/z 409 (M+H)⁺-   1-1287; A-36; B-03; MS m/z 367 (M+H)⁺-   1-1288; A-36; B-04; MS m/z 425 (M+H)⁺-   1-1289; A-36; B-05; MS m/z 437 (M+H)⁺-   1-1290; A-36; B-06; MS m/z 477 (M+H)⁺-   1-1291; A-36; B-07; MS m/z 457 (M+H)⁺-   1-1292; A-36; B-08; MS m/z 463 (M+H)⁺-   1-1293; A-36; B-09; MS m/z 465 (M+H)⁺-   1-1294; A-36; B-10; MS m/z 487 (M+H)⁺-   1-1295; A-36; B-11; MS m/z 491 (M+H)⁺-   1-1296; A-36; B-12; MS m/z 499 (M+H)⁺-   1-1297; A-36; B-13; MS m/z 413 (M+H)⁺-   1-1298; A-36; B-14; MS m/z 421 (M+H)⁺-   1-1299; A-36; B-15; MS m/z 435 (M+H)⁺-   1-1300; A-36; B-16; MS m/z 441 (M+H)⁺-   1-1301; A-36; B-17; MS m/z 447 (M+H)⁺-   1-1302; A-36; B-18; MS m/z 451 (M+H)⁺-   1-1303; A-36; B-19; MS m/z 461 (M+H)⁺-   1-1304; A-36; B-20; MS m/z 463 (M+H)⁺-   1-1305; A-36; B-21; MS m/z 467 (M+H)⁺-   1-1306; A-36; B-22; MS m/z 471 (M+H)⁺-   1-1307; A-36; B-23; MS m/z 483 (M+H)⁺-   1-1308; A-36; B-24; MS m/z 483 (M+H)⁺-   1-1309; A-36; B-25; MS m/z 452 (M+H)⁺-   1-1310; A-36; B-26; MS m/z 492 (M+H)⁺-   1-1311; A-36; B-27; MS m/z 492 (M+H) +-   1-1312; A-36; B-28-   1-1313; A-36; B-29; MS m/z 489 (M+H)⁺-   1-1314; A-36; B-30; MS m/z 501 (M+H)⁺-   1-1315; A-36; B-31; MS m/z 503 (M+H)⁺-   1-1316; A-36; B-32; MS m/z 505 (M+H)⁺-   1-1317; A-36; B-33; MS m/z 505 (M+H)⁺-   1-1318; A-36; B-34; MS m/z 515 (M+H)⁺-   1-1319; A-36; B-35; MS m/z 529 (M+H)⁺-   1-1320; A-36; B-36; MS m/z 547 (M+H)⁺-   1-1321; A-37; B-01; MS m/z 455 (M+H)⁺-   1-1322; A-37; B-02; MS m/z 459 (M+H)⁺-   1-1323; A-37; B-03; MS m/z 417 (M+H)⁺-   1-1324; A-37; B-04; MS m/z 475 (M+H)⁺-   1-1325; A-37; B-05; MS m/z 487 (M+H)⁺-   1-1326; A-37; B-06; MS m/z 527 (M+H)⁺-   1-1327; A-37; B-07; MS m/z 507 (M+H)⁺-   1-1328; A-37; B-08; MS m/z 513 (M+H)⁺-   1-1329; A-37; B-09; MS m/z 515 (M+H)⁺-   1-1330; A-37; B-10; MS m/z 537 (M+H)⁺-   1-1331; A-37; B-11; MS m/z 541 (M+H)⁺-   1-1332; A-37; B-12; MS m/z 549 (M+H)⁺-   1-1333; A-37; B-13; MS m/z 463 (M+H)⁺-   1-1334; A-37; B-14; MS m/z 471 (M+H)⁺-   1-1335; A-37; B-15; MS m/z 485 (M+H)⁺-   1-1336; A-37; B-16; MS m/z 491 (M+H)⁺-   1-1337; A-37; B-17; MS m/z 497 (M+H)⁺-   1-1338; A-37; B-18; MS m/z 501 (M+H)⁺-   1-1339; A-37; B-19; MS m/z 511 (M+H)⁺-   1-1340; A-37; B-20; MS m/z 513 (M+H)⁺-   1-1341; A-37; B-21; MS m/z 517 (M+H)⁺-   1-1342; A-37; B-22; MS m/z 521 (M+H)⁺-   1-1343; A-37; B-23; MS m/z 533 (M+H)⁺-   1-1344; A-37; B-24; MS m/z 533 (M+H)⁺-   1-1345; A-37; B-25; MS m/z 502 (M+H)⁺-   1-1346; A-37; B-26; MS m/z 542 (M+H)⁺-   1-1347; A-37; B-27; MS m/z 542 (M+H)⁺-   1-1348; A-37; B-28; MS m/z 535 (M+H)⁺-   1-1349; A-37; B-29; MS m/z 539 (M+H)⁺-   1-1350; A-37; B-30; MS m/z 551 (M+H)⁺-   1-1351; A-37; B-31; MS m/z 553 (M+H)⁺-   1-1352; A-37; B-32; MS m/z 555 (M+H)⁺-   1-1353; A-37; B-33; MS m/z 555 (M+H)⁺-   1-1354; A-37; B-34; MS m/z 565 (M+H)⁺-   1-1355; A-37; B-35; MS m/z 579 (M+H)⁺-   1-1356; A-37; B-36; MS m/z 597 (M+H)⁺-   1-1357; A-38; B-01; MS m/z 392 (M+H)⁺-   1-1358; A-38; B-02; MS m/z 396 (M+H)⁺-   1-1359; A-38; B-03; MS m/z 354 (M+H)⁺-   1-1360; A-38; B-04; MS m/z 412 (M+H)⁺-   1-1361; A-38; B-05; MS m/z 424 (M+H)⁺-   1-1362; A-38; B-06; MS m/z 464 (M+H)⁺-   1-1363; A-38; B-07; MS m/z 444 (M+H)⁺-   1-1364; A-38; B-08; MS m/z 450 (M+H)⁺-   1-1365; A-38; B-09; MS m/z 452 (M+H)⁺-   1-1366; A-38; B-10; MS m/z 474 (M+H)⁺-   1-1367; A-38; B-11; MS m/z 478 (M+H)⁺-   1-1368; A-38; B-12; MS m/z 486 (M+H)⁺-   1-1369; A-38; B-13-   1-1370; A-38; B-14; MS m/z 408 (M+H)⁺-   1-1371; A-38; B-15; MS m/z 422 (M+H)⁺-   1-1372; A-38; B-16; MS m/z 428 (M+H)⁺-   1-1373; A-38; B-17; MS m/z 434 (M+H)⁺-   1-1374; A-38; B-18; MS m/z 438 (M+H)⁺-   1-1375; A-38; B-19; MS m/z 448 (M+H)⁺-   1-1376; A-38; B-20; MS m/z 450 (M+H)⁺-   1-1377; A-38; B-21; MS m/z 454 (M+H)⁺-   1-1378; A-38; B-22; MS m/z 458 (M+H)⁺-   1-1379; A-38; B-23; MS m/z 470 (M+H)⁺-   1-1380; A-38; B-24; MS m/z 470 (M+H)⁺-   1-1381; A-38; B-25-   1-1382; A-38; B-26; MS m/z 479 (M+H)⁺-   1-1383; A-38; B-27; MS m/z 479 (M+H)⁺-   1-1384; A-38; B-28; MS m/z 472 (M+H)⁺-   1-1385; A-38; B-29; MS m/z 476 (M+H)⁺-   1-1386; A-38; B-30; MS m/z 488 (M+H)⁺-   1-1387; A-38; B-31; MS m/z 490 (M+H)⁺-   1-1388; A-38; B-32; MS m/z 492 (M+H)⁺-   1-1389; A-38; B-33; MS m/z 492 (M+H)⁺-   1-1390; A-38; B-34; MS m/z 502 (M+H)⁺-   1-1391; A-38; B-35; MS m/z 516 (M+H)⁺-   1-1392; A-38; B-36; MS m/z 534 (M+H)⁺-   1-1393; A-39; B-01; MS m/z 460 (M+H)⁺-   1-1394; A-39; B-02; MS m/z 464 (M+H)⁺-   1-1395; A-39; B-03; MS m/z 422 (M+H)⁺-   1-1396; A-39; B-04; MS m/z 480 (M+H)⁺-   1-1397; A-39; B-05; MS m/z 492 (M+H)⁺-   1-1398; A-39; B-06; MS m/z 532 (M+H)⁺-   1-1399; A-39; B-07; MS m/z 512 (M+H)⁺-   1-1400; A-39; B-08; MS m/z 518 (M+H)⁺-   1-1401; A-39; B-09-   1-1402; A-39; B-10; MS m/z 542 (M+H)⁺-   1-1403; A-39; B-11; MS m/z 546 (M+H)⁺-   1-1404; A-39; B-12; MS m/z 554 (M+H)⁺-   1-1405; A-39; B-13; MS m/z 468 (M+H)⁺-   1-1406; A-39; B-14; MS m/z 476 (M+H)⁺-   1-1407; A-39; B-15; MS m/z 490 (M+H)⁺-   1-1408; A-39; B-16; MS m/z 496 (M+H)⁺-   1-1409; A-39; B-17; MS m/z 502 (M+H)⁺-   1-1410; A-39; B-18-   1-1411; A-39; B-19; MS m/z 516 (M+H)⁺-   1-1412; A-39; B-20; MS m/z 518 (M+H)⁺-   1-1413; A-39; B-21-   1-1414; A-39; B-22-   1-1415; A-39; B-23; MS m/z 538 (M+H)⁺-   1-1416; A-39; B-24; MS m/z 538 (M+H)⁺-   1-1417; A-39; B-25-   1-1418; A-39; B-26; MS m/z 547 (M+H)⁺-   1-1419; A-39; B-27; MS m/z 547 (M+H)⁺-   1-1420; A-39; B-28; MS m/z 540 (M+H)⁺-   1-1421; A-39; B-29; MS m/z 544 (M+H)⁺-   1-1422; A-39; B-30; MS m/z 556 (M+H)⁺-   1-1423; A-39; B-31; MS m/z 558 (M+H)⁺-   1-1424; A-39; B-32; MS m/z 560 (M+H)⁺-   1-1425; A-39; B-33-   1-1426; A-39; B-34-   1-1427; A-39; B-35; MS m/z 584 (M+H)⁺-   1-1428; A-39; B-36; MS m/z 602 (M+H)⁺-   1-1429; A-41; B-11; MS m/z 465 (M+H)⁺-   1-1430; A-41; B-48; MS m/z 465 (M+H)⁺-   1-1431; A-41; B-49; MS m/z 463 (M+H)⁺-   1-1432; A-41; B-50; MS m/z 449 (M+H)⁺-   1-1433; A-41; B-51; MS m/z 465 (M+H)⁺-   1-1434; A-41; B-52; MS m/z 463 (M+H)⁺-   1-1435; A-41; B-53; MS m/z 451 (M+H)⁺-   1-1436; A-41; B-54; MS m/z 479 (M+H)⁺-   1-1437; A-41; B-55; MS m/z 449 (M+H)⁺-   1-1438; A-41; B-56; MS m/z 461 (M+H)⁺-   1-1439; A-41; B-57; MS m/z 467 (M+H)⁺-   1-1440; A-41; B-58; MS m/z 445 (M+H)⁺-   1-1441; A-54; B-02; MS m/z 417 (M+H)⁺-   1-1442; A-54; B-37; MS m/z 415 (M+H)⁺-   1-1443; A-54; B-38; MS m/z 429 (M+H)⁺-   1-1444; A-54; B-39; MS m/z 429 (M+H)⁺-   1-1445; A-54; B-40; MS m/z 431 (M+H)⁺-   1-1446; A-54; B-41; MS m/z 403 (M+H)⁺-   1-1447; A-54; B-42; MS m/z 431 (M+H)⁺-   1-1448; A-54; B-43; MS m/z 431 (M+H)⁺-   1-1449; A-54; B-44; MS m/z 443 (M+H)⁺-   1-1450; A-54; B-45; MS m/z 445 (M+H)⁺-   1-1451; A-54; B-46; MS m/z 443 (M+H)⁺-   1-1452; A-54; B-47; MS m/z 445 (M+H)⁺-   1-1453; A-55; B-02; MS m/z 417 (M+H)⁺-   1-1454; A-55; B-37; MS m/z 415 (M+H)⁺-   1-1455; A-55; B-38; MS m/z 429 (M+H)⁺-   1-1456; A-55; B-39; MS m/z 429 (M+H)⁺-   1-1457; A-55; B-40; MS m/z 431 (M+H)⁺-   1-1458; A-55; B-41; MS m/z 403 (M+H)⁺-   1-1459; A-55; B-42; MS m/z 431 (M+H)⁺-   1-1460; A-55; B-43; MS m/z 431 (M+H)⁺-   1-1461; A-55; B-44; MS m/z 443 (M+H)⁺-   1-1462; A-55; B-45; MS m/z 445 (M+H)⁺-   1-1463; A-55; B-46; MS m/z 443 (M+H)⁺-   1-1464; A-55; B-47; MS m/z 445 (M+H)⁺-   1-1465; A-56; B-02; MS m/z 417 (M+H)⁺-   1-1466; A-56; B-37; MS m/z 415 (M+H)⁺-   1-1467; A-56; B-38; MS m/z 429 (M+H)⁺-   1-1468; A-56; B-39; MS m/z 429 (M+H)⁺-   1-1469; A-56; B-40; MS m/z 431 (M+H)⁺-   1-1470; A-56; B-41; MS m/z 403 (M+H)⁺-   1-1471; A-56; B-42; MS m/z 431 (M+H)⁺-   1-1472; A-56; B-43; MS m/z 431 (M+H)⁺-   1-1473; A-56; B-44; MS m/z 443 (M+H)⁺-   1-1474; A-56; B-45; MS m/z 445 (M+H)⁺-   1-1475; A-56; B-46; MS m/z 443 (M+H)⁺-   1-1476; A-56; B-47; MS m/z 445 (M+H)⁺-   1-1477; A-57; B-02; MS m/z 431 (M+H)⁺-   1-1478; A-57; B-37; MS m/z 429 (M+H)⁺-   1-1479; A-57; B-38; MS m/z 443 (M+H)⁺-   1-1480; A-57; B-39; MS m/z 443 (M+H)⁺-   1-1481; A-57; B-40; MS m/z 445 (M+H)⁺-   1-1482; A-57; B-41; MS m/z 417 (M+H)⁺-   1-1483; A-57; B-42; MS m/z 445 (M+H)⁺-   1-1484; A-57; B-43; MS m/z 445 (M+H)⁺-   1-1485; A-57; B-44; MS m/z 457 (M+H)⁺-   1-1486; A-57; B-45; MS m/z 459 (M+H)⁺-   1-1487; A-57; B-46; MS m/z 457 (M+H)⁺-   1-1488; A-57; B-47; MS m/z 459 (M+H)⁺-   1-1489; A-58; B-02; MS m/z 403 (M+H)⁺-   1-1490; A-58; B-37; MS m/z 401 (M+H)⁺-   1-1491; A-58; B-38; MS m/z 415 (M+H)⁺-   1-1492; A-58; B-39; MS m/z 415 (M+H)⁺-   1-1493; A-58; B-40; MS m/z 417 (M+H)⁺-   1-1494; A-58; B-41; MS m/z 389 (M+H)⁺-   1-1495; A-58; B-42; MS m/z 417 (M+H)⁺-   1-1496; A-58; B-43; MS m/z 417 (M+H)⁺-   1-1497; A-58; B-44; MS m/z 429 (M+H)⁺-   1-1498; A-58; B-45; MS m/z 431 (M+H)⁺-   1-1499; A-58; B-46; MS m/z 429 (M+H)⁺-   1-1500; A-58; B-47; MS m/z 431 (M+H)⁺-   1-1501; A-59; B-02; MS m/z 435 (M+H)⁺-   1-1502; A-59; B-37; MS m/z 433 (M+H)⁺-   1-1503; A-59; B-38; MS m/z 447 (M+H)⁺-   1-1504; A-59; B-39; MS m/z 447 (M+H)⁺-   1-1505; A-59; B-40; MS m/z 449 (M+H)⁺-   1-1506; A-59; B-41; MS m/z 421 (M+H)⁺-   1-1507; A-59; B-42; MS m/z 449 (M+H)⁺-   1-1508; A-59; B-43; MS m/z 449 (M+H)⁺-   1-1509; A-59; B-44; MS m/z 461 (M+H)⁺-   1-1510; A-59; B-45; MS m/z 463 (M+H)⁺-   1-1511; A-59; B-46; MS m/z 461 (M+H)⁺-   1-1512; A-59; B-47; MS m/z 463 (M+H)⁺-   1-1513; A-60; B-02; MS m/z 423 (M+H)⁺-   1-1514; A-60; B-37; MS m/z 421 (M+H)⁺-   1-1515; A-60; B-38; MS m/z 435 (M+H)⁺-   1-1516; A-60; B-39; MS m/z 435 (M+H)⁺-   1-1517; A-60; B-40; MS m/z 437 (M+H)⁺-   1-1518; A-60; B-41; MS m/z 409 (M+H)⁺-   1-1519; A-60; B-42; MS m/z 437 (M+H)⁺-   1-1520; A-60; B-43; MS m/z 437 (M+H)⁺-   1-1521; A-60; B-44; MS m/z 449 (M+H)⁺-   1-1522; A-60; B-45; MS m/z 451 (M+H)⁺-   1-1523; A-60; B-46; MS m/z 449 (M+H)⁺-   1-1524; A-60; B-47; MS m/z 451 (M+H)⁺-   1-1525; A-61; B-11; MS m/z 477 (M+H)⁺-   1-1526; A-61; B-48; MS m/z 477 (M+H)⁺-   1-1527; A-61; B-49; MS m/z 475 (M+H)⁺-   1-1528; A-61; B-50; MS m/z 461 (M+H)⁺-   1-1529; A-61; B-51; MS m/z 477 (M+H)⁺-   1-1530; A-61; B-52; MS m/z 475 (M+H)⁺-   1-1531; A-61; B-53; MS m/z 463 (M+H)⁺-   1-1532; A-61; B-54; MS m/z 491 (M+H)⁺-   1-1533; A-61; B-55; MS m/z 461 (M+H)⁺-   1-1534; A-61; B-56; MS m/z 473 (M+H)⁺-   1-1535; A-61; B-57; MS m/z 479 (M+H)⁺-   1-1536; A-61; B-58; MS m/z 457 (M+H)⁺-   1-1537; A-62; B-11; MS m/z 477 (M+H)⁺-   1-1538; A-62; B-48; MS m/z 477 (M+H)⁺-   1-1539; A-62; B-49; MS m/z 475 (M+H)⁺-   1-1540; A-62; B-50; MS m/z 461 (M+H)⁺-   1-1541; A-62; B-51; MS m/z 477 (M+H)⁺-   1-1542; A-62; B-52; MS m/z 475 (M+H)⁺-   1-1543; A-62; B-53; MS m/z 463 (M+H)⁺-   1-1544; A-62; B-54; MS m/z 491 (M+H)⁺-   1-1545; A-62; B-55; MS m/z 461 (M+H)⁺-   1-1546; A-62; B-56; MS m/z 473 (M+H)⁺-   1-1547; A-62; B-57; MS m/z 479 (M+H)⁺-   1-1548; A-62; B-58; MS m/z 457 (M+H)⁺-   1-1549; A-63; B-11; MS m/z 477 (M+H)⁺-   1-1550; A-63; B-48; MS m/z 477 (M+H)⁺-   1-1551; A-63; B-49; MS m/z 475 (M+H)⁺-   1-1552; A-63; B-50; MS m/z 461 (M+H)⁺-   1-1553; A-63; B-51; MS m/z 477 (M+H)⁺-   1-1554; A-63; B-52; MS m/z 475 (M+H)⁺-   1-1555; A-63; B-53; MS m/z 463 (M+H)⁺-   1-1556; A-63; B-54; MS m/z 491 (M+H)⁺-   1-1557; A-63; B-55; MS m/z 461 (M+H)⁺-   1-1558; A-63; B-56; MS m/z 473 (M+H)⁺-   1-1559; A-63; B-57; MS m/z 479 (M+H)⁺-   1-1560; A-63; B-58; MS m/z 457 (M+H)⁺-   1-1561; A-64; B-11; MS m/z 477 (M+H)⁺-   1-1562; A-64; B-48; MS m/z 477 (M+H)⁺-   1-1563; A-64; B-49; MS m/z 475 (M+H)⁺-   1-1564; A-64; B-50; MS m/z 461 (M+H)⁺-   1-1565; A-64; B-51; MS m/z 477 (M+H)⁺-   1-1566; A-64; B-52; MS m/z 475 (M+H)⁺-   1-1567; A-64; B-53; MS m/z 463 (M+H)⁺-   1-1568; A-64; B-54; MS m/z 491 (M+H)⁺-   1-1569; A-64; B-55; MS m/z 461 (M+H)⁺-   1-1570; A-64; B-56; MS m/z 473 (M+H)⁺-   1-1571; A-64; B-57; MS m/z 479 (M+H)⁺-   1-1572; A-64; B-58; MS m/z 457 (M+H)⁺-   1-1573; A-65; B-11; MS m/z 463 (M+H)⁺-   1-1574; A-65; B-48; MS m/z 463 (M+H)⁺-   1-1575; A-65; B-49; MS m/z 461 (M+H)⁺-   1-1576; A-65; B-50; MS m/z 447 (M+H)⁺-   1-1577; A-65; B-51; MS m/z 463 (M+H)⁺-   1-1578; A-65; B-52; MS m/z 461 (M+H)⁺-   1-1579; A-65; B-53; MS m/z 449 (M+H)⁺-   1-1580; A-65; B-54; MS m/z 477 (M+H)⁺-   1-1581; A-65; B-55; MS m/z 447 (M+H)⁺-   1-1582; A-65; B-56; MS m/z 459 (M+H)⁺-   1-1583; A-65; B-57; MS m/z 465 (M+H)⁺-   1-1584; A-65; B-58; MS m/z 443 (M+H)⁺-   1-1585; A-66; B-11; MS m/z 463 (M+H)⁺-   1-1586; A-66; B-48; MS m/z 463 (M+H)⁺-   1-1587; A-66; B-49; MS m/z 461 (M+H)⁺-   1-1588; A-66; B-50; MS m/z 447 (M+H)⁺-   1-1589; A-66; B-51; MS m/z 463 (M+H)⁺-   1-1590; A-66; B-52; MS m/z 461 (M+H)⁺-   1-1591; A-66; B-53; MS m/z 449 (M+H)⁺-   1-1592; A-66; B-54; MS m/z 477 (M+H)⁺-   1-1593; A-66; B-55; MS m/z 447 (M+H)⁺-   1-1594; A-66; B-56; MS m/z 459 (M+H)⁺-   1-1595; A-66; B-57; MS m/z 465 (M+H)⁺-   1-1596; A-66; B-58; MS m/z 443 (M+H)⁺-   1-1597; A-72; B-01; MS m/z 379 (M+H)⁺-   1-1598; A-72; B-02; MS m/z 383 (M+H)⁺-   1-1599; A-72; B-03; MS m/z 341 (M+H)⁺-   1-1600; A-72; B-04; MS m/z 399 (M+H)⁺-   1-1601; A-72; B-05; MS m/z 411 (M+H)⁺-   1-1602; A-72; B-06; MS m/z 451 (M+H)⁺-   1-1603; A-72; B-07; MS m/z 431 (M+H)⁺-   1-1604; A-72; B-08; MS m/z 437 (M+H)⁺-   1-1605; A-72; B-09; MS m/z 439 (M+H)⁺-   1-1606; A-72; B-10; MS m/z 461 (M+H)⁺-   1-1607; A-72; B-11; MS m/z 465 (M+H)⁺-   1-1608; A-72; B-12; MS m/z 473 (M+H)⁺-   1-1609; A-72; B-13; MS m/z 387 (M+H)⁺-   1-1610; A-72; B-14; MS m/z 395 (M+H)⁺-   1-1611; A-72; B-15; MS m/z 409 (M+H)⁺-   1-1612; A-72; B-16; MS m/z 415 (M+H)⁺-   1-1613; A-72; B-17; MS m/z 421 (M+H)⁺-   1-1614; A-72; B-18; MS m/z 425 (M+H)⁺-   1-1615; A-72; B-19; MS m/z 435 (M+H)⁺-   1-1616; A-72; B-20; MS m/z 437 (M+H)⁺-   1-1617; A-72; B-21; MS m/z 441 (M+H)⁺-   1-1618; A-72; B-22; MS m/z 445 (M+H)⁺-   1-1619; A-72; B-23; MS m/z 457 (M+H)⁺-   1-1620; A-72; B-24; MS m/z 457 (M+H)⁺-   1-1621; A-72; B-25; MS m/z 426 (M+H)⁺-   1-1622; A-72; B-26; MS m/z 466 (M+H)⁺-   1-1623; A-72; B-27; MS m/z 466 (M+H)⁺-   1-1624; A-72; B-28; MS m/z 459 (M+H)⁺-   1-1625; A-72; B-29; MS m/z 463 (M+H)⁺-   1-1626; A-72; B-30; MS m/z 475 (M+H)⁺-   1-1627; A-72; B-31; MS m/z 477 (M+H)⁺-   1-1628; A-72; B-32; MS m/z 479 (M+H)⁺-   1-1629; A-72; B-33; MS m/z 479 (M+H)⁺-   1-1630; A-72; B-34; MS m/z 489 (M+H)⁺-   1-1631; A-72; B-35; MS m/z 503 (M+H)⁺-   1-1632; A-72; B-36; MS m/z 521 (M+H)⁺

(b) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —R⁵ and spectrum data thereof.

-   2-1; A-07; B-32; MS m/z 479 (M+H)⁺-   2-2; A-09; B-13; MS m/z 413 (M+H)⁺-   2-3; A-09; B-14; MS m/z 421 (M+H)⁺-   2-4; A-09; B-15; MS m/z 435 (M+H)⁺-   2-5; A-09; B-16; MS m/z 441 (M+H)⁺-   2-6; A-09; B-17; MS m/z 447 (M+H)⁺-   2-7; A-09; B-18; MS m/z 451 (M+H)⁺-   2-8; A-09; B-19; MS m/z 461 (M+H)⁺-   2-9; A-09; B-20; MS m/z 463 (M+H)⁺-   2-10; A-09; B-21; MS m/z 467 (M+H)⁺-   2-11; A-09; B-22; MS m/z 471 (M+H)⁺-   2-12; A-09; B-23; MS m/z 483 (M+H)⁺-   2-13; A-09; B-24; MS m/z 483 (M+H)⁺-   2-14; A-09; B-32; MS m/z 505 (M+H)⁺-   2-15; A-10; B-13; MS m/z 413 (M+H)⁺-   2-16; A-10; B-14; MS m/z 421 (M+H)⁺-   2-17; A-10; B-15; MS m/z 435 (M+H)⁺-   2-18; A-10; B-16; MS m/z 441 (M+H)⁺-   2-19; A-10; B-17; MS m/z 447 (M+H)⁺-   2-20; A-10; B-18; MS m/z 451 (M+H)⁺-   2-21; A-10; B-19; MS m/z 461 (M+H)⁺-   2-22; A-10; B-20; MS m/z 463 (M+H)⁺-   2-23; A-10; B-21; MS m/z 467 (M+H)⁺-   2-24; A-10; B-22; MS m/z 471 (M+H)⁺-   2-25; A-10; B-23; MS m/z 483 (M+H)⁺-   2-26; A-10; B-24; MS m/z 483 (M+H)⁺-   2-27; A-11; B-13; MS m/z 413 (M+H)⁺-   2-28; A-11; B-14; MS m/z 421 (M+H)⁺-   2-29; A-11; B-15; MS m/z 435 (M+H)⁺-   2-30; A-11; B-16; MS m/z 441 (M+H)⁺-   2-31; A-11; B-17; MS m/z 447 (M+H)⁺-   2-32; A-11; B-18; MS m/z 451 (M+H)⁺-   2-33; A-11; B-19; MS m/z 461 (M+H)⁺-   2-34; A-11; B-20; MS m/z 463 (M+H)⁺-   2-35; A-11; B-21; MS m/z 467 (M+H)⁺-   2-36; A-11; B-22; MS m/z 471 (M+H)⁺-   2-37; A-11; B-23; MS m/z 483 (M+H)⁺-   2-38; A-11; B-24; MS m/z 483 (M+H)⁺-   2-39; A-11; B-31; MS m/z 503 (M+H)⁺-   2-40; A-12; B-13; MS m/z 413 (M+H)⁺-   2-41; A-12; B-14; MS m/z 421 (M+H)⁺-   2-42; A-12; B-15; MS m/z 435 (M+H)⁺-   2-43; A-12; B-16; MS m/z 441 (M+H)⁺-   2-44; A-12; B-17; MS m/z 447 (M+H)⁺-   2-45; A-12; B-18; MS m/z 451 (M+H)⁺-   2-46; A-12; B-19; MS m/z 461 (M+H)⁺-   2-47; A-12; B-20; MS m/z 463 (M+H)⁺-   2-48; A-12; B-21; MS m/z 467 (M+H)⁺-   2-49; A-12; B-22; MS m/z 471 (M+H)⁺-   2-50; A-12; B-23; MS m/z 483 (M+H)⁺-   2-51; A-12; B-24; MS m/z 483 (M+H)⁺-   2-52; A-13; B-13; MS m/z 421 (M+H)⁺-   2-53; A-13; B-14; MS m/z 429 (M+H)⁺-   2-54; A-13; B-15; MS m/z 443 (M+H)⁺-   2-55; A-13; B-16; MS m/z 449 (M+H)⁺-   2-56; A-13; B-17; MS m/z 455 (M+H)⁺-   2-57; A-13; B-18; MS m/z 459 (M+H)⁺-   2-58; A-13; B-19; MS m/z 469 (M+H)⁺-   2-59; A-13; B-20; MS m/z 471 (M+H)⁺-   2-60; A-13; B-21; MS m/z 475 (M+H)⁺-   2-61; A-13; B-22; MS m/z 479 (M+H)⁺-   2-62; A-13; B-23; MS m/z 491 (M+H)⁺-   2-63; A-13; B-24; MS m/z 491 (M+H)⁺-   2-64; A-14; B-13; MS m/z 421 (M+H)⁺-   2-65; A-14; B-14; MS m/z 429 (M+H)⁺-   2-66; A-14; B-15; MS m/z 443 (M+H)⁺-   2-67; A-14; B-16; MS m/z 449 (M+H)⁺-   2-68; A-14; B-17; MS m/z 455 (M+H)⁺-   2-69; A-14; B-18; MS m/z 459 (M+H)⁺-   2-70; A-14; B-19; MS m/z 469 (M+H)⁺-   2-71; A-14; B-20; MS m/z 471 (M+H)⁺-   2-72; A-14; B-21; MS m/z 475 (M+H)⁺-   2-73; A-14; B-22; MS m/z 479 (M+H)⁺-   2-74; A-14; B-23; MS m/z 491 (M+H)⁺-   2-75; A-14; B-24; MS m/z 491 (M+H)⁺-   2-76; A-15; B-13; MS m/z 429 (M+H)⁺-   2-77; A-15; B-14; MS m/z 437 (M+H)⁺-   2-78; A-15; B-15; MS m/z 451 (M+H)⁺-   2-79; A-15; B-16; MS m/z 457 (M+H)⁺-   2-80; A-15; B-17; MS m/z 463 (M+H)⁺-   2-81; A-15; B-18; MS m/z 467 (M+H)⁺-   2-82; A-15; B-19; MS m/z 477 (M+H)⁺-   2-83; A-15; B-20; MS m/z 479 (M+H)⁺-   2-84; A-15; B-21; MS m/z 483 (M+H)⁺-   2-85; A-15; B-22; MS m/z 487 (M+H)⁺-   2-86; A-15; B-23; MS m/z 499 (M+H)⁺-   2-87; A-15; B-24; MS m/z 499 (M+H)⁺-   2-88; A-16; B-13; MS m/z 435 (M+H)⁺-   2-89; A-16; B-14; MS m/z 443 (M+H)⁺-   2-90; A-16; B-15; MS m/z 457 (M+H)⁺-   2-91; A-16; B-16; MS m/z 463 (M+H)⁺-   2-92; A-16; B-17; MS m/z 469 (M+H)⁺-   2-93; A-16; B-18; MS m/z 473 (M+H)⁺-   2-94; A-16; B-19; MS m/z 483 (M+H)⁺-   2-95; A-16; B-20; MS m/z 485 (M+H)⁺-   2-96; A-16; B-21; MS m/z 489 (M+H)⁺-   2-97; A-16; B-22; MS m/z 493 (M+H)⁺-   2-98; A-16; B-23; MS m/z 505 (M+H)⁺-   2-99; A-16; B-24; MS m/z 505 (M+H)⁺-   2-100; A-17; B-19; MS m/z 489 (M+H)⁺-   2-101; A-18; B-08; MS m/z 507 (M+H)⁺-   2-102; A-19; B-05; MS m/z 457 (M+H)⁺-   2-103; A-19; B-16; MS m/z 461 (M+H)⁺-   2-104; A-19; B-31; MS m/z 523 (M+H)⁺-   2-105; A-24; B-09; MS m/z 527 (M+H)⁺-   2-106; A-24; B-19; MS m/z 523 (M+H)⁺-   2-107; A-24; B-32; MS m/z 567 (M+H)⁺

(c) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —R⁵ and spectrum data thereof.

-   3-1; A-09; B-01-   3-2; A-09; B-02-   3-3; A-09; B-03-   3-4; A-09; B-04; MS m/z 377 (M+H)⁺-   3-5; A-09; B-05-   3-6; A-09; B-06-   3-7; A-09; B-07; MS m/z 409 (M+H)⁺-   3-8; A-09; B-08-   3-9; A-09; B-09-   3-10; A-09; B-10-   3-11; A-09; B-11-   3-12; A-09; B-12-   3-13; A-09; B-13; MS m/z 365 (M+H)⁺-   3-14; A-09; B-14; MS m/z 373 (M+H)⁺-   3-15; A-09; B-15; MS m/z 387 (M+H)⁺-   3-16; A-09; B-16; MS m/z 393 (M+H)⁺-   3-17; A-09; B-17; MS m/z 399 (M+H)⁺-   3-18; A-09; B-18; MS m/z 403 (M+H)⁺-   3-19; A-09; B-19; MS m/z 413 (M+H)⁺-   3-20; A-09; B-20; MS m/z 415 (M+H)⁺-   3-21; A-09; B-21; MS m/z 419 (M+H)⁺-   3-22; A-09; B-22; MS m/z 423 (M+H)⁺-   3-23; A-09; B-23; MS m/z 435 (M+H)⁺-   3-24; A-09; B-24; MS m/z 435 (M+H)⁺-   3-25; A-10; B-01; MS m/z 357 (M+H)⁺-   3-26; A-10; B-02; MS m/z 361 (M+H)⁺-   3-27; A-10; B-03; MS m/z 319 (M+H)⁺-   3-28; A-10; B-04; MS m/z 377 (M+H)⁺-   3-29; A-10; B-05; MS m/z 389 (M+H)⁺-   3-30; A-10; B-06; MS m/z 429 (M+H)⁺-   3-31; A-10; B-07; MS m/z 409 (M+H)⁺-   3-32; A-10; B-08; MS m/z 415 (M+H)⁺-   3-33; A-10; B-09; MS m/z 417 (M+H)⁺-   3-34; A-10; B-10; MS m/z 439 (M+H)⁺-   3-35; A-10; B-11; MS m/z 443 (M+H)⁺-   3-36; A-10; B-12; MS m/z 451 (M+H)⁺-   3-37; A-10; B-13; MS m/z 365 (M+H)⁺-   3-38; A-10; B-14; MS m/z 373 (M+H)⁺-   3-39; A-10; B-15; MS m/z 387 (M+H)⁺-   3-40; A-10; B-16; MS m/z 393 (M+H)⁺-   3-41; A-10; B-17; MS m/z 399 (M+H)⁺-   3-42; A-10; B-18; MS m/z 403 (M+H)⁺-   3-43; A-10; B-19; MS m/z 413 (M+H)⁺-   3-44; A-10; B-20; MS m/z 415 (M+H)⁺-   3-45; A-10; B-21; MS m/z 419 (M+H)⁺-   3-46; A-10; B-22; MS m/z 423 (M+H)⁺-   3-47; A-10; B-23; MS m/z 435 (M+H)⁺-   3-48; A-10; B-24; MS m/z 435 (M+H)⁺-   3-49; A-11; B-01; MS m/z 357 (M+H)⁺-   3-50; A-11; B-02; MS m/z 361 (M+H)⁺-   3-51; A-11; B-03; MS m/z 319 (M+H)⁺-   3-52; A-11; B-04; MS m/z 377 (M+H)⁺-   3-53; A-11; B-05; MS m/z 389 (M+H)⁺-   3-54; A-11; B-06; MS m/z 429 (M+H)⁺-   3-55; A-11; B-07; MS m/z 409 (M+H)⁺-   3-56; A-11; B-08; MS m/z 415 (M+H)⁺-   3-57; A-11; B-09; MS m/z 417 (M+H)⁺-   3-58; A-11; B-10; MS m/z 439 (M+H)⁺-   3-59; A-11; B-11; MS m/z 443 (M+H)⁺-   3-60; A-11; B-12; MS m/z 451 (M+H)⁺-   3-61; A-11; B-13; MS m/z 365 (M+H)⁺-   3-62; A-11; B-14; MS m/z 373 (M+H)⁺-   3-63; A-11; B-15; MS m/z 387 (M+H)⁺-   3-64; A-11; B-16; MS m/z 393 (M+H)⁺-   3-65; A-11; B-17; MS m/z 399 (M+H)⁺-   3-66; A-11; B-18; MS m/z 403 (M+H)⁺-   3-67; A-11; B-19; MS m/z 413 (M+H)⁺-   3-68; A-11; B-20; MS m/z 415 (M+H)⁺-   3-69; A-11; B-21; MS m/z 419 (M+H)⁺-   3-70; A-11; B-22; MS m/z 423 (M+H)⁺-   3-71; A-11; B-23; MS m/z 435 (M+H)⁺-   3-72; A-11; B-24; MS m/z 435 (M+H)⁺-   3-73; A-12; B-01; MS m/z 357 (M+H)⁺-   3-74; A-12; B-02; MS m/z 361 (M+H)⁺-   3-75; A-12; B-03; MS m/z 319 (M+H)⁺-   3-76; A-12; B-04; MS m/z 377 (M+H)⁺-   3-77; A-12; B-05; MS m/z 389 (M+H)⁺-   3-78; A-12; B-06; MS m/z 429 (M+H)⁺-   3-79; A-12; B-07; MS m/z 409 (M+H)⁺-   3-80; A-12; B-08; MS m/z 415 (M+H)⁺-   3-81; A-12; B-09; MS m/z 417 (M+H)⁺-   3-82; A-12; B-10; MS m/z 439 (M+H)⁺-   3-83; A-12; B-11; MS m/z 443 (M+H)⁺-   3-84; A-12; B-12; MS m/z 451 (M+H)⁺-   3-85; A-12; B-13; MS m/z 365 (M+H)⁺-   3-86; A-12; B-14; MS m/z 373 (M+H)⁺-   3-87; A-12; B-15; MS m/z 387 (M+H)⁺-   3-88; A-12; B-16; MS m/z 393 (M+H)⁺-   3-89; A-12; B-17; MS m/z 399 (M+H)⁺-   3-90; A-12; B-18; MS m/z 403 (M+H)⁺-   3-91; A-12; B-19; MS m/z 413 (M+H)⁺-   3-92; A-12; B-20; MS m/z 415 (M+H)⁺-   3-93; A-12; B-21; MS m/z 419 (M+H)⁺-   3-94; A-12; B-22; MS m/z 423 (M+H)⁺-   3-95; A-12; B-23; MS m/z 435 (M+H)⁺-   3-96; A-12; B-24; MS m/z 435 (M+H)⁺-   3-97; A-13; B-01; MS m/z 365 (M+H)⁺-   3-98; A-13; B-02; MS m/z 369 (M+H)⁺-   3-99; A-13; B-03; MS m/z 327 (M+H)⁺-   3-100; A-13; B-04; MS m/z 385 (M+H)⁺-   3-101; A-13; B-05; MS m/z 397 (M+H)⁺-   3-102; A-13; B-06; MS m/z 437 (M+H)⁺-   3-103; A-13; B-07; MS m/z 417 (M+H)⁺-   3-104; A-13; B-08; MS m/z 423 (M+H)⁺-   3-105; A-13; B-09; MS m/z 425 (M+H)⁺-   3-106; A-13; B-10; MS m/z 447 (M+H)⁺-   3-107; A-13; B-11; MS m/z 451 (M+H)⁺-   3-108; A-13; B-12; MS m/z 459 (M+H)⁺-   3-109; A-13; B-13; MS m/z 373 (M+H)⁺-   3-110; A-13; B-14; MS m/z 381 (M+H)⁺-   3-111; A-13; B-15; MS m/z 395 (M+H)⁺-   3-112; A-13; B-16; MS m/z 401 (M+H)⁺-   3-113; A-13; B-17; MS m/z 407 (M+H)⁺-   3-114; A-13; B-18; MS m/z 411 (M+H)⁺-   3-115; A-13; B-19; MS m/z 421 (M+H)⁺-   3-116; A-13; B-20; MS m/z 423 (M+H)⁺-   3-117; A-13; B-21; MS m/z 427 (M+H)⁺-   3-118; A-13; B-22; MS m/z 431 (M+H)⁺-   3-119; A-13; B-23; MS m/z 443 (M+H)⁺-   3-120; A-13; B-24; MS m/z 443 (M+H)⁺-   3-121; A-14; B-01; MS m/z 365 (M+H)⁺-   3-122; A-14; B-02; MS m/z 369 (M+H)⁺-   3-123; A-14; B-03; MS m/z 327 (M+H)⁺-   3-124; A-14; B-04; MS m/z 385 (M+H)⁺-   3-125; A-14; B-05; MS m/z 397 (M+H)⁺-   3-126; A-14; B-06; MS m/z 437 (M+H)⁺-   3-127; A-14; B-07; MS m/z 417 (M+H)⁺-   3-128; A-14; B-08; MS m/z 423 (M+H)⁺-   3-129; A-14; B-09; MS m/z 425 (M+H)⁺-   3-130; A-14; B-10; MS m/z 447 (M+H)⁺-   3-131; A-14; B-11; MS m/z 451 (M+H)⁺-   3-132; A-14; B-12; MS m/z 459 (M+H)⁺-   3-133; A-14; B-13; MS m/z 373 (M+H)⁺-   3-134; A-14; B-14; MS m/z 381 (M+H)⁺-   3-135; A-14; B-15; MS m/z 395 (M+H)⁺-   3-136; A-14; B-16; MS m/z 401 (M+H)⁺-   3-137; A-14; B-17; MS m/z 407 (M+H)⁺-   3-138; A-14; B-18; MS m/z 411 (M+H)⁺-   3-139; A-14; B-19; MS m/z 421 (M+H)⁺-   3-140; A-14; B-20; MS m/z 423 (M+H)⁺-   3-141; A-14; B-21; MS m/z 427 (M+H)⁺-   3-142; A-14; B-22; MS m/z 431 (M+H)⁺-   3-143; A-14; B-23; MS m/z 443 (M+H)⁺-   3-144; A-14; B-24; MS m/z 443 (M+H)⁺-   3-145; A-15; B-01; MS m/z 373 (M+H)⁺-   3-146; A-15; B-02; MS m/z 377 (M+H)⁺-   3-147; A-15; B-03; MS m/z 335 (M+H)⁺-   3-148; A-15; B-04; MS m/z 393 (M+H)⁺-   3-149; A-15; B-05; MS m/z 405 (M+H)⁺-   3-150; A-15; B-06-   3-151; A-15; B-07; MS m/z 425 (M+H)⁺-   3-152; A-15; B-08; MS m/z 431 (M+H)⁺-   3-153; A-15; B-09; MS m/z 433 (M+H)⁺-   3-154; A-15; B-10; MS m/z 455 (M+H)⁺-   3-155; A-15; B-11; MS m/z 459 (M+H)⁺-   3-156; A-15; B-12; MS m/z 467 (M+H)⁺-   3-157; A-15; B-13; MS m/z 381 (M+H)⁺-   3-158; A-15; B-14; MS m/z 389 (M+H)⁺-   3-159; A-15; B-15; MS m/z 403 (M+H)⁺-   3-160; A-15; B-16; MS m/z 409 (M+H)⁺-   3-161; A-15; B-17; MS m/z 415 (M+H)⁺-   3-162; A-15; B-18; MS m/z 419 (M+H)⁺-   3-163; A-15; B-19; MS m/z 429 (M+H)⁺-   3-164; A-15; B-20; MS m/z 431 (M+H)⁺-   3-165; A-15; B-21; MS m/z 435 (M+H)⁺-   3-166; A-15; B-22; MS m/z 439 (M+H)⁺-   3-167; A-15; B-23; MS m/z 451 (M+H)⁺-   3-168; A-15; B-24; MS m/z 451 (M+H)⁺-   3-169; A-16; B-01; MS m/z 379 (M+H)⁺-   3-170; A-16; B-02; MS m/z 383 (M+H)⁺-   3-171; A-16; B-03; MS m/z 341 (M+H)⁺-   3-172; A-16; B-04; MS m/z 399 (M+H)⁺-   3-173; A-16; B-05; MS m/z 411 (M+H)⁺-   3-174; A-16; B-06; MS m/z 451 (M+H)⁺-   3-175; A-16; B-07; MS m/z 431 (M+H)⁺-   3-176; A-16; B-08; MS m/z 437 (M+H)⁺-   3-177; A-16; B-09; MS m/z 439 (M+H)⁺-   3-178; A-16; B-10; MS m/z 461 (M+H)⁺-   3-179; A-16; B-11; MS m/z 465 (M+H)⁺-   3-180; A-16; B-12; MS m/z 473 (M+H)⁺-   3-181; A-16; B-13; MS m/z 387 (M+H)⁺-   3-182; A-16; B-14; MS m/z 395 (M+H)⁺-   3-183; A-16; B-15; MS m/z 409 (M+H)⁺-   3-184; A-16; B-16; MS m/z 415 (M+H)⁺-   3-185; A-16; B-17; MS m/z 421 (M+H)⁺-   3-186; A-16; B-18; MS m/z 425 (M+H)⁺-   3-187; A-16; B-19; MS m/z 435 (M+H)⁺-   3-188; A-16; B-20; MS m/z 437 (M+H)⁺-   3-189; A-16; B-21; MS m/z 441 (M+H)⁺-   3-190; A-16; B-22; MS m/z 445 (M+H)⁺-   3-191; A-16; B-23; MS m/z 457 (M+H)⁺-   3-192; A-16; B-24; MS m/z 457 (M+H)⁺-   3-193; A-19; B-08; MS m/z 435 (M+H)⁺-   3-194; A-19; B-19; MS m/z 433 (M+H)⁺

(d) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —R⁵ and spectrum data thereof.

-   4-1; A-09; B-01; MS m/z 411 (M+H)⁺-   4-2; A-09; B-02; MS m/z 415 (M+H)⁺-   4-3; A-09; B-03; MS m/z 373 (M+H)⁺-   4-4; A-09; B-04; MS m/z 431 (M+H)⁺-   4-5; A-09; B-05; MS m/z 443 (M+H)⁺-   4-6; A-09; B-06; MS m/z 483 (M+H)⁺-   4-7; A-09; B-07; MS m/z 463 (M+H)⁺-   4-8; A-09; B-08; MS m/z 469 (M+H)⁺-   4-9; A-09; B-09; MS m/z 471 (M+H)⁺-   4-10; A-09; B-10; MS m/z 493 (M+H)⁺-   4-11; A-09; B-11; MS m/z 497 (M+H)⁺-   4-12; A-09; B-12; MS m/z 505 (M+H)⁺-   4-13; A-10; B-01; MS m/z 411 (M+H)⁺-   4-14; A-10; B-02; MS m/z 415 (M+H)⁺-   4-15; A-10; B-03; MS m/z 373 (M+H)⁺-   4-16; A-10; B-04; MS m/z 431 (M+H)⁺-   4-17; A-10; B-05; MS m/z 443 (M+H)⁺-   4-18; A-10; B-06; MS m/z 483 (M+H)⁺-   4-19; A-10; B-07; MS m/z 463 (M+H)⁺-   4-20; A-10; B-08; MS m/z 469 (M+H)⁺-   4-21; A-10; B-09; MS m/z 471 (M+H)⁺-   4-22; A-10; B-10; MS m/z 493 (M+H)⁺-   4-23; A-10; B-11; MS m/z 497 (M+H)⁺-   4-24; A-10; B-12; MS m/z 505 (M+H)⁺-   4-25; A-11; B-01; MS m/z 411 (M+H)⁺-   4-26; A-11; B-02; MS m/z 415 (M+H)⁺-   4-27; A-11; B-03; MS m/z 373 (M+H)⁺-   4-28; A-11; B-04; MS m/z 431 (M+H)⁺-   4-29; A-11; B-05; MS m/z 443 (M+H)⁺-   4-30; A-11; B-06; MS m/z 483 (M+H)⁺-   4-31; A-11; B-07; MS m/z 463 (M+H)⁺-   4-32; A-11; B-08; MS m/z 469 (M+H)⁺-   4-33; A-11; B-09; MS m/z 471 (M+H)⁺-   4-34; A-11; B-10; MS m/z 493 (M+H)⁺-   4-35; A-11; B-11; MS m/z 497 (M+H)⁺-   4-36; A-11; B-12; MS m/z 505 (M+H)⁺-   4-37; A-12; B-01; MS m/z 411 (M+H)⁺-   4-38; A-12; B-02; MS m/z 415 (M+H)⁺-   4-39; A-12; B-03; MS m/z 373 (M+H)⁺-   4-40; A-12; B-04; MS m/z 431 (M+H)⁺-   4-41; A-12; B-05; MS m/z 443 (M+H)⁺-   4-42; A-12; B-06; MS m/z 483 (M+H)⁺-   4-43; A-12; B-07; MS m/z 463 (M+H)⁺-   4-44; A-12; B-08; MS m/z 469 (M+H)⁺-   4-45; A-12; B-09; MS m/z 471 (M+H)⁺-   4-46; A-12; B-10; MS m/z 493 (M+H)⁺-   4-47; A-12; B-11; MS m/z 497 (M+H)⁺-   4-48; A-12; B-12; MS m/z 505 (M+H)⁺-   4-49; A-13; B-01; MS m/z 419 (M+H)⁺-   4-50; A-13; B-02; MS m/z 423 (M+H)⁺-   4-51; A-13; B-03; MS m/z 381 (M+H)⁺-   4-52; A-13; B-04; MS m/z 439 (M+H)⁺-   4-53; A-13; B-05; MS m/z 451 (M+H)⁺-   4-54; A-13; B-06; MS m/z 491 (M+H)⁺-   4-55; A-13; B-07; MS m/z 471 (M+H)⁺-   4-56; A-13; B-08; MS m/z 477 (M+H)⁺-   4-57; A-13; B-09; MS m/z 479 (M+H)⁺-   4-58; A-13; B-10; MS m/z 501 (M+H)⁺-   4-59; A-13; B-11; MS m/z 505 (M+H)⁺-   4-60; A-13; B-12; MS m/z 513 (M+H)⁺-   4-61; A-14; B-01; MS m/z 419 (M+H)⁺-   4-62; A-14; B-02; MS m/z 423 (M+H)⁺-   4-63; A-14; B-03; MS m/z 381 (M+H)⁺-   4-64; A-14; B-04; MS m/z 439 (M+H)⁺-   4-65; A-14; B-05; MS m/z 451 (M+H)⁺-   4-66; A-14; B-06; MS m/z 491 (M+H)⁺-   4-67; A-14; B-07; MS m/z 471 (M+H)⁺-   4-68; A-14; B-08; MS m/z 477 (M+H)⁺-   4-69; A-14; B-09; MS m/z 479 (M+H)⁺-   4-70; A-14; B-10; MS m/z 501 (M+H)⁺-   4-71; A-14; B-11; MS m/z 505 (M+H)⁺-   4-72; A-14; B-12; MS m/z 513 (M+H)⁺-   4-73; A-15; B-01; MS m/z 427 (M+H)⁺-   4-74; A-15; B-02; MS m/z 431 (M+H)⁺-   4-75; A-15; B-03; MS m/z 389 (M+H)⁺-   4-76; A-15; B-04; MS m/z 447 (M+H)⁺-   4-77; A-15; B-05; MS m/z 459 (M+H)⁺-   4-78; A-15; B-06; MS m/z 499 (M+H)⁺-   4-79; A-15; B-07; MS m/z 479 (M+H)⁺-   4-80; A-15; B-08; MS m/z 485 (M+H)⁺-   4-81; A-15; B-09; MS m/z 487 (M+H)⁺-   4-82; A-15; B-10; MS m/z 509 (M+H)⁺-   4-83; A-15; B-11; MS m/z 513 (M+H)⁺-   4-84; A-15; B-12; MS m/z 521 (M+H)⁺-   4-85; A-16; B-01; MS m/z 433 (M+H)⁺-   4-86; A-16; B-02; MS m/z 437 (M+H)⁺-   4-87; A-16; B-03; MS m/z 395 (M+H)⁺-   4-88; A-16; B-04; MS m/z 453 (M+H)⁺-   4-89; A-16; B-05; MS m/z 465 (M+H)⁺-   4-90; A-16; B-06; MS m/z 505 (M+H)⁺-   4-91; A-16; B-07; MS m/z 485 (M+H)⁺-   4-92; A-16; B-08; MS m/z 491 (M+H)⁺-   4-93; A-16; B-09; MS m/z 493 (M+H)⁺-   4-94; A-16; B-10; MS m/z 515 (M+H)⁺-   4-95; A-16; B-11; MS m/z 519 (M+H)⁺-   4-96; A-16; B-12; MS m/z 527 (M+H)⁺-   4-97; A-25; B-01; MS m/z 400 (M+H)⁺-   4-98; A-25; B-02; MS m/z 404 (M+H)⁺-   4-99; A-25; B-03; MS m/z 362 (M+H)⁺-   4-100; A-25; B-04; MS m/z 420 (M+H)⁺-   4-101; A-25; B-05; MS m/z 432 (M+H)⁺-   4-102; A-25; B-06; MS m/z 472 (M+H)⁺-   4-103; A-25; B-07; MS m/z 452 (M+H)⁺-   4-104; A-25; B-08; MS m/z 458 (M+H)⁺-   4-105; A-25; B-09; MS m/z 460 (M+H)⁺-   4-106; A-25; B-10; MS m/z 482 (M+H)⁺-   4-107; A-25; B-11; MS m/z 486 (M+H)⁺-   4-108; A-25; B-12; MS m/z 494 (M+H)⁺-   4-109; A-26; B-01; MS m/z 406 (M+H)⁺-   4-110; A-26; B-02; MS m/z 410 (M+H)⁺-   4-111; A-26; B-03; MS m/z 368 (M+H)⁺-   4-112; A-26; B-04; MS m/z 426 (M+H)⁺-   4-113; A-26; B-05; MS m/z 438 (M+H)⁺-   4-114; A-26; B-06; MS m/z 478 (M+H)⁺-   4-115; A-26; B-07; MS m/z 458 (M+H)⁺-   4-116; A-26; B-08; MS m/z 464 (M+H)⁺-   4-117; A-26; B-09; MS m/z 466 (M+H)⁺-   4-118; A-26; B-10; MS m/z 488 (M+H)⁺-   4-119; A-26; B-11; MS m/z 492 (M+H)⁺-   4-120; A-26; B-12; MS m/z 500 (M+H)⁺-   4-121; A-27; B-01; MS m/z 440 (M+H)⁺-   4-122; A-27; B-02; MS m/z 444 (M+H)⁺-   4-123; A-27; B-03; MS m/z 402 (M+H)⁺-   4-124; A-27; B-04; MS m/z 460 (M+H)⁺-   4-125; A-27; B-05; MS m/z 472 (M+H)⁺-   4-126; A-27; B-06; MS m/z 512 (M+H)⁺-   4-127; A-27; B-07; MS m/z 492 (M+H)⁺-   4-128; A-27; B-08; MS m/z 498 (M+H)⁺-   4-129; A-27; B-09; MS m/z 500 (M+H)⁺-   4-130; A-27; B-10; MS m/z 522 (M+H)⁺-   4-131; A-27; B-11; MS m/z 526 (M+H)⁺-   4-132; A-27; B-12; MS m/z 534 (M+H)⁺-   4-133; A-28; B-01; MS m/z 470 (M+H)⁺-   4-134; A-28; B-02; MS m/z 474 (M+H)⁺-   4-135; A-28; B-03; MS m/z 432 (M+H)⁺-   4-136; A-28; B-04; MS m/z 490 (M+H)⁺-   4-137; A-28; B-05; MS m/z 502 (M+H)⁺-   4-138; A-28; B-06; MS m/z 542 (M+H)⁺-   4-139; A-28; B-07; MS m/z 522 (M+H)⁺-   4-140; A-28; B-08; MS m/z 528 (M+H)⁺-   4-141; A-28; B-09; MS m/z 530 (M+H)⁺-   4-142; A-28; B-10; MS m/z 552 (M+H)⁺-   4-143; A-28; B-11; MS m/z 556 (M+H)⁺-   4-144; A-28; B-12; MS m/z 564 (M+H)⁺-   4-145; A-29; B-01; MS m/z 385 (M+H)⁺-   4-146; A-29; B-02; MS m/z 389 (M+H)⁺-   4-147; A-29; B-03; MS m/z 347 (M+H)⁺-   4-148; A-29; B-04; MS m/z 405 (M+H)⁺-   4-149; A-29; B-05; MS m/z 417 (M+H)⁺-   4-150; A-29; B-06; MS m/z 457 (M+H)⁺-   4-151; A-29; B-07; MS m/z 437 (M+H)⁺-   4-152; A-29; B-08; MS m/z 443 (M+H)⁺-   4-153; A-29; B-09; MS m/z 445 (M+H)⁺-   4-154; A-29; B-10; MS m/z 467 (M+H)⁺-   4-155; A-29; B-11; MS m/z 471 (M+H)⁺-   4-156; A-29; B-12; MS m/z 479 (M+H)⁺-   4-157; A-30; B-01; MS m/z 428 (M+H)⁺-   4-158; A-30; B-02; MS m/z 432 (M+H)⁺-   4-159; A-30; B-03; MS m/z 390 (M+H)⁺-   4-160; A-30; B-04; MS m/z 448 (M+H)⁺-   4-161; A-30; B-05; MS m/z 460 (M+H)⁺-   4-162; A-30; B-06; MS m/z 500 (M+H)⁺-   4-163; A-30; B-07; MS m/z 480 (M+H)⁺-   4-164; A-30; B-08; MS m/z 486 (M+H)⁺-   4-165; A-30; B-09; MS m/z 488 (M+H)⁺-   4-166; A-30; B-10; MS m/z 510 (M+H)⁺-   4-167; A-30; B-11; MS m/z 514 (M+H)⁺-   4-168; A-30; B-12; MS m/z 522 (M+H)⁺-   4-169; A-31; B-01; MS m/z 428 (M+H)⁺-   4-170; A-31; B-02; MS m/z 432 (M+H)⁺-   4-171; A-31; B-03; MS m/z 390 (M+H)⁺-   4-172; A-31; B-04; MS m/z 448 (M+H)⁺-   4-173; A-31; B-05; MS m/z 460 (M+H)⁺-   4-174; A-31; B-06; MS m/z 500 (M+H)⁺-   4-175; A-31; B-07; MS m/z 480 (M+H)⁺-   4-176; A-31; B-08; MS m/z 486 (M+H)⁺-   4-177; A-31; B-09; MS m/z 488 (M+H)⁺-   4-178; A-31; B-10; MS m/z 510 (M+H)⁺-   4-179; A-31; B-11; MS m/z 514 (M+H)⁺-   4-180; A-31; B-12; MS m/z 522 (M+H)⁺-   4-181; A-32; B-01; MS m/z 454 (M+H)⁺-   4-182; A-32; B-02; MS m/z 458 (M+H)⁺-   4-183; A-32; B-03; MS m/z 416 (M+H)⁺-   4-184; A-32; B-04; MS m/z 474 (M+H)⁺-   4-185; A-32; B-05; MS m/z 486 (M+H)⁺-   4-186; A-32; B-06; MS m/z 526 (M+H)⁺-   4-187; A-32; B-07; MS m/z 506 (M+H)⁺-   4-188; A-32; B-08; MS m/z 512 (M+H)⁺-   4-189; A-32; B-09; MS m/z 514 (M+H)⁺-   4-190; A-32; B-10; MS m/z 536 (M+H)⁺-   4-191; A-32; B-11; MS m/z 540 (M+H)⁺-   4-192; A-32; B-12; MS m/z 548 (M+H)⁺

(e) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —R⁵ and spectrum data thereof.

-   5-1; A-09; B-01; MS m/z 343 (M+H)⁺-   5-2; A-09; B-02; MS m/z 347 (M+H)⁺-   5-3; A-09; B-03; MS m/z 305 (M+H)⁺-   5-4; A-09; B-04; MS m/z 363 (M+H)⁺-   5-5; A-09; B-05; MS m/z 375 (M+H)⁺-   5-6; A-09; B-06; MS m/z 415 (M+H)⁺-   5-7; A-09; B-07; MS m/z 395 (M+H)⁺-   5-8; A-09; B-08; MS m/z 401 (M+H)⁺-   5-9; A-09; B-09; MS m/z 403 (M+H)⁺-   5-10; A-09; B-10; MS m/z 425 (M+H)⁺-   5-11; A-09; B-11; MS m/z 429 (M+H)⁺-   5-12; A-09; B-12; MS m/z 437 (M+H)⁺-   5-13; A-10; B-01; MS m/z 343 (M+H)⁺-   5-14; A-10; B-02; MS m/z 347 (M+H)⁺-   5-15; A-10; B-03; MS m/z 305 (M+H)⁺-   5-16; A-10; B-04; MS m/z 363 (M+H)⁺-   5-17; A-10; B-05; MS m/z 375 (M+H)⁺-   5-18; A-10; B-06; MS m/z 415 (M+H)⁺-   5-19; A-10; B-07; MS m/z 395 (M+H)⁺-   5-20; A-10; B-08; MS m/z 401 (M+H)⁺-   5-21; A-10; B-09; MS m/z 403 (M+H)⁺-   5-22; A-10; B-10; MS m/z 425 (M+H)⁺-   5-23; A-10; B-11; MS m/z 429 (M+H)⁺-   5-24; A-10; B-12; MS m/z 437 (M+H)⁺-   5-25; A-11; B-01; MS m/z 343 (M+H)⁺-   5-26; A-11; B-02; MS m/z 347 (M+H)⁺-   5-27; A-11; B-03; MS m/z 305 (M+H)⁺-   5-28; A-11; B-04; MS m/z 363 (M+H)⁺-   5-29; A-11; B-05; MS m/z 375 (M+H)⁺-   5-30; A-11; B-06; MS m/z 415 (M+H)⁺-   5-31; A-11; B-07; MS m/z 395 (M+H)⁺-   5-32; A-11; B-08; MS m/z 401 (M+H)⁺-   5-33; A-11; B-09; MS m/z 403 (M+H)⁺-   5-34; A-11; B-10; MS m/z 425 (M+H)⁺-   5-35; A-11; B-11; MS m/z 429 (M+H)⁺-   5-36; A-11; B-12; MS m/z 437 (M+H)⁺-   5-37; A-12; B-01; MS m/z 343 (M+H)⁺-   5-38; A-12; B-02; MS m/z 347 (M+H)⁺-   5-39; A-12; B-03; MS m/z 305 (M+H)⁺-   5-40; A-12; B-04; MS m/z 363 (M+H)⁺-   5-41; A-12; B-05; MS m/z 375 (M+H)⁺-   5-42; A-12; B-06; MS m/z 415 (M+H)⁺-   5-43; A-12; B-07; MS m/z 395 (M+H)⁺-   5-44; A-12; B-08; MS m/z 401 (M+H)⁺-   5-45; A-12; B-09; MS m/z 403 (M+H)⁺-   5-46; A-12; B-10; MS m/z 425 (M+H)⁺-   5-47; A-12; B-11; MS m/z 429 (M+H)⁺-   5-48; A-12; B-12; MS m/z 437 (M+H)⁺-   5-49; A-13; B-01; MS m/z 351 (M+H)⁺-   5-50; A-13; B-02; MS m/z 355 (M+H)⁺-   5-51; A-13; B-03; MS m/z 313 (M+H)⁺-   5-52; A-13; B-04; MS m/z 371 (M+H)⁺-   5-53; A-13; B-05; MS m/z 383 (M+H)⁺-   5-54; A-13; B-06; MS m/z 423 (M+H)⁺-   5-55; A-13; B-07; MS m/z 403 (M+H)⁺-   5-56; A-13; B-08; MS m/z 409 (M+H)⁺-   5-57; A-13; B-09; MS m/z 411 (M+H)⁺-   5-58; A-13; B-10; MS m/z 433 (M+H)⁺-   5-59; A-13; B-11; MS m/z 437 (M+H)⁺-   5-60; A-13; B-12; MS m/z 445 (M+H)⁺-   5-61; A-14; B-01; MS m/z 351 (M+H)⁺-   5-62; A-14; B-02; MS m/z 355 (M+H)⁺-   5-63; A-14; B-03; MS m/z 313 (M+H)⁺-   5-64; A-14; B-04; MS m/z 371 (M+H)⁺-   5-65; A-14; B-05; MS m/z 383 (M+H)⁺-   5-66; A-14; B-06; MS m/z 423 (M+H)⁺-   5-67; A-14; B-07; MS m/z 403 (M+H)⁺-   5-68; A-14; B-08; MS m/z 409 (M+H)⁺-   5-69; A-14; B-09; MS m/z 411 (M+H)⁺-   5-70; A-14; B-10; MS m/z 433 (M+H)⁺-   5-71; A-14; B-11; MS m/z 437 (M+H)⁺-   5-72; A-14; B-12; MS m/z 445 (M+H)⁺-   5-73; A-15; B-01; MS m/z 359 (M+H)⁺-   5-74; A-15; B-02; MS m/z 363 (M+H)⁺-   5-75; A-15; B-03; MS m/z 321 (M+H)⁺-   5-76; A-15; B-04; MS m/z 379 (M+H)⁺-   5-77; A-15; B-05; MS m/z 391 (M+H)⁺-   5-78; A-15; B-06; MS m/z 431 (M+H)⁺-   5-79; A-15; B-07; MS m/z 411 (M+H)⁺-   5-80; A-15; B-08; MS m/z 417 (M+H)⁺-   5-81; A-15; B-09; MS m/z 419 (M+H)⁺-   5-82; A-15; B-10; MS m/z 441 (M+H)⁺-   5-83; A-15; B-11; MS m/z 445 (M+H)⁺-   5-84; A-15; B-12; MS m/z 453 (M+H)⁺-   5-85; A-16; B-01; MS m/z 365 (M+H)⁺-   5-86; A-16; B-02; MS m/z 369 (M+H)⁺-   5-87; A-16; B-03; MS m/z 327 (M+H)⁺-   5-88; A-16; B-04; MS m/z 385 (M+H)⁺-   5-89; A-16; B-05; MS m/z 397 (M+H)⁺-   5-90; A-16; B-06; MS m/z 437 (M+H)⁺-   5-91; A-16; B-07; MS m/z 417 (M+H)⁺-   5-92; A-16; B-08; MS m/z 423 (M+H)⁺-   5-93; A-16; B-09; MS m/z 425 (M+H)⁺-   5-94; A-16; B-10; MS m/z 447 (M+H)⁺-   5-95; A-16; B-11; MS m/z 451 (M+H)⁺-   5-96; A-16; B-12; MS m/z 459 (M+H)⁺-   5-97; A-17; B-01; MS m/z 371 (M+H)⁺-   5-98; A-17; B-02; MS m/z 375 (M+H)⁺-   5-99; A-17; B-03; MS m/z 333 (M+H)⁺-   5-100; A-17; B-04; MS m/z 391 (M+H)⁺-   5-101; A-17; B-05; MS m/z 403 (M+H)⁺-   5-102; A-17; B-06; MS m/z 443 (M+H)⁺-   5-103; A-17; B-07; MS m/z 423 (M+H)⁺-   5-104; A-17; B-08; MS m/z 429 (M+H)⁺-   5-105; A-17; B-09; MS m/z 431 (M+H)⁺-   5-106; A-17; B-10; MS m/z 453 (M+H)⁺-   5-107; A-17; B-11; MS m/z 457 (M+H)⁺-   5-108; A-17; B-12; MS m/z 465 (M+H)⁺-   5-109; A-18; B-01; MS m/z 387 (M+H)⁺-   5-110; A-18; B-02; MS m/z 391 (M+H)⁺-   5-111; A-18; B-03; MS m/z 349 (M+H)⁺-   5-112; A-18; B-04; MS m/z 407 (M+H)⁺-   5-113; A-18; B-05; MS m/z 419 (M+H)⁺-   5-114; A-18; B-06; MS m/z 459 (M+H)⁺-   5-115; A-18; B-07; MS m/z 439 (M+H)⁺-   5-116; A-18; B-08; MS m/z 445 (M+H)⁺-   5-117; A-18; B-09; MS m/z 447 (M+H)⁺-   5-118; A-18; B-10; MS m/z 469 (M+H)⁺-   5-119; A-18; B-11; MS m/z 473 (M+H)⁺-   5-120; A-18; B-12; MS m/z 481 (M+H)⁺-   5-121; A-19; B-01; MS m/z 363 (M+H)⁺-   5-122; A-19; B-02; MS m/z 367 (M+H)⁺-   5-123; A-19; B-03; MS m/z 325 (M+H)⁺-   5-124; A-19; B-04; MS m/z 383 (M+H)⁺-   5-125; A-19; B-05; MS m/z 395 (M+H)⁺-   5-126; A-19; B-06; MS m/z 435 (M+H)⁺-   5-127; A-19; B-07; MS m/z 415 (M+H)⁺-   5-128; A-19; B-08; MS m/z 421 (M+H)⁺-   5-129; A-19; B-09; MS m/z 423 (M+H)⁺-   5-130; A-19; B-10; MS m/z 445 (M+H)⁺-   5-131; A-19; B-11; MS m/z 449 (M+H)⁺-   5-132; A-19; B-12; MS m/z 457 (M+H)⁺-   5-133; A-20; B-01; MS m/z 367 (M+H)⁺-   5-134; A-20; B-02; MS m/z 371 (M+H)⁺-   5-135; A-20; B-03; MS m/z 329 (M+H)⁺-   5-136; A-20; B-04; MS m/z 387 (M+H)⁺-   5-137; A-20; B-05; MS m/z 399 (M+H)⁺-   5-138; A-20; B-06; MS m/z 439 (M+H)⁺-   5-139; A-20; B-07; MS m/z 419 (M+H)⁺-   5-140; A-20; B-08; MS m/z 425 (M+H)⁺-   5-141; A-20; B-09; MS m/z 427 (M+H)⁺-   5-142; A-20; B-10; MS m/z 449 (M+H)⁺-   5-143; A-20; B-11; MS m/z 453 (M+H)⁺-   5-144; A-20; B-12; MS m/z 461 (M+H)⁺-   5-145; A-21; B-01; MS m/z 373 (M+H)⁺-   5-146; A-21; B-02; MS m/z 377 (M+H)⁺-   5-147; A-21; B-03; MS m/z 335 (M+H)⁺-   5-148; A-21; B-04; MS m/z 393 (M+H)⁺-   5-149; A-21; B-05; MS m/z 405 (M+H)⁺-   5-150; A-21; B-06; MS m/z 445 (M+H)⁺-   5-151; A-21; B-07; MS m/z 425 (M+H)⁺-   5-152; A-21; B-08; MS m/z 431 (M+H)⁺-   5-153; A-21; B-09; MS m/z 433 (M+H)⁺-   5-154; A-21; B-10; MS m/z 455 (M+H)⁺-   5-155; A-21; B-11; MS m/z 459 (M+H)⁺-   5-156; A-21; B-12; MS m/z 467 (M+H)⁺-   5-157; A-22; B-01; MS m/z 397 (M+H)⁺-   5-158; A-22; B-02; MS m/z 401 (M+H)⁺-   5-159; A-22; B-03; MS m/z 359 (M+H)⁺-   5-160; A-22; B-04; MS m/z 417 (M+H)⁺-   5-161; A-22; B-05; MS m/z 429 (M+H)⁺-   5-162; A-22; B-06; MS m/z 469 (M+H)⁺-   5-163; A-22; B-07; MS m/z 449 (M+H)⁺-   5-164; A-22; B-08; MS m/z 455 (M+H)⁺-   5-165; A-22; B-09; MS m/z 457 (M+H)⁺-   5-166; A-22; B-10; MS m/z 479 (M+H)⁺-   5-167; A-22; B-11; MS m/z 483 (M+H)⁺-   5-168; A-22; B-12; MS m/z 491 (M+H)⁺-   5-169; A-23; B-01; MS m/z 401 (M+H)⁺-   5-170; A-23; B-02; MS m/z 405 (M+H)⁺-   5-171; A-23; B-03; MS m/z 363 (M+H)⁺-   5-172; A-23; B-04; MS m/z 421 (M+H)⁺-   5-173; A-23; B-05; MS m/z 433 (M+H)⁺-   5-174; A-23; B-06; MS m/z 473 (M+H)⁺-   5-175; A-23; B-07; MS m/z 453 (M+H)⁺-   5-176; A-23; B-08; MS m/z 459 (M+H)⁺-   5-177; A-23; B-09; MS m/z 461 (M+H)⁺-   5-178; A-23; B-10; MS m/z 483 (M+H)⁺-   5-179; A-23; B-11; MS m/z 487 (M+H)⁺-   5-180; A-23; B-12; MS m/z 495 (M+H)⁺-   5-181; A-24; B-01; MS m/z 405 (M+H)⁺-   5-182; A-24; B-02; MS m/z 409 (M+H)⁺-   5-183; A-24; B-03; MS m/z 367 (M+H)⁺-   5-184; A-24; B-04; MS m/z 425 (M+H)⁺-   5-185; A-24; B-05; MS m/z 437 (M+H)⁺-   5-186; A-24; B-06; MS m/z 477 (M+H)⁺-   5-187; A-24; B-07; MS m/z 457 (M+H)⁺-   5-188; A-24; B-08; MS m/z 463 (M+H)⁺-   5-189; A-24; B-09; MS m/z 465 (M+H)⁺-   5-190; A-24; B-10; MS m/z 487 (M+H)⁺-   5-191; A-24; B-11; MS m/z 491 (M+H)⁺-   5-192; A-24; B-12; MS m/z 499 (M+H)⁺

(f) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR⁶R⁷ and spectrum data thereof.

-   6-1; A-09; C-25; MS m/z 437 (M+H)⁺-   6-2; A-09; C-26-   6-3; A-09; C-27; MS m/z 457 (M+H)⁺-   6-4; A-09; C-28; MS m/z 560 (M+H)⁺-   6-5; A-09; C-29; MS m/z 463 (M+H)⁺-   6-6; A-09; C-30; MS m/z 479 (M+H)⁺-   6-7; A-09; C-31; MS m/z 479 (M+H)⁺-   6-8; A-09; C-32; MS m/z 505 (M+H)⁺-   6-9; A-09; C-33; MS m/z 517 (M+H)⁺-   6-10; A-09; C-34; MS m/z 525 (M+H)⁺-   6-11; A-09; C-35; MS m/z 534 (M+H)⁺-   6-12; A-09; C-36; MS m/z 529 (M+H)⁺-   6-13; A-10; C-25; MS m/z 437 (M+H)⁺-   6-14; A-10; C-26-   6-15; A-10; C-27; MS m/z 457 (M+H)⁺-   6-16; A-10; C-28; MS m/z 560 (M+H)⁺-   6-17; A-10; C-29; MS m/z 463 (M+H)⁺-   6-18; A-10; C-30; MS m/z 479 (M+H)⁺-   6-19; A-10; C-31; MS m/z 479 (M+H)⁺-   6-20; A-10; C-32; MS m/z 505 (M+H)⁺-   6-21; A-10; C-33; MS m/z 517 (M+H)⁺-   6-22; A-10; C-34-   6-23; A-10; C-35; MS m/z 534 (M+H)⁺-   6-24; A-10; C-36; MS m/z 529 (M+H)⁺-   6-25; A-11; C-25; MS m/z 437 (M+H)⁺-   6-26; A-11; C-26-   6-27; A-11; C-27; MS m/z 457 (M+H)⁺-   6-28; A-11; C-28; MS m/z 560 (M+H)⁺-   6-29; A-11; C-29; MS m/z 463 (M+H)⁺-   6-30; A-11; C-30; MS m/z 479 (M+H)⁺-   6-31; A-11; C-31; MS m/z 479 (M+H)⁺-   6-32; A-11; C-32; MS m/z 505 (M+H)⁺-   6-33; A-11; C-33; MS m/z 517 (M+H)⁺-   6-34; A-11; C-34; MS m/z 525 (M+H)⁺-   6-35; A-11; C-35; MS m/z 534 (M+H)⁺-   6-36; A-11; C-36; MS m/z 529 (M+H)⁺-   6-37; A-12; C-25; MS m/z 437 (M+H)⁺-   6-38; A-12; C-26-   6-39; A-12; C-27; MS m/z 457 (M+H)⁺-   6-40; A-12; C-28; MS m/z 560 (M+H)⁺-   6-41; A-12; C-29; MS m/z 463 (M+H)⁺-   6-42; A-12; C-30; MS m/z 479 (M+H)⁺-   6-43; A-12; C-31; MS m/z 479 (M+H)⁺-   6-44; A-12; C-32; MS m/z 505 (M+H)⁺-   6-45; A-12; C-33; MS m/z 517 (M+H)⁺-   6-46; A-12; C-34-   6-47; A-12; C-35; MS m/z 534 (M+H)⁺-   6-48; A-12; C-36; MS m/z 529 (M+H)⁺-   6-49; A-13; C-25; MS m/z 445 (M+H)⁺-   6-50; A-13; C-26-   6-51; A-13; C-27; MS m/z 465 (M+H)⁺-   6-52; A-13; C-28; MS m/z 568 (M+H)⁺-   6-53; A-13; C-29; MS m/z 471 (M+H)⁺-   6-54; A-13; C-30; MS m/z 487 (M+H)⁺-   6-55; A-13; C-31; MS m/z 487 (M+H)⁺-   6-56; A-13; C-32; MS m/z 513 (M+H)⁺-   6-57; A-13; C-33; MS m/z 525 (M+H)⁺-   6-58; A-13; C-34; MS m/z 533 (M+H)⁺-   6-59; A-13; C-35; MS m/z 542 (M+H)⁺-   6-60; A-13; C-36; MS m/z 537 (M+H)⁺-   6-61; A-14; C-25; MS m/z 445 (M+H)⁺-   6-62; A-14; C-26-   6-63; A-14; C-27; MS m/z 465 (M+H)⁺-   6-64; A-14; C-28; MS m/z 568 (M+H)⁺-   6-65; A-14; C-29; MS m/z 471 (M+H)⁺-   6-66; A-14; C-30; MS m/z 487 (M+H)⁺-   6-67; A-14; C-31; MS m/z 487 (M+H)⁺-   6-68; A-14; C-32; MS m/z 513 (M+H)⁺-   6-69; A-14; C-33; MS m/z 525 (M+H)⁺-   6-70; A-14; C-34-   6-71; A-14; C-35; MS m/z 542 (M+H)⁺-   6-72; A-14; C-36; MS m/z 537 (M+H)⁺-   6-73; A-15; C-25; MS m/z 453 (M+H)⁺-   6-74; A-15; C-26-   6-75; A-15; C-27; MS m/z 473 (M+H)⁺-   6-76; A-15; C-28; MS m/z 576 (M+H)⁺-   6-77; A-15; C-29; MS m/z 479 (M+H)⁺-   6-78; A-15; C-30; MS m/z 495 (M+H)⁺-   6-79; A-15; C-31; MS m/z 495 (M+H)⁺-   6-80; A-15; C-32; MS m/z 521 (M+H)⁺-   6-81; A-15; C-33; MS m/z 533 (M+H)⁺-   6-82; A-15; C-34-   6-83; A-15; C-35; MS m/z 550 (M+H)⁺-   6-84; A-15; C-36; MS m/z 545 (M+H)⁺-   6-85; A-16; C-25; MS m/z 459 (M+H)⁺-   6-86; A-16; C-26-   6-87; A-16; C-27; MS m/z 479 (M+H)⁺-   6-88; A-16; C-28; MS m/z 582 (M+H)⁺-   6-89; A-16; C-29; MS m/z 485 (M+H)⁺-   6-90; A-16; C-30; MS m/z 501 (M+H)⁺-   6-91; A-16; C-31; MS m/z 501 (M+H)⁺-   6-92; A-16; C-32; MS m/z 527 (M+H)⁺-   6-93; A-16; C-33; MS m/z 539 (M+H)⁺-   6-94; A-16; C-34-   6-95; A-16; C-35; MS m/z 556 (M+H)⁺-   6-96; A-16; C-36; MS m/z 551 (M+H)⁺

(g) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR⁶R⁷ and spectrum data thereof.

-   7-1; A-01; C-01; MS m/z 354 (M+H)⁺-   7-2; A-01; C-02; MS m/z 366 (M+H)⁺-   7-3; A-01; C-03; MS m/z 378 (M+H)⁺-   7-4; A-01; C-04; MS m/z 382 (M+H)⁺-   7-5; A-01; C-05; MS m/z 384 (M+H)⁺-   7-6; A-01; C-06; MS m/z 392 (M+H)⁺-   7-7; A-01; C-07; MS m/z 394 (M+H)⁺-   7-8; A-01; C-08; MS m/z 410 (M+H)⁺-   7-9; A-01; C-09; MS m/z 416 (M+H)⁺-   7-10; A-01; C-10; MS m/z 422 (M+H)⁺-   7-11; A-01; C-11; MS m/z 430 (M+H)⁺-   7-12; A-01; C-12; MS m/z 436 (M+H)⁺-   7-13; A-01; C-13; MS m/z 446 (M+H)⁺-   7-14; A-01; C-14; MS m/z 452 (M+H)⁺-   7-15; A-01; C-16; MS m/z 462 (M+H)⁺-   7-16; A-01; C-17; MS m/z 470 (M+H)⁺-   7-17; A-01; C-18; MS m/z 434 (M+H)⁺-   7-18; A-01; C-19; MS m/z 382 (M+H)⁺-   7-19; A-01; C-20; MS m/z 475 (M+H)⁺-   7-20; A-01; C-21; MS m/z 397 (M+H)⁺-   7-21; A-01; C-22; MS m/z 423 (M+H)⁺-   7-22; A-01; C-23; MS m/z 437 (M+H)⁺-   7-23; A-01; C-24; MS m/z 458 (M+H)⁺-   7-24; A-01; C-25; MS m/z 383 (M+H)⁺-   7-25; A-01; C-26; MS m/z 395 (M+H)⁺-   7-26; A-01; C-27; MS m/z 403 (M+H)⁺-   7-27; A-01; C-28; MS m/z 506 (M+H)⁺-   7-28; A-01; C-29; MS m/z 409 (M+H)⁺-   7-29; A-01; C-30; MS m/z 425 (M+H)⁺-   7-30; A-01; C-31; MS m/z 425 (M+H)⁺-   7-31; A-01; C-32; MS m/z 451 (M+H)⁺-   7-32; A-01; C-33; MS m/z 463 (M+H)⁺-   7-33; A-01; C-34; MS m/z 471 (M+H)⁺-   7-34; A-01; C-35; MS m/z 480 (M+H)⁺-   7-35; A-01; C-36; MS m/z 475 (M+H)⁺-   7-36; A-01; C-48; MS m/z 456 (M+H)⁺-   7-37; A-02; C-01; MS m/z 366 (M+H)⁺-   7-38; A-02; C-02; MS m/z 378 (M+H)⁺-   7-39; A-02; C-03; MS m/z 390 (M+H)⁺-   7-40; A-02; C-04; MS m/z 394 (M+H)⁺-   7-41; A-02; C-05; MS m/z 396 (M+H)⁺-   7-42; A-02; C-06; MS m/z 404 (M+H)⁺-   7-43; A-02; C-07; MS m/z 406 (M+H)⁺-   7-44; A-02; C-08; MS m/z 422 (M+H)⁺-   7-45; A-02; C-09; MS m/z 428 (M+H)⁺-   7-46; A-02; C-10; MS m/z 434 (M+H)⁺-   7-47; A-02; C-11; MS m/z 442 (M+H)⁺-   7-48; A-02; C-12; MS m/z 448 (M+H)⁺-   7-49; A-02; C-13; MS m/z 458 (M+H)⁺-   7-50; A-02; C-14; MS m/z 464 (M+H)⁺-   7-51; A-02; C-16; MS m/z 474 (M+H)⁺-   7-52; A-02; C-17; MS m/z 482 (M+H)⁺-   7-53; A-02; C-18; MS m/z 446 (M+H)⁺-   7-54; A-02; C-19; MS m/z 394 (M+H)⁺-   7-55; A-02; C-20; MS m/z 487 (M+H)⁺-   7-56; A-02; C-21; MS m/z 409 (M+H)⁺-   7-57; A-02; C-22; MS m/z 435 (M+H)⁺-   7-58; A-02; C-23; MS m/z 449 (M+H)⁺-   7-59; A-02; C-24; MS m/z 470 (M+H)⁺-   7-60; A-02; C-25; MS m/z 395 (M+H)⁺-   7-61; A-02; C-26; MS m/z 407 (M+H)⁺-   7-62; A-02; C-27; MS m/z 415 (M+H)⁺-   7-63; A-02; C-28; MS m/z 518 (M+H)⁺-   7-64; A-02; C-29; MS m/z 421 (M+H)⁺-   7-65; A-02; C-30; MS m/z 437 (M+H)⁺-   7-66; A-02; C-31; MS m/z 437 (M+H)⁺-   7-67; A-02; C-32; MS m/z 463 (M+H)⁺-   7-68; A-02; C-33; MS m/z 475 (M+H)⁺-   7-69; A-02; C-34; MS m/z 483 (M+H)⁺-   7-70; A-02; C-35; MS m/z 492 (M+H)⁺-   7-71; A-02; C-36; MS m/z 487 (M+H)⁺-   7-72; A-02; C-48; MS m/z 468 (M+H)⁺-   7-73; A-03; C-01; MS m/z 366 (M+H)⁺-   7-74; A-03; C-02; MS m/z 378 (M+H)⁺-   7-75; A-03; C-03; MS m/z 390 (M+H)⁺-   7-76; A-03; C-04; MS m/z 394 (M+H)⁺-   7-77; A-03; C-05; MS m/z 396 (M+H)⁺-   7-78; A-03; C-06; MS m/z 404 (M+H)⁺-   7-79; A-03; C-07; MS m/z 406 (M+H)⁺-   7-80; A-03; C-08; MS m/z 422 (M+H)⁺-   7-81; A-03; C-09; MS m/z 428 (M+H)⁺-   7-82; A-03; C-10; MS m/z 434 (M+H)⁺-   7-83; A-03; C-11; MS m/z 442 (M+H)⁺-   7-84; A-03; C-12; MS m/z 448 (M+H)⁺-   7-85; A-03; C-13; MS m/z 458 (M+H)⁺-   7-86; A-03; C-14; MS m/z 464 (M+H)⁺-   7-87; A-03; C-16; MS m/z 474 (M+H)⁺-   7-88; A-03; C-17; MS m/z 482 (M+H)⁺-   7-89; A-03; C-18; MS m/z 446 (M+H)⁺-   7-90; A-03; C-19; MS m/z 394 (M+H)⁺-   7-91; A-03; C-20; MS m/z 487 (M+H)⁺-   7-92; A-03; C-21; MS m/z 409 (M+H)⁺-   7-93; A-03; C-22; MS m/z 435 (M+H)⁺-   7-94; A-03; C-23; MS m/z 449 (M+H)⁺-   7-95; A-03; C-24; MS m/z 470 (M+H)⁺-   7-96; A-03; C-25; MS m/z 395 (M+H)⁺-   7-97; A-03; C-26; MS m/z 407 (M+H)⁺-   7-98; A-03; C-27; MS m/z 415 (M+H)⁺-   7-99; A-03; C-28; MS m/z 518 (M+H)⁺-   7-100; A-03; C-29; MS m/z 421 (M+H)⁺-   7-101; A-03; C-30; MS m/z 437 (M+H)⁺-   7-102; A-03; C-31; MS m/z 437 (M+H)⁺-   7-103; A-03; C-32; MS m/z 463 (M+H)⁺-   7-104; A-03; C-33; MS m/z 475 (M+H)⁺-   7-105; A-03; C-34; MS m/z 483 (M+H)⁺-   7-106; A-03; C-35; MS m/z 492 (M+H)⁺-   7-107; A-03; C-36; MS m/z 487 (M+H)⁺-   7-108; A-03; C-48; MS m/z 468 (M+H)⁺-   7-109; A-04; C-01; MS m/z 368 (M+H)⁺-   7-110; A-04; C-02; MS m/z 380 (M+H)⁺-   7-111; A-04; C-03; MS m/z 392 (M+H)⁺-   7-112; A-04; C-04; MS m/z 396 (M+H)⁺-   7-113; A-04; C-05; MS m/z 398 (M+H)⁺-   7-114; A-04; C-06; MS m/z 406 (M+H)⁺-   7-115; A-04; C-07; MS m/z 408 (M+H)⁺-   7-116; A-04; C-08; MS m/z 424 (M+H)⁺-   7-117; A-04; C-09; MS m/z 430 (M+H)⁺-   7-118; A-04; C-10; MS m/z 436 (M+H)⁺-   7-119; A-04; C-11; MS m/z 444 (M+H)⁺-   7-120; A-04; C-12; MS m/z 450 (M+H)⁺-   7-121; A-04; C-13; MS m/z 460 (M+H)⁺-   7-122; A-04; C-14; MS m/z 466 (M+H)⁺-   7-123; A-04; C-16; MS m/z 476 (M+H)⁺-   7-124; A-04; C-17; MS m/z 484 (M+H)⁺-   7-125; A-04; C-18; MS m/z 448 (M+H)⁺-   7-126; A-04; C-19; MS m/z 396 (M+H)⁺-   7-127; A-04; C-20; MS m/z 489 (M+H)⁺-   7-128; A-04; C-21; MS m/z 411 (M+H)⁺-   7-129; A-04; C-22; MS m/z 437 (M+H)⁺-   7-130; A-04; C-23; MS m/z 451 (M+H)⁺-   7-131; A-04; C-24; MS m/z 472 (M+H)⁺-   7-132; A-04; C-25; MS m/z 397 (M+H)⁺-   7-133; A-04; C-26; MS m/z 409 (M+H)⁺-   7-134; A-04; C-27; MS m/z 417 (M+H)⁺-   7-135; A-04; C-28; MS m/z 520 (M+H)⁺-   7-136; A-04; C-29; MS m/z 423 (M+H)⁺-   7-137; A-04; C-30; MS m/z 439 (M+H)⁺-   7-138; A-04; C-31; MS m/z 439 (M+H)⁺-   7-139; A-04; C-32; MS m/z 465 (M+H)⁺-   7-140; A-04; C-33; MS m/z 477 (M+H)⁺-   7-141; A-04; C-34; MS m/z 485 (M+H)⁺-   7-142; A-04; C-35; MS m/z 494 (M+H)⁺-   7-143; A-04; C-36; MS m/z 489 (M+H)⁺-   7-144; A-04; C-48; MS m/z 470 (M+H)⁺-   7-145; A-05; C-01; MS m/z 382 (M+H)⁺-   7-146; A-05; C-02; MS m/z 394 (M+H)⁺-   7-147; A-05; C-03; MS m/z 406 (M+H)⁺-   7-148; A-05; C-04; MS m/z 410 (M+H)⁺-   7-149; A-05; C-05; MS m/z 412 (M+H)⁺-   7-150; A-05; C-06; MS m/z 420 (M+H)⁺-   7-151; A-05; C-07; MS m/z 422 (M+H)⁺-   7-152; A-05; C-08; MS m/z 438 (M+H)⁺-   7-153; A-05; C-09; MS m/z 444 (M+H)⁺-   7-154; A-05; C-10; MS m/z 450 (M+H)⁺-   7-155; A-05; C-11; MS m/z 458 (M+H)⁺-   7-156; A-05; C-12; MS m/z 464 (M+H)⁺-   7-157; A-05; C-13; MS m/z 474 (M+H)⁺-   7-158; A-05; C-14; MS m/z 480 (M+H)⁺-   7-159; A-05; C-16; MS m/z 490 (M+H)⁺-   7-160; A-05; C-17; MS m/z 498 (M+H)⁺-   7-161; A-05; C-18; MS m/z 462 (M+H)⁺-   7-162; A-05; C-19; MS m/z 410 (M+H)⁺-   7-163; A-05; C-20; MS m/z 503 (M+H)⁺-   7-164; A-05; C-21; MS m/z 425 (M+H)⁺-   7-165; A-05; C-22; MS m/z 451 (M+H)⁺-   7-166; A-05; C-23; MS m/z 465 (M+H)⁺-   7-167; A-05; C-24; MS m/z 486 (M+H)⁺-   7-168; A-05; C-25; MS m/z 411 (M+H)⁺-   7-169; A-05; C-26; MS m/z 423 (M+H)⁺-   7-170; A-05; C-27; MS m/z 431 (M+H)⁺-   7-171; A-05; C-28; MS m/z 534 (M+H)⁺-   7-172; A-05; C-29; MS m/z 437 (M+H)⁺-   7-173; A-05; C-30; MS m/z 453 (M+H)⁺-   7-174; A-05; C-31; MS m/z 453 (M+H)⁺-   7-175; A-05; C-32; MS m/z 479 (M+H)⁺-   7-176; A-05; C-33; MS m/z 491 (M+H)⁺-   7-177; A-05; C-34; MS m/z 499 (M+H)⁺-   7-178; A-05; C-35; MS m/z 508 (M+H)⁺-   7-179; A-05; C-36; MS m/z 503 (M+H)⁺-   7-180; A-05; C-37; MS m/z 467 (M+H)⁺-   7-181; A-05; C-38; MS m/z 480 (M+H)⁺-   7-182; A-05; C-39; MS m/z 453 (M+H)⁺-   7-183; A-05; C-40; MS m/z 451 (M+H)⁺-   7-184; A-05; C-41; MS m/z 467 (M+H)⁺-   7-185; A-05; C-42; MS m/z 451 (M+H)⁺-   7-186; A-05; C-43; MS m/z 451 (M+H)⁺-   7-187; A-05; C-44; MS m/z 439 (M+H)⁺-   7-188; A-05; C-45; MS m/z 451 (M+H)⁺-   7-189; A-05; C-46; MS m/z 448 (M+H)⁺-   7-190; A-05; C-47; MS m/z 440 (M+H)⁺-   7-191; A-05; C-48; MS m/z 484 (M+H)⁺-   7-192; A-06; C-01; MS m/z 384 (M+H)⁺-   7-193; A-06; C-02; MS m/z 396 (M+H)⁺-   7-194; A-06; C-03; MS m/z 408 (M+H)⁺-   7-195; A-06; C-04; MS m/z 412 (M+H)⁺-   7-196; A-06; C-05; MS m/z 414 (M+H)⁺-   7-197; A-06; C-06; MS m/z 422 (M+H)⁺-   7-198; A-06; C-07; MS m/z 424 (M+H)⁺-   7-199; A-06; C-08; MS m/z 440 (M+H)⁺-   7-200; A-06; C-09; MS m/z 446 (M+H)⁺-   7-201; A-06; C-10; MS m/z 452 (M+H)⁺-   7-202; A-06; C-11; MS m/z 460 (M+H)⁺-   7-203; A-06; C-12; MS m/z 466 (M+H)⁺-   7-204; A-06; C-13; MS m/z 476 (M+H)⁺-   7-205; A-06; C-14; MS m/z 482 (M+H)⁺-   7-206; A-06; C-16; MS m/z 492 (M+H)⁺-   7-207; A-06; C-17; MS m/z 500 (M+H)⁺-   7-208; A-06; C-18; MS m/z 464 (M+H)⁺-   7-209; A-06; C-19; MS m/z 412 (M+H)⁺-   7-210; A-06; C-20; MS m/z 505 (M+H)⁺-   7-211; A-06; C-21; MS m/z 427 (M+H)⁺-   7-212; A-06; C-22; MS m/z 453 (M+H)⁺-   7-213; A-06; C-23; MS m/z 467 (M+H)⁺-   7-214; A-06; C-24; MS m/z 488 (M+H)⁺-   7-215; A-06; C-25; MS m/z 413 (M+H)⁺-   7-216; A-06; C-26; MS m/z 425 (M+H)⁺-   7-217; A-06; C-27; MS m/z 433 (M+H)⁺-   7-218; A-06; C-28; MS m/z 536 (M+H)⁺-   7-219; A-06; C-29; MS m/z 439 (M+H)⁺-   7-220; A-06; C-30; MS m/z 455 (M+H)⁺-   7-221; A-06; C-31; MS m/z 455 (M+H)⁺-   7-222; A-06; C-32; MS m/z 481 (M+H)⁺-   7-223; A-06; C-33; MS m/z 493 (M+H)⁺-   7-224; A-06; C-34; MS m/z 501 (M+H)⁺-   7-225; A-06; C-35; MS m/z 510 (M+H)⁺-   7-226; A-06; C-36; MS m/z 505 (M+H)⁺-   7-227; A-06; C-48; MS m/z 486 (M+H)⁺-   7-228; A-07; C-01; MS m/z 382 (M+H)⁺-   7-229; A-07; C-02; MS m/z 394 (M+H)⁺-   7-230; A-07; C-03; MS m/z 406 (M+H)⁺-   7-231; A-07; C-04; MS m/z 410 (M+H)⁺-   7-232; A-07; C-05; MS m/z 412 (M+H)⁺-   7-233; A-07; C-06; MS m/z 420 (M+H)⁺-   7-234; A-07; C-07; MS m/z 422 (M+H)⁺-   7-235; A-07; C-08; MS m/z 438 (M+H)⁺-   7-236; A-07; C-09; MS m/z 444 (M+H)⁺-   7-237; A-07; C-10; MS m/z 450 (M+H)⁺-   7-238; A-07; C-11; MS m/z 458 (M+H)⁺-   7-239; A-07; C-12; MS m/z 464 (M+H)⁺-   7-240; A-07; C-13; MS m/z 474 (M+H)⁺-   7-241; A-07; C-14; MS m/z 480 (M+H)⁺-   7-242; A-07; C-16; MS m/z 490 (M+H)⁺-   7-243; A-07; C-17; MS m/z 498 (M+H)⁺-   7-244; A-07; C-18; MS m/z 462 (M+H)⁺-   7-245; A-07; C-19; MS m/z 410 (M+H)⁺-   7-246; A-07; C-20; MS m/z 503 (M+H)⁺-   7-247; A-07; C-21; MS m/z 425 (M+H)⁺-   7-248; A-07; C-22; MS m/z 451 (M+H)⁺-   7-249; A-07; C-23; MS m/z 465 (M+H)⁺-   7-250; A-07; C-24; MS m/z 486 (M+H)⁺-   7-251; A-07; C-25; MS m/z 411 (M+H)⁺-   7-252; A-07; C-26; MS m/z 423 (M+H)⁺-   7-253; A-07; C-27; MS m/z 431 (M+H)⁺-   7-254; A-07; C-28; MS m/z 534 (M+H)⁺-   7-255; A-07; C-29; MS m/z 437 (M+H)⁺-   7-256; A-07; C-30; MS m/z 453 (M+H)⁺-   7-257; A-07; C-31; MS m/z 453 (M+H)⁺-   7-258; A-07; C-32; MS m/z 479 (M+H)⁺-   7-259; A-07; C-33; MS m/z 491 (M+H)⁺-   7-260; A-07; C-34; MS m/z 499 (M+H)⁺-   7-261; A-07; C-35; MS m/z 508 (M+H)⁺-   7-262; A-07; C-36; MS m/z 503 (M+H)⁺-   7-263; A-07; C-48; MS m/z 484 (M+H)⁺-   7-264; A-08; C-01; MS m/z 384 (M+H)⁺-   7-265; A-08; C-02; MS m/z 396 (M+H)⁺-   7-266; A-08; C-03; MS m/z 408 (M+H)⁺-   7-267; A-08; C-04; MS m/z 412 (M+H)⁺-   7-268; A-08; C-05; MS m/z 414 (M+H)⁺-   7-269; A-08; C-06; MS m/z 422 (M+H)⁺-   7-270; A-08; C-07; MS m/z 424 (M+H)⁺-   7-271; A-08; C-08; MS m/z 440 (M+H)⁺-   7-272; A-08; C-09; MS m/z 446 (M+H)⁺-   7-273; A-08; C-10; MS m/z 452 (M+H)⁺-   7-274; A-08; C-11; MS m/z 460 (M+H)⁺-   7-275; A-08; C-12; MS m/z 466 (M+H)⁺-   7-276; A-08; C-13; MS m/z 476 (M+H)⁺-   7-277; A-08; C-14; MS m/z 482 (M+H)⁺-   7-278; A-08; C-16; MS m/z 492 (M+H)⁺-   7-279; A-08; C-17; MS m/z 500 (M+H)⁺-   7-280; A-08; C-18; MS m/z 464 (M+H)⁺-   7-281; A-08; C-19; MS m/z 412 (M+H)⁺-   7-282; A-08; C-20; MS m/z 505 (M+H)⁺-   7-283; A-08; C-21; MS m/z 427 (M+H)⁺-   7-284; A-08; C-22; MS m/z 453 (M+H)⁺-   7-285; A-08; C-23; MS m/z 467 (M+H)⁺-   7-286; A-08; C-24; MS m/z 488 (M+H)⁺-   7-287; A-08; C-25; MS m/z 413 (M+H)⁺-   7-288; A-08; C-26; MS m/z 425 (M+H)⁺-   7-289; A-08; C-27; MS m/z 433 (M+H)⁺-   7-290; A-08; C-28; MS m/z 536 (M+H)⁺-   7-291; A-08; C-29; MS m/z 439 (M+H)⁺-   7-292; A-08; C-30; MS m/z 455 (M+H)⁺-   7-293; A-08; C-31; MS m/z 455 (M+H)⁺-   7-294; A-08; C-32; MS m/z 481 (M+H)⁺-   7-295; A-08; C-33; MS m/z 493 (M+H)⁺-   7-296; A-08; C-34; MS m/z 501 (M+H)⁺-   7-297; A-08; C-35; MS m/z 510 (M+H)⁺-   7-298; A-08; C-36; MS m/z 505 (M+H)⁺-   7-299; A-08; C-48; MS m/z 486 (M+H)⁺-   7-300; A-09; C-01; MS m/z 408 (M+H)⁺-   7-301; A-09; C-02; MS m/z 420 (M+H)⁺-   7-302; A-09; C-03; MS m/z 432 (M+H)⁺-   7-303; A-09; C-04; MS m/z 436 (M+H)⁺-   7-304; A-09; C-05; MS m/z 438 (M+H)⁺-   7-305; A-09; C-06; MS m/z 446 (M+H)⁺-   7-306; A-09; C-07; MS m/z 448 (M+H)⁺-   7-307; A-09; C-08; MS m/z 464 (M+H)⁺-   7-308; A-09; C-09; MS m/z 470 (M+H)⁺-   7-309; A-09; C-10; MS m/z 476 (M+H)⁺-   7-310; A-09; C-11; MS m/z 484 (M+H)⁺-   7-311; A-09; C-12; MS m/z 490 (M+H)⁺-   7-312; A-09; C-13; MS m/z 500 (M+H)⁺-   7-313; A-09; C-14; MS m/z 506 (M+H)⁺-   7-314; A-09; C-15; MS m/z 524 (M+H)⁺-   7-315; A-09; C-16; MS m/z 516 (M+H)⁺-   7-316; A-09; C-17; MS m/z 524 (M+H)⁺-   7-317; A-09; C-18; MS m/z 436 (M+H)⁺-   7-318; A-09; C-19; MS m/z 488 (M+H)⁺-   7-319; A-09; C-20; MS m/z 529 (M+H)⁺-   7-320; A-09; C-21; MS m/z 451 (M+H)⁺-   7-321; A-09; C-22; MS m/z 477 (M+H)⁺-   7-322; A-09; C-23; MS m/z 491 (M+H)⁺-   7-323; A-09; C-24; MS m/z 512 (M+H)⁺-   7-324; A-09; C-25; MS m/z 437 (M+H)⁺-   7-325; A-09; C-26; MS m/z 449 (M+H)⁺-   7-326; A-09; C-27; MS m/z 457 (M+H)⁺-   7-327; A-09; C-28; MS m/z 560 (M+H)⁺-   7-328; A-09; C-29; MS m/z 463 (M+H)⁺-   7-329; A-09; C-30; MS m/z 479 (M+H)⁺-   7-330; A-09; C-31; MS m/z 479 (M+H)⁺-   7-331; A-09; C-32; MS m/z 505 (M+H)⁺-   7-332; A-09; C-33; MS m/z 517 (M+H)⁺-   7-333; A-09; C-34; MS m/z 525 (M+H)⁺-   7-334; A-09; C-35; MS m/z 534 (M+H)⁺-   7-335; A-09; C-36; MS m/z 529 (M+H)⁺-   7-336; A-10; C-01; MS m/z 408 (M+H)⁺-   7-337; A-10; C-02; MS m/z 420 (M+H)⁺-   7-338; A-10; C-03; MS m/z 432 (M+H)⁺-   7-339; A-10; C-04; MS m/z 436 (M+H)⁺-   7-340; A-10; C-05; MS m/z 438 (M+H)⁺-   7-341; A-10; C-06; MS m/z 446 (M+H)⁺-   7-342; A-10; C-07; MS m/z 448 (M+H)⁺-   7-343; A-10; C-08; MS m/z 464 (M+H)⁺-   7-344; A-10; C-09; MS m/z 470 (M+H)⁺-   7-345; A-10; C-10; MS m/z 476 (M+H)⁺-   7-346; A-10; C-11; MS m/z 484 (M+H)⁺-   7-347; A-10; C-12; MS m/z 490 (M+H)⁺-   7-348; A-10; C-13; MS m/z 500 (M+H)⁺-   7-349; A-10; C-14; MS m/z 506 (M+H)⁺-   7-350; A-10; C-15; MS m/z 524 (M+H)⁺-   7-351; A-10; C-16; MS m/z 516 (M+H)⁺-   7-352; A-10; C-17; MS m/z 524 (M+H)⁺-   7-353; A-10; C-18; MS m/z 436 (M+H)⁺-   7-354; A-10; C-19; MS m/z 488 (M+H)⁺-   7-355; A-10; C-20; MS m/z 529 (M+H)⁺-   7-356; A-10; C-21; MS m/z 451 (M+H)⁺-   7-357; A-10; C-22; MS m/z 477 (M+H)⁺-   7-358; A-10; C-23; MS m/z 491 (M+H)⁺-   7-359; A-10; C-24; MS m/z 512 (M+H)⁺-   7-360; A-10; C-25; MS m/z 437 (M+H)⁺-   7-361; A-10; C-26; MS m/z 449 (M+H)⁺-   7-362; A-10; C-27; MS m/z 457 (M+H)⁺-   7-363; A-10; C-28; MS m/z 560 (M+H)⁺-   7-364; A-10; C-29; MS m/z 463 (M+H)⁺-   7-365; A-10; C-30; MS m/z 479 (M+H)⁺-   7-366; A-10; C-31; MS m/z 479 (M+H)⁺-   7-367; A-10; C-32; MS m/z 505 (M+H)⁺-   7-368; A-10; C-33; MS m/z 517 (M+H)⁺-   7-369; A-10; C-34; MS m/z 525 (M+H)⁺-   7-370; A-10; C-35; MS m/z 534 (M+H)⁺-   7-371; A-10; C-36; MS m/z 529 (M+H)⁺-   7-372; A-11; C-01; MS m/z 408 (M+H)⁺-   7-373; A-11; C-02; MS m/z 420 (M+H)⁺-   7-374; A-11; C-03; MS m/z 432 (M+H)⁺-   7-375; A-11; C-04; MS m/z 436 (M+H)⁺-   7-376; A-11; C-05; MS m/z 438 (M+H)⁺-   7-377; A-11; C-06; MS m/z 446 (M+H)⁺-   7-378; A-11; C-07; MS m/z 448 (M+H)⁺-   7-379; A-11; C-08; MS m/z 464 (M+H)⁺-   7-380; A-11; C-09; MS m/z 470 (M+H)⁺-   7-381; A-11; C-10; MS m/z 476 (M+H)⁺-   7-382; A-11; C-11; MS m/z 484 (M+H)⁺-   7-383; A-11; C-12; MS m/z 490 (M+H)⁺-   7-384; A-11; C-13; MS m/z 500 (M+H)⁺-   7-385; A-11; C-14; MS m/z 506 (M+H)⁺-   7-386; A-11; C-15; MS m/z 524 (M+H)⁺-   7-387; A-11; C-16; MS m/z 516 (M+H)⁺-   7-388; A-11; C-17; MS m/z 524 (M+H)⁺-   7-389; A-11; C-18; MS m/z 436 (M+H)⁺-   7-390; A-11; C-19; MS m/z 488 (M+H)⁺-   7-391; A-11; C-20; MS m/z 529 (M+H)⁺-   7-392; A-11; C-21; MS m/z 451 (M+H)⁺-   7-393; A-11; C-22; MS m/z 477 (M+H)⁺-   7-394; A-11; C-23; MS m/z 491 (M+H)⁺-   7-395; A-11; C-24; MS m/z 512 (M+H)⁺-   7-396; A-11; C-25; MS m/z 437 (M+H)⁺-   7-397; A-11; C-26; MS m/z 449 (M+H)⁺-   7-398; A-11; C-27; MS m/z 457 (M+H)⁺-   7-399; A-11; C-28; MS m/z 560 (M+H)⁺-   7-400; A-11; C-29; MS m/z 463 (M+H)⁺-   7-401; A-11; C-30; MS m/z 479 (M+H)⁺-   7-402; A-11; C-31; MS m/z 479 (M+H)⁺-   7-403; A-11; C-32; MS m/z 505 (M+H)⁺-   7-404; A-11; C-33; MS m/z 517 (M+H)⁺-   7-405; A-11; C-34; MS m/z 525 (M+H)⁺-   7-406; A-11; C-35; MS m/z 534 (M+H)⁺-   7-407; A-11; C-36; MS m/z 529 (M+H)⁺-   7-408; A-12; C-01; MS m/z 408 (M+H)⁺-   7-409; A-12; C-02; MS m/z 420 (M+H)⁺-   7-410; A-12; C-03; MS m/z 432 (M+H)⁺-   7-411; A-12; C-04; MS m/z 436 (M+H)⁺-   7-412; A-12; C-05; MS m/z 438 (M+H)⁺-   7-413; A-12; C-06; MS m/z 446 (M+H)⁺-   7-414; A-12; C-07; MS m/z 448 (M+H)⁺-   7-415; A-12; C-08; MS m/z 464 (M+H)⁺-   7-416; A-12; C-09; MS m/z 470 (M+H)⁺-   7-417; A-12; C-10; MS m/z 476 (M+H)⁺-   7-418; A-12; C-11; MS m/z 484 (M+H)⁺-   7-419; A-12; C-12; MS m/z 490 (M+H)⁺-   7-420; A-12; C-13; MS m/z 500 (M+H)⁺-   7-421; A-12; C-14; MS m/z 506 (M+H)⁺-   7-422; A-12; C-15; MS m/z 524 (M+H)⁺-   7-423; A-12; C-16; MS m/z 516 (M+H)⁺-   7-424; A-12; C-17; MS m/z 524 (M+H)⁺-   7-425; A-12; C-18; MS m/z 436 (M+H)⁺-   7-426; A-12; C-19; MS m/z 488 (M+H)⁺-   7-427; A-12; C-20; MS m/z 529 (M+H)⁺-   7-428; A-12; C-21; MS m/z 451 (M+H)⁺-   7-429; A-12; C-22; MS m/z 477 (M+H)⁺-   7-430; A-12; C-23; MS m/z 491 (M+H)⁺-   7-431; A-12; C-24; MS m/z 512 (M+H)⁺-   7-432; A-12; C-25; MS m/z 437 (M+H)⁺-   7-433; A-12; C-26; MS m/z 449 (M+H)⁺-   7-434; A-12; C-27; MS m/z 457 (M+H)⁺-   7-435; A-12; C-28; MS m/z 560 (M+H)⁺-   7-436; A-12; C-29; MS m/z 463 (M+H)⁺-   7-437; A-12; C-30; MS m/z 479 (M+H)⁺-   7-438; A-12; C-31; MS m/z 479 (M+H)⁺-   7-439; A-12; C-32; MS m/z 505 (M+H)⁺-   7-440; A-12; C-33; MS m/z 517 (M+H)⁺-   7-441; A-12; C-34; MS m/z 525 (M+H)⁺-   7-442; A-12; C-35; MS m/z 534 (M+H)⁺-   7-443; A-12; C-36; MS m/z 529 (M+H)⁺-   7-444; A-13; C-01; MS m/z 416 (M+H)⁺-   7-445; A-13; C-02; MS m/z 428 (M+H)⁺-   7-446; A-13; C-03; MS m/z 440 (M+H)⁺-   7-447; A-13; C-04; MS m/z 444 (M+H)⁺-   7-448; A-13; C-05; MS m/z 446 (M+H)⁺-   7-449; A-13; C-06; MS m/z 454 (M+H)⁺-   7-450; A-13; C-07; MS m/z 456 (M+H)⁺-   7-451; A-13; C-08; MS m/z 472 (M+H)⁺-   7-452; A-13; C-09; MS m/z 478 (M+H)⁺-   7-453; A-13; C-10; MS m/z 484 (M+H)⁺-   7-454; A-13; C-11; MS m/z 492 (M+H)⁺-   7-455; A-13; C-12; MS m/z 498 (M+H)⁺-   7-456; A-13; C-13; MS m/z 508 (M+H)⁺-   7-457; A-13; C-14; MS m/z 514 (M+H)⁺-   7-458; A-13; C-15; MS m/z 532 (M+H)⁺-   7-459; A-13; C-16; MS m/z 524 (M+H)⁺-   7-460; A-13; C-17; MS m/z 532 (M+H)⁺-   7-461; A-13; C-18; MS m/z 444 (M+H)⁺-   7-462; A-13; C-19; MS m/z 496 (M+H)⁺-   7-463; A-13; C-20; MS m/z 537 (M+H)⁺-   7-464; A-13; C-21; MS m/z 459 (M+H)⁺-   7-465; A-13; C-22; MS m/z 485 (M+H)⁺-   7-466; A-13; C-23; MS m/z 499 (M+H)⁺-   7-467; A-13; C-24; MS m/z 520 (M+H)⁺-   7-468; A-13; C-25; MS m/z 445 (M+H)⁺-   7-469; A-13; C-26; MS m/z 457 (M+H)⁺-   7-470; A-13; C-27; MS m/z 465 (M+H)⁺-   7-471; A-13; C-28; MS m/z 568 (M+H)⁺-   7-472; A-13; C-29; MS m/z 471 (M+H)⁺-   7-473; A-13; C-30; MS m/z 487 (M+H)⁺-   7-474; A-13; C-31; MS m/z 487 (M+H)⁺-   7-475; A-13; C-32; MS m/z 513 (M+H)⁺-   7-476; A-13; C-33; MS m/z 525 (M+H)⁺-   7-477; A-13; C-34; MS m/z 533 (M+H)⁺-   7-478; A-13; C-35; MS m/z 542 (M+H)⁺-   7-479; A-13; C-36; MS m/z 537 (M+H)⁺-   7-480; A-14; C-01; MS m/z 416 (M+H)⁺-   7-481; A-14; C-02; MS m/z 428 (M+H)⁺-   7-482; A-14; C-03; MS m/z 440 (M+H)⁺-   7-483; A-14; C-04; MS m/z 444 (M+H)⁺-   7-484; A-14; C-05; MS m/z 446 (M+H)⁺-   7-485; A-14; C-06; MS m/z 454 (M+H)⁺-   7-486; A-14; C-07; MS m/z 456 (M+H)⁺-   7-487; A-14; C-08; MS m/z 472 (M+H)⁺-   7-488; A-14; C-09; MS m/z 478 (M+H)⁺-   7-489; A-14; C-10; MS m/z 484 (M+H)⁺-   7-490; A-14; C-11; MS m/z 492 (M+H)⁺-   7-491; A-14; C-12; MS m/z 498 (M+H)⁺-   7-492; A-14; C-13; MS m/z 508 (M+H)⁺-   7-493; A-14; C-14; MS m/z 514 (M+H)⁺-   7-494; A-14; C-15; MS m/z 532 (M+H)⁺-   7-495; A-14; C-16; MS m/z 524 (M+H)⁺-   7-496; A-14; C-17; MS m/z 532 (M+H)⁺-   7-497; A-14; C-18; MS m/z 444 (M+H)⁺-   7-498; A-14; C-19; MS m/z 496 (M+H)⁺-   7-499; A-14; C-20; MS m/z 537 (M+H)⁺-   7-500; A-14; C-21; MS m/z 459 (M+H)⁺-   7-501; A-14; C-22; MS m/z 485 (M+H)⁺-   7-502; A-14; C-23; MS m/z 499 (M+H)⁺-   7-503; A-14; C-24; MS m/z 520 (M+H)⁺-   7-504; A-14; C-25; MS m/z 445 (M+H)⁺-   7-505; A-14; C-26; MS m/z 457 (M+H)⁺-   7-506; A-14; C-27; MS m/z 465 (M+H)⁺-   7-507; A-14; C-28; MS m/z 568 (M+H)⁺-   7-508; A-14; C-29; MS m/z 471 (M+H)⁺-   7-509; A-14; C-30; MS m/z 487 (M+H)⁺-   7-510; A-14; C-31; MS m/z 487 (M+H)⁺-   7-511; A-14; C-32; MS m/z 513 (M+H)⁺-   7-512; A-14; C-33; MS m/z 525 (M+H)⁺-   7-513; A-14; C-34; MS m/z 533 (M+H)⁺-   7-514; A-14; C-35; MS m/z 542 (M+H)⁺-   7-515; A-14; C-36; MS m/z 537 (M+H)⁺-   7-516; A-14; C-37; MS m/z 501 (M+H)⁺-   7-517; A-14; C-38; MS m/z 514 (M+H)⁺-   7-518; A-14; C-39; MS m/z 487 (M+H)⁺-   7-519; A-14; C-40; MS m/z 485 (M+H)⁺-   7-520; A-14; C-41; MS m/z 501 (M+H)⁺-   7-521; A-14; C-42; MS m/z 485 (M+H)⁺-   7-522; A-14; C-43; MS m/z 485 (M+H)⁺-   7-523; A-14; C-44; MS m/z 473 (M+H)⁺-   7-524; A-14; C-45; MS m/z 485 (M+H)⁺-   7-525; A-14; C-46; MS m/z 482 (M+H)⁺-   7-526; A-14; C-47; MS m/z 474 (M+H)⁺-   7-527; A-15; C-01; MS m/z 424 (M+H)⁺-   7-528; A-15; C-02; MS m/z 436 (M+H)⁺-   7-529; A-15; C-03; MS m/z 448 (M+H)⁺-   7-530; A-15; C-04; MS m/z 452 (M+H)⁺-   7-531; A-15; C-05; MS m/z 454 (M+H)⁺-   7-532; A-15; C-06; MS m/z 462 (M+H)⁺-   7-533; A-15; C-07; MS m/z 464 (M+H)⁺-   7-534; A-15; C-08; MS m/z 480 (M+H)⁺-   7-535; A-15; C-09; MS m/z 486 (M+H)⁺-   7-536; A-15; C-10; MS m/z 492 (M+H)⁺-   7-537; A-15; C-11; MS m/z 500 (M+H)⁺-   7-538; A-15; C-12; MS m/z 506 (M+H)⁺-   7-539; A-15; C-13; MS m/z 516 (M+H)⁺-   7-540; A-15; C-14; MS m/z 522 (M+H)⁺-   7-541; A-15; C-15; MS m/z 540 (M+H)⁺-   7-542; A-15; C-16; MS m/z 532 (M+H)⁺-   7-543; A-15; C-17; MS m/z 540 (M+H)⁺-   7-544; A-15; C-18; MS m/z 452 (M+H)⁺-   7-545; A-15; C-19; MS m/z 504 (M+H)⁺-   7-546; A-15; C-20; MS m/z 545 (M+H)⁺-   7-547; A-15; C-21; MS m/z 467 (M+H)⁺-   7-548; A-15; C-22; MS m/z 493 (M+H)⁺-   7-549; A-15; C-23; MS m/z 507 (M+H)⁺-   7-550; A-15; C-24; MS m/z 528 (M+H)⁺-   7-551; A-15; C-25; MS m/z 453 (M+H)⁺-   7-552; A-15; C-26; MS m/z 465 (M+H)⁺-   7-553; A-15; C-27; MS m/z 473 (M+H)⁺-   7-554; A-15; C-28; MS m/z 576 (M+H)⁺-   7-555; A-15; C-29; MS m/z 479 (M+H)⁺-   7-556; A-15; C-30; MS m/z 495 (M+H)⁺-   7-557; A-15; C-31; MS m/z 495 (M+H)⁺-   7-558; A-15; C-32; MS m/z 521 (M+H)⁺-   7-559; A-15; C-33; MS m/z 533 (M+H)⁺-   7-560; A-15; C-34; MS m/z 541 (M+H)⁺-   7-561; A-15; C-35; MS m/z 550 (M+H)⁺-   7-562; A-15; C-36; MS m/z 545 (M+H)⁺-   7-563; A-16; C-01; MS m/z 430 (M+H)⁺-   7-564; A-16; C-02; MS m/z 442 (M+H)⁺-   7-565; A-16; C-03; MS m/z 454 (M+H)⁺-   7-566; A-16; C-04; MS m/z 458 (M+H)⁺-   7-567; A-16; C-05; MS m/z 460 (M+H)⁺-   7-568; A-16; C-06; MS m/z 468 (M+H)⁺-   7-569; A-16; C-07; MS m/z 470 (M+H)⁺-   7-570; A-16; C-08; MS m/z 486 (M+H)⁺-   7-571; A-16; C-09; MS m/z 492 (M+H)⁺-   7-572; A-16; C-10; MS m/z 498 (M+H)⁺-   7-573; A-16; C-11; MS m/z 506 (M+H)⁺-   7-574; A-16; C-12; MS m/z 512 (M+H)⁺-   7-575; A-16; C-13; MS m/z 522 (M+H)⁺-   7-576; A-16; C-14; MS m/z 528 (M+H)⁺-   7-577; A-16; C-15; MS m/z 546 (M+H)⁺-   7-578; A-16; C-16; MS m/z 538 (M+H)⁺-   7-579; A-16; C-17; MS m/z 546 (M+H)⁺-   7-580; A-16; C-18; MS m/z 458 (M+H)⁺-   7-581; A-16; C-19; MS m/z 510 (M+H)⁺-   7-582; A-16; C-20; MS m/z 551 (M+H)⁺-   7-583; A-16; C-21; MS m/z 473 (M+H)⁺-   7-584; A-16; C-22; MS m/z 499 (M+H)⁺-   7-585; A-16; C-23; MS m/z 513 (M+H)⁺-   7-586; A-16; C-24; MS m/z 534 (M+H)⁺-   7-587; A-16; C-25; MS m/z 459 (M+H)⁺-   7-588; A-16; C-26; MS m/z 471 (M+H)⁺-   7-589; A-16; C-27; MS m/z 479 (M+H)⁺-   7-590; A-16; C-28; MS m/z 582 (M+H)⁺-   7-591; A-16; C-29; MS m/z 485 (M+H)⁺-   7-592; A-16; C-30; MS m/z 501 (M+H)⁺-   7-593; A-16; C-31; MS m/z 501 (M+H)⁺-   7-594; A-16; C-32; MS m/z 527 (M+H)⁺-   7-595; A-16; C-33; MS m/z 539 (M+H)⁺-   7-596; A-16; C-34; MS m/z 547 (M+H)⁺-   7-597; A-16; C-35; MS m/z 556 (M+H)⁺-   7-598; A-16; C-36; MS m/z 551 (M+H)⁺-   7-599; A-17; C-01; MS m/z 436 (M+H)⁺-   7-600; A-17; C-02; MS m/z 448 (M+H)⁺-   7-601; A-17; C-03; MS m/z 460 (M+H)⁺-   7-602; A-17; C-04; MS m/z 464 (M+H)⁺-   7-603; A-17; C-05; MS m/z 466 (M+H)⁺-   7-604; A-17; C-06; MS m/z 474 (M+H)⁺-   7-605; A-17; C-07; MS m/z 476 (M+H)⁺-   7-606; A-17; C-08; MS m/z 492 (M+H)⁺-   7-607; A-17; C-09; MS m/z 498 (M+H)⁺-   7-608; A-17; C-10; MS m/z 504 (M+H)⁺-   7-609; A-17; C-11; MS m/z 512 (M+H)⁺-   7-610; A-17; C-12; MS m/z 518 (M+H)⁺-   7-611; A-17; C-13; MS m/z 528 (M+H)⁺-   7-612; A-17; C-14; MS m/z 534 (M+H)⁺-   7-613; A-17; C-15; MS m/z 552 (M+H)⁺-   7-614; A-17; C-16; MS m/z 544 (M+H)⁺-   7-615; A-17; C-17; MS m/z 552 (M+H)⁺-   7-616; A-17; C-18; MS m/z 464 (M+H)⁺-   7-617; A-17; C-19; MS m/z 516 (M+H)⁺-   7-618; A-17; C-20; MS m/z 557 (M+H)⁺-   7-619; A-17; C-21; MS m/z 479 (M+H)⁺-   7-620; A-17; C-22; MS m/z 505 (M+H)⁺-   7-621; A-17; C-23; MS m/z 519 (M+H)⁺-   7-622; A-17; C-24; MS m/z 540 (M+H)⁺-   7-623; A-17; C-25; MS m/z 465 (M+H)⁺-   7-624; A-17; C-26; MS m/z 477 (M+H)⁺-   7-625; A-17; C-27; MS m/z 485 (M+H)⁺-   7-626; A-17; C-28; MS m/z 588 (M+H)⁺-   7-627; A-17; C-29; MS m/z 491 (M+H)⁺-   7-628; A-17; C-30; MS m/z 507 (M+H)⁺-   7-629; A-17; C-31; MS m/z 507 (M+H)⁺-   7-630; A-17; C-32; MS m/z 533 (M+H)⁺-   7-631; A-17; C-33; MS m/z 545 (M+H)⁺-   7-632; A-17; C-34; MS m/z 553 (M+H)⁺-   7-633; A-17; C-35; MS m/z 562 (M+H)⁺-   7-634; A-17; C-36; MS m/z 557 (M+H)⁺-   7-635; A-17; C-37; MS m/z 521 (M+H)⁺-   7-636; A-17; C-38; MS m/z 534 (M+H)⁺-   7-637; A-17; C-39; MS m/z 507 (M+H)⁺-   7-638; A-17; C-40; MS m/z 505 (M+H)⁺-   7-639; A-17; C-41; MS m/z 521 (M+H)⁺-   7-640; A-17; C-42; MS m/z 505 (M+H)⁺-   7-641; A-17; C-43; MS m/z 505 (M+H)⁺-   7-642; A-17; C-44; MS m/z 493 (M+H)⁺-   7-643; A-17; C-45; MS m/z 505 (M+H)⁺-   7-644; A-17; C-46; MS m/z 502 (M+H)⁺-   7-645; A-17; C-47; MS m/z 494 (M+H)⁺-   7-646; A-18; C-01; MS m/z 452 (M+H)⁺-   7-647; A-18; C-02; MS m/z 464 (M+H)⁺-   7-648; A-18; C-03; MS m/z 476 (M+H)⁺-   7-649; A-18; C-04; MS m/z 480 (M+H)⁺-   7-650; A-18; C-05; MS m/z 482 (M+H)⁺-   7-651; A-18; C-06; MS m/z 490 (M+H)⁺-   7-652; A-18; C-07; MS m/z 492 (M+H)⁺-   7-653; A-18; C-08; MS m/z 508 (M+H)⁺-   7-654; A-18; C-09; MS m/z 514 (M+H)⁺-   7-655; A-18; C-10; MS m/z 520 (M+H)⁺-   7-656; A-18; C-11; MS m/z 528 (M+H)⁺-   7-657; A-18; C-12; MS m/z 534 (M+H)⁺-   7-658; A-18; C-13; MS m/z 544 (M+H)⁺-   7-659; A-18; C-14; MS m/z 550 (M+H)⁺-   7-660; A-18; C-15; MS m/z 568 (M+H)⁺-   7-661; A-18; C-16; MS m/z 560 (M+H)⁺-   7-662; A-18; C-17; MS m/z 568 (M+H)⁺-   7-663; A-18; C-18; MS m/z 480 (M+H)⁺-   7-664; A-18; C-19; MS m/z 532 (M+H)⁺-   7-665; A-18; C-20; MS m/z 573 (M+H)⁺-   7-666; A-18; C-21; MS m/z 495 (M+H)⁺-   7-667; A-18; C-22; MS m/z 521 (M+H)⁺-   7-668; A-18; C-23; MS m/z 535 (M+H)⁺-   7-669; A-18; C-24; MS m/z 556 (M+H)⁺-   7-670; A-18; C-25; MS m/z 481 (M+H)⁺-   7-671; A-18; C-26; MS m/z 493 (M+H)⁺-   7-672; A-18; C-27; MS m/z 501 (M+H)⁺-   7-673; A-18; C-28; MS m/z 604 (M+H)⁺-   7-674; A-18; C-29; MS m/z 507 (M+H)⁺-   7-675; A-18; C-30; MS m/z 523 (M+H)⁺-   7-676; A-18; C-31; MS m/z 523 (M+H)⁺-   7-677; A-18; C-32; MS m/z 549 (M+H)⁺-   7-678; A-18; C-33; MS m/z 561 (M+H)⁺-   7-679; A-18; C-34; MS m/z 569 (M+H)⁺-   7-680; A-18; C-35; MS m/z 578 (M+H)⁺-   7-681; A-18; C-36; MS m/z 573 (M+H)⁺-   7-682; A-19; C-01; MS m/z 428 (M+H)⁺-   7-683; A-19; C-02; MS m/z 440 (M+H)⁺-   7-684; A-19; C-03; MS m/z 452 (M+H)⁺-   7-685; A-19; C-04; MS m/z 456 (M+H)⁺-   7-686; A-19; C-05; MS m/z 458 (M+H)⁺-   7-687; A-19; C-06; MS m/z 466 (M+H)⁺-   7-688; A-19; C-07; MS m/z 468 (M+H)⁺-   7-689; A-19; C-08; MS m/z 484 (M+H)⁺-   7-690; A-19; C-09; MS m/z 490 (M+H)⁺-   7-691; A-19; C-10; MS m/z 496 (M+H)⁺-   7-692; A-19; C-11; MS m/z 504 (M+H)⁺-   7-693; A-19; C-12; MS m/z 510 (M+H)⁺-   7-694; A-19; C-13; MS m/z 520 (M+H)⁺-   7-695; A-19; C-14; MS m/z 526 (M+H)⁺-   7-696; A-19; C-15; MS m/z 544 (M+H)⁺-   7-697; A-19; C-16; MS m/z 536 (M+H)⁺-   7-698; A-19; C-17; MS m/z 544 (M+H)⁺-   7-699; A-19; C-18; MS m/z 456 (M+H)⁺-   7-700; A-19; C-19; MS m/z 508 (M+H)⁺-   7-701; A-19; C-20; MS m/z 549 (M+H)⁺-   7-702; A-19; C-21; MS m/z 471 (M+H)⁺-   7-703; A-19; C-22; MS m/z 497 (M+H)⁺-   7-704; A-19; C-23; MS m/z 511 (M+H)⁺-   7-705; A-19; C-24; MS m/z 532 (M+H)⁺-   7-706; A-19; C-25; MS m/z 457 (M+H)⁺-   7-707; A-19; C-26; MS m/z 469 (M+H)⁺-   7-708; A-19; C-27; MS m/z 477 (M+H)⁺-   7-709; A-19; C-28; MS m/z 580 (M+H)⁺-   7-710; A-19; C-29; MS m/z 483 (M+H)-   7-711; A-19; C-30; MS m/z 499 (M+H)⁺-   7-712; A-19; C-31; MS m/z 499 (M+H)⁺-   7-713; A-19; C-32; MS m/z 525 (M+H)⁺-   7-714; A-19; C-33; MS m/z 537 (M+H)⁺-   7-715; A-19; C-34; MS m/z 545 (M+H)⁺-   7-716; A-19; C-35; MS m/z 554 (M+H)⁺-   7-717; A-19; C-36; MS m/z 549 (M+H)⁺-   7-718; A-20; C-01; MS m/z 432 (M+H)⁺-   7-719; A-20; C-02; MS m/z 444 (M+H)⁺-   7-720; A-20; C-03; MS m/z 456 (M+H)⁺-   7-721; A-20; C-04; MS m/z 460 (M+H)⁺-   7-722; A-20; C-05; MS m/z 462 (M+H)⁺-   7-723; A-20; C-06; MS m/z 470 (M+H)⁺-   7-724; A-20; C-07; MS m/z 472 (M+H)⁺-   7-725; A-20; C-08; MS m/z 488 (M+H)⁺-   7-726; A-20; C-09; MS m/z 494 (M+H)⁺-   7-727; A-20; C-10; MS m/z 500 (M+H)⁺-   7-728; A-20; C-11; MS m/z 508 (M+H)⁺-   7-729; A-20; C-12; MS m/z 514 (M+H)⁺-   7-730; A-20; C-13; MS m/z 524 (M+H)⁺-   7-731; A-20; C-14; MS m/z 530 (M+H)⁺-   7-732; A-20; C-15; MS m/z 548 (M+H)⁺-   7-733; A-20; C-16; MS m/z 540 (M+H)⁺-   7-734; A-20; C-17; MS m/z 548 (M+H)⁺-   7-735; A-20; C-18; MS m/z 460 (M+H)⁺-   7-736; A-20; C-19; MS m/z 512 (M+H)⁺-   7-737; A-20; C-20; MS m/z 553 (M+H)⁺-   7-738; A-20; C-21; MS m/z 475 (M+H)⁺-   7-739; A-20; C-22; MS m/z 501 (M+H)⁺-   7-740; A-20; C-23; MS m/z 515 (M+H)⁺-   7-741; A-20; C-24; MS m/z 536 (M+H)⁺-   7-742; A-20; C-25; MS m/z 461 (M+H)⁺-   7-743; A-20; C-26; MS m/z 473 (M+H)⁺-   7-744; A-20; C-27; MS m/z 481 (M+H)⁺-   7-745; A-20; C-28; MS m/z 584 (M+H)⁺-   7-746; A-20; C-29; MS m/z 487 (M+H)⁺-   7-747; A-20; C-30; MS m/z 503 (M+H)⁺-   7-748; A-20; C-31; MS m/z 503 (M+H)⁺-   7-749; A-20; C-32; MS m/z 529 (M+H)⁺-   7-750; A-20; C-33; MS m/z 541 (M+H)⁺-   7-751; A-20; C-34; MS m/z 549 (M+H)⁺-   7-752; A-20; C-35; MS m/z 558 (M+H)⁺-   7-753; A-20; C-36; MS m/z 553 (M+H)⁺-   7-754; A-21; C-01; MS m/z 438 (M+H)⁺-   7-755; A-21; C-02; MS m/z 450 (M+H)⁺-   7-756; A-21; C-03; MS m/z 462 (M+H)⁺-   7-757; A-21; C-04; MS m/z 466 (M+H)⁺-   7-758; A-21; C-05; MS m/z 468 (M+H)⁺-   7-759; A-21; C-06; MS m/z 476 (M+H)⁺-   7-760; A-21; C-07; MS m/z 478 (M+H)⁺-   7-761; A-21; C-08; MS m/z 494 (M+H)⁺-   7-762; A-21; C-09; MS m/z 500 (M+H)⁺-   7-763; A-21; C-10; MS m/z 506 (M+H)⁺-   7-764; A-21; C-11; MS m/z 514 (M+H)⁺-   7-765; A-21; C-12; MS m/z 520 (M+H)⁺-   7-766; A-21; C-13; MS m/z 530 (M+H)⁺-   7-767; A-21; C-14; MS m/z 536 (M+H)⁺-   7-768; A-21; C-15; MS m/z 554 (M+H)⁺-   7-769; A-21; C-16; MS m/z 546 (M+H)⁺-   7-770; A-21; C-17; MS m/z 554 (M+H)⁺-   7-771; A-21; C-18; MS m/z 466 (M+H)⁺-   7-772; A-21; C-19; MS m/z 518 (M+H)⁺-   7-773; A-21; C-20; MS m/z 559 (M+H)⁺-   7-774; A-21; C-21; MS m/z 481 (M+H)⁺-   7-775; A-21; C-22; MS m/z 507 (M+H)⁺-   7-776; A-21; C-23; MS m/z 521 (M+H)⁺-   7-777; A-21; C-24; MS m/z 542 (M+H)⁺-   7-778; A-21; C-25; MS m/z 467 (M+H)⁺-   7-779; A-21; C-26; MS m/z 479 (M+H)⁺-   7-780; A-21; C-27; MS m/z 487 (M+H)⁺-   7-781; A-21; C-28; MS m/z 590 (M+H)⁺-   7-782; A-21; C-29; MS m/z 493 (M+H)⁺-   7-783; A-21; C-30; MS m/z 509 (M+H)⁺-   7-784; A-21; C-31; MS m/z 509 (M+H)⁺-   7-785; A-21; C-32; MS m/z 535 (M+H)⁺-   7-786; A-21; C-33; MS m/z 547 (M+H)⁺-   7-787; A-21; C-34; MS m/z 555 (M+H)⁺-   7-788; A-21; C-35; MS m/z 564 (M+H)⁺-   7-789; A-21; C-36; MS m/z 559 (M+H)⁺-   7-790; A-22; C-01; MS m/z 462 (M+H)⁺-   7-791; A-22; C-02; MS m/z 474 (M+H)⁺-   7-792; A-22; C-03; MS m/z 486 (M+H)⁺-   7-793; A-22; C-04; MS m/z 490 (M+H)⁺-   7-794; A-22; C-05; MS m/z 492 (M+H)⁺-   7-795; A-22; C-06; MS m/z 500 (M+H)⁺-   7-796; A-22; C-07; MS m/z 502 (M+H)⁺-   7-797; A-22; C-08; MS m/z 518 (M+H)⁺-   7-798; A-22; C-09; MS m/z 524 (M+H)⁺-   7-799; A-22; C-10; MS m/z 530 (M+H)⁺-   7-800; A-22; C-11; MS m/z 538 (M+H)⁺-   7-801; A-22; C-12; MS m/z 544 (M+H)⁺-   7-802; A-22; C-13; MS m/z 554 (M+H)⁺-   7-803; A-22; C-14; MS m/z 560 (M+H)⁺-   7-804; A-22; C-15; MS m/z 578 (M+H)⁺-   7-805; A-22; C-16; MS m/z 570 (M+H)⁺-   7-806; A-22; C-17; MS m/z 578 (M+H)⁺-   7-807; A-22; C-18; MS m/z 490 (M+H)⁺-   7-808; A-22; C-19; MS m/z 542 (M+H)⁺-   7-809; A-22; C-20; MS m/z 583 (M+H)⁺-   7-810; A-22; C-21; MS m/z 505 (M+H)⁺-   7-811; A-22; C-22; MS m/z 531 (M+H)⁺-   7-812; A-22; C-23; MS m/z 545 (M+H)⁺-   7-813; A-22; C-24; MS m/z 566 (M+H)⁺-   7-814; A-22; C-25; MS m/z 491 (M+H)⁺-   7-815; A-22; C-26; MS m/z 503 (M+H)⁺-   7-816; A-22; C-27; MS m/z 511 (M+H)⁺-   7-817; A-22; C-28; MS m/z 614 (M+H)⁺-   7-818; A-22; C-29; MS m/z 517 (M+H)⁺-   7-819; A-22; C-30; MS m/z 533 (M+H)⁺-   7-820; A-22; C-31; MS m/z 533 (M+H)⁺-   7-821; A-22; C-32; MS m/z 559 (M+H)⁺-   7-822; A-22; C-33; MS m/z 571 (M+H)⁺-   7-823; A-22; C-34; MS m/z 579 (M+H)⁺-   7-824; A-22; C-35; MS m/z 588 (M+H)⁺-   7-825; A-22; C-36; MS m/z 583 (M+H)⁺-   7-826; A-23; C-01; MS m/z 466 (M+H)⁺-   7-827; A-23; C-02; MS m/z 478 (M+H)⁺-   7-828; A-23; C-03; MS m/z 490 (M+H)⁺-   7-829; A-23; C-04; MS m/z 494 (M+H)⁺-   7-830; A-23; C-05; MS m/z 496 (M+H)⁺-   7-831; A-23; C-06; MS m/z 504 (M+H)⁺-   7-832; A-23; C-07; MS m/z 506 (M+H)⁺-   7-833; A-23; C-08; MS m/z 522 (M+H)⁺-   7-834; A-23; C-09; MS m/z 528 (M+H)⁺-   7-835; A-23; C-10; MS m/z 534 (M+H)⁺-   7-836; A-23; C-11; MS m/z 542 (M+H)⁺-   7-837; A-23; C-12; MS m/z 548 (M+H)⁺-   7-838; A-23; C-13; MS m/z 558 (M+H)⁺-   7-839; A-23; C-14; MS m/z 564 (M+H)⁺-   7-840; A-23; C-15; MS m/z 582 (M+H)⁺-   7-841; A-23; C-16; MS m/z 574 (M+H)⁺-   7-842; A-23; C-17; MS m/z 582 (M+H)⁺-   7-843; A-23; C-18; MS m/z 494 (M+H)⁺-   7-844; A-23; C-19; MS m/z 546 (M+H)⁺-   7-845; A-23; C-20; MS m/z 587 (M+H)⁺-   7-846; A-23; C-21; MS m/z 509 (M+H)⁺-   7-847; A-23; C-22; MS m/z 535 (M+H)⁺-   7-848; A-23; C-23; MS m/z 549 (M+H)⁺-   7-849; A-23; C-24; MS m/z 570 (M+H)⁺-   7-850; A-23; C-25; MS m/z 495 (M+H)⁺-   7-851; A-23; C-26; MS m/z 507 (M+H)⁺-   7-852; A-23; C-27; MS m/z 515 (M+H)⁺-   7-853; A-23; C-28; MS m/z 618 (M+H)⁺-   7-854; A-23; C-29; MS m/z 521 (M+H)⁺-   7-855; A-23; C-30; MS m/z 537 (M+H)⁺-   7-856; A-23; C-31; MS m/z 537 (M+H)⁺-   7-857; A-23; C-32; MS m/z 563 (M+H)⁺-   7-858; A-23; C-33; MS m/z 575 (M+H)⁺-   7-859; A-23; C-34; MS m/z 583 (M+H)⁺-   7-860; A-23; C-35; MS m/z 592 (M+H)⁺-   7-861; A-23; C-36; MS m/z 587 (M+H)⁺-   7-862; A-24; C-01; MS m/z 470 (M+H)⁺-   7-863; A-24; C-02; MS m/z 482 (M+H)⁺-   7-864; A-24; C-03; MS m/z 494 (M+H)⁺-   7-865; A-24; C-04; MS m/z 498 (M+H)⁺-   7-866; A-24; C-05; MS m/z 500 (M+H)⁺-   7-867; A-24; C-06; MS m/z 508 (M+H)⁺-   7-868; A-24; C-07; MS m/z 510 (M+H)⁺-   7-869; A-24; C-08; MS m/z 526 (M+H)⁺-   7-870; A-24; C-09; MS m/z 532 (M+H)⁺-   7-871; A-24; C-10; MS m/z 538 (M+H)⁺-   7-872; A-24; C-11; MS m/z 546 (M+H)⁺-   7-873; A-24; C-12; MS m/z 552 (M+H)⁺-   7-874; A-24; C-13; MS m/z 562 (M+H)⁺-   7-875; A-24; C-14; MS m/z 568 (M+H)⁺-   7-876; A-24; C-15; MS m/z 586 (M+H)⁺-   7-877; A-24; C-16; MS m/z 578 (M+H)⁺-   7-878; A-24; C-17; MS m/z 586 (M+H)⁺-   7-879; A-24; C-18; MS m/z 498 (M+H)⁺-   7-880; A-24; C-19; MS m/z 550 (M+H)⁺-   7-881; A-24; C-20; MS m/z 591 (M+H)⁺-   7-882; A-24; C-21; MS m/z 513 (M+H)⁺-   7-883; A-24; C-22; MS m/z 539 (M+H)⁺-   7-884; A-24; C-23; MS m/z 553 (M+H)⁺-   7-885; A-24; C-24; MS m/z 574 (M+H)⁺-   7-886; A-24; C-25; MS m/z 499 (M+H)⁺-   7-887; A-24; C-26; MS m/z 511 (M+H)⁺-   7-888; A-24; C-27; MS m/z 519 (M+H)⁺-   7-889; A-24; C-28; MS m/z 622 (M+H)⁺-   7-890; A-24; C-29; MS m/z 525 (M+H)⁺-   7-891; A-24; C-30; MS m/z 541 (M+H)⁺-   7-892; A-24; C-31; MS m/z 541 (M+H)⁺-   7-893; A-24; C-32; MS m/z 567 (M+H)⁺-   7-894; A-24; C-33; MS m/z 579 (M+H)⁺-   7-895; A-24; C-34; MS m/z 587 (M+H)⁺-   7-896; A-24; C-35; MS m/z 596 (M+H)⁺-   7-897; A-24; C-36; MS m/z 591 (M+H)⁺-   7-898; A-25; C-01; MS m/z 397 (M+H)⁺-   7-899; A-25; C-02; MS m/z 409 (M+H)⁺-   7-900; A-25; C-03; MS m/z 421 (M+H)⁺-   7-901; A-25; C-04; MS m/z 425 (M+H)⁺-   7-902; A-25; C-05; MS m/z 427 (M+H)⁺-   7-903; A-25; C-06; MS m/z 435 (M+H)⁺-   7-904; A-25; C-07; MS m/z 437 (M+H)⁺-   7-905; A-25; C-08; MS m/z 453 (M+H)⁺-   7-906; A-25; C-09; MS m/z 459 (M+H)⁺-   7-907; A-25; C-10; MS m/z 465 (M+H)⁺-   7-908; A-25; C-11; MS m/z 473 (M+H)⁺-   7-909; A-25; C-12; MS m/z 479 (M+H)⁺-   7-910; A-25; C-13; MS m/z 489 (M+H)⁺-   7-911; A-25; C-14; MS m/z 495 (M+H)⁺-   7-912; A-25; C-15; MS m/z 513 (M+H)⁺-   7-913; A-25; C-16; MS m/z 505 (M+H)⁺-   7-914; A-25; C-17; MS m/z 513 (M+H)⁺-   7-915; A-25; C-18; MS m/z 425 (M+H)⁺-   7-916; A-25; C-19; MS m/z 477 (M+H)⁺-   7-917; A-25; C-20; MS m/z 518 (M+H)⁺-   7-918; A-25; C-21; MS m/z 440 (M+H)⁺-   7-919; A-25; C-22; MS m/z 466 (M+H)⁺-   7-920; A-25; C-23; MS m/z 480 (M+H)⁺-   7-921; A-25; C-24; MS m/z 501 (M+H)⁺-   7-922; A-25; C-25; MS m/z 426 (M+H)⁺-   7-923; A-25; C-26; MS m/z 438 (M+H)⁺-   7-924; A-25; C-27; MS m/z 446 (M+H)⁺-   7-925; A-25; C-28; MS m/z 549 (M+H)⁺-   7-926; A-25; C-29; MS m/z 452 (M+H)⁺-   7-927; A-25; C-30; MS m/z 468 (M+H)⁺-   7-928; A-25; C-31; MS m/z 468 (M+H)⁺-   7-929; A-25; C-32; MS m/z 494 (M+H)⁺-   7-930; A-25; C-33; MS m/z 506 (M+H)⁺-   7-931; A-25; C-34; MS m/z 514 (M+H)⁺-   7-932; A-25; C-35; MS m/z 523 (M+H)⁺-   7-933; A-25; C-36; MS m/z 518 (M+H)⁺-   7-934; A-27; C-01; MS m/z 437 (M+H)⁺-   7-935; A-27; C-02; MS m/z 449 (M+H)⁺-   7-936; A-27; C-03; MS m/z 461 (M+H)⁺-   7-937; A-27; C-04; MS m/z 465 (M+H)⁺-   7-938; A-27; C-05; MS m/z 467 (M+H)⁺-   7-939; A-27; C-06; MS m/z 475 (M+H)⁺-   7-940; A-27; C-07; MS m/z 477 (M+H)⁺-   7-941; A-27; C-08; MS m/z 493 (M+H)⁺-   7-942; A-27; C-09; MS m/z 499 (M+H)⁺-   7-943; A-27; C-10; MS m/z 505 (M+H)⁺-   7-944; A-27; C-11; MS m/z 513 (M+H)⁺-   7-945; A-27; C-12; MS m/z 519 (M+H)⁺-   7-946; A-27; C-13; MS m/z 529 (M+H)⁺-   7-947; A-27; C-14; MS m/z 535 (M+H)⁺-   7-948; A-27; C-15; MS m/z 553 (M+H)⁺-   7-949; A-27; C-16; MS m/z 545 (M+H)⁺-   7-950; A-27; C-17; MS m/z 553 (M+H)⁺-   7-951; A-27; C-18; MS m/z 465 (M+H)⁺-   7-952; A-27; C-19; MS m/z 517 (M+H)⁺-   7-953; A-27; C-20; MS m/z 558 (M+H)⁺-   7-954; A-27; C-21; MS m/z 480 (M+H)⁺-   7-955; A-27; C-22; MS m/z 506 (M+H)⁺-   7-956; A-27; C-23; MS m/z 520 (M+H)⁺-   7-957; A-27; C-24; MS m/z 541 (M+H)⁺-   7-958; A-27; C-25; MS m/z 466 (M+H)⁺-   7-959; A-27; C-26; MS m/z 478 (M+H)⁺-   7-960; A-27; C-27; MS m/z 486 (M+H)⁺-   7-961; A-27; C-28; MS m/z 589 (M+H)⁺-   7-962; A-27; C-29; MS m/z 492 (M+H)⁺-   7-963; A-27; C-30; MS m/z 508 (M+H)⁺-   7-964; A-27; C-31; MS m/z 508 (M+H)⁺-   7-965; A-27; C-32; MS m/z 534 (M+H)⁺-   7-966; A-27; C-33; MS m/z 546 (M+H)⁺-   7-967; A-27; C-34; MS m/z 554 (M+H)⁺-   7-968; A-27; C-35; MS m/z 563 (M+H)⁺-   7-969; A-27; C-36; MS m/z 558 (M+H)^(+.)-   7-970; A-28; C-01; MS m/z 467 (M+H)⁺-   7-971; A-28; C-02; MS m/z 479 (M+H)⁺-   7-972; A-28; C-03; MS m/z 491 (M+H)⁺-   7-973; A-28; C-04; MS m/z 495 (M+H)⁺-   7-974; A-28; C-05; MS m/z 497 (M+H)⁺-   7-975; A-28; C-06; MS m/z 505 (M+H)⁺-   7-976; A-28; C-07; MS m/z 507 (M+H)⁺-   7-977; A-28; C-08; MS m/z 523 (M+H)⁺-   7-978; A-28; C-09; MS m/z 529 (M+H)⁺-   7-979; A-28; C-10; MS m/z 535 (M+H)⁺-   7-980; A-28; C-11; MS m/z 543 (M+H)⁺-   7-981; A-28; C-12; MS m/z 549 (M+H)⁺-   7-982; A-28; C-13; MS m/z 559 (M+H)⁺-   7-983; A-28; C-14; MS m/z 565 (M+H)⁺-   7-984; A-28; C-15; MS m/z 583 (M+H)⁺-   7-985; A-28; C-16; MS m/z 575 (M+H)⁺-   7-986; A-28; C-17; MS m/z 583 (M+H)⁺-   7-987; A-28; C-18; MS m/z 495 (M+H)⁺-   7-988; A-28; C-19; MS m/z 547 (M+H)⁺-   7-989; A-28; C-20; MS m/z 588 (M+H)⁺-   7-990; A-28; C-21; MS m/z 510 (M+H)⁺-   7-991; A-28; C-22; MS m/z 536 (M+H)⁺-   7-992; A-28; C-23; MS m/z 550 (M+H)⁺-   7-993; A-28; C-24; MS m/z 571 (M+H)⁺-   7-994; A-28; C-25; MS m/z 496 (M+H)⁺-   7-995; A-28; C-26; MS m/z 508 (M+H)⁺-   7-996; A-28; C-27; MS m/z 516 (M+H)⁺-   7-997; A-28; C-28; MS m/z 619 (M+H)⁺-   7-998; A-28; C-29; MS m/z 522 (M+H)⁺-   7-999; A-28; C-30; MS m/z 538 (M+H)⁺-   7-1000; A-28; C-31; MS m/z 538 (M+H)⁺-   7-1001; A-28; C-32; MS m/z 564 (M+H)⁺-   7-1002; A-28; C-33; MS m/z 576 (M+H)⁺-   7-1003; A-28; C-34; MS m/z 584 (M+H)⁺-   7-1004; A-28; C-35; MS m/z 593 (M+H)⁺-   7-1005; A-28; C-36; MS m/z 588 (M+H)⁺-   7-1006; A-33; C-01; MS m/z 366 (M+H)⁺-   7-1007; A-33; C-02; MS m/z 378 (M+H)⁺-   7-1008; A-33; C-03; MS m/z 390 (M+H)⁺-   7-1009; A-33; C-04; MS m/z 394 (M+H)⁺-   7-1010; A-33; C-05; MS m/z 396 (M+H)⁺-   7-1011; A-33; C-06; MS m/z 404 (M+H)⁺-   7-1012; A-33; C-07; MS m/z 406 (M+H)⁺-   7-1013; A-33; C-08; MS m/z 422 (M+H)⁺-   7-1014; A-33; C-09; MS m/z 428 (M+H)⁺-   7-1015; A-33; C-10; MS m/z 434 (M+H)⁺-   7-1016; A-33; C-11; MS m/z 442 (M+H)⁺-   7-1017; A-33; C-12; MS m/z 448 (M+H)⁺-   7-1018; A-33; C-13; MS m/z 458 (M+H)⁺-   7-1019; A-33; C-14; MS m/z 464 (M+H)⁺-   7-1020; A-33; C-15; MS m/z 482 (M+H)⁺-   7-1021; A-33; C-16; MS m/z 474 (M+H)⁺-   7-1022; A-33; C-17; MS m/z 482 (M+H)⁺-   7-1023; A-33; C-18; MS m/z 394 (M+H)⁺-   7-1024; A-33; C-19; MS m/z 446 (M+H)⁺-   7-1025; A-33; C-20; MS m/z 487 (M+H)⁺-   7-1026; A-33; C-21; MS m/z 409 (M+H)⁺-   7-1027; A-33; C-22; MS m/z 435 (M+H)⁺-   7-1028; A-33; C-23; MS m/z 449 (M+H)⁺-   7-1029; A-33; C-24; MS m/z 470 (M+H)⁺-   7-1030; A-33; C-25; MS m/z 395 (M+H)⁺-   7-1031; A-33; C-26; MS m/z 407 (M+H)⁺-   7-1032; A-33; C-27; MS m/z 415 (M+H)⁺-   7-1033; A-33; C-28; MS m/z 518 (M+H)⁺-   7-1034; A-33; C-29; MS m/z 421 (M+H)⁺-   7-1035; A-33; C-30; MS m/z 437 (M+H)⁺-   7-1036; A-33; C-31; MS m/z 437 (M+H)⁺-   7-1037; A-33; C-32; MS m/z 463 (M+H)⁺-   7-1038; A-33; C-33; MS m/z 475 (M+H)⁺-   7-1039; A-33; C-34; MS m/z 483 (M+H)⁺-   7-1040; A-33; C-35; MS m/z 492 (M+H)⁺-   7-1041; A-33; C-36; MS m/z 487 (M+H)⁺-   7-1042; A-34; C-01; MS m/z 379 (M+H)⁺-   7-1043; A-34; C-02; MS m/z 391 (M+H)⁺-   7-1044; A-34; C-03; MS m/z 403 (M+H)⁺-   7-1045; A-34; C-04; MS m/z 407 (M+H)⁺-   7-1046; A-34; C-05; MS m/z 409 (M+H)⁺-   7-1047; A-34; C-06; MS m/z 417 (M+H)⁺-   7-1048; A-34; C-07; MS m/z 419 (M+H)⁺-   7-1049; A-34; C-08; MS m/z 435 (M+H)⁺-   7-1050; A-34; C-09; MS m/z 441 (M+H)⁺-   7-1051; A-34; C-10; MS m/z 447 (M+H)⁺-   7-1052; A-34; C-11; MS m/z 455 (M+H)⁺-   7-1053; A-34; C-12; MS m/z 461 (M+H)⁺-   7-1054; A-34; C-13; MS m/z 471 (M+H)⁺-   7-1055; A-34; C-14; MS m/z 477 (M+H)⁺-   7-1056; A-34; C-15; MS m/z 495 (M+H)⁺-   7-1057; A-34; C-16; MS m/z 487 (M+H)⁺-   7-1058; A-34; C-17; MS m/z 495 (M+H)⁺-   7-1059; A-34; C-18; MS m/z 407 (M+H)⁺-   7-1060; A-34; C-19; MS m/z 459 (M+H)⁺-   7-1061; A-34; C-20; MS m/z 500 (M+H)⁺-   7-1062; A-34; C-21; MS m/z 422 (M+H)⁺-   7-1063; A-34; C-22; MS m/z 448 (M+H)⁺-   7-1064; A-34; C-23; MS m/z 462 (M+H)⁺-   7-1065; A-34; C-24; MS m/z 483 (M+H)⁺-   7-1066; A-34; C-25; MS m/z 408 (M+H)⁺-   7-1067; A-34; C-26; MS m/z 420 (M+H)⁺-   7-1068; A-34; C-27; MS m/z 428 (M+H)⁺-   7-1069; A-34; C-28; MS m/z 531 (M+H)⁺-   7-1070; A-34; C-29; MS m/z 434 (M+H)⁺-   7-1071; A-34; C-30; MS m/z 450 (M+H)⁺-   7-1072; A-34; C-31; MS m/z 450 (M+H)⁺-   7-1073; A-34; C-32; MS m/z 476 (M+H)⁺-   7-1074; A-34; C-33; MS m/z 488 (M+H)⁺-   7-1075; A-34; C-34; MS m/z 496 (M+H)⁺-   7-1076; A-34; C-35; MS m/z 505 (M+H)⁺-   7-1077; A-34; C-36; MS m/z 500 (M+H)⁺-   7-1078; A-35; C-01; MS m/z 394 (M+H)⁺-   7-1079; A-35; C-02; MS m/z 406 (M+H)⁺-   7-1080; A-35; C-03; MS m/z 418 (M+H)⁺-   7-1081; A-35; C-04; MS m/z 422 (M+H)⁺-   7-1082; A-35; C-05; MS m/z 424 (M+H)⁺-   7-1083; A-35; C-06; MS m/z 432 (M+H)⁺-   7-1084; A-35; C-07; MS m/z 434 (M+H)⁺-   7-1085; A-35; C-08; MS m/z 450 (M+H)⁺-   7-1086; A-35; C-09; MS m/z 456 (M+H)⁺-   7-1087; A-35; C-10; MS m/z 462 (M+H)⁺-   7-1088; A-35; C-11; MS m/z 470 (M+H)⁺-   7-1089; A-35; C-12; MS m/z 476 (M+H)⁺-   7-1090; A-35; C-13; MS m/z 486 (M+H)⁺-   7-1091; A-35; C-14; MS m/z 492 (M+H)⁺-   7-1092; A-35; C-15; MS m/z 510 (M+H)⁺-   7-1093; A-35; C-16; MS m/z 502 (M+H)⁺-   7-1094; A-35; C-17; MS m/z 510 (M+H)⁺-   7-1095; A-35; C-18; MS m/z 422 (M+H)⁺-   7-1096; A-35; C-19; MS m/z 474 (M+H)⁺-   7-1097; A-35; C-20; MS m/z 515 (M+H)⁺-   7-1098; A-35; C-21; MS m/z 437 (M+H)⁺-   7-1099; A-35; C-22; MS m/z 463 (M+H)⁺-   7-1100; A-35; C-23; MS m/z 477 (M+H)⁺-   7-1101; A-35; C-24; MS m/z 498 (M+H)⁺-   7-1102; A-35; C-25; MS m/z 423 (M+H)⁺-   7-1103; A-35; C-26; MS m/z 435 (M+H)⁺-   7-1104; A-35; C-27; MS m/z 443 (M+H)⁺-   7-1105; A-35; C-28; MS m/z 546 (M+H)⁺-   7-1106; A-35; C-29; MS m/z 449 (M+H)⁺-   7-1107; A-35; C-30; MS m/z 465 (M+H)⁺-   7-1108; A-35; C-31; MS m/z 465 (M+H)⁺-   7-1109; A-35; C-32; MS m/z 491 (M+H)⁺-   7-1110; A-35; C-33; MS m/z 503 (M+H)⁺-   7-1111; A-35; C-34; MS m/z 511 (M+H)⁺-   7-1112; A-35; C-35; MS m/z 520 (M+H)⁺-   7-1113; A-35; C-36; MS m/z 515 (M+H)⁺-   7-1114; A-36; C-01; MS m/z 408 (M+H)⁺-   7-1115; A-36; C-02; MS m/z 420 (M+H)⁺-   7-1116; A-36; C-03; MS m/z 432 (M+H)⁺-   7-1117; A-36; C-04; MS m/z 436 (M+H)⁺-   7-1118; A-36; C-05; MS m/z 438 (M+H)⁺-   7-1119; A-36; C-06; MS m/z 446 (M+H)⁺-   7-1120; A-36; C-07; MS m/z 448 (M+H)⁺-   7-1121; A-36; C-08; MS m/z 464 (M+H)⁺-   7-1122; A-36; C-09; MS m/z 470 (M+H)⁺-   7-1123; A-36; C-10; MS m/z 476 (M+H)⁺-   7-1124; A-36; C-11; MS m/z 484 (M+H)⁺-   7-1125; A-36; C-12; MS m/z 490 (M+H)⁺-   7-1126; A-36; C-13; MS m/z 500 (M+H)⁺-   7-1127; A-36; C-14; MS m/z 506 (M+H)⁺-   7-1128; A-36; C-15; MS m/z 524 (M+H)⁺-   7-1129; A-36; C-16; MS m/z 516 (M+H)⁺-   7-1130; A-36; C-17; MS m/z 524 (M+H)⁺-   7-1131; A-36; C-18; MS m/z 436 (M+H)⁺-   7-1132; A-36; C-19; MS m/z 488 (M+H)⁺-   7-1133; A-36; C-20; MS m/z 529 (M+H)⁺-   7-1134; A-36; C-21; MS m/z 451 (M+H)⁺-   7-1135; A-36; C-22; MS m/z 477 (M+H)⁺-   7-1136; A-36; C-23; MS m/z 491 (M+H)⁺-   7-1137; A-36; C-24; MS m/z 512 (M+H)⁺-   7-1138; A-36; C-25; MS m/z 437 (M+H)⁺-   7-1139; A-36; C-26; MS m/z 449 (M+H)⁺-   7-1140; A-36; C-27; MS m/z 457 (M+H)⁺-   7-1141; A-36; C-28; MS m/z 560 (M+H)⁺-   7-1142; A-36; C-29; MS m/z 463 (M+H)⁺-   7-1143; A-36; C-30; MS m/z 479 (M+H)⁺-   7-1144; A-36; C-31; MS m/z 479 (M+H)⁺-   7-1145; A-36; C-32; MS m/z 505 (M+H)⁺-   7-1146; A-36; C-33; MS m/z 517 (M+H)⁺-   7-1147; A-36; C-34; MS m/z 525 (M+H)⁺-   7-1148; A-36; C-35; MS m/z 534 (M+H)⁺-   7-1149; A-36; C-36; MS m/z 529 (M+H)⁺-   7-1150; A-37; C-01; MS m/z 458 (M+H)⁺-   7-1151; A-37; C-02; MS m/z 470 (M+H)⁺-   7-1152; A-37; C-03; MS m/z 482 (M+H)⁺-   7-1153; A-37; C-04; MS m/z 486 (M+H)⁺-   7-1154; A-37; C-05; MS m/z 488 (M+H)⁺-   7-1155; A-37; C-06; MS m/z 496 (M+H)⁺-   7-1156; A-37; C-07; MS m/z 498 (M+H)⁺-   7-1157; A-37; C-08; MS m/z 514 (M+H)⁺-   7-1158; A-37; C-09; MS m/z 520 (M+H)⁺-   7-1159; A-37; C-10; MS m/z 526 (M+H)⁺-   7-1160; A-37; C-11; MS m/z 534 (M+H)⁺-   7-1161; A-37; C-12; MS m/z 540 (M+H)⁺-   7-1162; A-37; C-13; MS m/z 550 (M+H)⁺-   7-1163; A-37; C-14; MS m/z 556 (M+H)⁺-   7-1164; A-37; C-15; MS m/z 574 (M+H)⁺-   7-1165; A-37; C-16; MS m/z 566 (M+H)⁺-   7-1166; A-37; C-17; MS m/z 574 (M+H)⁺-   7-1167; A-37; C-18; MS m/z 486 (M+H)⁺-   7-1168; A-37; C-19; MS m/z 538 (M+H)⁺-   7-1169; A-37; C-20; MS m/z 579 (M+H)⁺-   7-1170; A-37; C-21; MS m/z 501 (M+H)⁺-   7-1171; A-37; C-22; MS m/z 527 (M+H)⁺-   7-1172; A-37; C-23; MS m/z 541 (M+H)⁺-   7-1173; A-37; C-24; MS m/z 562 (M+H)⁺-   7-1174; A-37; C-25; MS m/z 487 (M+H)⁺-   7-1175; A-37; C-26; MS m/z 499 (M+H)⁺-   7-1176; A-37; C-27; MS m/z 507 (M+H)⁺-   7-1177; A-37; C-28; MS m/z 610 (M+H)⁺-   7-1178; A-37; C-29; MS m/z 513 (M+H)⁺-   7-1179; A-37; C-30; MS m/z 529 (M+H)⁺-   7-1180; A-37; C-31; MS m/z 529 (M+H)⁺-   7-1181; A-37; C-32; MS m/z 555 (M+H)⁺-   7-1182; A-37; C-33; MS m/z 567 (M+H)⁺-   7-1183; A-37; C-34; MS m/z 575 (M+H)⁺-   7-1184; A-37; C-35; MS m/z 584 (M+H)⁺-   7-1185; A-37; C-36; MS m/z 579 (M+H)⁺-   7-1186; A-40; C-01; MS m/z 423 (M+H)⁺-   7-1187; A-40; C-02; MS m/z 435 (M+H)⁺-   7-1188; A-40; C-03; MS m/z 447 (M+H)⁺-   7-1189; A-40; C-04; MS m/z 451 (M+H)⁺-   7-1190; A-40; C-05; MS m/z 453 (M+H)⁺-   7-1191; A-40; C-06; MS m/z 461 (M+H)⁺-   7-1192; A-40; C-07; MS m/z 463 (M+H)⁺-   7-1193; A-40; C-08; MS m/z 479 (M+H)⁺-   7-1194; A-40; C-09; MS m/z 485 (M+H)⁺-   7-1195; A-40; C-10; MS m/z 491 (M+H)⁺-   7-1196; A-40; C-11; MS m/z 499 (M+H)⁺-   7-1197; A-40; C-12; MS m/z 505 (M+H)⁺-   7-1198; A-40; C-13; MS m/z 515 (M+H)⁺-   7-1199; A-40; C-14; MS m/z 521 (M+H)⁺-   7-1200; A-40; C-15; MS m/z 539 (M+H)⁺-   7-1201; A-40; C-16; MS m/z 531 (M+H)⁺-   7-1202; A-40; C-17; MS m/z 539 (M+H)⁺-   7-1203; A-40; C-18; MS m/z 451 (M+H)⁺-   7-1204; A-40; C-19; MS m/z 503 (M+H)⁺-   7-1205; A-40; C-20; MS m/z 544 (M+H)⁺-   7-1206; A-40; C-21; MS m/z 466 (M+H)⁺-   7-1207; A-40; C-22; MS m/z 492 (M+H)⁺-   7-1208; A-40; C-23; MS m/z 506 (M+H)⁺-   7-1209; A-40; C-24; MS m/z 527 (M+H)⁺-   7-1210; A-40; C-25; MS m/z 452 (M+H)⁺-   7-1211; A-40; C-26; MS m/z 464 (M+H)⁺-   7-1212; A-40; C-27; MS m/z 472 (M+H)⁺-   7-1213; A-40; C-28; MS m/z 575 (M+H)⁺-   7-1214; A-40; C-29; MS m/z 478 (M+H)⁺-   7-1215; A-40; C-30; MS m/z 494 (M+H)⁺-   7-1216; A-40; C-31; MS m/z 494 (M+H)⁺-   7-1217; A-40; C-32; MS m/z 520 (M+H)⁺-   7-1218; A-40; C-33; MS m/z 532 (M+H)⁺-   7-1219; A-40; C-34; MS m/z 540 (M+H)⁺-   7-1220; A-40; C-35; MS m/z 549 (M+H)⁺-   7-1221; A-40; C-36; MS m/z 544 (M+H)⁺-   7-1222; A-41; C-32; MS m/z 479 (M+H)⁺-   7-1223; A-41; C-37; MS m/z 467 (M+H)⁺-   7-1224; A-41; C-38; MS m/z 480 (M+H)⁺-   7-1225; A-41; C-39; MS m/z 453 (M+H)⁺-   7-1226; A-41; C-40; MS m/z 451 (M+H)⁺-   7-1227; A-41; C-41; MS m/z 467 (M+H)⁺-   7-1228; A-41; C-42; MS m/z 451 (M+H)⁺-   7-1229; A-41; C-43; MS m/z 451 (M+H)⁺-   7-1230; A-41; C-44; MS m/z 439 (M+H)⁺-   7-1231; A-41; C-45; MS m/z 451 (M+H)⁺-   7-1232; A-41; C-46; MS m/z 448 (M+H)⁺-   7-1233; A-41; C-47; MS m/z 440 (M+H)⁺-   7-1234; A-42; C-01; MS m/z 382 (M+H)⁺-   7-1235; A-42; C-02; MS m/z 394 (M+H)⁺-   7-1236; A-42; C-03; MS m/z 406 (M+H)⁺-   7-1237; A-42; C-04; MS m/z 410 (M+H)⁺-   7-1238; A-42; C-05; MS m/z 412 (M+H)⁺-   7-1239; A-42; C-06; MS m/z 420 (M+H)⁺-   7-1240; A-42; C-07; MS m/z 422 (M+H)⁺-   7-1241; A-42; C-08; MS m/z 438 (M+H)⁺-   7-1242; A-42; C-09; MS m/z 444 (M+H)⁺-   7-1243; A-42; C-10; MS m/z 450 (M+H)⁺-   7-1244; A-42; C-11; MS m/z 458 (M+H)⁺-   7-1245; A-42; C-12; MS m/z 464 (M+H)⁺-   7-1246; A-42; C-13; MS m/z 474 (M+H)⁺-   7-1247; A-42; C-14; MS m/z 480 (M+H)⁺-   7-1248; A-42; C-15; MS m/z 498 (M+H)⁺-   7-1249; A-42; C-16; MS m/z 490 (M+H)⁺-   7-1250; A-42; C-17; MS m/z 498 (M+H)⁺-   7-1251; A-42; C-18; MS m/z 410 (M+H)⁺-   7-1252; A-42; C-19; MS m/z 462 (M+H)⁺-   7-1253; A-42; C-20; MS m/z 503 (M+H)⁺-   7-1254; A-42; C-21; MS m/z 425 (M+H)⁺-   7-1255; A-42; C-22; MS m/z 451 (M+H)⁺-   7-1256; A-42; C-23; MS m/z 465 (M+H)⁺-   7-1257; A-42; C-24; MS m/z 486 (M+H)⁺-   7-1258; A-42; C-25; MS m/z 411 (M+H)⁺-   7-1259; A-42; C-26; MS m/z 423 (M+H)⁺-   7-1260; A-42; C-27; MS m/z 431 (M+H)⁺-   7-1261; A-42; C-28; MS m/z 534 (M+H)⁺-   7-1262; A-42; C-29; MS m/z 437 (M+H)⁺-   7-1263; A-42; C-30; MS m/z 453 (M+H)⁺-   7-1264; A-42; C-31; MS m/z 453 (M+H)⁺-   7-1265; A-42; C-32; MS m/z 479 (M+H)⁺-   7-1266; A-42; C-33; MS m/z 491 (M+H)⁺-   7-1267; A-42; C-34; MS m/z 499 (M+H)⁺-   7-1268; A-42; C-35; MS m/z 508 (M+H)⁺-   7-1269; A-42; C-36; MS m/z 503 (M+H)⁺-   7-1270; A-42; C-37; MS m/z 467 (M+H)⁺-   7-1271; A-42; C-38; MS m/z 480 (M+H)⁺-   7-1272; A-42; C-39; MS m/z 453 (M+H)⁺-   7-1273; A-42; C-40; MS m/z 451 (M+H)⁺-   7-1274; A-42; C-41; MS m/z 467 (M+H)⁺-   7-1275; A-42; C-42; MS m/z 451 (M+H)⁺-   7-1276; A-42; C-43; MS m/z 451 (M+H)⁺-   7-1277; A-42; C-44; MS m/z 439 (M+H)⁺-   7-1278; A-42; C-45; MS m/z 451 (M+H)⁺-   7-1279; A-42; C-46; MS m/z 448 (M+H)⁺-   7-1280; A-42; C-47; MS m/z 440 (M+H)⁺-   7-1281; A-43; C-32; MS m/z 465 (M+H)⁺-   7-1282; A-43; C-37; MS m/z 453 (M+H)⁺-   7-1283; A-43; C-38; MS m/z 466 (M+H)⁺-   7-1284; A-43; C-39; MS m/z 439 (M+H)⁺-   7-1285; A-43; C-40; MS m/z 437 (M+H)⁺-   7-1286; A-43; C-41; MS m/z 453 (M+H)⁺-   7-1287; A-43; C-42; MS m/z 437 (M+H)⁺-   7-1288; A-43; C-43; MS m/z 437 (M+H)⁺-   7-1289; A-43; C-44; MS m/z 425 (M+H)⁺-   7-1290; A-43; C-45; MS m/z 437 (M+H)⁺-   7-1291; A-43; C-46; MS m/z 434 (M+H)⁺-   7-1292; A-43; C-47; MS m/z 426 (M+H)⁺-   7-1293; A-44; C-32; MS m/z 493 (M+H)⁺-   7-1294; A-44; C-37; MS m/z 481 (M+H)⁺-   7-1295; A-44; C-38; MS m/z 494 (M+H)⁺-   7-1296; A-44; C-39; MS m/z 467 (M+H)⁺-   7-1297; A-44; C-40; MS m/z 465 (M+H)⁺-   7-1298; A-44; C-41; MS m/z 481 (M+H)⁺-   7-1299; A-44; C-42; MS m/z 465 (M+H)⁺-   7-1300; A-44; C-43; MS m/z 465 (M+H)⁺-   7-1301; A-44; C-44; MS m/z 453 (M+H)⁺-   7-1302; A-44; C-45; MS m/z 465 (M+H)⁺-   7-1303; A-44; C-46; MS m/z 462 (M+H)⁺-   7-1304; A-44; C-47; MS m/z 454 (M+H)⁺-   7-1305; A-45; C-32-   7-1306; A-45; C-37; MS m/z 467 (M+H)⁺-   7-1307; A-45; C-38-   7-1308; A-45; C-39; MS m/z 453 (M+H)⁺-   7-1309; A-45; C-40; MS m/z 451 (M+H)⁺-   7-1310; A-45; C-41; MS m/z 467 (M+H)⁺-   7-1311; A-45; C-42; MS m/z 451 (M+H)⁺-   7-1312; A-45; C-43-   7-1313; A-45; C-44; MS m/z 439 (M+H)⁺-   7-1314; A-45; C-45-   7-1315; A-45; C-46; MS m/z 448 (M+H)⁺-   7-1316; A-45; C-47; MS m/z 440 (M+H)⁺-   7-1317; A-46; C-32; MS m/z 489 (M+H)⁺-   7-1318; A-46; C-37; MS m/z 477 (M+H)⁺-   7-1319; A-46; C-38-   7-1320; A-46; C-39; MS m/z 463 (M+H)⁺-   7-1321; A-46; C-40; MS m/z 461 (M+H)⁺-   7-1322; A-46; C-41; MS m/z 477 (M+H)⁺-   7-1323; A-46; C-42; MS m/z 461 (M+H)⁺-   7-1324; A-46; C-43; MS m/z 461 (M+H)⁺-   7-1325; A-46; C-44; MS m/z 449 (M+H)⁺-   7-1326; A-46; C-45-   7-1327; A-46; C-46; MS m/z 458 (M+H)⁺-   7-1328; A-46; C-47; MS m/z 450 (M+H)⁺-   7-1329; A-47; C-32; MS m/z 479 (M+H)⁺-   7-1330; A-47; C-37; MS m/z 467 (M+H)⁺-   7-1331; A-47; C-38; MS m/z 480 (M+H)⁺-   7-1332; A-47; C-39; MS m/z 453 (M+H)⁺-   7-1333; A-47; C-40; MS m/z 451 (M+H)⁺-   7-1334; A-47; C-41; MS m/z 467 (M+H)⁺-   7-1335; A-47; C-42; MS m/z 451 (M+H)⁺-   7-1336; A-47; C-43; MS m/z 451 (M+H)⁺-   7-1337; A-47; C-44; MS m/z 439 (M+H)⁺-   7-1338; A-47; C-45; MS m/z 451 (M+H)⁺-   7-1339; A-47; C-46; MS m/z 448 (M+H)⁺-   7-1340; A-47; C-47; MS m/z 440 (M+H)⁺-   7-1341; A-48; C-32; MS m/z 533 (M+H)⁺-   7-1342; A-48; C-37; MS m/z 521 (M+H)⁺-   7-1343; A-48; C-38; MS m/z 534 (M+H)⁺-   7-1344; A-48; C-39; MS m/z 507 (M+H)⁺-   7-1345; A-48; C-40; MS m/z 505 (M+H)⁺-   7-1346; A-48; C-41; MS m/z 521 (M+H)⁺-   7-1347; A-48; C-42; MS m/z 505 (M+H)⁺-   7-1348; A-48; C-43; MS m/z 505 (M+H)⁺-   7-1349; A-48; C-44; MS m/z 493 (M+H)⁺-   7-1350; A-48; C-45; MS m/z 505 (M+H)⁺-   7-1351; A-48; C-46; MS m/z 502 (M+H)⁺-   7-1352; A-48; C-47; MS m/z 494 (M+H)⁺-   7-1353; A-49; C-32; MS m/z 531 (M+H)⁺-   7-1354; A-49; C-37; MS m/z 519 (M+H)⁺-   7-1355; A-49; C-38; MS m/z 532 (M+H)⁺-   7-1356; A-49; C-39; MS m/z 505 (M+H)⁺-   7-1357; A-49; C-40; MS m/z 503 (M+H)⁺-   7-1358; A-49; C-41; MS m/z 519 (M+H)⁺-   7-1359; A-49; C-42; MS m/z 503 (M+H)⁺-   7-1360; A-49; C-43; MS m/z 503 (M+H)⁺-   7-1361; A-49; C-44; MS m/z 491 (M+H)⁺-   7-1362; A-49; C-45; MS m/z 503 (M+H)⁺-   7-1363; A-49; C-46; MS m/z 500 (M+H)⁺-   7-1364; A-49; C-47; MS m/z 492 (M+H)⁺-   7-1365; A-50; C-32; MS m/z 529 (M+H)⁺-   7-1366; A-50; C-37; MS m/z 517 (M+H)⁺-   7-1367; A-50; C-38; MS m/z 530 (M+H)⁺-   7-1368; A-50; C-39; MS m/z 503 (M+H)⁺-   7-1369; A-50; C-40; MS m/z 501 (M+H)⁺-   7-1370; A-50; C-41; MS m/z 517 (M+H)⁺-   7-1371; A-50; C-42; MS m/z 501 (M+H)⁺-   7-1372; A-50; C-43; MS m/z 501 (M+H)⁺-   7-1373; A-50; C-44; MS m/z 489 (M+H)⁺-   7-1374; A-50; C-45; MS m/z 501 (M+H)⁺-   7-1375; A-50; C-46; MS m/z 498 (M+H)⁺-   7-1376; A-50; C-47; MS m/z 490 (M+H)⁺-   7-1377; A-51; C-32; MS m/z 547 (M+H)⁺-   7-1378; A-51; C-37; MS m/z 535 (M+H)⁺-   7-1379; A-51; C-38-   7-1380; A-51; C-39; MS m/z 521 (M+H)⁺-   7-1381; A-51; C-40; MS m/z 519 (M+H)⁺-   7-1382; A-51; C-41; MS m/z 535 (M+H)⁺-   7-1383; A-51; C-42; MS m/z 519 (M+H)⁺-   7-1384; A-51; C-43; MS m/z 519 (M+H)⁺-   7-1385; A-51; C-44; MS m/z 507 (M+H)⁺-   7-1386; A-51; C-45; MS m/z 519 (M+H)⁺-   7-1387; A-51; C-46; MS m/z 516 (M+H)⁺-   7-1388; A-51; C-47; MS m/z 508 (M+H)⁺-   7-1389; A-52; C-32; MS m/z 535 (M+H)⁺-   7-1390; A-52; C-37; MS m/z 523 (M+H)⁺-   7-1391; A-52; C-38-   7-1392; A-52; C-39; MS m/z 509 (M+H)⁺-   7-1393; A-52; C-40; MS m/z 507 (M+H)⁺-   7-1394; A-52; C-41; MS m/z 523 (M+H)⁺-   7-1395; A-52; C-42; MS m/z 507 (M+H)⁺-   7-1396; A-52; C-43; MS m/z 507 (M+H)⁺-   7-1397; A-52; C-44; MS m/z 495 (M+H)⁺-   7-1398; A-52; C-45; MS m/z 507 (M+H)⁺-   7-1399; A-52; C-46; MS m/z 504 (M+H)⁺-   7-1400; A-52; C-47; MS m/z 496 (M+H)⁺-   7-1401; A-53; C-32; MS m/z 517 (M+H)⁺-   7-1402; A-53; C-37; MS m/z 505 (M+H)⁺-   7-1403; A-53; C-38-   7-1404; A-53; C-39; MS m/z 491 (M+H)⁺-   7-1405; A-53; C-40; MS m/z 489 (M+H)⁺-   7-1406; A-53; C-41; MS m/z 505 (M+H)⁺-   7-1407; A-53; C-42; MS m/z 489 (M+H)⁺-   7-1408; A-53; C-43; MS m/z 489 (M+H)⁺-   7-1409; A-53; C-44; MS m/z 477 (M+H)⁺-   7-1410; A-53; C-45; MS m/z 489 (M+H)⁺-   7-1411; A-53; C-46; MS m/z 486 (M+H)⁺-   7-1412; A-53; C-47; MS m/z 478 (M+H)⁺-   7-1413; A-59; C-01; MS m/z 434 (M+H)⁺-   7-1414; A-59; C-02; MS m/z 446 (M+H)⁺-   7-1415; A-59; C-03; MS m/z 458 (M+H)⁺-   7-1416; A-59; C-04; MS m/z 462 (M+H)⁺-   7-1417; A-59; C-05; MS m/z 464 (M+H)⁺-   7-1418; A-59; C-06; MS m/z 472 (M+H)⁺-   7-1419; A-59; C-07; MS m/z 474 (M+H)⁺-   7-1420; A-59; C-08; MS m/z 490 (M+H)⁺-   7-1421; A-59; C-09; MS m/z 496 (M+H)⁺-   7-1422; A-59; C-10; MS m/z 502 (M+H)⁺-   7-1423; A-59; C-11; MS m/z 510 (M+H)⁺-   7-1424; A-59; C-12; MS m/z 516 (M+H)⁺-   7-1425; A-59; C-13; MS m/z 526 (M+H)⁺-   7-1426; A-59; C-14; MS m/z 532 (M+H)⁺-   7-1427; A-59; C-15; MS m/z 550 (M+H)⁺-   7-1428; A-59; C-16; MS m/z 542 (M+H)⁺-   7-1429; A-59; C-17; MS m/z 550 (M+H)⁺-   7-1430; A-59; C-18; MS m/z 462 (M+H)⁺-   7-1431; A-59; C-19; MS m/z 514 (M+H)⁺-   7-1432; A-59; C-20; MS m/z 555 (M+H)⁺-   7-1433; A-59; C-21; MS m/z 477 (M+H)⁺-   7-1434; A-59; C-22; MS m/z 503 (M+H)⁺-   7-1435; A-59; C-23; MS m/z 517 (M+H)⁺-   7-1436; A-59; C-24; MS m/z 538 (M+H)⁺-   7-1437; A-59; C-25; MS m/z 463 (M+H)⁺-   7-1438; A-59; C-26; MS m/z 475 (M+H)⁺-   7-1439; A-59; C-27; MS m/z 483 (M+H)⁺-   7-1440; A-59; C-28; MS m/z 586 (M+H)⁺-   7-1441; A-59; C-29; MS m/z 489 (M+H)⁺-   7-1442; A-59; C-30; MS m/z 505 (M+H)⁺-   7-1443; A-59; C-31; MS m/z 505 (M+H)⁺-   7-1444; A-59; C-32; MS m/z 531 (M+H)⁺-   7-1445; A-59; C-33; MS m/z 543 (M+H)⁺-   7-1446; A-59; C-34; MS m/z 551 (M+H)⁺-   7-1447; A-59; C-35; MS m/z 560 (M+H)⁺-   7-1448; A-59; C-36; MS m/z 555 (M+H)⁺-   7-1449; A-67; C-01; MS m/z 446 (M+H)⁺-   7-1450; A-67; C-02; MS m/z 458 (M+H)⁺-   7-1451; A-67; C-03; MS m/z 470 (M+H)⁺-   7-1452; A-67; C-04; MS m/z 474 (M+H)⁺-   7-1453; A-67; C-05; MS m/z 476 (M+H)⁺-   7-1454; A-67; C-06; MS m/z 484 (M+H)⁺-   7-1455; A-67; C-07; MS m/z 486 (M+H)⁺-   7-1456; A-67; C-08; MS m/z 502 (M+H)⁺-   7-1457; A-67; C-09; MS m/z 508 (M+H)⁺-   7-1458; A-67; C-10; MS m/z 514 (M+H)⁺-   7-1459; A-67; C-11; MS m/z 522 (M+H)⁺-   7-1460; A-67; C-12; MS m/z 528 (M+H)⁺-   7-1461; A-67; C-13; MS m/z 538 (M+H)⁺-   7-1462; A-67; C-14; MS m/z 544 (M+H)⁺-   7-1463; A-67; C-15; MS m/z 562 (M+H)⁺-   7-1464; A-67; C-16; MS m/z 554 (M+H)⁺-   7-1465; A-67; C-17; MS m/z 562 (M+H)⁺-   7-1466; A-67; C-18; MS m/z 474 (M+H)⁺-   7-1467; A-67; C-19; MS m/z 526 (M+H)⁺-   7-1468; A-67; C-20; MS m/z 567 (M+H)⁺-   7-1469; A-67; C-21; MS m/z 489 (M+H)⁺-   7-1470; A-67; C-22; MS m/z 515 (M+H)⁺-   7-1471; A-67; C-23; MS m/z 529 (M+H)⁺-   7-1472; A-67; C-24; MS m/z 550 (M+H)⁺-   7-1473; A-67; C-25; MS m/z 475 (M+H)⁺-   7-1474; A-67; C-26; MS m/z 487 (M+H)⁺-   7-1475; A-67; C-27; MS m/z 495 (M+H)⁺-   7-1476; A-67; C-28; MS m/z 598 (M+H)⁺-   7-1477; A-67; C-29; MS m/z 501 (M+H)⁺-   7-1478; A-67; C-30; MS m/z 517 (M+H)⁺-   7-1479; A-67; C-31; MS m/z 517 (M+H)⁺-   7-1480; A-67; C-32; MS m/z 543 (M+H)⁺-   7-1481; A-67; C-33; MS m/z 555 (M+H)⁺-   7-1482; A-67; C-34; MS m/z 563 (M+H)⁺-   7-1483; A-67; C-35; MS m/z 572 (M+H)⁺-   7-1484; A-67; C-36; MS m/z 567 (M+H)⁺-   7-1485; A-68; C-01; MS m/z 416 (M+H)⁺-   7-1486; A-68; C-02; MS m/z 428 (M+H)⁺-   7-1487; A-68; C-03; MS m/z 440 (M+H)⁺-   7-1488; A-68; C-04; MS m/z 444 (M+H)⁺-   7-1489; A-68; C-05; MS m/z 446 (M+H)⁺-   7-1490; A-68; C-06; MS m/z 454 (M+H)⁺-   7-1491; A-68; C-07; MS m/z 456 (M+H)⁺-   7-1492; A-68; C-08; MS m/z 472 (M+H)⁺-   7-1493; A-68; C-09; MS m/z 478 (M+H)⁺-   7-1494; A-68; C-10; MS m/z 484 (M+H)⁺-   7-1495; A-68; C-11; MS m/z 492 (M+H)⁺-   7-1496; A-68; C-12; MS m/z 498 (M+H)⁺-   7-1497; A-68; C-13; MS m/z 508 (M+H)⁺-   7-1498; A-68; C-14; MS m/z 514 (M+H)⁺-   7-1499; A-68; C-15; MS m/z 532 (M+H)⁺-   7-1500; A-68; C-16; MS m/z 524 (M+H)⁺-   7-1501; A-68; C-17; MS m/z 532 (M+H)⁺-   7-1502; A-68; C-18; MS m/z 444 (M+H)⁺-   7-1503; A-68; C-19; MS m/z 496 (M+H)⁺-   7-1504; A-68; C-20; MS m/z 537 (M+H)⁺-   7-1505; A-68; C-21; MS m/z 459 (M+H)⁺-   7-1506; A-68; C-22; MS m/z 485 (M+H)⁺-   7-1507; A-68; C-23; MS m/z 499 (M+H)⁺-   7-1508; A-68; C-24; MS m/z 520 (M+H)⁺-   7-1509; A-68; C-25; MS m/z 445 (M+H)⁺-   7-1510; A-68; C-26; MS m/z 457 (M+H)⁺-   7-1511; A-68; C-27; MS m/z 465 (M+H)⁺-   7-1512; A-68; C-28; MS m/z 568 (M+H)⁺-   7-1513; A-68; C-29; MS m/z 471 (M+H)⁺-   7-1514; A-68; C-30; MS m/z 487 (M+H)⁺-   7-1515; A-68; C-31; MS m/z 487 (M+H)⁺-   7-1516; A-68; C-32; MS m/z 513 (M+H)⁺-   7-1517; A-68; C-33; MS m/z 525 (M+H)⁺-   7-1518; A-68; C-34; MS m/z 533 (M+H)⁺-   7-1519; A-68; C-35; MS m/z 542 (M+H)⁺-   7-1520; A-68; C-36; MS m/z 537 (M+H)⁺-   7-1521; A-69; C-01; MS m/z 446 (M+H)⁺-   7-1522; A-69; C-02; MS m/z 458 (M+H)⁺-   7-1523; A-69; C-03; MS m/z 470 (M+H)⁺-   7-1524; A-69; C-04; MS m/z 474 (M+H)⁺-   7-1525; A-69; C-05; MS m/z 476 (M+H)⁺-   7-1526; A-69; C-06; MS m/z 484 (M+H)⁺-   7-1527; A-69; C-07; MS m/z 486 (M+H)⁺-   7-1528; A-69; C-08; MS m/z 502 (M+H)⁺-   7-1529; A-69; C-09; MS m/z 508 (M+H)⁺-   7-1530; A-69; C-10; MS m/z 514 (M+H)⁺-   7-1531; A-69; C-11; MS m/z 522 (M+H)⁺-   7-1532; A-69; C-12; MS m/z 528 (M+H)⁺-   7-1533; A-69; C-13; MS m/z 538 (M+H)⁺-   7-1534; A-69; C-14; MS m/z 544 (M+H)⁺-   7-1535; A-69; C-15; MS m/z 562 (M+H)⁺-   7-1536; A-69; C-16; MS m/z 554 (M+H)⁺-   7-1537; A-69; C-17; MS m/z 562 (M+H)⁺-   7-1538; A-69; C-18; MS m/z 474 (M+H)⁺-   7-1539; A-69; C-19; MS m/z 526 (M+H)⁺-   7-1540; A-69; C-20; MS m/z 567 (M+H)⁺-   7-1541; A-69; C-21; MS m/z 489 (M+H)⁺-   7-1542; A-69; C-22; MS m/z 515 (M+H)⁺-   7-1543; A-69; C-23; MS m/z 529 (M+H)⁺-   7-1544; A-69; C-24; MS m/z 550 (M+H)⁺-   7-1545; A-69; C-25; MS m/z 475 (M+H)⁺-   7-1546; A-69; C-26; MS m/z 487 (M+H)⁺-   7-1547; A-69; C-27; MS m/z 495 (M+H)⁺-   7-1548; A-69; C-28; MS m/z 598 (M+H)⁺-   7-1549; A-69; C-29; MS m/z 501 (M+H)⁺-   7-1550; A-69; C-30; MS m/z 517 (M+H)⁺-   7-1551; A-69; C-31; MS m/z 517 (M+H)⁺-   7-1552; A-69; C-32; MS m/z 543 (M+H)⁺-   7-1553; A-69; C-33; MS m/z 555 (M+H)⁺-   7-1554; A-69; C-34; MS m/z 563 (M+H)⁺-   7-1555; A-69; C-35; MS m/z 572 (M+H)⁺-   7-1556; A-69; C-36; MS m/z 567 (M+H)⁺-   7-1557; A-70; C-01; MS m/z 378 (M+H)⁺-   7-1558; A-70; C-02; MS m/z 390 (M+H)⁺-   7-1559; A-70; C-03; MS m/z 402 (M+H)⁺-   7-1560; A-70; C-04; MS m/z 406 (M+H)⁺-   7-1561; A-70; C-05; MS m/z 408 (M+H)⁺-   7-1562; A-70; C-06; MS m/z 416 (M+H)⁺-   7-1563; A-70; C-07; MS m/z 418 (M+H)⁺-   7-1564; A-70; C-08; MS m/z 434 (M+H)⁺-   7-1565; A-70; C-09; MS m/z 440 (M+H)⁺-   7-1566; A-70; C-10; MS m/z 446 (M+H)⁺-   7-1567; A-70; C-11; MS m/z 454 (M+H)⁺-   7-1568; A-70; C-12; MS m/z 460 (M+H)⁺-   7-1569; A-70; C-13; MS m/z 470 (M+H)⁺-   7-1570; A-70; C-14; MS m/z 476 (M+H)⁺-   7-1571; A-70; C-15; MS m/z 494 (M+H)⁺-   7-1572; A-70; C-16; MS m/z 486 (M+H)⁺-   7-1573; A-70; C-17; MS m/z 494 (M+H)⁺-   7-1574; A-70; C-18; MS m/z 406 (M+H)⁺-   7-1575; A-70; C-19; MS m/z 458 (M+H)⁺-   7-1576; A-70; C-20; MS m/z 499 (M+H)⁺-   7-1577; A-70; C-21; MS m/z 421 (M+H)⁺-   7-1578; A-70; C-22; MS m/z 447 (M+H)⁺-   7-1579; A-70; C-23; MS m/z 461 (M+H)⁺-   7-1580; A-70; C-24; MS m/z 482 (M+H)⁺-   7-1581; A-70; C-25; MS m/z 407 (M+H)⁺-   7-1582; A-70; C-26; MS m/z 419 (M+H)⁺-   7-1583; A-70; C-27; MS m/z 427 (M+H)⁺-   7-1584; A-70; C-28; MS m/z 530 (M+H)⁺-   7-1585; A-70; C-29; MS m/z 433 (M+H)⁺-   7-1586; A-70; C-30; MS m/z 449 (M+H)⁺-   7-1587; A-70; C-31; MS m/z 449 (M+H)⁺-   7-1588; A-70; C-32; MS m/z 475 (M+H)⁺-   7-1589; A-70; C-33; MS m/z 487 (M+H)⁺-   7-1590; A-70; C-34; MS m/z 495 (M+H)⁺-   7-1591; A-70; C-35; MS m/z 504 (M+H)⁺-   7-1592; A-70; C-36; MS m/z 499 (M+H)⁺-   7-1593; A-71; C-01; MS m/z 452 (M+H)⁺-   7-1594; A-71; C-02; MS m/z 464 (M+H)⁺-   7-1595; A-71; C-03; MS m/z 476 (M+H)⁺-   7-1596; A-71; C-04; MS m/z 480 (M+H)⁺-   7-1597; A-71; C-05; MS m/z 482 (M+H)⁺-   7-1598; A-71; C-06; MS m/z 490 (M+H)⁺-   7-1599; A-71; C-07; MS m/z 492 (M+H)⁺-   7-1600; A-71; C-08; MS m/z 508 (M+H)⁺-   7-1601; A-71; C-09; MS m/z 514 (M+H)⁺-   7-1602; A-71; C-10; MS m/z 520 (M+H)⁺-   7-1603; A-71; C-11; MS m/z 528 (M+H)⁺-   7-1604; A-71; C-12; MS m/z 534 (M+H)⁺-   7-1605; A-71; C-13; MS m/z 544 (M+H)⁺-   7-1606; A-71; C-14; MS m/z 550 (M+H)⁺-   7-1607; A-71; C-15; MS m/z 568 (M+H)⁺-   7-1608; A-71; C-16; MS m/z 560 (M+H)⁺-   7-1609; A-71; C-17; MS m/z 568 (M+H)⁺-   7-1610; A-71; C-18; MS m/z 480 (M+H)⁺-   7-1611; A-71; C-19; MS m/z 532 (M+H)⁺-   7-1612; A-71; C-20; MS m/z 573 (M+H)⁺-   7-1613; A-71; C-21; MS m/z 495 (M+H)⁺-   7-1614; A-71; C-22; MS m/z 521 (M+H)⁺-   7-1615; A-71; C-23; MS m/z 535 (M+H)⁺-   7-1616; A-71; C-24; MS m/z 556 (M+H)⁺-   7-1617; A-71; C-25; MS m/z 481 (M+H)⁺-   7-1618; A-71; C-26; MS m/z 493 (M+H)⁺-   7-1619; A-71; C-27; MS m/z 501 (M+H)⁺-   7-1620; A-71; C-28; MS m/z 604 (M+H)⁺-   7-1621; A-71; C-29; MS m/z 507 (M+H)⁺-   7-1622; A-71; C-30; MS m/z 523 (M+H)⁺-   7-1623; A-71; C-31; MS m/z 523 (M+H)⁺-   7-1624; A-71; C-32; MS m/z 549 (M+H)⁺-   7-1625; A-71; C-33; MS m/z 561 (M+H)⁺-   7-1626; A-71; C-34; MS m/z 569 (M+H)⁺-   7-1627; A-71; C-35; MS m/z 578 (M+H)⁺-   7-1628; A-71; C-36; MS m/z 573 (M+H)⁺

(h) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR⁶R⁷ and spectrum data thereof.

-   8-1; A-25; C-13; MS m/z 495 (M+H)⁺-   8-2; A-25; C-14; MS m/z 501 (M+H)⁺-   8-3; A-25; C-15; MS m/z 519 (M+H)⁺-   8-4; A-25; C-16; MS m/z 511 (M+H)⁺-   8-5; A-25; C-17; MS m/z 519 (M+H)⁺-   8-6; A-25; C-18; MS m/z 431 (M+H)⁺-   8-7; A-25; C-19; MS m/z 483 (M+H)⁺-   8-8; A-25; C-20; MS m/z 524 (M+H)⁺-   8-9; A-25; C-21; MS m/z 446 (M+H)⁺-   8-10; A-25; C-22; MS m/z 472 (M+H)⁺-   8-11; A-25; C-23; MS m/z 486 (M+H)⁺-   8-12; A-25; C-24; MS m/z 507 (M+H)⁺-   8-13; A-27; C-13; MS m/z 535 (M+H)⁺-   8-14; A-27; C-14; MS m/z 541 (M+H)⁺-   8-15; A-27; C-15; MS m/z 559 (M+H)⁺-   8-16; A-27; C-16; MS m/z 551 (M+H)⁺-   8-17; A-27; C-17; MS m/z 559 (M+H)⁺-   8-18; A-27; C-18; MS m/z 471 (M+H)⁺-   8-19; A-27; C-19; MS m/z 523 (M+H)⁺-   8-20; A-27; C-20-   8-21; A-27; C-21; MS m/z 486 (M+H)⁺-   8-22; A-27; C-22-   8-23; A-27; C-23; MS m/z 526 (M+H)⁺-   8-24; A-27; C-24; MS m/z 547 (M+H)⁺-   8-25; A-28; C-13; MS m/z 565 (M+H)⁺-   8-26; A-28; C-14; MS m/z 571 (M+H)⁺-   8-27; A-28; C-15; MS m/z 589 (M+H)⁺-   8-28; A-28; C-16; MS m/z 581 (M+H)⁺-   8-29; A-28; C-17; MS m/z 589 (M+H)⁺-   8-30; A-28; C-18; MS m/z 501 (M+H)⁺-   8-31; A-28; C-19; MS m/z 553 (M+H)⁺-   8-32; A-28; C-20; MS m/z 594 (M+H)⁺-   8-33; A-28; C-21; MS m/z 516 (M+H)⁺-   8-34; A-28; C-22-   8-35; A-28; C-23; MS m/z 556 (M+H)⁺-   8-36; A-28; C-24; MS m/z 577 (M+H)⁺-   8-37; A-42; C-13; MS m/z 480 (M+H)⁺-   8-38; A-42; C-14; MS m/z 486 (M+H)⁺-   8-39; A-42; C-15; MS m/z 504 (M+H)⁺-   8-40; A-42; C-16; MS m/z 496 (M+H)⁺-   8-41; A-42; C-17; MS m/z 504 (M+H)⁺-   8-42; A-42; C-18; MS m/z 416 (M+H)⁺-   8-43; A-42; C-19; MS m/z 468 (M+H)⁺-   8-44; A-42; C-20; MS m/z 509 (M+H)⁺-   8-45; A-42; C-21; MS m/z 431 (M+H)⁺-   8-46; A-42; C-22-   8-47; A-42; C-23; MS m/z 471 (M+H)⁺-   8-48; A-42; C-24; MS m/z 492 (M+H)⁺-   8-49; A-59; C-13; MS m/z 532 (M+H)⁺-   8-50; A-59; C-14; MS m/z 538 (M+H)⁺-   8-51; A-59; C-15; MS m/z 556 (M+H)⁺-   8-52; A-59; C-16; MS m/z 548 (M+H)⁺-   8-53; A-59; C-17; MS m/z 556 (M+H)⁺-   8-54; A-59; C-18; MS m/z 468 (M+H)⁺-   8-55; A-59; C-19; MS m/z 520 (M+H)⁺-   8-56; A-59; C-20-   8-57; A-59; C-21; MS m/z 483 (M+H)⁺-   8-58; A-59; C-22-   8-59; A-59; C-23; MS m/z 523 (M+H)⁺-   8-60; A-59; C-24; MS m/z 544 (M+H)⁺-   8-61; A-67; C-13; MS m/z 544 (M+H)⁺-   8-62; A-67; C-14; MS m/z 550 (M+H)⁺-   8-63; A-67; C-15; MS m/z 568 (M+H)⁺-   8-64; A-67; C-16; MS m/z 560 (M+H)⁺-   8-65; A-67; C-17; MS m/z 568 (M+H)⁺-   8-66; A-67; C-18; MS m/z 480 (M+H)⁺-   8-67; A-67; C-19; MS m/z 532 (M+H)⁺-   8-68; A-67; C-20-   8-69; A-67; C-21; MS m/z 495 (M+H)⁺-   8-70; A-67; C-22-   8-71; A-67; C-23; MS m/z 535 (M+H)⁺-   8-72; A-67; C-24; MS m/z 556 (M+H)⁺-   8-73; A-68; C-13; MS m/z 514 (M+H)⁺-   8-74; A-68; C-14; MS m/z 520 (M+H)⁺-   8-75; A-68; C-15; MS m/z 538 (M+H)⁺-   8-76; A-68; C-16; MS m/z 530 (M+H)⁺-   8-77; A-68; C-17; MS m/z 538 (M+H)⁺-   8-78; A-68; C-18; MS m/z 450 (M+H)⁺-   8-79; A-68; C-19; MS m/z 502 (M+H)⁺-   8-80; A-68; C-20-   8-81; A-68; C-21; MS m/z 465 (M+H)⁺-   8-82; A-68; C-22-   8-83; A-68; C-23; MS m/z 505 (M+H)⁺-   8-84; A-68; C-24; MS m/z 526 (M+H)⁺-   8-85; A-69; C-13; MS m/z 544 (M+H)⁺-   8-86; A-69; C-14; MS m/z 550 (M+H)⁺-   8-87; A-69; C-15; MS m/z 568 (M+H)⁺-   8-88; A-69; C-16; MS m/z 560 (M+H)⁺-   8-89; A-69; C-17; MS m/z 568 (M+H)⁺-   8-90; A-69; C-18; MS m/z 480 (M+H)⁺-   8-91; A-69; C-19; MS m/z 532 (M+H)⁺-   8-92; A-69; C-20-   8-93; A-69; C-21; MS m/z 495 (M+H)⁺-   8-94; A-69; C-22-   8-95; A-69; C-23; MS m/z 535 (M+H)⁺-   8-96; A-69; C-24; MS m/z 556 (M+H)⁺

(i) The examples of compounds describe in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR⁶R⁷ and spectrum data thereof.

-   9-1; A-09; C-01; MS m/z 438 (M+H)⁺-   9-2; A-09; C-02; MS m/z 450 (M+H)⁺-   9-3; A-09; C-03; MS m/z 462 (M+H)⁺-   9-4; A-09; C-04; MS m/z 466 (M+H)⁺-   9-5; A-09; C-05; MS m/z 468 (M+H)⁺-   9-6; A-09; C-06; MS m/z 476 (M+H)⁺-   9-7; A-09; C-07; MS m/z 478 (M+H)⁺-   9-8; A-09; C-08; MS m/z 494 (M+H)⁺-   9-9; A-09; C-09; MS m/z 500 (M+H)⁺-   9-10; A-09; C-10; MS m/z 506 (M+H)⁺-   9-11; A-09; C-11; MS m/z 514 (M+H)⁺-   9-12; A-09; C-12; MS m/z 520 (M+H)⁺-   9-13; A-10; C-01; MS m/z 438 (M+H)⁺-   9-14; A-10; C-02; MS m/z 450 (M+H)⁺-   9-15; A-10; C-03; MS m/z 462 (M+H)⁺-   9-16; A-10; C-04; MS m/z 466 (M+H)⁺-   9-17; A-10; C-05; MS m/z 468 (M+H)⁺-   9-18; A-10; C-06; MS m/z 476 (M+H)⁺-   9-19; A-10; C-07; MS m/z 478 (M+H)⁺-   9-20; A-10; C-08; MS m/z 494 (M+H)⁺-   9-21; A-10; C-09; MS m/z 500 (M+H)⁺-   9-22; A-10; C-10; MS m/z 506 (M+H)⁺-   9-23; A-10; C-11; MS m/z 514 (M+H)⁺-   9-24; A-10; C-12; MS m/z 520 (M+H)⁺-   9-25; A-11; C-01; MS m/z 438 (M+H)⁺-   9-26; A-11; C-02; MS m/z 450 (M+H)⁺-   9-27; A-11; C-03; MS m/z 462 (M+H)⁺-   9-28; A-11; C-04; MS m/z 466 (M+H)⁺-   9-29; A-11; C-05; MS m/z 468 (M+H)⁺-   9-30; A-11; C-06; MS m/z 476 (M+H)⁺-   9-31; A-11; C-07; MS m/z 478 (M+H)⁺-   9-32; A-11; C-08; MS m/z 494 (M+H)⁺-   9-33; A-11; C-09; MS m/z 500 (M+H)⁺-   9-34; A-11; C-10; MS m/z 506 (M+H)⁺-   9-35; A-11; C-11; MS m/z 514 (M+H)⁺-   9-36; A-11; C-12; MS m/z 520 (M+H)⁺-   9-37; A-12; C-01; MS m/z 438 (M+H)⁺-   9-38; A-12; C-02; MS m/z 450 (M+H)⁺-   9-39; A-12; C-03; MS m/z 462 (M+H)⁺-   9-40; A-12; C-04; MS m/z 466 (M+H)⁺-   9-41; A-12; C-05; MS m/z 468 (M+H)⁺-   9-42; A-12; C-06; MS m/z 476 (M+H)⁺-   9-43; A-12; C-07; MS m/z 478 (M+H)⁺-   9-44; A-12; C-08; MS m/z 494 (M+H)⁺-   9-45; A-12; C-09; MS m/z 500 (M+H)⁺-   9-46; A-12; C-10; MS m/z 506 (M+H)⁺-   9-47; A-12; C-11; MS m/z 514 (M+H)⁺-   9-48; A-12; C-12; MS m/z 520 (M+H)⁺-   9-49; A-13; C-01; MS m/z 446 (M+H)⁺-   9-50; A-13; C-02; MS m/z 458 (M+H)⁺-   9-51; A-13; C-03; MS m/z 470 (M+H)⁺-   9-52; A-13; C-04; MS m/z 474 (M+H)⁺-   9-53; A-13; C-05; MS m/z 476 (M+H)⁺-   9-54; A-13; C-06; MS m/z 484 (M+H)⁺-   9-55; A-13; C-07; MS m/z 486 (M+H)⁺-   9-56; A-13; C-08; MS m/z 502 (M+H)⁺-   9-57; A-13; C-09; MS m/z 508 (M+H)⁺-   9-58; A-13; C-10; MS m/z 514 (M+H)⁺-   9-59; A-13; C-11; MS m/z 522 (M+H)⁺-   9-60; A-13; C-12; MS m/z 528 (M+H)⁺-   9-61; A-14; C-01; MS m/z 446 (M+H)⁺-   9-62; A-14; C-02; MS m/z 458 (M+H)⁺-   9-63; A-14; C-03; MS m/z 470 (M+H)⁺-   9-64; A-14; C-04; MS m/z 474 (M+H)⁺-   9-65; A-14; C-05; MS m/z 476 (M+H)⁺-   9-66; A-14; C-06; MS m/z 484 (M+H)⁺-   9-67; A-14; C-07; MS m/z 486 (M+H)⁺-   9-68; A-14; C-08; MS m/z 502 (M+H)⁺-   9-69; A-14; C-09; MS m/z 508 (M+H)⁺-   9-70; A-14; C-10; MS m/z 514 (M+H)⁺-   9-71; A-14; C-11; MS m/z 522 (M+H)⁺-   9-72; A-14; C-12; MS m/z 528 (M+H)⁺-   9-73; A-15; C-01; MS m/z 454 (M+H)⁺-   9-74; A-15; C-02; MS m/z 466 (M+H)⁺-   9-75; A-15; C-03; MS m/z 478 (M+H)⁺-   9-76; A-15; C-04; MS m/z 482 (M+H)⁺-   9-77; A-15; C-05; MS m/z 484 (M+H)⁺-   9-78; A-15; C-06; MS m/z 492 (M+H)⁺-   9-79; A-15; C-07; MS m/z 494 (M+H)⁺-   9-80; A-15; C-08; MS m/z 510 (M+H)⁺-   9-81; A-15; C-09; MS m/z 516 (M+H)⁺-   9-82; A-15; C-10; MS m/z 522 (M+H)⁺-   9-83; A-15; C-11; MS m/z 530 (M+H)⁺-   9-84; A-15; C-12; MS m/z 536 (M+H)⁺-   9-85; A-16; C-01; MS m/z 460 (M+H)⁺-   9-86; A-16; C-02; MS m/z 472 (M+H)⁺-   9-87; A-16; C-03; MS m/z 484 (M+H)⁺-   9-88; A-16; C-04; MS m/z 488 (M+H)⁺-   9-89; A-16; C-05; MS m/z 490 (M+H)⁺-   9-90; A-16; C-06; MS m/z 498 (M+H)⁺-   9-91; A-16; C-07; MS m/z 500 (M+H)⁺-   9-92; A-16; C-08; MS m/z 516 (M+H)⁺-   9-93; A-16; C-09; MS m/z 522 (M+H)⁺-   9-94; A-16; C-10; MS m/z 528 (M+H)⁺-   9-95; A-16; C-11; MS m/z 536 (M+H)⁺-   9-96; A-16; C-12; MS m/z 542 (M+H)⁺

(j) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR⁶R⁷ and spectrum data thereof.

-   10-1; A-25; C-01; MS m/z 335 (M+H)⁺-   10-2; A-25; C-02; MS m/z 347 (M+H)⁺-   10-3; A-25; C-03; MS m/z 359 (M+H)⁺-   10-4; A-25; C-04; MS m/z 363 (M+H)⁺-   10-5; A-25; C-05; MS m/z 365 (M+H)⁺-   10-6; A-25; C-06; MS m/z 373 (M+H)⁺-   10-7; A-25; C-07-   10-8; A-25; C-08; MS m/z 391 (M+H)⁺-   10-9; A-25; C-09; MS m/z 397 (M+H)⁺-   10-10; A-25; C-10; MS m/z 403 (M+H)⁺-   10-11; A-25; C-11; MS m/z 411 (M+H)⁺-   10-12; A-25; C-12; MS m/z 417 (M+H)⁺-   10-13; A-27; C-01; MS m/z 375 (M+H)⁺-   10-14; A-27; C-02; MS m/z 387 (M+H)⁺-   10-15; A-27; C-03; MS m/z 399 (M+H)⁺-   10-16; A-27; C-04; MS m/z 403 (M+H)⁺-   10-17; A-27; C-05; MS m/z 405 (M+H)⁺-   10-18; A-27; C-06; MS m/z 413 (M+H)⁺-   10-19; A-27; C-07; MS m/z 415 (M+H)⁺-   10-20; A-27; C-08; MS m/z 431 (M+H)⁺-   10-21; A-27; C-09; MS m/z 437 (M+H)⁺-   10-22; A-27; C-10; MS m/z 443 (M+H)⁺-   10-23; A-27; C-11; MS m/z 451 (M+H)⁺-   10-24; A-27; C-12; MS m/z 457 (M+H)⁺-   10-25; A-28; C-01; MS m/z 405 (M+H)⁺-   10-26; A-28; C-02; MS m/z 417 (M+H)⁺-   10-27; A-28; C-03; MS m/z 429 (M+H)⁺-   10-28; A-28; C-04; MS m/z 433 (M+H)⁺-   10-29; A-28; C-05; MS m/z 435 (M+H)⁺-   10-30; A-28; C-06; MS m/z 443 (M+H)⁺-   10-31; A-28; C-07; MS m/z 445 (M+H)⁺-   10-32; A-28; C-08; MS m/z 461 (M+H)⁺-   10-33; A-28; C-09; MS m/z 467 (M+H)⁺-   10-34; A-28; C-10; MS m/z 473 (M+H)⁺-   10-35; A-28; C-11; MS m/z 481 (M+H)⁺-   10-36; A-28; C-12; MS m/z 487 (M+H)⁺-   10-37; A-42; C-01; MS m/z 320 (M+H)⁺-   10-38; A-42; C-02; MS m/z 332 (M+H)⁺-   10-39; A-42; C-03; MS m/z 344 (M+H)⁺-   10-40; A-42; C-04; MS m/z 348 (M+H)⁺-   10-41; A-42; C-05; MS m/z 350 (M+H)⁺-   10-42; A-42; C-06; MS m/z 358 (M+H)⁺-   10-43; A-42; C-07; MS m/z 360 (M+H)⁺-   10-44; A-42; C-08; MS m/z 376 (M+H)⁺-   10-45; A-42; C-09; MS m/z 382 (M+H)⁺-   10-46; A-42; C-10; MS m/z 388 (M+H)⁺-   10-47; A-42; C-11; MS m/z 396 (M+H)⁺-   10-48; A-42; C-12; MS m/z 402 (M+H)⁺-   10-49; A-59; C-01; MS m/z 372 (M+H)⁺-   10-50; A-59; C-02; MS m/z 384 (M+H)⁺-   10-51; A-59; C-03; MS m/z 396 (M+H)⁺-   10-52; A-59; C-04; MS m/z 400 (M+H)⁺-   10-53; A-59; C-05; MS m/z 402 (M+H)⁺-   10-54; A-59; C-06; MS m/z 410 (M+H)⁺-   10-55; A-59; C-07; MS m/z 412 (M+H)⁺-   10-56; A-59; C-08; MS m/z 428 (M+H)⁺-   10-57; A-59; C-09; MS m/z 434 (M+H)⁺-   10-58; A-59; C-10; MS m/z 440 (M+H)⁺-   10-59; A-59; C-11; MS m/z 448 (M+H)⁺-   10-60; A-59; C-12; MS m/z 454 (M+H)⁺-   10-61; A-67; C-01; MS m/z 384 (M+H)⁺-   10-62; A-67; C-02; MS m/z 396 (M+H)⁺-   10-63; A-67; C-03; MS m/z 408 (M+H)⁺-   10-64; A-67; C-04; MS m/z 412 (M+H)⁺-   10-65; A-67; C-05; MS m/z 414 (M+H)⁺-   10-66; A-67; C-06; MS m/z 422 (M+H)⁺-   10-67; A-67; C-07; MS m/z 424 (M+H)⁺-   10-68; A-67; C-08; MS m/z 440 (M+H)⁺-   10-69; A-67; C-09; MS m/z 446 (M+H)⁺-   10-70; A-67; C-10; MS m/z 452 (M+H)⁺-   10-71; A-67; C-11; MS m/z 460 (M+H)⁺-   10-72; A-67; C-12; MS m/z 466 (M+H)⁺-   10-73; A-68; C-01; MS m/z 354 (M+H)⁺-   10-74; A-68; C-02; MS m/z 366 (M+H)⁺-   10-75; A-68; C-03; MS m/z 378 (M+H)⁺-   10-76; A-68; C-04; MS m/z 382 (M+H)⁺-   10-77; A-68; C-05; MS m/z 384 (M+H)⁺-   10-78; A-68; C-06; MS m/z 392 (M+H)⁺-   10-79; A-68; C-07; MS m/z 394 (M+H)⁺-   10-80; A-68; C-08; MS m/z 410 (M+H)⁺-   10-81; A-68; C-09; MS m/z 416 (M+H)⁺-   10-82; A-68; C-10; MS m/z 422 (M+H)⁺-   10-83; A-68; C-11; MS m/z 430 (M+H)⁺-   10-84; A-68; C-12; MS m/z 436 (M+H)⁺-   10-85; A-69; C-01; MS m/z 384 (M+H)⁺-   10-86; A-69; C-02; MS m/z 396 (M+H)⁺-   10-87; A-69; C-03; MS m/z 408 (M+H)⁺-   10-88; A-69; C-04; MS m/z 412 (M+H)⁺-   10-89; A-69; C-05; MS m/z 414 (M+H)⁺-   10-90; A-69; C-06; MS m/z 422 (M+H)⁺-   10-91; A-69; C-07; MS m/z 424 (M+H)⁺-   10-92; A-69; C-08; MS m/z 440 (M+H)⁺-   10-93; A-69; C-09; MS m/z 446 (M+H)⁺-   10-94; A-69; C-10; MS m/z 452 (M+H)⁺-   10-95; A-69; C-11; MS m/z 460 (M+H)⁺-   10-96; A-69; C-12; MS m/z 466 (M+H)⁺

(k) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR⁶R⁷ and spectrum data thereof.

-   11-1; A-19; C-13; MS m/z 472 (M+H)⁺-   11-2; A-25; C-01; MS m/z 349 (M+H)⁺-   11-3; A-25; C-02; MS m/z 361 (M+H)⁺-   11-4; A-25; C-03; MS m/z 373 (M+H)⁺-   11-5; A-25; C-04; MS m/z 377 (M+H)⁺-   11-6; A-25; C-05; MS m/z 379 (M+H)⁺-   11-7; A-25; C-06; MS m/z 387 (M+H)⁺-   11-8; A-25; C-07; MS m/z 389 (M+H)⁺-   11-9; A-25; C-08; MS m/z 405 (M+H)⁺-   11-10; A-25; C-09; MS m/z 411 (M+H)⁺-   11-11; A-25; C-10; MS m/z 417 (M+H)⁺-   11-12; A-25; C-11; MS m/z 425 (M+H)⁺-   11-13; A-25; C-12; MS m/z 431 (M+H)⁺-   11-14; A-27; C-01; MS m/z 389 (M+H)⁺-   11-15; A-27; C-02; MS m/z 401 (M+H)⁺-   11-16; A-27; C-03; MS m/z 413 (M+H)⁺-   11-17; A-27; C-04; MS m/z 417 (M+H)⁺-   11-18; A-27; C-05; MS m/z 419 (M+H)⁺-   11-19; A-27; C-06; MS m/z 427 (M+H)⁺-   11-20; A-27; C-07; MS m/z 429 (M+H)⁺-   11-21; A-27; C-08; MS m/z 445 (M+H)⁺-   11-22; A-27; C-09; MS m/z 451 (M+H)⁺-   11-23; A-27; C-10; MS m/z 457 (M+H)⁺-   11-24; A-27; C-11; MS m/z 465 (M+H)⁺-   11-25; A-27; C-12; MS m/z 471 (M+H)⁺-   11-26; A-28; C-01; MS m/z 419 (M+H)⁺-   11-27; A-28; C-02; MS m/z 431 (M+H)⁺-   11-28; A-28; C-03; MS m/z 443 (M+H)⁺-   11-29; A-28; C-04; MS m/z 447 (M+H)⁺-   11-30; A-28; C-05; MS m/z 449 (M+H)⁺-   11-31; A-28; C-06; MS m/z 457 (M+H)⁺-   11-32; A-28; C-07; MS m/z 459 (M+H)⁺-   11-33; A-28; C-08; MS m/z 475 (M+H)⁺-   11-34; A-28; C-09; MS m/z 481 (M+H)⁺-   11-35; A-28; C-10; MS m/z 487 (M+H)⁺-   11-36; A-28; C-11; MS m/z 495 (M+H)⁺-   11-37; A-28; C-12; MS m/z 501 (M+H)⁺-   11-38; A-42; C-01; MS m/z 334 (M+H)⁺-   11-39; A-42; C-02; MS m/z 346 (M+H)⁺-   11-40; A-42; C-03; MS m/z 358 (M+H)⁺-   11-41; A-42; C-04; MS m/z 362 (M+H)⁺-   11-42; A-42; C-05; MS m/z 364 (M+H)⁺-   11-43; A-42; C-06; MS m/z 372 (M+H)⁺-   11-44; A-42; C-07; MS m/z 374 (M+H)⁺-   11-45; A-42; C-08; MS m/z 390 (M+H)⁺-   11-46; A-42; C-09; MS m/z 396 (M+H)⁺-   11-47; A-42; C-10; MS m/z 402 (M+H)⁺-   11-48; A-42; C-11; MS m/z 410 (M+H)⁺-   11-49; A-42; C-12; MS m/z 416 (M+H)⁺-   11-50; A-59; C-01; MS m/z 386 (M+H)⁺-   11-51; A-59; C-02; MS m/z 398 (M+H)⁺-   11-52; A-59; C-03; MS m/z 410 (M+H)⁺-   11-53; A-59; C-04; MS m/z 414 (M+H)⁺-   11-54; A-59; C-05; MS m/z 416 (M+H)⁺-   11-55; A-59; C-06; MS m/z 424 (M+H)⁺-   11-56; A-59; C-07; MS m/z 426 (M+H)⁺-   11-57; A-59; C-08; MS m/z 442 (M+H)⁺-   11-58; A-59; C-09; MS m/z 448 (M+H)⁺-   11-59; A-59; C-10; MS m/z 454 (M+H)⁺-   11-60; A-59; C-11; MS m/z 462 (M+H)⁺-   11-61; A-59; C-12; MS m/z 468 (M+H)⁺-   11-62; A-67; C-01; MS m/z 398 (M+H)⁺-   11-63; A-67; C-02; MS m/z 410 (M+H)⁺-   11-64; A-67; C-03; MS m/z 422 (M+H)⁺-   11-65; A-67; C-04; MS m/z 426 (M+H)⁺-   11-66; A-67; C-05; MS m/z 428 (M+H)⁺-   11-67; A-67; C-06; MS m/z 436 (M+H)⁺-   11-68; A-67; C-07; MS m/z 438 (M+H)⁺-   11-69; A-67; C-08; MS m/z 454 (M+H)⁺-   11-70; A-67; C-09; MS m/z 460 (M+H)⁺-   11-71; A-67; C-10; MS m/z 466 (M+H)⁺-   11-72; A-67; C-11; MS m/z 474 (M+H)⁺-   11-73; A-67; C-12; MS m/z 480 (M+H)⁺-   11-74; A-68; C-01; MS m/z 368 (M+H)⁺-   11-75; A-68; C-02; MS m/z 380 (M+H)⁺-   11-76; A-68; C-03; MS m/z 392 (M+H)⁺-   11-77; A-68; C-04; MS m/z 396 (M+H)⁺-   11-78; A-68; C-05; MS m/z 398 (M+H)⁺-   11-79; A-68; C-06; MS m/z 406 (M+H)⁺-   11-80; A-68; C-07; MS m/z 408 (M+H)⁺-   11-81; A-68; C-08; MS m/z 424 (M+H)⁺-   11-82; A-68; C-09; MS m/z 430 (M+H)⁺-   11-83; A-68; C-10; MS m/z 436 (M+H)⁺-   11-84; A-68; C-11; MS m/z 444 (M+H)⁺-   11-85; A-68; C-12; MS m/z 450 (M+H)⁺-   11-86; A-69; C-01; MS m/z 398 (M+H)⁺-   11-87; A-69; C-02; MS m/z 410 (M+H)⁺-   11-88; A-69; C-03; MS m/z 422 (M+H)⁺-   11-89; A-69; C-04; MS m/z 426 (M+H)⁺-   11-90; A-69; C-05; MS m/z 428 (M+H)⁺-   11-91; A-69; C-06; MS m/z 436 (M+H)⁺-   11-92; A-69; C-07; MS m/z 438 (M+H)⁺-   11-93; A-69; C-08; MS m/z 454 (M+H)⁺-   11-94; A-69; C-09; MS m/z 460 (M+H)⁺-   11-95; A-69; C-10; MS m/z 466 (M+H)⁺-   11-96; A-69; C-11; MS m/z 474 (M+H)⁺-   11-97; A-69; C-12; MS m/z 480 (M+H)⁺

(l) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR^(6a)R^(7a) and spectrum data thereof.

-   12-1; A-05; C-32; MS m/z 478 (M+H)⁺-   12-2; A-05; C-37; MS m/z 466 (M+H)⁺-   12-3; A-05; C-38; MS m/z 479 (M+H)⁺-   12-4; A-05; C-39; MS m/z 452 (M+H)⁺-   12-5; A-05; C-40; MS m/z 450 (M+H)⁺-   12-6; A-05; C-41; MS m/z 466 (M+H)⁺-   12-7; A-05; C-42; MS m/z 450 (M+H)⁺-   12-8; A-05; C-43; MS m/z 450 (M+H)⁺-   12-9; A-05; C-44; MS m/z 438 (M+H)⁺-   12-10; A-05; C-45; MS m/z 450 (M+H)⁺-   12-11; A-05; C-46; MS m/z 447 (M+H)⁺-   12-12; A-05; C-47; MS m/z 439 (M+H)⁺-   12-13; A-14; C-32; MS m/z 512 (M+H)⁺-   12-14; A-14; C-37; MS m/z 500 (M+H)⁺-   12-15; A-14; C-38; MS m/z 513 (M+H)⁺-   12-16; A-14; C-39; MS m/z 486 (M+H)⁺-   12-17; A-14; C-40; MS m/z 484 (M+H)⁺-   12-18; A-14; C-41; MS m/z 500 (M+H)⁺-   12-19; A-14; C-42; MS m/z 484 (M+H)⁺-   12-20; A-14; C-43; MS m/z 484 (M+H)⁺-   12-21; A-14; C-44; MS m/z 472 (M+H)⁺-   12-22; A-14; C-45; MS m/z 484 (M+H)⁺-   12-23; A-14; C-46; MS m/z 481 (M+H)⁺-   12-24; A-14; C-47; MS m/z 473 (M+H)⁺-   12-25; A-17; C-32; MS m/z 532 (M+H)⁺-   12-26; A-17; C-37; MS m/z 520 (M+H)⁺-   12-27; A-17; C-38; MS m/z 533 (M+H)⁺-   12-28; A-17; C-39; MS m/z 506 (M+H)⁺-   12-29; A-17; C-40; MS m/z 504 (M+H)⁺-   12-30; A-17; C-41; MS m/z 520 (M+H)⁺-   12-31; A-17; C-42; MS m/z 504 (M+H)⁺-   12-32; A-17; C-43; MS m/z 504 (M+H)⁺-   12-33; A-17; C-44; MS m/z 492 (M+H)⁺-   12-34; A-17; C-45; MS m/z 504 (M+H)⁺-   12-35; A-17; C-46; MS m/z 501 (M+H)⁺-   12-36; A-17; C-47; MS m/z 493 (M+H)⁺-   12-37; A-41; C-32; MS m/z 478 (M+H)⁺-   12-38; A-41; C-37; MS m/z 466 (M+H)⁺-   12-39; A-41; C-38; MS m/z 479 (M+H)⁺-   12-40; A-41; C-39; MS m/z 452 (M+H)⁺-   12-41; A-41; C-40; MS m/z 450 (M+H)⁺-   12-42; A-41; C-41; MS m/z 466 (M+H)⁺-   12-43; A-41; C-42; MS m/z 450 (M+H)⁺-   12-44; A-41; C-43; MS m/z 450 (M+H)⁺-   12-45; A-41; C-44; MS m/z 438 (M+H)⁺-   12-46; A-41; C-45; MS m/z 450 (M+H)⁺-   12-47; A-41; C-46; MS m/z 447 (M+H)⁺-   12-48; A-41; C-47; MS m/z 439 (M+H)⁺-   12-49; A-42; C-32; MS m/z 478 (M+H)⁺-   12-50; A-42; C-37; MS m/z 466 (M+H)⁺-   12-51; A-42; C-38; MS m/z 479 (M+H)⁺-   12-52; A-42; C-39; MS m/z 452 (M+H)⁺-   12-53; A-42; C-40; MS m/z 450 (M+H)⁺-   12-54; A-42; C-41; MS m/z 466 (M+H)⁺-   12-55; A-42; C-42; MS m/z 450 (M+H)⁺-   12-56; A-42; C-43; MS m/z 450 (M+H)⁺-   12-57; A-42; C-44; MS m/z 438 (M+H)⁺-   12-58; A-42; C-45; MS m/z 450 (M+H)⁺-   12-59; A-42; C-46; MS m/z 447 (M+H)⁺-   12-60; A-42; C-47; MS m/z 439 (M+H)⁺-   12-61; A-43; C-32; MS m/z 464 (M+H)⁺-   12-62; A-43; C-37; MS m/z 452 (M+H)⁺-   12-63; A-43; C-38; MS m/z 465 (M+H)⁺-   12-64; A-43; C-39; MS m/z 438 (M+H)⁺-   12-65; A-43; C-40; MS m/z 436 (M+H)⁺-   12-66; A-43; C-41; MS m/z 452 (M+H)⁺-   12-67; A-43; C-42; MS m/z 436 (M+H)⁺-   12-68; A-43; C-43; MS m/z 436 (M+H)⁺-   12-69; A-43; C-44; MS m/z 424 (M+H)⁺-   12-70; A-43; C-45; MS m/z 436 (M+H)⁺-   12-71; A-43; C-46; MS m/z 433 (M+H)⁺-   12-72; A-43; C-47; MS m/z 425 (M+H)⁺-   12-73; A-44; C-32; MS m/z 492 (M+H)⁺-   12-74; A-44; C-37; MS m/z 480 (M+H)⁺-   12-75; A-44; C-38; MS m/z 493 (M+H)⁺-   12-76; A-44; C-39; MS m/z 466 (M+H)⁺-   12-77; A-44; C-40; MS m/z 464 (M+H)⁺-   12-78; A-44; C-41; MS m/z 480 (M+H)⁺-   12-79; A-44; C-42; MS m/z 464 (M+H)⁺-   12-80; A-44; C-43; MS m/z 464 (M+H)⁺-   12-81; A-44; C-44; MS m/z 452 (M+H)⁺-   12-82; A-44; C-45; MS m/z 464 (M+H)⁺-   12-83; A-44; C-46; MS m/z 461 (M+H)⁺-   12-84; A-44; C-47; MS m/z 453 (M+H)⁺-   12-85; A-45; C-32-   12-86; A-45; C-37; MS m/z 466 (M+H)⁺-   12-87; A-45; C-38-   12-88; A-45; C-39; MS m/z 450 (M−H)⁺-   12-89; A-45; C-40; MS m/z 450 (M+H)⁺-   12-90; A-45; C-41-   12-91; A-45; C-42; MS m/z 450 (M+H)⁺-   12-92; A-45; C-43-   12-93; A-45; C-44-   12-94; A-45; C-45-   12-95; A-45; C-46-   12-96; A-45; C-47-   12-97; A-46; C-32-   12-98; A-46; C-37; MS m/z 476 (M+H)⁺-   12-99; A-46; C-38-   12-100; A-46; C-39; MS m/z 462 (M+H)⁺-   12-101; A-46; C-40; MS m/z 460 (M+H)⁺-   12-102; A-46; C-41-   12-103; A-46; C-42; MS m/z 460 (M+H)⁺-   12-104; A-46; C-43-   12-105; A-46; C-44; MS m/z 448 (M+H)⁺-   12-106; A-46; C-45-   12-107; A-46; C-46; MS m/z 457 (M+H)⁺-   12-108; A-46; C-47; MS m/z 449 (M+H)⁺-   12-109; A-47; C-32-   12-110; A-47; C-37; MS m/z 466 (M+H)⁺-   12-111; A-47; C-38-   12-112; A-47; C-39; MS m/z 452 (M+H)⁺-   12-113; A-47; C-40; MS m/z 450 (M+H)⁺-   12-114; A-47; C-41; MS m/z 466 (M+H)⁺-   12-115; A-47; C-42; MS m/z 450 (M+H)⁺-   12-116; A-47; C-43-   12-117; A-47; C-44; MS m/z 438 (M+H)⁺-   12-118; A-47; C-45; MS m/z 450 (M+H)⁺-   12-119; A-47; C-46; MS m/z 447 (M+H)⁺-   12-120; A-47; C-47; MS m/z 439 (M+H)⁺-   12-121; A-48; C-32; MS m/z 532 (M+H)⁺-   12-122; A-48; C-37; MS m/z 520 (M+H)⁺-   12-123; A-48; C-38; MS m/z 533 (M+H)⁺-   12-124; A-48; C-39; MS m/z 506 (M+H)⁺-   12-125; A-48; C-40; MS m/z 504 (M+H)⁺-   12-126; A-48; C-41; MS m/z 520 (M+H)⁺-   12-127; A-48; C-42; MS m/z 504 (M+H)⁺-   12-128; A-48; C-43; MS m/z 504 (M+H)⁺-   12-129; A-48; C-44; MS m/z 492 (M+H)⁺-   12-130; A-48; C-45; MS m/z 504 (M+H)⁺-   12-131; A-48; C-46; MS m/z 501 (M+H)⁺-   12-132; A-48; C-47; MS m/z 493 (M+H)⁺-   12-133; A-49; C-32; MS m/z 530 (M+H)⁺-   12-134; A-49; C-37; MS m/z 518 (M+H)⁺-   12-135; A-49; C-38; MS m/z 531 (M+H)⁺-   12-136; A-49; C-39; MS m/z 504 (M+H)⁺-   12-137; A-49; C-40; MS m/z 502 (M+H)⁺-   12-138; A-49; C-41; MS m/z 518 (M+H)⁺-   12-139; A-49; C-42; MS m/z 502 (M+H)⁺-   12-140; A-49; C-43; MS m/z 502 (M+H)⁺-   12-141; A-49; C-44; MS m/z 490 (M+H)⁺-   12-142; A-49; C-45; MS m/z 502 (M+H)⁺-   12-143; A-49; C-46; MS m/z 499 (M+H)⁺-   12-144; A-49; C-47; MS m/z 491 (M+H)⁺-   12-145; A-50; C-32; MS m/z 528 (M+H)⁺-   12-146; A-50; C-37; MS m/z 516 (M+H)⁺-   12-147; A-50; C-38; MS m/z 529 (M+H)⁺-   12-148; A-50; C-39; MS m/z 502 (M+H)⁺-   12-149; A-50; C-40; MS m/z 500 (M+H)⁺-   12-150; A-50; C-41; MS m/z 516 (M+H)⁺-   12-151; A-50; C-42; MS m/z 500 (M+H)⁺-   12-152; A-50; C-43; MS m/z 500 (M+H)⁺-   12-153; A-50; C-44; MS m/z 488 (M+H)⁺-   12-154; A-50; C-45; MS m/z 500 (M+H)⁺-   12-155; A-50; C-46; MS m/z 497 (M+H)⁺-   12-156; A-50; C-47; MS m/z 489 (M+H)⁺-   12-157; A-51; C-32; MS m/z 546 (M+H)⁺-   12-158; A-51; C-37; MS m/z 534 (M+H)⁺-   12-159; A-51; C-38; MS m/z 547 (M+H)⁺-   12-160; A-51; C-39; MS m/z 520 (M+H)⁺-   12-161; A-51; C-40; MS m/z 518 (M+H)⁺-   12-162; A-51; C-41; MS m/z 534 (M+H)⁺-   12-163; A-51; C-42; MS m/z 518 (M+H)⁺-   12-164; A-51; C-43; MS m/z 518 (M+H)⁺-   12-165; A-51; C-44; MS m/z 506 (M+H)⁺-   12-166; A-51; C-45; MS m/z 518 (M+H)⁺-   12-167; A-51; C-46; MS m/z 515 (M+H)⁺-   12-168; A-51; C-47; MS m/z 507 (M+H)⁺-   12-169; A-52; C-32; MS m/z 534 (M+H)⁺-   12-170; A-52; C-37; MS m/z 522 (M+H)⁺-   12-171; A-52; C-38; MS m/z 535 (M+H)⁺-   12-172; A-52; C-39; MS m/z 508 (M+H)⁺-   12-173; A-52; C-40; MS m/z 506 (M+H)⁺-   12-174; A-52; C-41; MS m/z 522 (M+H)⁺-   12-175; A-52; C-42; MS m/z 506 (M+H)⁺-   12-176; A-52; C-43; MS m/z 506 (M+H)⁺-   12-177; A-52; C-44; MS m/z 494 (M+H)⁺-   12-178; A-52; C-45; MS m/z 506 (M+H)⁺-   12-179; A-52; C-46; MS m/z 503 (M+H)⁺-   12-180; A-52; C-47; MS m/z 495 (M+H)⁺-   12-181; A-53; C-32; MS m/z 516 (M+H)⁺-   12-182; A-53; C-37; MS m/z 504 (M+H)⁺-   12-183; A-53; C-38; MS m/z 517 (M+H)⁺-   12-184; A-53; C-39; MS m/z 490 (M+H)⁺-   12-185; A-53; C-40; MS m/z 488 (M+H)⁺-   12-186; A-53; C-41; MS m/z 504 (M+H)⁺-   12-187; A-53; C-42; MS m/z 488 (M+H)⁺-   12-188; A-53; C-43; MS m/z 488 (M+H)⁺-   12-189; A-53; C-44; MS m/z 476 (M+H)⁺-   12-190; A-53; C-45; MS m/z 488 (M+H)⁺-   12-191; A-53; C-46; MS m/z 485 (M+H)⁺-   12-192; A-53; C-47; MS m/z 477 (M+H)⁺

(m) The examples of compounds described in:

which are included in Compound (I), are listed below in order ofcompound number, —NR³R⁴, —NR^(6a)R^(7a) and spectrum data thereof.

-   13-1; A-05; C-32; MS m/z 478 (M+H)⁺-   13-2; A-05; C-37; MS m/z 466 (M+H)⁺-   13-3; A-05; C-38; MS m/z 479 (M+H)⁺-   13-4; A-05; C-39; MS m/z 452 (M+H)⁺-   13-5; A-05; C-40; MS m/z 450 (M+H)⁺-   13-6; A-05; C-41; MS m/z 466 (M+H)⁺-   13-7; A-05; C-42; MS m/z 450 (M+H)⁺-   13-8; A-05; C-43; MS m/z 450 (M+H)⁺-   13-9; A-05; C-44; MS m/z 438 (M+H)⁺-   13-10; A-05; C-45; MS m/z 450 (M+H)⁺-   13-11; A-05; C-46; MS m/z 447 (M+H)⁺-   13-12; A-05; C-47; MS m/z 439 (M+H)⁺-   13-13; A-14; C-32; MS m/z 512 (M+H)⁺-   13-14; A-14; C-37; MS m/z 500 (M+H)⁺-   13-15; A-14; C-38; MS m/z 513 (M+H)⁺-   13-16; A-14; C-39; MS m/z 486 (M+H)⁺-   13-17; A-14; C-40; MS m/z 484 (M+H)⁺-   13-18; A-14; C-41; MS m/z 500 (M+H)⁺-   13-19; A-14; C-42; MS m/z 484 (M+H)⁺-   13-20; A-14; C-43; MS m/z 484 (M+H)⁺-   13-21; A-14; C-44; MS m/z 472 (M+H)⁺-   13-22; A-14; C-45; MS m/z 484 (M+H)⁺-   13-23; A-14; C-46; MS m/z 481 (M+H)⁺-   13-24; A-14; C-47; MS m/z 473 (M+H)⁺-   13-25; A-17; C-32; MS m/z 532 (M+H)⁺-   13-26; A-17; C-37; MS m/z 520 (M+H)⁺-   13-27; A-17; C-38; MS m/z 533 (M+H)⁺-   13-28; A-17; C-39; MS m/z 506 (M+H)⁺-   13-29; A-17; C-40; MS m/z 504 (M+H)⁺-   13-30; A-17; C-41; MS m/z 520 (M+H)⁺-   13-31; A-17; C-42; MS m/z 504 (M+H)⁺-   13-32; A-17; C-43; MS m/z 504 (M+H)⁺-   13-33; A-17; C-44; MS m/z 492 (M+H)⁺-   13-34; A-17; C-45; MS m/z 504 (M+H)⁺-   13-35; A-17; C-46; MS m/z 501 (M+H)⁺-   13-36; A-17; C-47; MS m/z 493 (M+H)⁺-   13-37; A-41; C-32; MS m/z 478 (M+H)⁺-   13-38; A-41; C-37; MS m/z 466 (M+H)⁺-   13-39; A-41; C-38; MS m/z 479 (M+H)⁺-   13-40; A-41; C-39; MS m/z 452 (M+H)⁺-   13-41; A-41; C-40; MS m/z 450 (M+H)⁺-   13-42; A-41; C-41; MS m/z 466 (M+H)⁺-   13-43; A-41; C-42; MS m/z 450 (M+H)⁺-   13-44; A-41; C-43; MS m/z 450 (M+H)⁺-   13-45; A-41; C-44; MS m/z 438 (M+H)⁺-   13-46; A-41; C-45; MS m/z 450 (M+H)⁺-   13-47; A-41; C-46; MS m/z 447 (M+H)⁺-   13-48; A-41; C-47; MS m/z 439 (M+H)⁺-   13-49; A-42; C-32; MS m/z 478 (M+H)⁺-   13-50; A-42; C-37; MS m/z 466 (M+H)⁺-   13-51; A-42; C-38; MS m/z 479 (M+H)⁺-   13-52; A-42; C-39; MS m/z 452 (M+H)⁺-   13-53; A-42; C-40; MS m/z 450 (M+H)⁺-   13-54; A-42; C-41; MS m/z 466 (M+H)⁺-   13-55; A-42; C-42; MS m/z 450 (M+H)⁺-   13-56; A-42; C-43; MS m/z 450 (M+H)⁺-   13-57; A-42; C-44; MS m/z 438 (M+H)⁺-   13-58; A-42; C-45; MS m/z 450 (M+H)⁺-   13-59; A-42; C-46; MS m/z 447 (M+H)⁺-   13-60; A-42; C-47; MS m/z 439 (M+H)⁺-   13-61; A-43; C-32; MS m/z 464 (M+H)⁺-   13-62; A-43; C-37; MS m/z 452 (M+H)⁺-   13-63; A-43; C-38; MS m/z 465 (M+H)⁺-   13-64; A-43; C-39; MS m/z 438 (M+H)⁺-   13-65; A-43; C-40; MS m/z 436 (M+H)⁺-   13-66; A-43; C-41; MS m/z 452 (M+H)⁺-   13-67; A-43; C-42; MS m/z 436 (M+H)⁺-   13-68; A-43; C-43; MS m/z 436 (M+H)⁺-   13-69; A-43; C-44; MS m/z 424 (M+H)⁺-   13-70; A-43; C-45; MS m/z 436 (M+H)⁺-   13-71; A-43; C-46; MS m/z 433 (M+H)⁺-   13-72; A-43; C-47; MS m/z 425 (M+H)⁺-   13-73; A-44; C-32; MS m/z 492 (M+H)⁺-   13-74; A-44; C-37; MS m/z 480 (M+H)⁺-   13-75; A-44; C-38; MS m/z 493 (M+H)⁺-   13-76; A-44; C-39; MS m/z 466 (M+H)⁺-   13-77; A-44; C-40; MS m/z 464 (M+H)⁺-   13-78; A-44; C-41; MS m/z 480 (M+H)⁺-   13-79; A-44; C-42; MS m/z 464 (M+H)⁺-   13-80; A-44; C-43; MS m/z 464 (M+H)⁺-   13-81; A-44; C-44; MS m/z 452 (M+H)⁺-   13-82; A-44; C-45; MS m/z 464 (M+H)⁺-   13-83; A-44; C-46; MS m/z 461 (M+H)⁺-   13-84; A-44; C-47; MS m/z 453 (M+H)⁺-   13-85; A-45; C-32-   13-86; A-45; C-37; MS m/z 466 (M+H)⁺-   13-87; A-45; C-38; MS m/z 477 (M−H)⁺-   13-88; A-45; C-39-   13-89; A-45; C-40-   13-90; A-45; C-41-   13-91; A-45; C-42; MS m/z 450 (M+H)⁺-   13-92; A-45; C-43-   13-93; A-45; C-44-   13-94; A-45; C-45-   13-95; A-45; C-46-   13-96; A-45; C-47-   13-97; A-46; C-32-   13-98; A-46; C-37; MS m/z 476 (M+H)⁺-   13-99; A-46; C-38-   13-100; A-46; C-39-   13-101; A-46; C-40; MS m/z 460 (M+H)⁺-   13-102; A-46; C-41-   13-103; A-46; C-42; MS m/z 460 (M+H)⁺-   13-104; A-46; C-43; MS m/z 460 (M+H)⁺-   13-105; A-46; C-44; MS m/z 448 (M+H)⁺-   13-106; A-46; C-45-   13-107; A-46; C-46-   13-108; A-46; C-47; MS m/z 449 (M+H)⁺-   13-109; A-47; C-32-   13-110; A-47; C-37; MS m/z 466 (M+H)⁺-   13-111; A-47; C-38-   13-112; A-47; C-39-   13-113; A-47; C-40; MS m/z 450 (M+H)⁺-   13-114; A-47; C-41-   13-115; A-47; C-42; MS m/z 450 (M+H)⁺-   13-116; A-47; C-43-   13-117; A-47; C-44-   13-118; A-47; C-45; MS m/z 450 (M+H)⁺-   13-119; A-47; C-46-   13-120; A-47; C-47-   13-121; A-48; C-32; MS m/z 532 (M+H)⁺-   13-122; A-48; C-37; MS m/z 520 (M+H)⁺-   13-123; A-48; C-38; MS m/z 533 (M+H)⁺-   13-124; A-48; C-39; MS m/z 506 (M+H)⁺-   13-125; A-48; C-40; MS m/z 504 (M+H)⁺-   13-126; A-48; C-41; MS m/z 520 (M+H)⁺-   13-127; A-48; C-42; MS m/z 504 (M+H)⁺-   13-128; A-48; C-43; MS m/z 504 (M+H)⁺-   13-129; A-48; C-44; MS m/z 492 (M+H)⁺-   13-130; A-48; C-45; MS m/z 504 (M+H)⁺-   13-131; A-48; C-46; MS m/z 501 (M+H)⁺-   13-132; A-48; C-47; MS m/z 493 (M+H)⁺-   13-133; A-49; C-32; MS m/z 530 (M+H)⁺-   13-134; A-49; C-37; MS m/z 518 (M+H)⁺-   13-135; A-49; C-38; MS m/z 531 (M+H)⁺-   13-136; A-49; C-39; MS m/z 504 (M+H)⁺-   13-137; A-49; C-40; MS m/z 502 (M+H)⁺-   13-138; A-49; C-41; MS m/z 518 (M+H)⁺-   13-139; A-49; C-42; MS m/z 502 (M+H)⁺-   13-140; A-49; C-43; MS m/z 502 (M+H)⁺-   13-141; A-49; C-44; MS m/z 490 (M+H)⁺-   13-142; A-49; C-45; MS m/z 502 (M+H)⁺-   13-143; A-49; C-46; MS m/z 499 (M+H)⁺-   13-144; A-49; C-47; MS m/z 491 (M+H)⁺-   13-145; A-50; C-32; MS m/z 528 (M+H)⁺-   13-146; A-50; C-37; MS m/z 516 (M+H)⁺-   13-147; A-50; C-38; MS m/z 529 (M+H)⁺-   13-148; A-50; C-39; MS m/z 502 (M+H)⁺-   13-149; A-50; C-40; MS m/z 500 (M+H)⁺-   13-150; A-50; C-41; MS m/z 516 (M+H)⁺-   13-151; A-50; C-42; MS m/z 500 (M+H)⁺-   13-152; A-50; C-43; MS m/z 500 (M+H)⁺-   13-153; A-50; C-44; MS m/z 488 (M+H)⁺-   13-154; A-50; C-45; MS m/z 500 (M+H)⁺-   13-155; A-50; C-46; MS m/z 497 (M+H)⁺-   13-156; A-50; C-47; MS m/z 489 (M+H)⁺-   13-157; A-51; C-32; MS m/z 546 (M+H)⁺-   13-158; A-51; C-37; MS m/z 534 (M+H)⁺-   13-159; A-51; C-38; MS m/z 547 (M+H)⁺-   13-160; A-51; C-39; MS m/z 520 (M+H)⁺-   13-161; A-51; C-40; MS m/z 518 (M+H)⁺-   13-162; A-51; C-41; MS m/z 534 (M+H)⁺-   13-163; A-51; C-42; MS m/z 518 (M+H)⁺-   13-164; A-51; C-43; MS m/z 518 (M+H)⁺-   13-165; A-51; C-44; MS m/z 506 (M+H)⁺-   13-166; A-51; C-45; MS m/z 518 (M+H)⁺-   13-167; A-51; C-46; MS m/z 515 (M+H)⁺-   13-168; A-51; C-47; MS m/z 507 (M+H)⁺-   13-169; A-52; C-32; MS m/z 534 (M+H)⁺-   13-170; A-52; C-37; MS m/z 522 (M+H)⁺-   13-171; A-52; C-38; MS m/z 535 (M+H)⁺-   13-172; A-52; C-39; MS m/z 508 (M+H)⁺-   13-173; A-52; C-40; MS m/z 506 (M+H)⁺-   13-174; A-52; C-41; MS m/z 522 (M+H)⁺-   13-175; A-52; C-42; MS m/z 506 (M+H)⁺-   13-176; A-52; C-43; MS m/z 506 (M+H)⁺-   13-177; A-52; C-44; MS m/z 494 (M+H)⁺-   13-178; A-52; C-45; MS m/z 506 (M+H)⁺-   13-179; A-52; C-46; MS m/z 503 (M+H)⁺-   13-180; A-52; C-47; MS m/z 495 (M+H)⁺-   13-181; A-53; C-32; MS m/z 516 (M+H)⁺-   13-182; A-53; C-37; MS m/z 504 (M+H)⁺-   13-183; A-53; C-38; MS m/z 517 (M+H)⁺-   13-184; A-53; C-39; MS m/z 490 (M+H)⁺-   13-185; A-53; C-40; MS m/z 488 (M+H)⁺-   13-186; A-53; C-41; MS m/z 504 (M+H)⁺-   13-187; A-53; C-42; MS m/z 488 (M+H)⁺-   13-188; A-53; C-43; MS m/z 488 (M+H)⁺-   13-189; A-53; C-44; MS m/z 476 (M+H)⁺-   13-190; A-53; C-45; MS m/z 488 (M+H)⁺-   13-191; A-53; C-46; MS m/z 485 (M+H)⁺-   13-192; A-53; C-47; MS m/z 477 (M+H)⁺

The use of Compound (I) of the present invention is not limited to anactive ingredient of a medicament but can also be used as an activeingredient of other medicaments or as an intermediate in the manufactureof other compounds. Other applications like these are included in theuse of Compound (I) as well. Examples of the Compound (I) whichencompass the present invention include any salt includingpharmaceutically acceptable salts described above, in addition to anyhydrate or solvate. Any solvent can be used, so long as it formssolvate. Examples of the solvent that forms solvate include ethanol,tetrahydrofuran, dioxane and the like, although there is no limitationthereto. When one or more asymmetric carbon atom exists in the structureof Compound (I), pure isomers such as optical isomers anddiastereoisomers, mixtures of isomers, and racemic mixtures are includedin the present invention.

The pharmacological activity of Compound (I) will now be described.

TEST EXAMPLE 1 Insulin Secretion Promoting Activity for Cultured β-Cells

The established pancreas β-cell, MIN6 cell, reported by Miyazaki et al.(Endocrinology, vol. 127, p. 126-131, 1990), exhibits insulin contentand insulin secretion amount by stimulation with glucose similar tothose of pancreas β-cells in living bodies, and well preservescharacteristics of pancreas β-cells in living bodies from a view pointthat it shows increase of insulin secretion in a glucoseconcentration-dependent manner (the above reference, and Diabetologia,vol. 36, p. 1139-1145, 1993). Further, the insulin secretion of the MIN6cell is prompted in response to sulfonylurea-agents such asglibenclamide, which are used as a medicament for treatment of diabetes(Cellular Signalling, vol. 5, p. 777-786, 1993).

Culture of the MIN6 cells above and insulin secretion test utilizing theMIN6 cells were performed according to the methods described inDiabetologia, vol. 36, p. 1139-1145, 1993. The effect of a compound onthe insulin secretion in the presence of 14.5 mmol/L glucose wasdetermined by measuring insulin amounts in cell culture supernatantscollected as follows. MIN6 cells cultured on a 24-well plate were washedtwice by using 1 mL of Buffer A (119 mmol/L sodium chloride, 4.74 mmol/Lpotassium chloride, 2.54 mmol/L calcium chloride, 1.19 mmol/L magnesiumsulfate, 1.19 mmol/L potassium dihydrogenphosphate, 10 mmol/L2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid, and 0.1% bovineserum albumin, pH 7.3) containing 2 mmol/L glucose, and then wereincubated in 1 mL of Buffer A containing 2 mmol/L glucose at 37° C. for45 minutes. After the incubation, the culture supernatant was changed toBuffer A (0.9 mL) containing a test compound at various concentrationsand 2 mmol/L glucose, and the cells were further incubated at 37° C. for15 minutes. The MIN6 cells were stimulated with glucose by the additionof Buffer A (0.1 mL) containing 127 mmol/L glucose to the culture (finalglucose concentration: 14.5 mmol/L). After the stimulation, the cellswere further incubated at 37° C. for 45 minutes, and then the culturesupernatant was collected.

Separately, the effect of a compound on the insulin secretion in thepresence of 5 mmol/L glucose was determined by measuring insulin amountsin cell culture supernatants collected as follows. MIN6 cells culturedon a 24-well plate were washed twice by using 1 mL of Buffer Acontaining 5 mmol/L glucose, and then the culture supernatant waschanged to Buffer A (0.9 mL) containing a test compound at variousconcentrations and 5 mmol/L glucose. Then, the cells were incubated at37° C. for 45 minutes (final glucose concentration: 5 mmol/L), and theculture supernatant was collected.

After the culture supernatant was diluted with a phosphate buffercontaining 1% bovine serum albumin, 0.1% Tween 20, 0.12% disodiumethylenediaminetetraacetate (EDTA), and 0.1% sodium azide,antibody-reactive insulin secreted in the culture supernatant wasqualified by enzyme immunoassay or radio immunoassay. The insulin levelwas indicated as the amount of human insulin (ng/mL). The results areindicated as average (avg) of 3 to 4 samples with standard error values(se).

The results are shown in Table 4. TABLE 4 (1) (In the presence of 14.5mmol/L of glucose) Drug Insulin secretion Concentration amount (ng/mL)Compound No. (μmol/L) Avg se none — 148.4 4.8 1-447 1 174 5.4 1-482 1170.7 4.2 1-484 1 173.5 8.8 1-485 1 172 1.6 1-486 1 176.6 3.2 1-487 1185.1 5.3  1-1259 1 171 4.1  1-1279 1 171.8 2.9  1-1490 1 184 16.2 1-1494 1 202 3.4  1-1496 1 173.5 5  1-1477 1 191.1 5  1-1506 1 170.5 5 1-1515 1 172.6 6  1-1516 1 176.8 8.4 2-41  1 188.5 6.9 2-42  1 179.61.6 2-45  1 177.7 6.5 7-175 1 182.8 8.1 7-183 1 171.3 4.7 7-185 1 172.48.5 7-187 1 175.5 1.8 7-188 1 182.4 5.4 7-258 1 171.1 6.6 7-523 1 173.315.8 7-630 1 193.5 17 7-635 1 187.1 0.7 7-640 1 188.3 9.1 7-641 1 176.610.8 7-642 1 192 11.8 7-713 1 196 8.2 7-785 1 198 2.7 7-892 1 176.9 97-893 1 193.7 12.7  7-1223 1 172.4 3.5

TABLE 4 (2) (In the presence of 14.5 mmol/L of glucose) Drug Insulinsecretion amount Concentration (ng/mL) Compound No. (μmol/L) avg se7-1270 1 177.2 4.1 7-1275 1 180 10.6 7-1277 1 179.6 6.7 7-1278 1 192.712.2 7-1281 1 182.4 2.7 7-1290 1 205.3 10 7-1454 1 174.7 9.8 7-1374 1193.8 2 7-1389 1 194 6.1 7-1397 1 219 7.2 7-1398 1 164.5 14 7-1410 1206.9 3.9 11-60   1 175.9 2.3 11-70   1 176.7 3.2 AY4166 10 195.1 4.3Glibenclamide 0.1 177.8 3.3

TABLE 4 (3) (In the presence of 5 mmol/L of glucose) Drug Insulinsecretion Concentration amount(ng/mL) Compound No. (μmol/L) Avg se None— 51.2 11.3 7-640  10 138 4.3 7-1290 10 88.5 2.8 7-1398 10 118.2 5.9AY-4166   10 170.8 4.2 Glibenclamide 0.1 156.8 8.4

As shown in Table 4, it was revealed that the compounds of the presentinvention had insulin secretion action. Whilst as shown in Table 4, inthe presence of glucose at a low concentration (5 mmol/L), thesecompounds did not show marked secretion promoting action even at a 10times higher concentration. Glibenclamide (Pharmacotherapy, vol. 5, p.43, 1985) and AY-4166 (Yakuri to Rinsho, vol. 7, p. 121, 1997), used ascontrols for comparison showed marked secretion promoting action even ata low glucose concentration.

TEST EXAMPLE 2 Hyperglycemia Suppressing Action After Glucose Loading inNormal Rats

Wistar male rats (body weight: about 280 g) were used for the experimentafter starvation for 24 hours. A test compound was orally administeredto the rats 30 minutes before oral administration of glucose (2 g/kg).Blood was collected from a tail vein before the administration of thetest compound, and at 30, 60, 120, and 180 minutes after the glucoseloading. Blood glucose level was measured by using a simplified bloodsugar level measuring apparatus.

The results are shown in Table 5. TABLE 5 Plasma glucose Concentration(mg/dl) Dose (mg/kg, Compound po) n 0 min 30 min 60 min Control — 6 65 ±3.0 135 ± 7.9  145 ± 7.8  7-640  30 6 68 ± 2.4 121 ± 5.2* 121 ± 5.9*7-1398 30 6 65 ± 2.3 112 ± 6.3* 109 ± 4.9* 7-1290 30 6 69 ± 2.9 112 ±6.2* 107 ± 5.5* Dose (mg/kg, Compound po) n 120 min 180 min Control — 683 ± 2.4 73 ± 2.5 7-640  30 6 97 ± 2.6 77 ± 3.1 7-1398 30 6 98 ± 3.9 79± 4.1 7-1290 30 6 93 ± 1.5 79 ± 3.5

Significance; *P<0.05 (Student's t-test or Aspin-Welch test) Everycompound was used in the form of trihydrochloride in

the experiment.

As clearly shown in Table 5, the compound of the present inventionexhibited hyperglycemia suppressing action at 30 minutes and 60 minutesafter the glucose loading. However, the compound exhibited nohypoglycemic action at 120 minutes and 180 minutes after the glucoseloading.

Compound (I) or a pharmaceutically acceptable salt thereof has insulinsecretion promoting action in cultured β-cells and shows hypoglycemicaction in rats, and accordingly, Compound (I) or a pharmaceuticallyacceptable salt thereof is useful as an active ingredient of amedicament for preventing and/or treating diabetes. Further, Compound(I) or a pharmaceutically acceptable salt thereof is also useful as anactive ingredient of a medicament for preventing and/or treating variouscomplications of diabetes, for example, retinopathy, nephropathy,neuropathy or the like. As the active ingredient of these medicaments,one or more compounds selected from the group consisting of Compound (I)and pharmaceutically acceptable salts thereof, as well as hydratesthereof and solvates thereof can be used. Although the aforementionedsubstances, per se, can also be administered, it is generally desirableto provide the medicament in a form of a pharmaceutical compositioncomprising the aforementioned substance as the active ingredient and oneor more additives for pharmaceutical preparations. These medicaments canbe administered to humans and mammals other than humans.

The form of the pharmaceutical composition is not particularly limitedand an appropriate form most suitable for a purpose of therapeutic orpreventive treatment can be selected from forms of pharmaceuticalpreparations for oral or parenteral administration. Examples ofpharmaceutical preparations suitable for oral administration include,for example, tablets and the like. Examples of pharmaceuticalpreparations suitable for parenteral administration include, forexample, injections and the like. However, the preparations are notlimited to these examples.

For the preparation of solid preparations such as tablets, excipientssuch as lactose, mannitol and the like, disintegrating agents such asstarch and the like, lubricants such as magnesium stearate and the like,binders such as hydroxypropylcellulose and the like, surface activeagents such as fatty acid esters and the like, and plasticizers such asglycerin and the like may be used.

Pharmaceutical preparations for injection, which are suitable forparenteral administration, contain the aforementioned substance as theactive ingredient preferably in a sterilized aqueous medium isotonicwith blood of a recipient in a dissolved or suspended state. Forexample, as for injections, a solution can be prepared by using anaqueous medium consisting of saline, a glucose solution, a mixture ofsaline and a glucose solution, and the like. To these pharmaceuticalpreparations for parenteral administration, one or more auxiliaryingredients selected from glycols, oils, flavors, preservatives,excipients, disintegrating agents, lubricants, binders, surface activeagents, plasticizers, and the like may also be added.

Dose and frequency of administration of Compound (I) may preferably beincreased or decreased depending on various factors such as type andseverity of diseases, dosage form, conditions of a patient such as ageand body weight, and presence or absence of complications. In general,Compound (I) may preferably be administered in an amount of 1 to 1,000mg/kg per day for an adult dividedly as 3 or 4 times of administrations.

BEST MODE FOR CARRYING OUT THE INVENTION

The present invention will be more specifically explained with referenceto the following Examples. However, the scope of the present inventionis not limited to the following Examples. Compound numbers in thefollowing Examples correspond to the aforementioned compound numbersdefined in (a) to (m) as preferable compounds.

Physicochemical data of each compound in following Examples andReference Examples were measured by following apparatuses:

¹H-NMR: JEOL JNM-EX270 (270 MHz) or JEOL JNM-GX270 (270 MHz) MS:Micromass LCT or Micromass Quatro (measured by an APCI method or an ESImethod)

EXAMPLES 1

Compounds shown in above (a) to (e) were synthesized as follows:

Step 1: Synthesis of Compound (VIII)

To a mixture of Compound (VI) (0.5 mL, 0.1 mol/L chloroform suspension,0.05 mmol) obtained in Reference Examples 6 to 9 and1-hydroxybenzotriazole (0.2 mL, 0.25 mol/L solution inchloroform:tetrahydrofuran=3:1 mixture, 0.05 mmol) was added primary orsecondary amine [Compound (VII)] (0.065 mL, 1 mol/L chloroform solution,0.065 mmol) corresponding to R³R⁴N moiety. Polymer-boundN-ethyl-N′-[3-(dimethylamino)propyl]carbodiimide (70 mg, 0.1 mmol) wasthen added and the mixture was stirred at 55° C. overnight. Theresulting reaction solution was filtered and then concentrated. Beforefiltering the solution, if necessary, methanol or tetrahydrofuran wasadded to dissolve the precipitates. To the resulting residue, ethanol(0.6 mL) and Bio-Rad AG1-X8 OH-form resin (90 mg, 0.18 mmol) were addedand the mixture was stirred at 70° C. for 2 hours. Resin obtained byremoving the solution was washed with methanol (0.3 ml×3). The resultingresin was then suspended in a chloroform-methanol mixture (1:1, 0.5 mL),followed with addition of 4 mol/L solution of hydrogen chloride in ethylacetate (0.1 mL) and stirred at room temperature for 2 hours. Theresulting reaction solution was filtered and concentrated. The resultingresidue was dissolved in chloroform (0.5 mL), and to the mixture wasadded 4-polyvinylpyridine (23 mg, 0.22 mmol) or Bio-Rad AG1-X8 OH⁻ formresin (90 mg, 0.18 mmol) and was stirred at room temperature overnight.The reaction solution was filtered and concentrated to obtain Compound(VIII).

Step 2: Synthesis of Compound (I-A)

Compound (VIII) obtained in Step 1 was dissolved in tetrahydrofuran (0.2mL). To the solution were added triphenylphosphine (0.08 mL, 1 mol/Ltetrahydrofuran solution, 0.08 mmol) and alcohol [Compound (IX)] (0.08mL, 1 mol/L tetrahydrofuran solution, 0.08 mmol) corresponding to R⁵moiety, then diethyl azodicarboxylate (0.08 mL, 1 mol/L tetrahydrofuransolution, 0.08 mmol) was added and the mixture was stirred at roomtemperature overnight. The resulting reaction solution was passedthrough a Bondesil SCX column (Varian Inc.) and then eluted impuritieswith a chloroform-methanol mixture (50% v/v, 2.2 mL). Further, thetarget compound was eluted by 2 mol/L ammonia-methanol solution (1.6 mL)and the resulting solution was concentrated to obtain Compound (I-A)with yield of 30 to 40% in total.

The resulting compounds were identified by mass spectrometry. Thestructures and analytical results of each compound are the same asaforementioned (a) to (e).

The proton nuclear magnetic resonance spectra of typical compounds areshown below:

Compound 1-447

¹H-NMR (CDCl₃) δ (ppm) (main peaks): 0.94 (t, J=7.4 Hz, 3H), 1.6-1.8 (m,2H), 2.5-3.1 (m, 4H), 3.5-3.7 (m, 6H), 4.4-4.6 (m, 1H), 7.1-7.3 (m,10H).

Compound 1-1259

¹H-NMR (CDCl₃) δ (ppm): 0.95 (d, J=6.1 Hz, 3H) , 1.5-1.7 (m, 5H),2.8-2.95 (m, 2H), 3.25-3.35 (m, 2H), 3.7-3.85 (m, 2H), 3.85-4.0 (m, 2H),5.1-5.25 (m, 1H), 5.25-5.45 (m, 2H), 7.2-7.4 (m, 9H), 7.4-7.5 (br d,1H).

Compound 1-1279

¹H-NMR (CDCl₃) δ (ppm): 0.96 (d, J=6.3 Hz, 3H), 1.5-1.75 (m, 8H), 1.68(s, 3H), 1.75 (s, 3H), 2.1-2.2 (br s, 4H), 3.1-3.25 (m, 2H), 3.4-3.55(m, 2H), 4.0-4.2 (m, 3H), 4.4-4.5 (m, 2H), 4.8-4.95 (m, 1H), 4.95-5.1(m, 1H), 5.1-5.2 (m, 1H), 7.2-7.4 (m, 5H), 7.78 (s, 1H).

Compound 2-1

¹H-NMR (CDCl₃) δ (ppm): 0.93 (d, J=6.6 Hz, 3H), 0.94 (d, J=6.6 Hz, 6H),1.1-1.25 (m, 1H), 1.25-1.4 (m, 1H), 1.4-1.5 (m, 4H), 1.5-1.7 (m, 2H),1.60 (s, 3H), 1.67 (s, 3H), 1.9-2.05 (m, 2H), 2.82 (dd, J =7.1, 13.7 Hz,1H), 3.02 (dd, J=6.7, 13.7 Hz, 1H), 3.25-3.55 (m, 2H), 3.6-3.8 (m, 3H),3.90 (t, J=10.8 Hz, 1H), 4.45-4.6 (m, 1H), 5.0-5.1 (m, 1H), 7.15-7.35(m, 5H), 8.0 (br d, 1H), 9.20 (br s, 1H);

Compound 2-41

¹H-NMR (CDCl₃) δ (ppm): 0.3-0.4 (m, 2H) , 0.55-0.65 (m, 2H), 1.05-1.2(m, 1H), 1.45-1.7 (m, 1OH), 1.8-2.0 (m, 2H), 2.85 (dd, J=6.6, 13.6 Hz,1H), 2.98 (dd, J=7.1, 13.6 Hz, 1H), 3.5-3.7 (m, 3H), 3.85-4.0 (m, 1H),4.0-4.15 (m, 1H), 4.45-4.6 (m, 1H), 7.15-7.35 (m, 5H), 7.98 (s, 1H),9.2-9.35 (m, 1H).

Compound 2-42

¹H-NMR (CDCl₃) δ (ppm): 1.45-1.65 (m, 1OH) , 1.75 (s, 6H) 1.8-2.0 (m,2H), 2.84 (dd, J=6.6, 13.5 Hz, 1H), 2.96 (dd, J=6.6, 13.5 Hz, 1H),3.55-3.7 (m, 1H), 3.85-3.95 (m, 1H), 4.0-4.15 (m, 1H), 4.28 (d, J=7.3Hz, 2H), 4.45-4.6 (m, 1H), 5.15-5.25 (m, 1H), 7.2-7.35 (m, 5H), 7.88 (s,1H), 9.26 (br d, J=7.3 Hz, 1H).

Compound 2-45

¹H-NMR (CDCl₃) δ (ppm): 1. 35-1.7 (m, 1OH) , 1.75-2.0 (m, 4H), 2.5-2.65(m, 1H), 2.80 (dd, J=6.6, 13.5 Hz, 1H), 2.91 (dd, J=7.1, 13.5 Hz, 1H),3.46 (dd, J=5.3, 8.9 Hz, 1H), 3.55-3.75 (m, 5H), 3.8-3.9 (m, 2H),3.95-4.05 (m, 1H), 4.4-4.55 (m, 1H), 7.1-7.3 (m, 5H), 7.85 (br d, 1H),9.19 (d, J=7.9 Hz, 1H).

Compound 3-91

¹H-NMR (CDCl₃) δ (ppm): 0.96 (d, J=6.8 Hz, 3H), 1.02 (d, J=6.8 Hz, 3H),1.2-1.4 (m, 2H), 2.0-2.15 (m, 10H), 2.15-2.35 (m, 2H), 2.35-2.5 (m, 2H),2.5-2.6 (m, 4H), 3.5-3.7 (m, 3H), 3.8-4.2 (m, 3H), 4.55-4.65 (m, 2H),7.86 (s, 1H), 9.41 (s, 1H).

Compound 3-193

¹H-NMR (CDCl₃) δ (ppm): 0.8-1.0 (m, 8H), 1.1-1.35 (m, 4H), 1.6-1.8 (m,8H), 1.8-2.0 (m, 1H), 2.55-2.7 (m, 1H), 2.8-3.1 (m, 2H), 3.45-3.7 (m,2H), 3.8-4.0 (m, 1H), 5.45-5.6 (m, 1H), 7.2-7.4 (m, 4H), 7.9-8.0 (m,1H), 9.7-9.8 (m, 1H).

Compound 3-194

¹H-NMR (CDCl₃) δ (ppm): 0.8-0.95 (m, 6H) , 1.2-1.45 (m, 3H) 1.65-1.8 (m,4H), 2.0-2.15 (m, 4H), 2.55-2.7 (m, 1H), 2.8-3.1 (m, 2H), 3.5-3.75 (m,2H), 3.8-4.0 (m, 1H), 5.45-5.6 (m, 1H), 5.6-5.75 (m, 2H), 7.2-7.4 (m,4H), 7.9-8.0 (m, 1H), 9.7-9.8 (m, 1H).

EXAMPLE 2

Compounds shown in above (f) to (k) were synthesized by the methoddescribed below:

Step 1: Synthesis of Compound (XI)

To a mixture of Compound (X) (0.5 mL, 0.1 mol/L solution inchloroform:tetrahydrofuran=2:1 mixture, 0.05 mmol) obtained in ReferenceExamples 1 to 5 and 1-hydroxybenzotriazole (0.2 mL, 0.25 mol/L solutionin chloroform:tetrahydrofuran=2:1 mixture, 0.05 mmol) was added primaryor secondary amine [Compound (VII)] (0.065 mL, 1 mol/L chloroformsolution, 0.065 mmol) corresponding to R³R⁴N moiety. Polymer-boundN-ethyl-N′-[3-(dimethylamino)propyl]carbodiimide (70 mg, 0.1 mmol) wasthen added and the mixture was stirred at room temperature for 24 hours.The resulting reaction solution was filtered and then concentrated.Before filtering the solution, if necessary, methanol was added todissolve the precipitates. The resulting residue was dissolved inchloroform (0.6 mL), and then 4-polyvinylpyridine (23 mg, 0.22 mmol) andpolymer-bound benzoyl chloride (23 mg, 0.05 mmol) were added. Themixture was stirred at room temperature overnight. The reaction solutionwas filtered and concentrated to obtain Compound (XI).

Step 2: Synthesis of Compound (XII)

Compound (XI) obtained in Step 1 was dissolved in chloroform (0.2 mL),and to the solution was added thionyl chloride (0.1 mL, 1 mol/Lchloroform solution, 0.1 mmol). The solution was hermetically sealed andstirred at 60° C. for 6 hours. To the resulting residue obtained byconcentrating the reaction solution were added chloroform (0.6 mL) and4-polyvinylpyridine (23 mg, 0.22 mmol) and the mixture was stirred at65° C. overnight. The resulting reaction solution was filtered andconcentrated to obtain Compound (XII).

Step 3: Synthesis of Compound (I-B)

Compound (XII) obtained in Step 2 was dissolved in tetrahydrofuran (0.2mL) and to the solution was added primary or secondary amine [Compound(XIII)] (0.06 mL, 1 mol/L chloroform solution, 0.06 mmol) correspondingto R⁶R⁷N moiety and the mixture was stirred at a temperature between 70°C. to 75° C. for 3 days. Further, to the solution were added, chloroform(0.4 mL), 4-polyvinylpyridine (23 mg, 0.22 mmol) and polymer-boundbenzoyl chloride (23 mg, 0.05 mmol), and the mixture was stirred at roomtemperature overnight. If a precipitate was observed, methanol was addedto the solution to completely dissolve the precipitate and then thereaction solution was filtered and concentrated to obtain Compound (I-B)with yield of 50 to 60% in total.

The resulting compounds were identified by mass spectrometry. Thestructures and analytical results of each compound are the same asaforementioned (f) to (k).

The proton nuclear magnetic resonance spectra of typical compounds areshown below:

Compound 7-31

¹H-NMR (CDCl₃) δ (ppm): 0.89 (t, J=6.6 Hz, 3H), 1.2-1.4 (m, 7H),1.45-1.7 (m, 4H), 1.75-1.95 (m, 2H), 1.95-2.3 (m, 6H), 2.8-3.4 (m, 5H),3.45-3.75 (m, 4H), 4.55-4.7 (m, 2H), 4.85-5.0 (m, 1H), 7.15-7.4 (m, 5H),8.60 (br s, 1H), 8.92 (br s, 1H), 9.29 (br s, 1H).

Compound 7-251

¹H-NMR (CDCl₃) δ (ppm): 0.92 (d, J=6.2 Hz, 6H), 1.2-1.3 (m, 3H), 1.3-1.7(m, 5H), 1.75-1.95 (m, 2H), 1.95-2.3 (m, 6H), 2.8-3.4 (m, 5H), 3.45-3.75(m, 4H), 4.55-4.7 (m, 2H), 4.8-5.0 (m, 1H), 7.15-7.4 (m, 5H), 8.58 (brs, 1H), 8.92 (br s, 1H), 9.29 (br s, 1H).

Compound 7-258

¹H-NMR (CDCl₃) δ (ppm): 1.2-1.3 (m, 3H) , 1.3-1.4 (m, 1H) 1.45-1.55 (m,2H), 1.7-1.9 (m, 4H), 1.9-2.1 (m, 1H), 2.1-2.3 (m, 2H), 2.9-3.2 (m, 5H),3.4-3.75 (m, 4H), 4.4-4.5 (m, 2H), 4.5-4.7 (m, 2H), 4.8-5.0 (m, 1H),7.15-7.35 (m, 8H), 7.41 (s, 1H), 8.87 (br s, 1H), 9.39 (br s, 1H), 9.55(br s, 1H).

Compound 7-713

¹H-NMR (CDC1₃) δ (ppm): 1.2-1.3 (m, 3H), 1.3-1.4 (m, 1H), 1.45-1.55 (m,2H), 1.65-2.05 (m, 6H), 2.05-2.3 (m, 4H), 2.45-2.6 (m, 1H), 2.8-3.25 (m,3H), 3.5-3.75 (m, 4H), 4.5-4.7 (m, 2H), 4.8-5.0 (m, 1H), 5.45-5.6 (m,1H), 7.1-7.4 (m, 9H), 8.0-8.2 (m, 1H), 8.85 (br s, 1H), 9.0-9.2 (m, 1H)

Compound 7-785

¹H-NMR (CDCl₃) δ (ppm): 1.2-1.3 (m, 3H) , 1.3-1.4 (m, 1H), 1.45-1.55 (m,2H), 1.7-1.9 (m, 4H), 1.9-2.1 (m, 1H), 2.1-2.3 (m, 2H), 2.9-3.2 (m, 3H),3.5-3.75 (m, 4H), 4.5-4.7 (m, 4H), 4.85-5.0 (m, 1H), 6.8-6.9 (m, 2H),7.15-7.35 (m, 6H), 8.45-8.6 (m, 1H) , 8.80 (s, 1H) , 9.10 (br s, 1H)

Compound 7-892

¹H-NMR (CDCl₃) δ (ppm): 1.2-1.45 (m, 6H), 1.65-1.85 (m, 2H), 2.15-2.35(m, 2H), 2.9-3.2 (m, 4H), 3.25-3.45 (m, 1H), 3.6-3.8 (m, 3H), 4.55-4.75(m, 4H), 4.85-5.0 (m, 1H), 7.15-7.35 (m, 6H), 7.45-7.6 (m, 2H), 7.63 (d,J=7.6 Hz, 1H), 8.75-8.9 (m, 2H), 9.22 (br s, 1H).

Compound 7-893

¹H-NMR (CDCl₃) δ (ppm): 1.2-1.3 (m, 3H) , 1.3-1.4 (m, 1H) 1.5-1.6 (m,2H), 1.7-1.9 (m, 4H), 1.95-2.1 (m, 1H), 2.15-2.35 (m, 2H), 2.9-3.25 (m,3H), 3.5-3.8 (m, 4H), 4.55-4.75 (m, 4H), 4.8-5.0 (m, 1H), 7.15-7.35 (m,6H), 7.4-7.55 (m, 2H), 7.62 (d, J=7.6 Hz, 1H), 8.82 (br s, 1H), 8.95-9.1(m, 1H), 9.27 (br s, 1H).

Compound 7-1454

¹H-NMR (CDCl₃) δ (ppm): 2.8-2.9 (m, 1H), 2.94 (t, J=6.3 Hz, 2H),3.15-3.25 (m, 1H), 3.55-3.65 (m, 2H), 3.65-3.9 (m, 2H), 3.89 (s, 3H),4.55-4.65 (m, 1H), 4.75-4.85 (m, 2H), 6.28 (br s, 1H), 6.34 (br s, 1H),6.9-7.0 (m, 3H), 7.15-7.35 (m, 7H), 8.33 (s, 1H), 8.68 (br s, 1H).

Compound 11-60

¹H-NMR (CDCl₃) δ (ppm): 0.8-0.95 (m, 6H), 2.3-2.4 (m, 1H), 2.33 (s, 3H),2.85-2.95 (m, 4H), 3.5-3.75 (m, 6H), 3.95-4.1 (m, 1H), 6.8-7.3 (m, 8H),8.85 (s, 1H).

Compound 11-70

¹H-NMR (CDCl₃) δ (ppm): 0.8-1.0 (m, 6H) , 2.3-2.4 (m, 1H), 2.37 (s, 3H),2.90 (t, J=6.9 Hz, 2H), 3.5-3.85 (m, 4H), 3.82 (s, 3H), 4.0-4.15 (m,1H), 4.66 (s, 2H), 6.8-6.9 (m, 2H), 7.15-7.35 (m, 6H), 8.31 (s, 1H).

EXAMPLE 3

Compounds shown in above (l) and (m) were synthesized by the methoddescribed below:

Step 1: Synthesis of Compound (XVI)

To compound (XV) (0.1 mol/L chloroform solution, 0.50 mL, 0.050 mmol)obtained in Reference Example 10 or 11 were added, Compound (VII) (1mmol/L chloroform solution, 0.065 mL, 0.065 mmol) represented by R³R⁴NH,1-hydroxybenzotriazole (0.20 mL, 0.25 mol/L solution inchloroform:tetrahydrofuran=3:1 mixture, 0.050 mmol) and polymer-boundN-ethyl-N′-[3-(dimethylamino)propyl]carbodiimide (70 mg, 0.1 mmol), andthe mixture was stirred at a temperature between 50° C. and 55° C. for20 hours. The resin in the reaction mixture was separated by filtrationand after resulting resin was washed with chloroform (1.8 mL), organiclayers were all collected together, and the solvent was then evaporated.The residue was dissolved in chloroform (0.60 mL), and thenpolyvinylpyridine (23 mg, 0.22 mmol) and polymer-bound benzoyl chloride(23 mg, 0.05 mmol) were added. The mixture was stirred at roomtemperature for one day. The resin in the reaction mixture was separatedby filtration and the resulting resin was washed with achloroform-methanol mixture (3:1, 1.8 mL). Organic layers were allcollected together, and the solvent was then evaporated to obtainCompound (XVI).

Step 2: Synthesis of Compound (XVII)

Total amount of compound (XVI) obtained in step 1 was dissolved inchloroform (0.50 mL), and to the solution was added thionyl chloride(0.005 mL). The solution was stirred at room temperature overnight.After confirming the completion of reaction by thin layerchromatography, the solvent was evaporated to obtain Compound (XVII).

Step 3: Synthesis of Compound (I-C)

Total amount of compound (XVII) obtained in Step 2 was dissolved inchloroform (0.50 mL), and to the solution were added(cyanomethylene)triphenylphosphorane (1 mmol/L toluene solution, 0.10mL, 0.10 mmol) and Compound (XIIIa) (1 mol/L chloroform solution, 0.10mL, 0.10 mmol) represented by R^(6a)R^(7a)NH. The mixture was stirred at50° C. overnight. After confirming the completion of reaction by thinlayer chromatography, the solvent was evaporated. The residue wasdissolved in chloroform (0.70 mL), and to the solution were addedpolyvinylpyridine (23 mg, 0.22 mmol) and polymer-bound benzoyl chloride(23 mg, 0.05 mmol). The solution was hermetically sealed and stirred atroom temperature for one day. The resin in the reaction mixture wasseparated by filtration and after resulting resin was washed with achloroform-methanol mixture (3:1, 1.8 mL), organic layers were allcollected together, and the solvent was then evaporated to obtainCompound (I-C).

The resulting compounds were identified by mass spectrometry. Thestructures and analytical results of each compound are the same asaforementioned (l) and (m).

REFERENCE EXAMPLE 1(S)-4-(1-hydroxymethyl-2-phenylethylamino)-2-methylthiopyrimidine-5-carboxylicacid

To a solution of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate(25.0 g, 107 mmol) in tetrahydrofuran (100 mL) was added triethylamine(29.9 mL, 215 mmol) under ice-cooling, then a solution of(S)-(−)-2-amino-3-phenyl-1-propanol (16.6g, 110 mmol) in tetrahydrofuran(150 mL) was added. The reaction solution was stirred at roomtemperature overnight. Ethyl ester of the titled compound (37.8 g,quantitative yield) was obtained by adding the reaction solution towater (1,000 mL), stirring the solution to collect deposited salt byfiltration and drying under reduced pressure.

The resulting ethyl ester (30.0 g, 86.4 mmol) was dissolved in a mixedsolvent of ethanol (300 mL) and tetrahydrofuran (150 mL), then aqueoussodium hydroxide solution (2 mol/L, 100 mL) was added and stirred atroom temperature for 2 hours. The residue obtained by evaporating thesolvent under reduced pressure was dissolved in water and was adjustedto pH 5 with 2 mol/L hydrochloric acid. The deposited crystals werecollected by filtration and dried under reduced pressure to obtain thetitled compound (27.9 g, quantitative yield).

¹H-NMR (DMSO-d₆) δ (ppm): 2.49 (s, 3H) , 2.85-2.95 (m, 2H) 3.45-3.55 (m,2H), 4.4-4.55 (m, 1H), 4.85-5.05 (m, 1H), 7.1-7.3 (m, 5H), 8.49 (s, 1H),8.64 (d, J=8.3 Hz, 1H).

IR (KBr tablet): 1658, 1583, 1495, 1373, 1284, 1271, 1176 cm⁻¹

Melting point (H₂O): 162-164° C.

APCI-MS m/z 320 ([M+H]⁺).

Elemental analysis Calcd. for C₁₅H₁₇N₃O₃S 0.5 H₂O: C, 54.86; H, 5.52; N,12.80. Found: C, 54.89; H, 5.44; N, 12.73.

The other enantiomer [(R)-form] of this compound was synthesized byusing the corresponding amine [(R)-form] in the same manner. Theanalytical data of (R)-form of title compound was completely identicalto those of (S)-form.

In Reference Examples 2 to 5, target compounds were obtained insubstantially the same manner as Reference Example 1 by usingcorresponding amines instead of (S)-(−)-2-amino-3-phenyl-1-propanol.

REFERENCE EXAMPLE 2(s)-4-(2-cyclohexyl-1-hydroxymethylethylamino)-2-methylthiopyrimidine-5-carboxylicacid

¹H-NMR (DMSO-d₆) δ (ppm): 0.8-1.05 (m, 2H), 1.05-1.35 (m, 4H), 1.35-1.55(m, 2H), 1.55-1.75 (m, 4H), 1.75-1.9 (m, 1H), 2.46 (s, 3H), 3.45-3.65(m, 2H), 4.3-4.5 (m, 1H), 4.7-4.9 (m, 1H), 8.44 (d, J=8.2 Hz, 1H), 8.50(s, 1H).

IR (KBr tablet): 1683, 1581, 1383, 1172 cm⁻¹

Melting point (H₂O): 170-173° C.

APCI-MS m/z 326 ([M+H]⁺).

Elemental analysis Calcd. for C₁₅H₂₃N₃O₃S 0.3 H₂O: C, 54.46; H, 7.19; N,12.70. Found: C, 54.55; H, 6.99; N, 12.64.

REFERENCE EXAMPLE 34-[1-hydroxymethyl-2-(4-methoxyphenyl)ethylamino]-2-methylthiopyrimidine-5-carboxylicacid

¹H-NMR (DMSO-d₆) δ (ppm): 2.48 (s, 3H), 2.75-2.85 (m, 2H), 3.4-3.5 (m,2H), 3.71 (s, 3H), 4.3-4.45 (m, 1H), 5.02 (br s, 1H), 6.83 (d, J=8.6 Hz,2H), 7.15 (d, J=8.6 Hz, 2H), 8.49 (s, 1H) , 8.59 (d, J=8.2 Hz, 1H).

IR (KBr tablet): 1606, 1576, 1512, 1379, 1248, 1198 cm⁻¹

Melting point (H₂O—CH₃OH) : 165-167° C.

APCI-MS m/z 350 ([M+H]⁺).

Elemental analysis Calcd. for C₁₆H₁₉N₃O₄S 2.4 H₂O: C, 48.94; H, 6.11; N,10.70. Found: C, 48.88; H, 5.61; N, 10.70.

REFERENCE EXAMPLE 44-(2-hydroxy-1,1-dimethylethylamino)-2-methylthiopyrimidine-5-carboxylicacid

¹H-NMR (DMSO-d₆) δ (ppm): 1.44 (s, 6H), 2.50 (s, 3H), 3.62 (s, 2H), 4.88(br s, 1H), 8.51 (s, 1H), 8.70 (s, 1H).

IR (KBr tablet): 1653, 1628, 1596, 1576, 1296, 1173 cm⁻¹

Melting point (H₂O): 227-229° C.

APCI-MS m/z 258 ([M+H]⁺).

Elemental analysis Calcd. for C₁₀H₁₅N₃O₃S 0.5 H₂O: C, 45.10; H, 6.06; N,15.78. Found: C, 45.08; H, 5.85; N, 15.58.

REFERENCE EXAMPLE 5(R)-4-(1-hydroxymethyl-2-methylpropylamino)-2-methylthiopyrimidine-5-carboxylicacid

¹H-NMR (CDCl₃) δ (ppm): 0.85-1.05 (m, 6H), 1.9-2.1 (m, 1H), 2.54 (s,3H), 3.7-3.8 (m, 1H), 3.9-4.0 (m, 1H), 4.05-4.2 (m, 1H), 8.78 (br s,1H), 9.28 (br s, 1H).

IR (KBr tablet): 1693, 1604, 1597, 1390, 1281, 1174 cm⁻¹

Melting point (CH₃OH): 123-125° C.

APCI-MS m/z 272 ([M+H]⁺).

Elemental analysis Calcd. for C₁₁H₁₇N₃O₃S 2.3 H₂O: C, 42.24; H, 6.96; N,13.43. Found: C, 42.10; H, 5.74; N, 13.27.

REFERENCE EXAMPLE 6(S)-2-benzyl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-c]pyrimidine-8-carboxylicacid

To a solution of ethyl ester of(S)-4-(1-hydroxymethyl-2-phenylethylamino)-2-methylthiopyrimidine-5-carboxylicacid (27.4 g, 79.0 mmol), obtained in the initial stage of ReferenceExample 1, in chloroform (270 mL) was added thionyl chloride (17.3 mL,237 mmol), and the mixture was heated under reflux for 7.5 hours. Theresulting reaction solution was concentrated under reduced pressure. Tothe resulting residue were added, chloroform (220 mL), water (60 mL) andpotassium carbonate (43.7 g, 316 mmol), and the mixture was then heatedunder reflux for 24 hours. The chloroform layer was separated from theresulting reaction solution and then concentrated under reducedpressure. To the resulting residue were added, the aqueous layerseparated from the reaction solution, ethanol (200 mL) and potassiumcarbonate (10.9 g, 79.0 mmol), and the mixture was then heated underreflux for 20 hours. Potassium carbonate (10.9 g, 79.0 mmol) was furtheradded to the reaction solution, and the mixture was then heated underreflux for 5 hours. The resulting reaction solution was thenconcentrated under reduced pressure. The resulting residue was dissolvedin water and washed with chloroform. The aqueous layer was adjusted topH 5 to collect deposited crystals by filtration and then was driedunder reduced pressure to obtain the titled compound (18.8 g, a totalyield of 88%).

¹H-NMR (DMSO-d₆) δ (ppm): 2.93 (dd, J=7.9, 13.5 Hz, 1H), 3.10 (dd,J=4.3, 13.5 Hz, 1H), 3.77 (dd, J=6.3, 12.2 Hz, 1H), 3.96 (dd, J=10.3,12.2 Hz, 1H), 4.4-4.5 (m, 1H), 7.2-7.4 (m, 5H), 8.40 (s, 1 H).

The other enantiomer [(R)-form] of this compound was synthesized byusing an ethyl ester prepared from the corresponding amine [(R)-form] asin the initial stage of Reference Example 1. The analytical data of the(R)-form was completely identical to those of (S)-form.

In following Reference Examples 7 to 9, target compounds were obtainedin substantially the same manner as in Reference Example 6 by usingcorresponding esters instead of ethyl ester of(S)-4-(1-hydroxymethyl-2-phenylethylamino)-2-methylthiopyrimidine-5-carboxylicacid.

REFERENCE EXAMPLE 7(S)-2-isopropyl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-c]pyrimidine-8-carboxylicacid

¹H-NMR (DMSO-d₆) δ (ppm): 0.89 (d, J=6.9 Hz, 3H), 0.94 (d, J=6.9 Hz,3H), 1.95-2.1 (m, 1H), 3.81 (dd, J=11.9, 17.2 Hz, 1H), 4.0-4.15 (m, 2H),8.47 (s, 1H)

REFERENCE EXAMPLE 8(s)-2-(cyclohexylmethyl)-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-c]pyrimidine-8-carboxylicacid

¹ H-NMR (DMSO-d₆) δ (ppm): 0.85-1.05 (m, 2H) , 1.1-1.3 (m, 3H), 1.3-1.55(m, 2H), 1.55-1.8 (m, 6H), 3.55-3.75 (m, 1H), 4.1-4.3 (m, 2H), 8.45 (s,1H).

REFERENCE EXAMPLE 92,2-dimethyl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-c]pyrimidine-8-carboxylicacid

¹H-NMR (DMSO-d₆) δ (ppm): 1.42 (s, 6H), 3.79 (s, 2H), 8.45 (s, 1H).

REFERENCE EXAMPLE 10(S)-6-chloro-2-(1-hydroxymethyl-2-phenylethylamino)nicotinic acid

Commercially available 2,6-dichloronicotinic acid (30.0 g, 156 mmol) wasdissolved in dioxane (500 mL), and then to the solution were added(S)-(−)-2-amino-3-phenyl-1-propanol (35.43 g, 234 mmol, 1.5 equivalent)and triethylamine (65.3 mL, 469 mmol). The mixture was heated underreflux for 3 days. To the reaction mixture was added water, and themixture was extracted with chloroform, then resulting organic layer waswashed with water and dried over anhydrous sodium sulfate. The resultingresidue, obtained after the evaporation of the solvent, was purifiedwith silica gel column chromatography (chloroform:methanol:aceticacid=10:1:0.1) to obtain yellow crystals of the titled compound (28.1 g.91.6 mmol, a yield of 59%).

¹H-NMR (DMSO-d₆) δ (ppm): 2.82 (m, 2H), 3.2-3.7 (2H, overlapped peakwith others), 4.14 (m, 1H), 4.41 (br s, 1H), 6.44 (d, J=7.8 Hz, 1H),7.1-7.4 (m, 5H), 8.06 (d, J=7.9 Hz, 1H), 9.38 (br s, 1H).

REFERENCE EXAMPLE 11(R)-6-chloro-2-(1-hydroxymethyl-2-phenylethylamino)nicotinic acid

Commercially available 2,6-dichloronicotinic acid (30.0 g, 156 mmol) wasdissolved in dioxane (500 mL), and then to the solution were added(R)-(+)-2-amino-3-phenyl-1-propanol (35.43 g, 234 mmol, 1.5 equivalents)and triethylamine (65.3 mL, 469 mmol). The mixture was heated underreflux for 6 days. To the reaction mixture was added water, and themixture was extracted with chloroform, then resulting organic layer waswashed with water and dried over anhydrous sodium sulfate. After thesolvent was evaporated, n-hexane:ethyl acetate (3:1) was added andevaporated again to obtain yellow crystals of the titled compound (35.8g. 117 mmol, a yield of 75%).

¹H-NMR (DMSO-d₆) δ (ppm): 2.86 (m, 2H), 3.1-3.6 (2H, overlapped peakwith others), 4.24 (m, 1H), 5.0 (br s, 1H), 6.59 (d, J=8.1 Hz, 1H),7.1-7.3 (m, 5H), 8.02 (d, J=8.1 Hz, 1H), 10.45 (d, J=7.9 Hz, 1H)

INDUSTRIAL APPLICABILITY

According to the present invention, heterobicyclic compounds orpharmaceutically acceptable salts thereof, which have glucoseconcentration-dependent insulin secretion promoting action orhypoglycemic action and is useful as a therapeutic agent for diabetes orthe like, are provided.

1. A compound represented by formula (I):

{wherein X—Y-Z represents R⁵N—C═O (wherein R⁵ represents a hydrogenatom, substituted or unsubstituted lower alkyl, substituted orunsubstituted aralkyl, substituted or unsubstituted lower alkenyl, orsubstituted or unsubstituted lower alkynyl), N═C—NR⁶R⁷ [wherein R⁶ andR⁷ may be the same or different and each represents a hydrogen atom,substituted or unsubstituted lower alkyl, substituted or unsubstitutedaralkyl, substituted or unsubstituted lower alkenyl, substituted orunsubstituted lower alkynyl, substituted or unsubstituted aryl, or asubstituted or unsubstituted heterocyclic group; or R⁶ and R⁷ arecombined together with the adjacent nitrogen atom thereto to form:

(wherein n represents an integer of 1 to 3; W represents —CH₂—, —CH═CH—,—NH—, a sulfur atom, or an oxygen atom; and R⁸ and R⁹ may be the same ordifferent and each represents a hydrogen atom, substituted orunsubstituted lower alkyl, substituted or unsubstituted aralkyl,substituted or unsubstituted aryl, a substituted or unsubstitutedheterocyclic group, substituted or unsubstituted lower alkoxycarbonyl,substituted or unsubstituted lower alkanoyl, substituted orunsubstituted aroyl, substituted or unsubstituted heteroaroyl, a halogenatom, amino, nitro, cyano, hydroxy, oxo, carboxy, carbamoyl, mono ordi(substituted or unsubstituted lower alkyl)amino, substituted orunsubstituted lower alkanoylamino, substituted or unsubstituted loweralkoxy, substituted or unsubstituted aralkyloxy, or substituted orunsubstituted lower alkanoyloxy)], or C═C—NR^(6a)R^(7a) (wherein R^(6a)and R^(7a) have the same meanings as R⁶ and R⁷ defined above,respectively); R¹ and R² may be the same or different and eachrepresents a hydrogen atom, substituted or unsubstituted lower alkyl,substituted or unsubstituted aralkyl, substituted or unsubstituted loweralkenyl, substituted or unsubstituted lower alkynyl, substituted orunsubstituted aryl, a substituted or unsubstituted heterocyclic group, ahalogen atom, carboxy, substituted or unsubstituted loweralkoxycarbonyl, or C(═O)—NR^(6b)R^(7b) (wherein R^(6b) and R^(7b) havethe same meanings as R⁶ and R⁷ defined above, respectively); and R³ andR⁴ may be the same or different and each represents a hydrogen atom,substituted or unsubstituted lower alkyl, substituted or unsubstitutedlower alkenyl, substituted or unsubstituted aralkyl, or a substituted orunsubstituted heterocyclic group; or R³ and R⁴ are combined togetherwith the adjacent nitrogen atom thereto to form:

(wherein na, W^(a), R^(8a) and R^(9a) have the same meanings as n, W, R⁸and R⁹ defined above, respectively)}, or a pharmaceutically acceptablesalt thereof.
 2. The compound or the pharmaceutically acceptable saltthereof according to claim 1, wherein X—Y-Z is R⁵N—C═O (wherein R⁵ hasthe same meaning as defined above).
 3. The compound or thepharmaceutically acceptable salt thereof according to claim 1, whereinX—Y-Z is N═C—NR⁶R⁷ (wherein R⁶ and R⁷ have the same meanings as definedabove, respectively).
 4. The compound or the pharmaceutically acceptablesalt thereof according to claim 3, wherein R⁶ and R⁷ are not hydrogenatoms simultaneously.
 5. The compound or the pharmaceutically acceptablesalt thereof according to claim 3, wherein R⁶ is a hydrogen atom and R⁷is substituted or unsubstituted pyrrolidinyl.
 6. The compound or thepharmaceutically acceptable salt thereof according to claim 1, whereinX—Y-Z is C═C—NR^(6a)R^(7a) (wherein R^(6a) and R^(7a) have the samemeanings as defined above, respectively).
 7. The compound or thepharmaceutically acceptable salt thereof according to claim 6, whereinR^(6a) and R^(7a) are not hydrogen atoms simultaneously.
 8. The compoundor the pharmaceutically acceptable salt thereof according to claim 1,wherein either R¹ or R² is a hydrogen atom and the other is substitutedor unsubstituted lower alkyl, or substituted or unsubstituted aralkyl;or R¹ and R² may be the same or different and each is substituted orunsubstituted lower alkyl.
 9. The compound or the pharmaceuticallyacceptable salt thereof according to claim 1, wherein R¹ is a hydrogenatom and R² is aralkyl.
 10. The compound or the pharmaceuticallyacceptable salt thereof according to claim 1, wherein R³ is a hydrogenatom and R⁴ is lower alkyl.
 11. The compound or the pharmaceuticallyacceptable salt thereof according to claim 1, wherein R³ is a hydrogenatom and R⁴ is substituted or unsubstituted aralkyl.
 12. Apharmaceutical composition which comprises the compound or thepharmaceutically acceptable salt thereof according to claim
 1. 13. Apreventive and/or therapeutic agent for diabetes, which comprises thecompound or the pharmaceutically acceptable salt thereof according toclaim
 1. 14. A preventive and/or therapeutic agent for complication ofdiabetes, which comprises the compound or the pharmaceuticallyacceptable salt thereof according to claim
 1. 15. An insulin secretionpromoter which comprises the compound or the pharmaceutically acceptablesalt thereof according to claim
 1. 16. A hypoglycemic agent whichcomprises the compound or the pharmaceutically acceptable salt thereofaccording to claim
 1. 17. A method for preventing and/or treatingdiabetes, which comprises administering an effective amount of thecompound or the pharmaceutically acceptable salt thereof according toclaim
 1. 18. A method for preventing and/or treating a complication ofdiabetes, which comprises administering an effective amount of thecompound or the pharmaceutically acceptable salt thereof according toclaim
 1. 19. A method for promoting insulin secretion, which comprisesadministering an effective amount of the compound or thepharmaceutically acceptable salt thereof according to claim
 1. 20. Amethod for decreasing blood glucose level, which comprises administeringan effective amount of the compound or the pharmaceutically acceptablesalt thereof according to claim
 1. 21-24. (canceled)